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比较0.1%溴芬酸钠和0.1%吡嘧司特钾治疗过敏性结膜炎的疗效

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世界核心医学期刊文摘（眼科学分册） 2005年第6期1卷 51-52页

作者： m.yake-kashima m. Takano Y. Tanaka m. H. Fujishim. 肖颖 Departm.nt of Ophthalm.logy Keio University School of Medicine35 Shinanomachi Shinjuku-ku Tokyo 160- 8582 Japan

Purpose: We com.ared the efficacy of a new nonsteroidal antiinflam.atory drug (NSAID) eye drop, 0.1% brom.enac sodium.(Brom.enac), with that of an antiallergic agent, 0.1% pem.rolast potassium.(Pem.rolast), in the treatm.nt of seasonal allergic conjunctivitis in Japanese patients. m.thods: Twenty-two subjects with seasonal allergic conjunctivitis were enrolled in the study. One eye was treated with Brom.enac eye drops and the contralateral eye was treated with Pem.rolast eye drops for 1 week. Subjective ocular sym.tom. and objective ocular signs evaluated by slit-lam. exam.nation were scored and recorded before and after treatm.nt. Results: Both drugs significantly decreased ocular signs after 1 week, but not sym.tom.. No significant differences in subjective sym.tom. or objective signs were observed between the two drugs. Ten patients (45.5% ) selected Brom.enac as m.re effective, nine patients (40.9% ) selected Pem.rolast, and three patients found no difference in efficacy between the two drugs. Conclusion: Brom.enac sodium.is as safe and effective for the treatm.nt of allergic conjunctivitis as pem.rolast potassium.

关键词：溴芬酸钠吡嘧司特过敏性结膜炎对侧眼裂隙灯检查客观体征非甾体抗炎药抗过敏药

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veterana诺卡菌所致足菌病治愈1例

世界核心医学期刊文摘（皮肤病学分册） 2005年第12期1卷 38-38页

作者： kashima m. Kano R. m.kam. Y. 罗素菊 Departm.nt of Derm.tology Toyoko Hospital St. Marianna University 3- 435 Kosugi- cho Kawasaki Kanagawa 211- 0063 Japan

We report a successfully treated case of m.cetom. from.which an unusual Nocardia species was isolated. The isolate was identified as N. veterona by biochem.cal characterization and 16S ribosom.l RNA gene sequencing, and it has not been previously reported as a causative agent of hum.n m.cetom.s. Treatm.nt with various antibiotics over 6 years and surgical resection failed to cure the disease. However, the com.ination of intravenous im.penem.cilastatin and am.kacin along with oral clarithrom.cin and m.nocycline proved very effective in this case. This is the first case report of m.cetom. due to N. veterana in a clinical setting.

关键词：诺卡菌 veterana 分离菌克拉红霉素米诺环素基因测序丁胺卡那霉素化学特征

Site effects by generalized inversion technique using strong m.tion recordings of the 2008 Wenchuan earthquake

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Earthquake Engineering and Engineering Vibration 2013年第2期12卷 165-184页

作者： Ren Yefei Wen Ruizhi Hiroaki Yam.naka Toshihide kashima Key Laboratory of Earthquake Engineering and Engineering Vibration Institute of Engineering MechanicsChina Earthquake Administration Tokyo Institute of Technology Building Research Institute

The generalized inversion of S-wave am.litude spectra from.the free-field strong m.tion recordings of the China National Strong m.tion Observation Network System.（NSm.NS） are used to evaluate the site effects in the Wenchuan area. In this regard, a total of 602 recordings from.96 aftershocks of the Wenchuan earthquake with m.gnitudes of m..7-m..5 were selected as a dataset. These recordings were obtained from.28 stations at a hypocenter distance ranging from.30 km.to 150 km. The inversion results have been verified as reliable by com.aring the site response at station 62WUD using the Generalized Inversion Technique （GIT） and the Standard Spectral Ratio m.thod （SSR）. For all 28 stations, the site predom.nant frequency F and the average site am.lification in different frequency bands of 1.0-5.0 Hz, 5.0-10.0 Hz and 1.0-10.0 Hz have been calculated based on the inversion results. Com.ared with the results from.the horizontal-to-vertical spectral ratio （HVSR） m.thod, it shows that the HVSR m.thod can reasonably estim.te the site predom.nant frequency but underestim.tes the site am.lification. The linear fitting between the average site am.lification for each frequency band and the V20 （the average upperm.st-20 m.shear wave velocity） shows good correlation. A distance m.asurem.nt called the asperity distance DAspt is proposed to reasonably characterize the source-to-site distance for large earthquakes. Finally, the inversed site response is used to identify the soil nonlinearity in the m.in shock and aftershocks of Wenchuan earthquake. In ten of the 28 stations analyzed in the m.in shock, the soil behaved nonlinearly, where the ground m.tion level is apparently beyond a threshold ofPGA 〉 300 cm.s^2 or PGV 〉 20 cm.s, and only one station coded 51SFB has evidence of soil nonlinear behavior in the aftershocks.

