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Evaluation of the reducing potential of PsMA-containing endosomes by FRET imaging

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Cancer Drug Resistance 2021年第1期4卷 223-232页

作者： Chelvam Venkatesh Jiayin shen karson s.putt Philip s.Low Discipline of Chemistry Indian Institute of TechnologyMadhya PradeshIndore 453552India Discipline of Bioscience and Biomedical Engineering Indian Institute of TechnologyMadhya PradeshIndore 453552India Department of Chemistry Purdue UniversityWest LafayetteIN 47907USA Institute for Drug Discovery Purdue UniversityWest LafayetteIN 47907USA

Aim:Ligand-targeted therapeutics are experiencing increasing use for treatment of human diseases due to their ability to concentrate a desired drug at a pathologic site while reducing accumulation in healthy *** many ligand-targeted drug conjugates,a critical aspect of conjugate design lies in engineering release of the therapeutic payload to occur only after its internalization by targeted *** disulfide bond reduction is frequently exploited to ensure intracellular drug release,an understanding of the redox properties of endocytic compartments can be critical to ligand-targeted drug *** the redox properties of folate receptor trafficking endosomes have been previously reported,little is known about the trafficking of prostate-specific membrane antigen(PsMA),a receptor that is experiencing increasing use for drug targeting in ***:To obtain this information,we have constructed a PsMA-targeted fluorescence resonance energy transfer pair that reports on disulfide bond reduction by changing fluorescence from red to ***:We show here that this reporter exhibits rapid and selective uptake by PsMA-positive cells,and that reduction of its disulfide bond proceeds steadily but incompletely following *** fact that maximal disulfide reduction reaches only~50%,even after 24 h incubation,suggests that roughly half of the conjugates must traffic through endosomes that display no reducing ***:As the level of disulfide reduction differs between PsMA trafficked and previously published folate trafficked conjugates,it also follows that not all internalizing receptors are translocated through similar intracellular *** together,these data suggest that the efficiency of disulfide bond reduction must be independently analyzed for each receptor trafficking pathway when disulfide bond reduction is exploited for intracellular drug release.

关键词： DUPA prostate-specific membrane antigen endosomes endocytosis

The investigation of DARC etch back in DRAM capacitor oxide mask opening

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Journal of semiconductors 2021年第7期42卷 88-92页

作者： Jianqiu Hou Zengwen Hu Kuowen Lai Yule sun Bo shao Chunyang Wang Xinran Liu karson Liu Advanced Micro-Fabrication Equipment Inc.China Shanghai 201201China ChangXin Memory Technologies Inc. Hefei 230093China

Opening the silicon oxide mask of a capacitor in dynamic random access memory is a critical process on a capacitive coupled plasma(CCP)etch *** steps,dielectric anti-reflective coating(DARC)etch back,silicon oxide etch and strip,are *** acquire good performance,such as low leakage current and high capacitance,for further fabricating capacitors,we should firstly optimize DARC etch *** developed some experiments,focusing on etch time and chemistry,to evalu-ate the profile of a silicon oxide mask,DARC remain and critical *** result shows that etch back time should be con-trolled in the range from 50 to 60 s,based on the current equipment and *** will make B/T ratio higher than 70%mean-while resolve the DARC remain *** also found that CH_(2)F_(2) flow should be~15 sccm to avoid reversed CD trend and keep in-line CD.

关键词： dynamic random access memory(DRAM) oxide mask open of capacitor capacitive coupled plasma(CCP)etch dielectric anti-reflective coating(DARC) etch back(EB)

一项盐酸多奈哌齐治疗帕金森病痴呆的随机、双盲、安慰剂对照的交叉研究

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世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 24-25页

作者： Ravina B. putt M. siderowfA. 陈云春 Clinical Trials NINDS Neuroscience Center 6001 Executive Blvd Rockville MD 20892- 9257 United States Dr.

Objective: To study the safety and efficacy of a cholinesterase inhibitor, do nepezil hydrochloride, for the treatment of dementia in Parkinson’ s disease (P D). Methods: This was a randomised double blind, placebo controlled, crossover s tudy in 22 subjects with PD and dementia. Participants were randomised to receiv e either donepezil followed by identical placebo, or placebo followed by donepezil. Do nepezil was administered at 5- 10 mg/day. Treatment periods were 10 weeks with a washout period of 6 weeks between the two periods. The primary outcome measure was the Alzheimer’ s Disease Assessment scale Cognitive subscale (ADAscog). Re sults: Donepezil was well tolerated and most adverse events were mild. There was no worsening of PD symptoms as measured by the total or motor sections of the U nified Parkinson’ s Disease Rating scale. There was a 1.9 point trend toward be tter scores on the ADAscog on treatment compared with placebo that was not stati stically significant. The secondary cognitive measures showed a statistically si gnificant 2 point benefit on the Mini Mental status Examination and no change on the Mattis Dementia Rating scale (MDRs). The Clinical Global Impression of Chan ge (CGI) showed a significant 0.37 point improvement on donepezil. No improvemen t was observed on the MDRs or the Brief Psychiatric Rating scale. Carryover betw een treatment periods was observed but was not statistically significant. Conclu sions: Donepezil was well tolerated and did not worsen PD. There may be a modest benefit on aspects of cognitive function. The possible clinical benefit measure d by CGI was reflected in only one of the cognitive scales used in this study.

