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Methyl gallate isolated from Mangifera pajang kernel induces proliferation inhibition and apoptosis in MCF-7 breast cancer cells via oxidative stress

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Asian Pacific Journal of Tropical Biomedicine 2022年第4期12卷 175-184页

作者： Ranneh Yazan Abu Bakar Mohd Fadzelly Rahim Azlen-Che kassim nur kartinee Stanslas Johnson Teh Yuan-Han Fadel Abdulmannan Ellulu Mohammed S Department of Technology and Natural Resources Faculty of Applied Science and TechnologyUniversiti Tun Hussein Onn MalaysiaPagoh CampusKM1 Panchor RoadMuar JohorMalaysia Department of Chemistry Faculty of ScienceUniversiti Putra MalaysiaSerdang 43300Malaysia Department of Medicine Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaSelangorMalaysia Sport and Exercises Sciences School Faculty of ScienceLiverpool John Moores UniversityLiverpoolUK Department of Clinical Nutrition Faculty of Applied Medical SciencesAl-Azhar University of GazaGaza CityState of Palestine

Objective:To determine the lead bioactive compound in kernel extract of Mangifera pajang and its anti-cancer activity against human breast cancer cell lines with positive estrogen receptor(MCF-7).Methods:The methanolic extract of dried powder kernel of Mangifera pajang was exposed to column chromatography for *** structural elucidation of the isolated compound was characterized using infrared,nuclear magnetic resonance,mass ***,cytotoxicity,morphological changes,flow cytometry and cell cycle arrest analyses were performed to examine the mechanism of anti-proliferation and apoptosis induced by methyl gallate against ***:One compound was isolated from the methanolic extract of Mangifera pajang kernel and identified as methyl *** flow cytometric results demonstrated induction of apoptosis in MCF-7 cells by three concentrations of methyl *** cell cycle arrest showed a significant(P<0.05)decrease in cell progression at G2/M phase of MCF-7 after treatment with 100μM of methyl *** cell percentage of early and late apoptosis was significant at 10 and 100μM of methyl ***,methyl gallate treatment induced up-regulation of reactive oxygen species levels in MCF-7 cells with a reduction in superoxide dismutase ***:These findings indicate that isolated methyl gallate from Mangifera pajang kernel extracts induces growth inhibition and apoptosis in MCF-7 cells via up-regulating oxidative stress pathway.

关键词： Mangifera pajang Methyl gallate Breast cancer Cell cycle Apoptosis Oxidative stress

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The Measurement of Antioxidant Capacity of Melicope glabra by ORAC-FL and DPPH and its Chemical Constituents

The Measurement of Antioxidant Capacity of Melicope glabra b...

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2012 3rd International Conference on Chemistry and Chemical Engineering

作者： nur kartinee kassim Mawardi Rahmani Amin Ismail Aminah Abdullah Khalid Hamid Musa Chemistry Department Faculty of ScienceUniversiti Putra Malaysia43400 UPM SerdangSelangorMalaysia Department of Nutrition and Dietetics Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400 UPM SerdangSelangorMalaysia School of Chemical Sciences and Food Technology Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 UKMBangiSelangorMalaysia

The hexane,ethyl acetate and methanol extracts from bark of Melicope glabra were evaluated for their antioxidant capacity by measuring DPPH free radical scaveging activity and their oxygen radical absorbance capacity （ORAC）.Both ethyl acetate and methanol extracts showed strong antioxidant capacity against DPPH and ORAC *** DPPH scaveging activity assay,the IC 50 values of 24.81 μg/mL and 13.01 μg/mL were obtained for ethyl acatate and methanol,*** ORAC values （μmolTE/kg） quantified for ethyl acetate and methanol extracts were 190160 and 272760,*** IC 50 value recorded for hexane extract was higher than 500 μg/mL,thus no further chemical and biological investigations were performed on hexane *** assay guided isolation of ethyl acetate and methanol extracts by various column chromatography techniques revealed that two known coumarins and one lignan present in both *** structural identification by detail spectroscopic methods showed the structures as umbelliferone （1）,sopoletin （2） and sesamin（3）.These compounds were first time reported to be isolated from this *** data were compared to the literature values published earlier.