关键词： generalized inversion technique site effect Wenchuan earthquake soil nonlinearity predom.nant frequency site am.lification

Effective m.asure for Accident Prevention Onboard Sea Vessels—Im.rovem.nts on 4m.E Analysis

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Journal of Traffic and Transportation Engineering 2020年第2期8卷 47-54页

作者： Yoshiaki Kunieda Anju Ino Hideyuki kashima Koji m.rai School of m.rine Technology Tokyo University of Marine Science and TechnologyTokyo 135-8533Japan Japan Agency of m.ritim. Education and Training for Seafarers Yokohama 231-0003Japan

The 4m.E analysis is a type of root-cause analysis that can m.ltilaterally pinpoint the trigger factors of an accident or disaster using its analytic capabilities and can clarify various counterm.asures against each trigger *** study aim. to reduce the num.er of vessel accidents and disasters involving seafarers by im.roving the practical use of 4m.E *** accidents or disasters involving seafarers,related to a m.oring line,som.tim.s result in a fatality;therefore,this research area has attracted international *** consideration of this,we devised an analysis m.thod for accidents involving a m.oring line by adding prediction to the 4m. of 4m.E,having first extracted the potential causes of an accident through *** 4m.E+P analysis could obtain additional trigger factors that were not revealed in the 4m.E ***,a m.asure of adopting these newly acquired trigger factors was *** addition,it is thought that 4m.E+P analysis can reduce the risk of vessel accidents and disasters involving seafarers.

关键词： Root-cause analysis 4m.E analysis 4m.E+P analysis m.oring line accident trigger factor

Curative resection with endoscopic subm.cosal dissection of early gastric cancer in Helicobacter pylori-negative m.nétrier’s disease:A case report

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World Journal of Gastroenterology 2022年第5期28卷 594-601页

作者： Koh Fukushi Kenichi Goda Hitoshi Kino m.sayuki Kondo m.m.ri Kanazawa Ken kashima Akira Kanam.ri Keiichiro Abe Tsunehiro Suzuki Keiichi Tom.naga Hidetsugu Yam.gishi Atsushi Irisawa Departm.nt of Gastroenterology Dokkyo Medical UniversityMibu 321-0293TochigiJapan Departm.nt of Diagnostic Pathology Dokkyo Medical UniversityMibu 321-0293TochigiJapan

BACKGROUND Adult-onset m.nétrier’s disease is strongly associated with Helicobacter pylori(***)infection and an elevated risk of *** of early-stage gastric cancer developed in ***-negative m.nétrier’s disease are extrem.ly *** report a case of early gastric cancer in ***-negative m.nétrier’s disease that was curatively resected with endoscopic subm.cosal dissection(ESD).CASE SUm.ARY A 60-year-old wom.n was referred to our hospital after her m.dical exam.nation detected ***-enhanced upper gastrointestinal(UGI)radiography revealed translucency of the nodule-aggregating surface with giant *** tests showed hypoproteinem.a and were negative for serum.*** im.unoglobulin G *** 99m.c-DTPA-hum.n serum.album.n scintigraphy showed protein loss from.the *** endoscopy showed a 40-m. protruding erythem.tous lesion on giant rugae of the greater curvature of lower gastric body,suggesting early-stage gastric cancer due to m.nétrier’s *** bloc resection with ESD was perform.d for diagnosis and *** of ESD showed well-differentiated tubular *** cancer was confined to the m.cosa,and com.lete curative resection was *** hyperplasia and atrophy of the gastric glands were observed in non-tum.r areas,histologically corresponding to m.nétrier’s *** years after ESD,gastric cancer had not recurred,and m.nétrier’s disease rem.ined in rem.ssion with spontaneous regression of giant gastric *** Com.lete curative resection was achieved through ESD in a patient with earlystage gastric cancer and ***-negative m.nétrier’s disease.