关键词：盐酸多奈哌齐帕金森病痴呆交叉研究安慰剂对照认知功能阿尔茨海默病胆碱酯酶抑制剂预后指标临床改善等级量表

Impact of the 2010 resuscitation guidelines training on layperson chest compressions

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World Journal of Emergency Medicine 2015年第4期6卷 270-276页

作者： Audrey L.Blewer David G.Buckler Jiaqi Li Marion Leary Lance B.Becker Judy A.shea Peter W.Groeneveld Mary E.putt Benjamin s.Abella Department of Emergency Medicine and Center for Resuscitation science University of Pennsylvania school of Nursing University of Pennsylvania Department of Medicine University of Pennsylvania Department of Biostatistics and Epidemiology University of Pennsylvania

BACKGROUND: survival from cardiac arrest is sensitive to the quality of delivered CPR. In 2010, updated international resuscitation guidelines emphasized deeper chest compressions and faster rates, yet it is unknown whether training laypersons using updated guidelines resulted in changed CPR performance. We hypothesized that laypersons taught CPR using the 2010 guidelines performed deeper and faster compressions than those taught using the 2005 ***: This work represents a secondary analysis of a study conducted at eight hospitals where family members of hospitalized cardiac patients were trained in CPR. An initial cohort was trained using the 2005 guidelines, and a subsequent cohort was trained using the 2010 guideline materials. Post training, CPR skills were quantified using a recording ***: Between May 2009 to August 2013, 338 subjects completed the assessment. Among the subjects, 176 received 2005 training and 162 underwent 2010 training. The mean compression rate in the 2005 cohort was 87(95%CI 83–90) per minute, and in the 2010 cohort was 86(95%CI 83–90) per minute(P=ns), while the mean compression depth was 34(95%CI 32–35) mm in the 2005 cohort and 46(95%CI 44–47) mm in the 2010 cohort(PsIONs: Training with the 2010 CPR guidelines resulted in a statistically significant increase in trainees' compression depth but there was no change in compression rate. Nevertheless, the majority of CPR performed by trainees in both cohorts was below the guideline recommendation, highlighting an important gap between training goals and trainee performance.

关键词： Cardiopulmonary resuscitation Cardiac arrest sudden death Education Guidelines

建立和验证胎儿MR成像中脑成熟度的半定量评分方法:初步结果

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国际医学放射学杂志 2013年第5期 474-474页

作者： A.Vossough C.Limperopoulos M.E.putt A.J.du Plessis P.J.schwab J.Wu 林伶 Department of Radiology Children’s Hospital of Philadelphia

摘要目的建立临床胎儿MR影像中评价和判读胎儿脑成熟度的有效、可靠且简单的半定量目测评分方法。方法本研究是对先前通过机构审查委员会批准并遵循HIPAA法案的一项前瞻性研究的数据的回顾性分析。研究对象为48例正常妊娠的25～35周胎龄... 详细信息

摘要目的建立临床胎儿MR影像中评价和判读胎儿脑成熟度的有效、可靠且简单的半定量目测评分方法。方法本研究是对先前通过机构审查委员会批准并遵循HIPAA法案的一项前瞻性研究的数据的回顾性分析。研究对象为48例正常妊娠的25～35周胎龄(GA)的胎儿头颅MRI。胎儿脑总成熟度评分(fTMs)为脑皮质沟、髓鞘及胚胎基质等6个部分发育程度的单项评分的总和,以fTMs分值作为判断脑成

关键词：胎儿成熟度纤维性能胎儿脑 MR

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大学生体育能力及培养对策

体育学刊 2002年第6期9卷 80-82页

作者：钟振新陈中林涂伟仕长沙电力学院体育部湖南长沙410077 怀化师范专科学校体育系湖南怀化418008

培养大学生的体育能力 ,为其终身体育奠定基础是学校体育的重要环节。文中阐述了大学生体育能力的涵义及其所包含的基本内容 ,提出了高校体育应把体育能力放在重要位置 ,从教学思想、内容体系和方法等方面有目的、有计划地培养大学生体... 详细信息

培养大学生的体育能力 ,为其终身体育奠定基础是学校体育的重要环节。文中阐述了大学生体育能力的涵义及其所包含的基本内容 ,提出了高校体育应把体育能力放在重要位置 ,从教学思想、内容体系和方法等方面有目的、有计划地培养大学生体育能力的对策。

关键词：大学生体育体育能力