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Giant cyst in heterotopic pregnancy:A case report

World Journal of Clinical Cases 2023年第16期11卷 3864-3869页

作者： Yi-Yan Kong kasonde chanda Xiao-Yan Ying Department of Obstetrics and Gynecology Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina

BACKGROUND The coexistence of a heterotopic pregnancy with a giant ovarian cyst is an incredibly rare abnormal pregnancy in cases of natural *** incidence of this condition has increased significantly as a result of the continuous development of assisted reproductive *** this type of pregnancy occurs,both the continuation of intrauterine pregnancy and the life of the pregnant woman are severely *** diagnosis and treatment using safe and effective methods are paramount in this *** SUMMARY A 30-year-old primigravida at a gestation age determined as 8 wk 4 d by scan was admitted to the hospital with heterotopic pregnancy and a right ovarian *** resection of the ectopic pregnancy was performed,but the intrauterine pregnancy and ovarian cyst were *** The approach to a patient with heterotopic pregnancy and a giant ovarian cyst is individualized base on the fertility *** recommend the following:(1)If the patient satisfies parity and has no fertility requirement,a laparoscopic salpingectomy should be performed and the giant ovarian cyst and intrauterine pregnancy removed;(2)If the patient has fertility requirements wishes to have more children in the future,laparoscopic salpingectomy or salpingostomy should be performed and the intrauterine pregnancy *** ovarian cyst aspiration can be performed under ultrasound and resection can be done after delivery;and(3)Heterotopic pregnancy should be diagnosed early by active surveillance during antenatal visits using ultra sound as this is important for the avoidance of catastrophic complications.

关键词： Heterotopic pregnancy Ectopic pregnancy Giant ovarian cyst Case report

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Endocrine-Disrupting Chemicals: Possible Genesis of Ovarian Tumors

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Open Journal of Obstetrics and Gynecology 2023年第6期13卷 1025-1037页

作者： kasonde chanda Ziwei Wang Shen Ning Xue Bin Yingxiao Yan Department of Obstetrics and Gynecology Second Affiliated Hospital of Nanjing Medical University Nanjing China Core Laboratory Department of Clinical Laboratory Sir Run Run Hospital Nanjing Medical University Nanjing China China Exposomics Institute (CEI) Precision Medicine Co. Ltd. Shanghai China Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical University Nanjing China

Background: Prolonged exposure to environmental toxicants like endocrine-disrupting chemicals has been linked to several ovarian pathologies. Exposure to endocrine-disrupting chemicals may start at any time of life from the fetal stage to adulthood resulting in various health complications The purpose of our study is to compare the concentration levels and association of benzopyrene, bisphenol A and genistein in patients with ovarian tumors and normal control group. We also sort to evaluate the predictive performance of benzopyrene, bisphenol A and genistein in patients with ovarian tumors. Methods: A case-control study was conducted for randomly selected participants involving 30 patients and 30 controls. 30 patients with radiologically diagnosed and histopathological confirmed ovarian tumors were included in the study between January 2022 and December 2022. Urine samples from each group were analyzed using liquid chromatography-mass spectrometry. Descriptive analysis for normally distributed continuous variables was done accordingly. Concentration levels of endocrine-disrupting chemicals were assessed using the Mann-Whitney test. The association of endocrine-disrupting chemicals with pathological ovarian tumors was analyzed using binary logistic regression. Evaluation of the diagnostic performance of endocrine-disrupting chemicals was analyzed using the ROC curve. Results: Overall, patients were significantly (P = 0.000) older than the healthy controls. Mean years (SD) were 36.7 (7.90) and 28.8 years (4.89) for patients and normal women respectively. Endometriomas had the highest incidence of 50%. The level of benzopyrene and bisphenol A in patients was significantly higher than those in the control group, while the level of genistein was significantly higher in normal controls. Benzopyrene and bisphenol A were significantly associated with ovarian cysts, and the incidence of pathological ovarian cysts was positively correlated to these EDCs, with OR value 64.79 (

关键词： Environmental Toxicants Endocrine-Disrupting Chemical Ovarian Cyst Ovarian Tumor

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