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Angiosarcoma of the scalp diagnosed by the presence of neck.inflammation:a case report

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International Journal of Oral Science 2012年第3期4卷 166-169页

作者： Rei karube Hiroyoshi Sasak. k.iji Shinozuk. Yasuhiro Fujisawa Toru Yanagawa k.nji Yamagata k.jiro Onizawa Fujio Otsuk. Hirok. Buk.wa Department of Oral and Maxillofacial Surgery Faculty of MedicineUniversity of Tsukuba Department of Dermatology Faculty of MedicineUniversity of Tsukuba

Angiosarcoma is an uncommon malignancy, which spread out from the endothelial cells of vessels. Scalp angiosarcoma with cervical lymph node metastasis is particularly rare. This article describes a rare case of angiosarcoma of the scalp, presenting as neck.inflammation. Imaging procedures such as computed tomography （CT）, magnetic resonance image （MRI） and ultrasonography （US） were not sufficient to diagnose this case. A needle biopsy provided an effective and accurate diagnosis of cervical lymph node metastasis. Additional observation and physical examination was required to diagnose the origin of the primary cancerous lesion. Once the angiosarcoma diagnosis was confirmed histologically, sequential week.y and monthly docetaxel （DTX） treatment was effective in preventing reoccurrence. Nonetheless, the optimization of angiosarcoma treatment remains a future goal. Although patients generally describe pain and swelling at the primary lesion site, this patient complained only of painful neck.inflammation, without any indication of pain or swelling of the scalp. A revised diagnostic protocol should note that cervical lymph node metastasis of unk.own primary origin may result from angiosarcoma of the scalp.

关键词： angiosarcoma docetaxel neck.inflammation needle biopsy scalp

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单克隆B淋巴细胞增多症和“原位”淋巴瘤

临床与实验病理学杂志 2016年第1期32卷 68-79页

作者：刘芳(译) 周小鸽(审校) karube k.Scarfò L Campo E Ghia P 中山大学附属佛山医院病理科佛山528000 首都医科大学附属北京友谊医院病理科北京100050 不详

最新研究发现“单克隆B细胞群”并不能诊断为淋巴系统恶性肿瘤,其促使人们探索淋巴瘤的发生机制、B细胞前体转化成真正淋巴组织增殖性疾病的致病因子。单克隆B淋巴细胞扩增,最初在不同健康个体的外周血中发现,因此定义为单克隆B淋巴细... 详细信息

最新研究发现“单克隆B细胞群”并不能诊断为淋巴系统恶性肿瘤,其促使人们探索淋巴瘤的发生机制、B细胞前体转化成真正淋巴组织增殖性疾病的致病因子。单克隆B淋巴细胞扩增,最初在不同健康个体的外周血中发现,因此定义为单克隆B淋巴细胞增多症（monoclonalB-celllym-phocytosis,MBL）,同时分析显示许多患者与慢性淋巴细胞性白血病（chroniclymphocyticleuk.mia,CLL）具有相似的免疫表型。依据B细胞数量的不同,临床相关性也不同：高数量MBL被认为是肿瘤前期状态,且每年以1%-2%的比率进展成CLL;而低数量的MBL可存在多年。目前,临床上尚未显示与真正白血病相关。非CLL-样的MBL代表一小部分病例,其临床及生物学意义仍不清楚。原位滤泡淋巴瘤（follicularlymphoma,FL）和套细胞淋巴瘤（mantlecelllym-phoma,MCL）是以非典型淋巴样细胞的定位为特点,分别具有生发中心t（14;18）（q32;q21）或套区t（11;14）（q13;q32）易位,且有正常细胞对应体存在。生发中心或套区为这些携带致癌基因的细胞提供恰当的微环境,促进其生存或增殖。然而这些病变进展成真正淋巴瘤的机率较低,也许需要其他基因改变的蓄积。因此,这些淋巴组织增殖的患者应受到更多的关注。

关键词：单克隆B淋巴细胞增多症慢性淋巴细胞性白血病 t(14 18)(q32 q21)或 t(11 14)(q13 q32)原位淋巴瘤滤泡性淋巴瘤套细胞淋巴瘤

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Effects of Propofol on Glutamate-Induced Calcium Mobilization in Presynaptic Boutons of Rat Hippocampal Neurons

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Open Journal of Anesthesiology 2016年第3期6卷 27-36页

