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Elevated blood pressure: Our family's fault?The genetics of essential hypertension

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World Journal of Cardiology 2014年第5期6卷 327-337页

作者： Aniket Natekar Randi L Olds Meghann W Lau Kathleen Min karra imoto Thomas P Slavin The John A. Burns School of Medicine University of Hawaii Honolulu HI 96813 United States Hawaii Community Genetics Honolulu HI96814 United States

AIM: To provide an updated review on current genetic aspects possibly affecting essential hypertension(EH), and to further elucidate their role in EH. METHODS: We searched for genetic and epigenetic factors in major studies associated with EH between Jan 2008-Oct 2013 using PubMed. We limited our search to reviews that discussed mostly human studies, and were accessible through the university online re-source. We found 11 genome wide association studies(GWAS), as well as five methylation and three miRNA studies that fit our search criteria. A distinction was not made between genes with protective effects or nega-tive effects, as this article is only meant to be a sum-mary of genes associated with any aspect of ***: We found 130 genes from the studies that met our inclusion/exclusion criteria. Of note, genes withmultiple study references include: STK39, CYP17A1, MTHFR-NPPA, MTHFR-NPPB, ATP2B1, CSK, ZNF652, UMOD, CACNB2, PLEKHA7, SH2B3, TBX3-TBX5, ULK4, CSK-ULK3, CYP1A2, NT5C2, CYP171A, PLCD3, SH2B3, ATXN2, CACNB2, PLEKHA7, SH2B3, TBX3-TBX5, ULK4, and HFE. The following genes overlapped between the genetic studies and epigenetic studies: WNK4 and BDKRB2. Several of the identified genes were found to have functions associated with EH. Many epigenetic factors were also correlated with EH. Of the epigenetic factors, there were no articles discussing siRNA and its effects on EH that met the search criteria, thus the topic was not included in this review. Among the miRNA tar-gets found to be associated with EH, many of the genes involved were also identified in the GWAS ***: Genetic hypertension risk algorithms could be developed in the future but may be of limited benefit due to the multi-factorial nature of EH. With emerging technologies, like next-generation sequenc-ing, more direct causal relationships between genetic and epigenetic factors affecting EH will likely be discov-ered creating a tremendous potential for personalized medicine using phar

关键词： Essential hypertension Epigenomics Genome-wide association study Genes MicroRNAs

Impact of Data Quality on Question Answering System Performances

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Intelligent Automation & Soft Computing 2023年第1期35卷 335-349页

作者： Rachid karra Abdelali Lasfar LASTIMI Laboratory Mohammadia School of EngineersMohammed V University in RabatMorocco

In contrast with the research of new models,little attention has been paid to the impact of low or high-quality data feeding a dialogue *** present paper makes thefirst attempt tofill this gap by extending our previous work on question-answering(QA)systems by investigating the effect of misspelling on QA agents and how context changes can enhance the *** of using large language models trained on huge datasets,we propose a method that enhances the model's score by modifying only the quality and structure of the data feed to the *** is important to identify the features that modify the agent performance because a high rate of wrong answers can make the students lose their interest in using the QA agent as an additional tool for distant *** results demonstrate the accuracy of the proposed context simplification exceeds 85%.Thesefindings shed light on the importance of question data quality and context complexity construct as key dimensions of the QA *** conclusion,the experimental results on questions and contexts showed that controlling and improving the various aspects of data quality around the QA system can significantly enhance his robustness and performance.

关键词： DataOps data quality QA system nlp context simplification

Topological Modeling of a One Stage Spur Gear Transmission

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Chinese Journal of Mechanical Engineering 2014年第5期27卷 900-908页

作者： MILADI CHAABANE Mariem PLATEAUX Régis CHOLEY Jean-Yves karra Chafik RIVIERE Alain HADDAR Mohamed Mechanical Modeling and Manufacturing Unit National Engineering School of Sfax(ENIS) BP 1173 – 3038 – Sfax – Tunisia Laboratory of Engineering of the Mechanical Structures and Materials High Institute of Mechanic of Paris(SUPMECA)3 rue Fernand HainautNational 93407 Saint-Ouen Cedex Mechanical Modeling and Manufacturing Unit National Engineering School of Sfax(ENIS) BP 1173–3038–Sfax–Tunisia

Finding a basis of unification for the modeling of mechatronic systems is the search subject of several *** paper is a part of a general research designed to the application of topology as a new approach for the modeling of mechatronic ***,the modeling of a one stage spur gear transmission using a topological approach is *** approach is based on the concepts of topological collections and transformations and implemented using the MGS（modeling of general systems）*** topological collections are used to specify the interconnection laws of the one stage spur gear transmission and the transformations are used to specify the local behavior laws of its different *** order to validate this approach,simulation results are presented and compared with those obtained with MODELICA language using Dymola *** good results are achieved,this approach might be used as a basis of unification for the modeling of mechatronic systems.