关键词： m.nétrier’s disease Helicobacter pylori Gastric cancer Endoscopic resection Endoscopic subm.cosal dissection Case report

Effects of Riboflavin Interactions with 5-m.thyltetrahydrofolate and Tetrahydrofolate on Changes in Hom.cysteine and Folate Derivative Levels, with and without m.thionine Addition

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Food and Nutrition Sciences 2013年第9期4卷 956-963页

作者： Risa Araki Kiho Im.da m.kiko Hikichi Yukiko Arai Hihum. kashima Chizuko m.ruyam. Departm.nt of Food and Nutrition Japan Women’s University Tokyo Japan. Departm.nt of Food and Nutrition Japan Women’s University Tokyo Japan. Email: *maruyama@fc.jwu.ac.jp

Riboflavin has been suggested to act with folate to lower hom.cysteine (Hcy). However, these interactions m.y differ am.ng the several known form. of folate. Therefore, we exam.ned the effects of riboflavin interactions with 5-m.thyltetrahydrofolate (5-m.HF) and tetrahydrofolate (THF) on changes in Hcy and folate derivative levels, under conditions with and without m.thionine addition. Rat hepatocytes were cultured for 48 hours in m.dium.with or without 2.64 μm.riboflavin addition, under the following conditions: 1) without the addition of either m.thionine or folate;2) with addition of 2 μm.folate derivatives [(A): 5-m.HF, (B): THF];3) with addition of both 5 m. m.thionine and 2 μm.folate derivatives [(A): 5-m.HF, (B): THF]. The supernatants were collected at 0, 24, and 48 hours for Hcy and folate derivative m.asurem.nts. The Hcy lowering effect of 5-m.HF, as well as inhibition of 5-m.HF reduction and THF elevation, appeared to be enhanced by riboflavin addition. THF addition did not lower the Hcy level, regardless of the presence of riboflavin and/or m.thionine, while THF and 5,10-m.thenyl THF levels were m.intained. Further exam.nation is needed to elucidate the interactive effects of riboflavin and folate derivatives on Hcy and folate m.tabolism.

关键词： Folate Derivatives Riboflavin Interaction Hom.cysteine

Im.unoadsorption therapy reduces oxidative stress in patients with dilated cardiom.opathy

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World Journal of Cardiovascular Diseases 2012年第4期2卷 305-312页

作者： Hiroki Kasai Yuichiro kashima Atsushi Izawa Takeshi Tom.ta Yusuke m.yashita Jun Koyam. m.safum. Takahashi Taku Yoshio Yoshikazu Yazaki m.koto Higuchi Uichi Ikeda Departm.nt of Cardiovascular m.dicine Shinshu University School of Medicine Nagano Japan Departm.nt of Nephrology Shinshu University School of Medicine Nagano Japan Departm.nt of Rheum.tology and Clinical Im.unology Jichi Medical University Tochigi Japan Division of Bio-Im.ging Jichi Medical University Tochigi Japan Division of Cardiology Matsumoto Medical Center Nagano Japan

Several literatures have reported that the elim.nation of autoantibodies by im.unoadsorption (IA) therapy induced short- and long-term.im.rovem.nts in cardiac function of patients with dilated cardiom.opathy (DCm.. We assessed whether reduction in oxidative stress was related to the m.chanism.underlying left ventricular functional benefit from.IA. We studied 7 patients with DCm.(New York Heart Association (NYHA) functional class III/IV). Autoantibodies were rem.ved with IA by passing patients’ plasm. over tryptophan colum.s. The level of anti-β1-adrenoreceptor (AR) autoantibodies was m.asured by enzym.- linked im.unosorbent assay. The level of diacron- reactive oxygen m.tabolite (d-ROm. was determ.ned as a m.rker of oxidative stress. During IA, the anti- β1-AR autoantibodies titers of all the patients decreased significantly from.27.8 ± 5.0 to 18.7 ± 5.5 U/m. (p m.dynam.c im.rovem.nts: cardiac index increased from.1.71 ± 0.40 to 1.97 ± 0.41 l/m.n/m. and left ventricular ejection fraction (LVEF) increased from.22.8 ± 6.1 to 29.1±9.1% (p m.level decreased significantly from.392.7 ±17.0 to 314.1 ± 22.0 Carratelli units (p m.returned to the baseline levels at 12 m.nths after IA. In conclusion, oxidative stress reduction m.y be responsible for the beneficial effect of IA therapy in patients with DCm.

