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Multiparametric characterization of red blood cell physiology after hypotonic dialysis based drug encapsulation process

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Acta Pharmaceutica sinica B 2022年第4期12卷 2089-2102页

作者： Mélanie Robert Bastien Laperrousaz Diana Piedrahita Emilie-Fleur Gautier Travis Nemkov Florian Dupuy Elie Nader Virginie salnot Patrick Mayeux Angelo D’Alessandro Catherine Lavazec Philippe Joly Alexander scheer Philippe Connes Agnès Cibiel Erytech Pharma Lyon 69008France Laboratoire interuniversitaire de Biologie de la Motricité(LIBM)EA7424 Team«Vascular Biology and Red Blood Cell»Universite´Claude Bernard Lyon 1Universite´de LyonLyon 69008France Labex GR-Ex Paris 75015France 3P5 proteom’IC facility Universitéde ParisInstitut CochinINSERMCNRSParis 75014France University of Colorado Anschutz Medical CampusAuroraCO 80045USA Omix Technologies Inc.AuroraCO 80045USA Inserm U1016 CNRS 8104Universitéde ParisInstitut CochinParis 75014France Laboratoire de Biochimie et de Biologie Moléculaire UF de biochimie des pathologies e´rythrocytairesCentre de Biologie et de Pathologie EstHospices Civils de LyonBron 69500France

Red blood cells(RBCs)can act as carriers for therapeutic agents and can substantially improve the safety,pharmacokinetics,and pharmacodynamics of many *** RBCs integrity and lifespan is important for the efficacy of RBCs as drug *** investigated the impact of drug encapsulation by hypotonic dialysis on RBCs physiology and *** parameters were compared between processed RBCs loaded with l-asparaginase(“eryaspase”),processed RBCs without drug and non-processed *** RBCs were less hydrated and displayed a reduction of intracellular *** observed a change in the metabolomic but not in the proteomic profile of processed *** process caused moderate morphological changes and was accompanied by an increase of RBCs-derived Extracellular Vesicles *** a decrease in deformability,processed RBCs were not mechanically retained in a spleen-mimicking device and had increased surface-to-volume ratio and osmotic *** RBCs half-life was not significantly affected in a mouse model and our previous phase 1 clinical study showed that encapsulation of asparaginase in RBCs prolonged its in vivo half-life compared to free *** study demonstrated that encapsulation by hypotonic dialysis may affect certain characteristics of RBCs but does not significantly affect the in vivo longevity of RBCs or their drug carrier function.

关键词： Red blood cells Drug carrier Hypotonic dialysis L-Asparaginase Omics Rheology Morphology senescence markers

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Feasibility of pancreatectomy following high-dose proton therapy for unresectable pancreatic cancer

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World Journal of Gastrointestinal surgery 2017年第4期9卷 103-108页

作者： Kathryn E Hitchcock R Charles Nichols Christopher G Morris Debashish Bose steven J Hughes John A stauffer scott A Celinski Elizabeth A Johnson Robert A Zaiden Nancy P Mendenhall Michael s Rutenberg Department of Radiation Oncology University of Florida Department of surgical Oncology UF Health Cancer Center-Orlando Health Department of surgery University of Florida Department of surgery Mayo Clinic Department of surgery Baylor University Medical Center at Dallas Department of Hematology/Oncology Mayo Clinic Department of Hematology/Oncology Baptist Health

AIM To review surgical outcomes for patients undergoing pancreatectomy after proton therapy with concomitant capecitabine for initially unresectable pancreatic *** From April 2010 to september 2013,15 patients with initially unresectable pancreatic cancer were treated withproton therapy with concomitant capecitabine at 1000 mg orally twice daily. All patients received 59.40 Gy(RBE) to the gross disease and 1 patient received 50.40 Gy(RBE) to high-risk nodal targets. There were no treatment interruptions and no chemotherapy dose reductions. six patients achieved a radiographic response sufficient to justify surgical exploration,of whom 1 was identified as having intraperitoneal dissemination at the time of surgery and the planned pancreatectomy was aborted. Five patients underwent resection. Procedures included:Laparoscopic standard pancreaticoduodenectomy(n = 3),open pyloris-sparing pancreaticoduodenectomy(n = 1),and open distal pancreatectomy with irreversible electroporation(IRE) of a pancreatic head mass(n = 1). REsULTs The median patient age was 60 years(range,51-67). The median duration of surgery was 419 min(range,290-484),with a median estimated blood loss of 850 cm^3(range,300-2000),median ICU stay of 1 d(range,0-2),and median hospital stay of 10 d(range,5-14). Three patients were re-admitted to a hospital within 30 d after discharge for wound infection(n = 1),delayed gastric emptying(n = 1),and ischemic gastritis(n = 1). Two patients underwent R0 resections and demonstrated minimal residual disease in the final pathology specimen. One patient,after negative pancreatic head biopsies,underwent IRE followed by distal pancreatectomy with no tumor seen in the specimen. Two patients underwent R2 resections. Only 1 patient demonstrated ultimate local progression at the primary site. Median survival for the 5 resected patients was 24 mo(range,10-30).CONCLUsION Pancreatic resection for patients with initially unresectable cancers is feasible after