作者： Shinichi Ito Norik. karube Hitomi Sugiyama Jun Hirok.wa Seik. k.tahara Tak.shi Yok.yama Department of Dental Anesthesiology Faculty of Dental Science Kyushu University Fukuoka Japan

Recent reports have suggested that various general anesthetics affect presynaptic processes in the central nervous system. However, characterizations of the influence of intravenous anesthetics on neurotransmitter release from presynaptic nerve terminals (boutons) are insufficient. Because the presynaptic calcium concentration ([Ca2+]pre) regulates neurotransmitter release, we investigate the effects of the intravenous anesthetic propofol on neurotransmitter release by measuring [Ca2+]pre in the presynaptic boutons of individual dissociated hippocampal neurons. Brain slices were prepared from Sprague–Dawley rats (10 - 14 days of age). The hippocampal CA1 area was isolated with a fire-polished glass pipette, which vibrated horizontally to dissociate hippocampal CA1 neurons along with their attached presynaptic boutons. Presynaptic boutons were visualized under a confocal laser scanning microscope after staining with FM1-43 dye, and [Ca2+]pre was measured using fluo-3 AM dye. Glutamate (3 – 100 μM) administration increased [Ca2+]pre in Ca2+- containing external solution in a concentration-dependent manner. Propofol (3 – 30 μM) dose-dependently suppressed this glutamate (30 μM)-induced increase in [Ca2+]pre in boutons attached to dendrites, but not to the soma or base of the dendritic tree. The large majority of excitatory synapses on CA1 neurons are located on dendritic spines;therefore, propofol may affect glutamate-induced Ca2+ mobilization in excitatory, but not inhibitory, presynaptic boutons. Propofol may possibly have some effect on glutamate-regulated neurotransmitter release from excitatory presynaptic nerve terminals through inhibiting the increase in [Ca2+]pre induced by glutamate.

关键词： Propofol Calcium Signaling Presynaptic Terminals Hippocampus Glutamic Acid

Intravesical Infusion of Budesonide Foam Improves Symptoms in a Bladder Pain Syndrome/Interstitial Cystitis Rat Model

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Open Journal of Urology 2020年第5期10卷 123-133页

作者： k.mio Sugaya Saori Nishijima k.tsuhik. Noguchi Shiho Ok.tsu k.tsumi k.dek.wa k.nnosuk. karube Hideyuk. Yamamoto Southern k.ights’ Laboratory Okinawa Japan Department of Biochemistry Graduate School of Medicine University of the Ryukyus Okinawa Japan Department of Cytopathology Graduate School of Medicine University of the Ryukyus Okinawa Japan

Purpose: Since intravesically administered steroid therapy may treat bladder pain syndrome/interstitial cystitis (BPS/IC) with fewer side effects than the current treatment of orally administered steroids, we investigated whether the intravesical infusion of budesonide foam can effectively treat BPS/IC symptoms in a rat model of tranilast-induced BPS/IC. Methods: There were 6 rat treatment groups (n = 8 per group): control + single or daily saline infusion, tranilast + single or daily saline infusion, and tranilast + single or daily budesonide infusion. All groups except for the controls were fed a tranilast supplemented diet for 5 week.. Budesonide and saline were infused intravesically. After the BPS/IC rat model underwent single infusion treatments, we measured the paw pain threshold using the von Frey test and continuous cystometry was tak.n. After two week. of daily intravesical infusions, we measured locomotor activity and serum cortisol levels;harvested bladders underwent histological analysis. Results: Both pain threshold and locomotor activity were significantly lower in the saline-infused groups receiving the tranilast diet, but there were no differences between the budesonide-infused groups and the controls. The interval between bladder contractions was significantly shorter in the tranilast group than the control or tranilast + budesonide infusion groups. The serum cortisol levels did not change. Hematoxylin-Eosin stainings of the bladder showed thick.ning of the bladder muscle layer and mucosal edema in the tranilast group, while the tranilast + budesonide infusion group showed only mild changes. Conclusion: Intravesical infusion of budesonide effectively treated BPS/IC symptoms in a rat model of BPS/IC.

