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Promising therapeutic potential of tumor suppressor microRNAs for malignant pleural mesothelioma

Journal of Cancer Metastasis and Treatment 2022年第1期8卷 91-101页

作者： shivani Dixit Agnes Y.Choi Anand singh karthik Pittala Nathan Pruett Chuong D.Hoang Thoracic surgery Branch National Cancer InstituteNational Institutes of HealthBethesdaMD 20892USA

Malignant pleural mesothelioma(MPM)is an aggressive and recalcitrant surface neoplasm that defies current multimodality ***(miRNAs)are small noncoding RNAs that epigenetically regulate multiple gene networks and cellular *** cancer,miRNA dysregulation is associated with tumorigenesis,with tumor suppressor miRNAs underexpressed or lost,while oncogenic miRNAs are ***,miRNAs have emerged as potential therapeutic *** loss of tumor suppressors predominates the pathophysiology of MPM,re-expressing tumor suppressor miRNAs could be an effective therapeutic *** review highlights the most promising MPM-specific tumor suppressor miRNAs that could be developed into novel therapeutics,the supporting data,and what is known about their molecular mechanism(s).

关键词： Malignant pleural mesothelioma microRNA tumor suppressor therapeutic

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Hash Function Based Keyword searchable Encryption Framework in Cloud server Using MD5 and MECC

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Journal of Information Hiding and Privacy Protection 2021年第4期3卷 201-226页

作者： R.Lakshmana Kumar R.subramanian s.karthik Department of Computer science and Engineering SNS College of TechnologyCoimbatoreTamil NaduIndia Department of Electrical and Electronics Engineering SNS College of TechnologyCoimbatoreTamil NaduIndia

Cloud Computing expands its usability to various fields that utilize data and store it in a common space that is required for computing and the purpose of analysis as like the IoT *** devices utilize the cloud for storing and retrieving data since the devices are not capable of storing processing data on its *** Computing provides various services to the users like the Iaas,Paas and *** major drawback that is faced by cloud computing include the Utilization of Cloud services for the storage of data that could be accessed by all the users related to *** use of Public Key Encryptions with keyword search(PEKs)provides security against the untrustworthy third-party search capability on publicly encryption keys without revealing the data’s *** the security concerns of PEKs arise when Inside Keywords Guessing attacks(IKGA),is identified in the system due to the untrusted server presume the keyword in *** issue could be solved by using various algorithms like the Certificateless Hashed Public Key Authenticated Encryption with Keyword search(CL-HPAEKs)which utilizes the Modified Elliptic Curve Cryptography(MECC)along with the Mutation Centred flower pollinations algorithm(CM-FPA)that is used in enhancing the performance of the algorithm using the Optimization in *** additional use of Message Digests 5(MD5)hash function in the system enhances the security Level that is associated with the *** system that is proposed achieves the security level performance of 96 percent and the effort consumed by the algorithm is less compared to the other encryption techniques.

关键词： Certificateless Hashed Public Key Authenticated Encryption with Keyword search(CL-HPAEKs) modified elliptic curve cryptography(MECC) digest 5(MD5) inside keywords guessing attacks(IKGA) public key encryptions with keyword search(PEKs)

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The Journey of sRs: An Initial Experience of starting sterotactic Radiosurgery Facility at Purbanchal Cancer Hospital—First in Nepal

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2023年第2期12卷 37-50页

作者： Birendra Kumar Yadav karthik Nagamuthu Alok Thakur Kushal Rizal Umesh Kumar sharma Ujwal Rai Dinesh Thapa shishir Thapa Kumar Chinnappan Amit Kumar Dubey suraj Gurung Aman Yadav Utpalkant Kumar Ranjay Kumar Department of Radiation Oncology Purbanchal Cancer Hospital Jhapa Nepal Department of Radiology Purbanchal Cancer Hospital Jhapa Nepal Deapartment of Pathology Purbanchal Cancer Hospital Jhapa Nepal Department of Neurosurgery Purbanchal Cancer Hospital Jhapa Nepal

Introduction: Radiotherapy (RT) is a vital cancer treatment modality for both curative and palliative purposes. Nepal is a developing country with a population of around 30 million people. Cancer affects 100 - 120 people out of every 100,000, and the figure is increasing. The number of radiation facility machines in the country is still countable in fingers. Purbanchal Cancer Hospital, Nepal is the first comprehensive cancer facility capable of performing stereotactic radiosurgery (sRs). Our facility has cutting-edge Varian Truebeam Linear Accelerators with millennium MLC, which makes sRs and sRT’s for intracranial lesions such as small benign and malignant tumors much easier. In addition to sRs, we are the pioneers of sBRT for lung using 4DCT, interstitial & intraluminal brachytherapy, RPM Gated & DIBH modalities in Nepal. Methods & Materials: The purpose of this study is to share our experience in establishing an sRs facility in the country, which includes training the RT team on the importance of process accuracy, patient selection, patient assessment, mould preparation, and describing image data acquisition, target, and organ at risk delineation on CT and MRI images, treatment planning process, and quality assurance. Results & Discussion: The plans for all sRs and sRT cases are based on target coverage, OAR sparing, hotspot inside the target, conformity index, heterogeneity index, and dose fall off. To select the final plan, we used strict passing criteria such as a conformity index Paddick (CIPaddick) more than 0.85, a falloff between 100% and 50% of less than 5.5 mm (maximum 6 mm in irregular targets), and a hotspot inside the target between 115 to 140 percent, as per clinical standards. In addition, we determined the CILomax and CIRTOG for each case. Passing criteria for verification plans are set as minimum of 95% for a 2% percentage dose difference (% DD) and a 2-mm distance to an agreement (DTA). We also gathered demographic data from patients treated in t

关键词： Conformity Index Double shell Positioning system Electronic Portal Imaging Device Linear Accelerator Millennium MLC Octavius Detector 1500 setup Field

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