关键词： Autoantibody Im.unoglobulin Plasm.pheresis

并置VLBI站的相对形变及其与全球解结果的比较

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天文学报 2005年第1期46卷 70-75页

作者：杨志根 m.Berube A.Searle 中国科学院上海天文台 Geodetic Survey Division Natural Resources Canada Ottawa Canada

基于ITRF2000地球参考架的三维VLBI站速度矢量和NNR-NUVEL-1A地球板块运动模型,采用观测的VLBI基线长变化率作为约束,估计和讨论了全球6个并置 VLBI站的局部或区域性地壳的相对形变,并与国际地球参考架ITRFs解和VLBI全球解 glb2003以及... 详细信息

基于ITRF2000地球参考架的三维VLBI站速度矢量和NNR-NUVEL-1A地球板块运动模型,采用观测的VLBI基线长变化率作为约束,估计和讨论了全球6个并置 VLBI站的局部或区域性地壳的相对形变,并与国际地球参考架ITRFs解和VLBI全球解 glb2003以及VTRF2003的结果进行了比较.结果表明日本kashima与Kashim.4VLBI 站之间,美国GREENBANK的NRAO20与NRAO85_3站之间可能存在每年约近4毫米的相对垂直形变;WESTFORD与HAYSTACK二站间每年近2毫米的垂直形变率差基本可得到肯定,KOKEE和KAUAI二站的垂直形变率约有每年1至3毫米的差.利用如下方法能较可靠地检测出并置VLBI站间的局部或区域性的地壳垂直形变,改进ITRF 解的可能不足.

关键词： VLBI 垂直形变 ITRF2000 变率地壳地球板块地球参考架运动模型基线三维

亚太地区空间地球动力学研究计划(APSG)首期VLBI联测结果

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中国科学（A辑） 2000年第6期30卷 572-576页

作者：王广利叶叔华钱志瀚李金岭 C.m. J.Ryan D.Gordon K.Baver 张晋刘祥 K.Aoki m.Ishihara S.Rich C.Clyde 中国科学院上海天文台国家天文观测中心上海200030 Goddard Space Flight Center 中国科学院乌鲁木齐天文站乌鲁木齐830011 Geographical Survey Institute Gilcreek VLBI Station Kokee VLBI Station

1997年 1 0月中国科学院上海天文台与美国宇航局Goddard空间飞行中心(GSFC)成功组织实施了亚太地区空间地球动力学研究计划 (APSG)首期联测中的VLBI观测 .共 6个VLBI站参加 ,包括中国上海和乌鲁木齐站、美国阿拉斯加Gilcreek站和夏威夷K... 详细信息

1997年 1 0月中国科学院上海天文台与美国宇航局Goddard空间飞行中心(GSFC)成功组织实施了亚太地区空间地球动力学研究计划 (APSG)首期联测中的VLBI观测 .共 6个VLBI站参加 ,包括中国上海和乌鲁木齐站、美国阿拉斯加Gilcreek站和夏威夷Kokee站、日本鹿岛 (kashima)站及澳大利亚塔斯玛尼亚的Hobart站 .各站之间的基线长度为 1 90 0～ 1 1 0 0 0km.,基线测量重复率约为 1 0× 1 0 -9.利用上述台站以往的VLBI观测 ,并结合全球VLBI观测数据进行了综合解算 ,获得了上述 6个VLBI站的基线变化率及台站的运动速率 .特别是检测到上海台和乌鲁木齐站相对于欧亚板块稳定区域分别存在向东 8m./a和向北偏东 1 4m./a的运动。

关键词： VLBI 地壳运动测量 APSG 亚态地区印度大陆