关键词： Bladder Pain Budesonide Interstitial Cystitis Rats Tranilast

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日本生物工业发展趋势

世界科学 1991年第4期 10-12页

作者： Isao karube 龚威

近几年生物技术进展惊人,它在许多工业领域中的应用引起了广泛注意.自从生物技术被承认为先进科学技术的带头领域以来,不少日本企业迅速投入该领域的研究. 最先应用生物技术的是那些业已与发酵、制药或化学剂制造有关的企业.它们研制各... 详细信息

近几年生物技术进展惊人,它在许多工业领域中的应用引起了广泛注意.自从生物技术被承认为先进科学技术的带头领域以来,不少日本企业迅速投入该领域的研究. 最先应用生物技术的是那些业已与发酵、制药或化学剂制造有关的企业.它们研制各种医药,有些研

关键词：海洋生物工程日元本位币生物技术科学技术协会国际贸易日本

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生物技术的新领域

世界科学 1989年第12期 23-24页

作者： Isao karube 龚威

蛋白质工程可以说,生命活动必需的蛋白质由DNA设计.由于氨基酸序列中的顺序是由DNA决定的,所以DNA基本序列的部分改变,会引起氨基酸序列的改变,结果会造成改变后的蛋白质结构,从而形成新的功能。实际上,我们知道,通过改变DNA的基本结构... 详细信息

蛋白质工程可以说,生命活动必需的蛋白质由DNA设计.由于氨基酸序列中的顺序是由DNA决定的,所以DNA基本序列的部分改变,会引起氨基酸序列的改变,结果会造成改变后的蛋白质结构,从而形成新的功能。实际上,我们知道,通过改变DNA的基本结构,酶的1个氨基酸的改变就会导致产生该种酶的新的性质,或增强其活性。这种技术称之为“基因诱变”,由于DNA

关键词：序列功能生物电子学基因操作技术信息加工信息处理生物传感器电子装置生物技术胚胎工程 DNA 领域

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固定化活细胞生产抗生素

国外药学(抗生素分册) 1987年第3期 165-173页

作者： karube I 朱汝锦

一、引言目前商品化抗生素大约有150个,尽管人们已经知道许多重要抗生素的化学合成途径,但是并未采用化学合成方法来制备(结构简单的氯霉素和杀细胞素除外)。这是因为生物合成的那些化合物结构复杂,需多步化学合成反应,太不经济。关于... 详细信息

一、引言目前商品化抗生素大约有150个,尽管人们已经知道许多重要抗生素的化学合成途径,但是并未采用化学合成方法来制备(结构简单的氯霉素和杀细胞素除外)。这是因为生物合成的那些化合物结构复杂,需多步化学合成反应,太不经济。关于半合成新青霉素迅猛发展也并非起始于青霉素母核6-氨基青霉烷酸(6-APA)化学合成途径的发现,而是不久发现产黄青霉菌在特定发酵条件下分泌6-APA,由6-APA再转化成各种新青霉素。大规模地化学合成抗生素类事实上是

关键词：固定化全细胞固定化细胞发酵杆菌抗生素类菌体青霉素抗菌素

Conserved properties of dendritic trees in four cortical nonpyramidal cell subtypes

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Conserved properties of dendritic trees in four cortical non...

2012国际生理学学术大会

作者： Yoshiyuk. k.bota Fuyuk. karube Masak. Nomura Allan T.Gulledge Atsushi Mochizuk. Andreas Schertel Yasuo k.waguchi National Institute for Physiological Sciences Japan SOk.NDAI Japan CREST-JST Japan RIk.N Research Center for Allergy and Immunology(RCAI) Japan Dartmouth Medical School USA. RIk.N Advanced Science Institute Japan

＜正＞Dendritic trees influence synaptic integration and neuronal excitability,yet appear to develop in rather arbitrary *** electron microscopy and serial reconstructions,we analyzed the dendritic trees of four morphologically distinct neocortical interneuron subtypes to reveal two underlying organizational principles common to ***,cross-sectional area at any given point within a dendrite is proportional to the summed length of all distal segments spanning beyond ***,the total cross-sectional area is perfectly conserved at bifurcation ***,dendritic cross-sections become more elliptic at proximal locations,resulting in a conservation of the surface to volume ratio throughout the dendritic ***,computer simulations revealed that these conserved morphological features limit distance dependent filtering of somatic EPSPs and facilitate distribution of somatic depolarization into all dendritic *** these features were shared by all interneurons studied,they may represent common organizational principles underlying the otherwise diverse morphology of dendritic trees.

关键词： dendrite microtubule EPSP conduction

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面对21世纪挑战的生物工艺学

世界科学 1998年第2期 10-13页

作者： Isao　karube,张长青