关键词： Dpph Melicope Glabra Orac Scopoletin Sesamin Umbelliferone

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Contribution of public places in proliferation of dengue vectors in Penang Island,Malaysia

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Asian Pacific Journal of Tropical Biomedicine 2017年第3期7卷 183-187页

作者： Alhaji Hamisu Maimusa Abu Hassan Ahmad nur Faeza Abu kassim Hamdan Ahmad Hamady Dieng Junaid Rahim School of Biological Sciences Universiti Sains Malaysia11800Pulau PinangMalaysia Vector Control Research Unit School of Biological SciencesUniversiti Sains Malaysia11800Pulau PinangMalaysia Institute of Biodiversity and Environmental Conservation Universiti Malaysia Sarawak94300Kota SamarahanSarawakMalaysia

Objective: To determine abundance, distribution and diversity of potential breeding container habitats of the dengue vectors in public places including schools, restaurants,mosques and parks in southwest areas of Penang Island, ***: Premises at restaurants, schools, parks and mosques were surveyed simultaneously and inspected visually for container habitats and production of immature mosquitoes from March 2015 to March 2016. Abundance(mean ± SE) of breeding containers between sites was compared using One-way ANOVA. Independent sample ttest was used to compare total number of Aedes albopictus(Ae. albopictus) and Aedes aegypti(Ae. aegypti) ***: The surveyed locations yielded a total of 3 741 breeding containers and 19 537 immature mosquitoes from four areas. Concurrent artificial and natural containers produced 78.4% immature Ae. albopictus and 6.3% Ae. aegypti mosquitoes in wet season,with 14.2% Ae. albopictus and 1.1% Ae. aegypti mosquitoes in dry season. Artificial containers accounted for 98.1% of the total containers recorded, with restaurants being the most productive locations(8 012) and schools being the least productive(2 234).Conclusions: It was concluded that public places are good sources of potential container habitats of Aedes mosquitoes in Penang Island, Malaysia and Ae. albopictus has exclusively replaced the home-grown Ae. aegypti even in urban areas. Therefore, treatment of artificial containers in such locations is critical in Aedes mosquito control campaigns during dengue outbreaks.

关键词： Public places Breeding containers Abundance Aedes albopictus Aedes aegypti

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Performance Characterization of the Hydrophilic SiO2/TiO2 Double Layers Using a Sol-gel Dip Coating Method for Automotive Glass Applications

Performance Characterization of the Hydrophilic SiO2/TiO2 Do...

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International Conference on Environment and Industrial Innovation（ICEII 2011）

作者： Muhammad Zahiruddin Bin Ramli nur Fadzeelah Abu kassim nurulhuda Amri Faculty of Chemical Engineering Universiti Teknologi MARA Pulau Pinang Malaysia

Unclear vision through the automotive glass is always occurring when accumulated water droplets create reflection and refraction of light especially on a rainy day. This is due to the hydrophobic characteristic of the conventional glass surface. In this study, TiO2, SiO2 and SiO2/TiO2 double layers thin film was prepared and coated on the glass plate using sol-gel dip coating method to enhance its surface and light transmittance characteristic. Surface morphology study using Scanning Electron Microscopy （SEM）justifies the reliability of the method used. As expected for the double layers SiO2/TiO2 film, SiO2 particles aggregates which randomly distributed on the surface of TiO2. Furthermore, the heat treatment employed during the coating and curing process was perfectly done as proven by zero crack spot exist on the coating surface. Performance wise, the prepared coatings were also shown a positive result whereby good agreements between visual observations of water droplet profile with water contact angle analyses were obtained. This finding that served the hydrophilic and self-cleaning function of the coating revealed that SiO2/TiO2 double layers film has demonstrated hydrophilic property based on the 13.9°of contact angle achieved. Moreover,light transmittance characterization on the double layers coating sample shows a significantly high transmission percentage of 71% which is higher than what have been permitted by regulation from Malaysian Road Transport Department. Based on its inexpensive coating method as well as all the positive characteristics, it concludes the feasibility of this type of coating to be used in automotive industry in the near future.

关键词： SiO2/TiO2 double layer thin film Sol-gel dip coating Hydrophilic Water contact angle

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Knowledge and attitudes toward corneal donation among Singaporean youth: a cross-sectional study

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Eye and Vision 2016年第1期3卷 131-140页

作者： Carisa Mariella Alvarez Paraz Ha Thi Thu Truong Darren Kyauk Sai Howard Yu Cajucom-Uy Cherry Lay Li Chan Selina Md kassim Singapore Eye Bank Singapore National Eye Centre11 Third Hospital AvenueSingapore 168751Singapore SingHealth Transplant Singapore Health Services Pte LtdTransplant Administrative and Resource OfficeSingapore General HospitalBlock 1Level 31 Hospital DriveSingapore 169608Singapore School of Applied Science Republic Polytechnic 9 Woodlands Avenue 9Singapore 738964Singapore