关键词： Pancreatic cancer Pancreatectomy Pancreas Proton therapy Radiotherapy

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用膜技术生产蔬菜汁

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河南科技 1991年第11期10卷 30-31页

作者： s.s.koseoglu 赵海珍

蔬菜汁富含矿质元素以及维生素A,B和C,是最有营养的饮料之一。在加工过程中,蔬菜汁的原有风味很容易丧失。此外,蒸发浓缩和杀菌时的高温也经常引起蔬菜中一些成分的凝结、絮凝和沉淀。达尔等许多人将蒸汽机械压缩蒸发器、反渗透(RO)和... 详细信息

蔬菜汁富含矿质元素以及维生素A,B和C,是最有营养的饮料之一。在加工过程中,蔬菜汁的原有风味很容易丧失。此外,蒸发浓缩和杀菌时的高温也经常引起蔬菜中一些成分的凝结、絮凝和沉淀。达尔等许多人将蒸汽机械压缩蒸发器、反渗透(RO)和离心浓缩与标准三效刮板式蒸发器的能量消耗进行了对比,认为将离心技术、RO技术和蒸汽机械压缩蒸发器结合使用是降低在本的最有效方法。奥托莫等人曾多次报导有关用超滤(uf)和反渗透(RO)技术生产水果汁的研究。用uf生产的透明果汁优于传统澄清法生产的果汁。其主要优点是该法减少废渣排出,增加出汁率,并明显降低原材料和劳力成本。据商业时代报导。

关键词：饮料蔬菜汁膜技术

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sCIENCE OF REVERsE OsMOsIs—KEY TO PROGREss IN REVERsE OsMOsIs,ULTRAFILTRATION AND sYNTHETIC MEMBRANE TECHNOLOGY

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膜科学与技术 1981年第1期 8-11页

作者： s.sourirajan Division of Chemistry National Research, Council of Canada Ottawa, Canada KIA OR9

During the past two decades, technological activities in the areas ofreverse osmosis(RO),uitrafiltration(uf)and synthetic membranes(sM)have grown and spread extensively in different parts of the *** first UCLA announc... 详细信息

关键词： RO sM uf KEY TO PROGREss IN REVERsE OsMOsIs,ULTRAFILTRATION AND sYNTHETIC MEMBRANE TECHNOLOGY sCIENCE OF REVERsE OsMOsIs

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Unidirectional reflection from an integrated“taiji”microresonator

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Photonics Research 2020年第8期8卷 1333-1341页

作者： A.CALABREsE F.RAMIRO-MANZANO H.M.PRICE s.BIAsI M.BERNARD M.GHULINYAN I.CARUsOTTO L.PAVEsI Laboratoire de Physique de l’Ecole Normale superieure ENSParis Sciences et LettresCNRSUniversitéde Paris75005 ParisFrance Instituto de Tecnologı´a Quı´mica(CsIC-UPV).Av.de los Naranjos 46022 ValenciaSpain school of Physics and Astronomy University of BirminghamEdgbastonBirmingham B152TTUK Nanoscience Laboratory Dipartimento di FisicaUniversity of TrentoVia Sommarive 1438123 Povo(TN)Italy Centre for Materials and Microsystems Fondazione Bruno KesslerVia Sommarive 1838123 Povo(TN)Italy INO-CNR BEC Center and Department of Physics University of TrentoVia Sommarive 1438123 PovoItaly

We study light transmission and reflection from an integrated microresonator device,formed by a circular microresonator coupled to a bus waveguide,with an embedded s-shaped additional crossover waveguide element that selectively couples counter-propagating modes in a propagation-direction-dependent *** overall shape of the device resembles a“taiji”symbol,hence its *** Lorentz reciprocity is preserved in transmission,the peculiar geometry allows us to exploit the non-Hermitian nature of the system to obtain high-contrast unidirectional reflection with negligible reflection for light incident in one direction and a significant reflection in the opposite direction.

关键词： hence negligible crossover

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Efficiency of Coir Particle Board for Acoustic &Thermal Applications

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Open Journal of Acoustics 2019年第3期9卷 39-47页

作者： M. C. Kiran B. s. Mamatha N. Anand V. Prakash Narasimha Murthy IPIRTI Tumkur Road Bangalore Karnataka India

Coir fibre is extracted from the husk of coconut and is used in products such as floor mats, door mats, brushes and mattresses and in many applications. Here coir fibres are used to make particle boards of densities 300, 400 and 500 kg/m3 using uf resin to determine its efficiency for interior applications like acoustic and thermal properties and also tested for Indian standard 3129. Noise Reduction Coefficient (NRC) of all the boards decreases with an increase in density. Maximum sound absorption coefficient for all three densities was found in the frequency range of 2500 to 30,000 Hz. Among three densities, 300 kg/m3 board shows the maximum absorption coefficient at frequency 3000 Hz. The thermal conductivity results of all three densities boards increase with an increase in density. Modulus of Rupture for all three densities were meeting the requirement of standard. Results reveal that particle board manufactured from coir fibre can be used for acoustic and thermal insulation applications.