Background:To assess the knowledge of Singaporean youth regarding corneal donation and gauge their willingness to donate their ***:We conducted a cross-sectional study among 500 students from five tertiary institutions in *** students answered self-administered questionnaires which included seven questions that tested knowledge and three questions that determined willingness to donate ***:Among 500 Singaporean youth aged 18 to 25,most students(73.2%)answered 3 or fewer of the 7 questions about corneal donation *** regards to the willingness to donate,155(31%)were willing to donate their corneas,111(22.2%)were not willing to donate their corneas,and 234(46.8%)were *** to donate corneas was associated with an older age group(21 to 25 years old),those who are non-Muslims,and have good basic ***,students with good basic knowledge were 1.71 times more likely to willingly donate their ***:The knowledge of the Singaporean youth regarding corneal donation and transplantation is *** insufficient information was cited as the most common reason for being undecided in regards to corneal donation,specific and tailored programs to increase knowledge and awareness are needed to convince the youth to support corneal donation.

关键词： Corneal donation Donation knowledge Willingness Corneal transplant

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Residual Spray for the Control of <i>Aedes</i>Vectors in Dengue Outbreak Residential Areas

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Advances in Entomology 2019年第4期7卷 105-123页

作者： nurulhusna Ab Hamid Siti nurfadhlina Mohd Noor Mitra Saadatian-Elahi nur Rasyidah Isa Rohaiyu Md Rodzay Balqis Md Ruslan Topek Omar Mohd Iqbal Mohd Norsham Noor Hasmiza Amanzuri nurliyana Abd Khalil Izzah Farhah Zambari Muhammad Anwar Mohd kassim Muhammad Khairi Kamarul Zaman Ainaa Mardia Bachtiar Effendi Afiq Ahnaf Hafisool Lee Teck Peng Brian Poong Mustafakamal Ibrahim nurul Ashikin Roslan Lee Han Lim Medical Entomology Unit WHO Collaborating Centre for Vectors Institute for Medical Research Kuala Lumpur Malaysia Pôle Santé Recherche Risques et Vigilances Groupement Hospitalier Edouard Herriot Unité d’Hygiène Epidémiologie et Prévention Lyon France Vector Borne Disease Sector Disease Control Division Ministry of Health Malaysia Putrajaya Malaysia Bayer Co. (Malaysia) Sdn. Bhd. Petaling Jaya Malaysia Hulu Langat District Health Office Kajang Malaysia

The incidence of dengue in Malaysia has shown an increasing trend since the year 2000. Vector control is the primary approach for dengue control in Malaysia. There is an urgent need for new or modified approaches such as the residual spraying on the outer walls that can potentially last long enough to control the Aedes population, particularly in the outbreak-prone areas. In this field study, we conducted outdoor residual spraying (ORS) using a newly formulated polymer-enhanced suspension concentrate (SC-PE) of deltamethrin. The objectives of this study were to evaluate the efficacy of ORS using deltamethrin SC-PE and its effect on wild Aedes populations and to assess its residual bio-efficacy on painted cement walls against the pyrethroid-susceptible strains of laboratory-reared Aedes mosquitoes. Three rounds of spraying in a four-month cycle were conducted between 2014 and 2015 in four residential areas (low-rise and high-rise housing types) in Hulu Langat, Selangor. The bio-efficacy of the insecticide was evaluated by assessing its impact on vector population using ovitrap surveillance. Standard WHO wall deposit bioassay was adapted to determine bio-efficacy of deltamethrin, i.e. post 30 min knockdown and post 24 h mortality after exposure. During the treatment period, we observed significant reductions in the population of Ae. albopictus in the sprayed low-rise housing in both semi-indoor and outdoor environments, while in the high-rise housing, there was also a significant decline in Ae. aegypti population in the semi-indoor environment. The evaluation of the residual bio-efficacy of deltamethrin SC-PE against laboratory-reared Aedes mosquitoes showed that the insecticide lasted longer in the high-rise housing compared to the low-rise housing with >80% mortality achieved continuously for 16 weeks. We provide initial evidence on residual efficacy of deltamethrin SC-PE in reducing Aedes population size in the low-rise and high-rise housing. Our results showed tha

关键词： Indoor Residual Spraying Outdoor Residual Spraying Aedes Deltamethrin SC-PE Dengue Vector Control Ovitrap Index Malaysia

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