关键词： Thermal Conductivity sound Absorption Coefficient

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Heart Transplantation for Adult Congenital Heart Disease:Overview and special Considerations

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Cardiovascular Innovations and Applications 2018年第B5期3卷 73-84页

作者： Dipankar Gupta Jana Reid Diego Moguillansky Renata shih Mark s.Bleiweis Frederick J.Fricker Biagio A.Pietra Congenital Heart Center Department of PediatricsUF Health Shands Children’s HospitalUniversity of FloridaGainesvilleFLUSA

With improvements in their surgical and medical management,the number of patients with congenital heart disease(CHD)reaching adulthood has increased over the last *** the population of adult CHD patients continues to rise,an increasing number of these patients will require evaluation for heart *** is important to recognize advanced heart failure and other associated complications early in this cohort of complex patients for early referral to an adult CHD *** these patients present with unique challenges because of their multiple comorbidities and complex anatomy,there needs to be a careful selection process for transplantation to optimize the utilization of donor organs.

关键词： heart transplantation adult congenital heart disease congenital heart disease heart failure

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反渗透科学第一章反渗透分离的物理化学本质

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膜科学与技术 1984年第1期 3+1-37页

作者： s.索里拉金刘廷惠加拿大国家科学院化学研究所中国科学院环境化学研究所

反渗透是应用化学和化工的一个新领域,它的应用和潜力对各国工业发展十分重要,与全人类的健康和福利密切相关。本书详细介绍我们对反渗透作的基本研究和发展。这一章讲解优先吸附毛细孔流动机理,并用这个机理揭示反渗透本质。以这个机... 详细信息

反渗透是应用化学和化工的一个新领域,它的应用和潜力对各国工业发展十分重要,与全人类的健康和福利密切相关。本书详细介绍我们对反渗透作的基本研究和发展。这一章讲解优先吸附毛细孔流动机理,并用这个机理揭示反渗透本质。以这个机理作为本书开头原因如下:(1)第一张成功的脱盐膜是基于这个机理发展的,并迅速发展成今天的盛况。 (2)这个机理是理解反渗透的有效手段。

关键词：反渗透迁移方程积分微分方程溶质分子分离率优先吸附克分子分数摩尔分数平均孔径对氯苯酚物理化学

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两性氧化物超微过滤及纳米过滤陶瓷膜的过滤性能与材料性能之间的关系(英文)

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陶瓷学报 2005年第1期26卷 29-34页

作者： M.Persin s.Condom A.Larbot Institut Europeen des Membranes (IEM) UMR 5635 CNRs ENsCM UM Ⅱ CNRs 1919 Route de Mende 34293-Montpellier cedex 5 France Institut Europeen des Membranes (IEM) UMR 5635 CNRS ENSCM UM Ⅱ CNRS 1919 Route de Mende 34293-Montpellier cedex 5 FranceInstitut Europeen des Membranes (IEM) UMR 5635 CNRS ENSCM UM Ⅱ CNRS 1919 Route de Mende 34293-Montpellier cedex 5 France

各类陶瓷膜在电解质溶液中的过滤性能试验表明:各种盐分的滤出率取决于溶液的pH值、盐的种类及其浓度。在过滤过程中,脉动电势与盐滤出率存在相关性,脉动电势是影响过滤材料表面电荷特性的相关参数。

关键词：陶瓷膜材料性能过滤性能纳米过滤超微过滤氧化物两性表面电荷特性电解质溶液性能试验过滤过程过滤材料 pH值相关性出率电势脉动

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反渗透科学—反渗透、超滤及合成膜技术发展的关键

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膜科学与技术 1981年第1期 12-13页

作者： s·索里拉金林树勋加拿大国立研究会化学分会甘肃省科学院苦咸水淡化研究所

二十年来,反渗透(RO)、超滤(uf)、及合成膜(sM)等领域的技术活动不断地增长、并遍及世界各个地区。自从第一份详细介绍最初开发用于水脱盐的醋酸纤维素反渗透膜的 UCLA 报告于1960年公布以来,已经开发了几种用不同材料制成的膜,它们制... 详细信息

二十年来,反渗透(RO)、超滤(uf)、及合成膜(sM)等领域的技术活动不断地增长、并遍及世界各个地区。自从第一份详细介绍最初开发用于水脱盐的醋酸纤维素反渗透膜的 UCLA 报告于1960年公布以来,已经开发了几种用不同材料制成的膜,它们制成各种形状(平板、管状、中空纤维、和薄膜组合件)、并具有不同的物理、化学、机械和热性质

关键词：反渗透 UCLA RO 超滤合成膜 uf

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