关键词： topological modeling topological collections transformations MGS language one stage spur gear

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Simultaneous determination of pioglitazone and candesartan in human plasma by LC-MS/MS and its application to a human pharmacokinetic study

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Journal of Pharmaceutical Analysis 2012年第3期2卷 167-173页

作者： Vijaya Kumari karra Nageswara Rao Pilli Jaswanth Kumar Inamadugu J.V.L.N.Seshagiri Rao University College of Pharmaceutical Sciences Jawaharlal Nehru Technological UniversityKukatpallyHyderabad-500085India Analytical and Environmental Chemistry Division Department of ChemistrySri Venkateswara UniversityTirupati-517502India College of Pharmaceutical Sciences Andhra UniversityVisakhapatnam-530003India

A simple and rapid liquid chromatography-tandem mass spectrometric(LC-MS/MS) assay method has been developed and fully validated for simultaneous quantification of pioglitazone and candesartan in human *** was used as an internal *** analytes were extracted from human plasma samples by solid-phase extraction technique using a Strata-X 33 mm polymeric *** reconstituted samples were chromatographed on a C18 column by using a 80:20(v/v) mixture of acetonitrile and 0.1% formic acid as the mobile phase at a flow rate of 0.8 mL/*** calibration curves obtained were linear(rZ0.99) over the concentration range of 15-3000 ng/mL for pioglitazone and 5-608 ng/mL for *** results of the intra-and inter-day precision and accuracy studies were well within the acceptable limits.A run time of 2.7 min for each sample made it possible to analyze more than 300 plasma samples per *** proposed method was found to be applicable to clinical studies.

关键词： Pioglitazone Candesartan Human plasma Solid-phase extraction LC-MS/MS Pharmacokinetics

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Influence of Cutting and Geometrical Parameters on the Cutting Force in Milling

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Engineering（科研） 2010年第10期2卷 751-761页

作者： Hedi Yangui Bacem Zghal Amir Kessentini Gael Chevallier Alain Riviere Mohamed Haddar Chafik karra Unite de Mecanique Modélisation et Production(U2MP)Ecole Nationale d’Ingénieurs de Sfax(E.N.I.S.)route soukra km 4 Sfax–TUNISIEFrance Laboratoire d’Ingénierie des Structures Mécanique et de Matériaux(LISMMA) Institut Supérieur de Mécanique de Paris(SUPMECA)3 rue Fernand Hainaut93407 cedex Saint ouenParis–France

This paper presents a numerical modelling of the dynamic behaviour of the Machine-Tool-Part system (MOP) in milling. The numerical study of such complex structure requires the use of sophisticated method like finite elements one. Simulation is employed to predict cutting forces and dynamic response of Machine-Tool-Part system (MOP) during end-milling operation. Finally, spectral analysis is presented to see the influence of feed direction in the vibration.

关键词： Milling Modelling Cutting Force Finite Element

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破碎流程循环负荷的计算

国外金属矿选矿 1979年第9期 40-43页

作者： V.K.karra 杨希明

在选择破碎设备、制定流程和设计车间时,对闭路流程循环负荷的计算,须要有一个简便准确而又非常实用的公式。闭路流程主要有两种类型:一种是新给矿给到流程的破碎机上(正闭路流程);另一种是新给矿给到筛子上(反闭路流程)。两种流程类型... 详细信息

在选择破碎设备、制定流程和设计车间时,对闭路流程循环负荷的计算,须要有一个简便准确而又非常实用的公式。闭路流程主要有两种类型:一种是新给矿给到流程的破碎机上(正闭路流程);另一种是新给矿给到筛子上(反闭路流程)。两种流程类型的循环负荷,都可计算出。

关键词：循环负荷百分数筛分效率破碎机粗碎机给矿

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喷孔几何形状对降低柴油机排放的影响

国外内燃机车 2010年第5期 9-18页

作者： Prashanth K karra[美] 范立铁（译者）程永陆（校者）

在一台采用高压共轨喷射系统的多缸柴油机上对3种喷嘴形状各异的喷油器进行了试验。试验采用多种喷射压力,并结合使用废气再循环技术,以获得低的NOx和碳烟排放。研究中采用的喷油器包括6孔喷嘴的、10孔喷嘴的和K系数为3的6孔收敛形喷嘴... 详细信息

在一台采用高压共轨喷射系统的多缸柴油机上对3种喷嘴形状各异的喷油器进行了试验。试验采用多种喷射压力,并结合使用废气再循环技术,以获得低的NOx和碳烟排放。研究中采用的喷油器包括6孔喷嘴的、10孔喷嘴的和K系数为3的6孔收敛形喷嘴的。所有3种喷油器具有相同的流量值。所试的所有3种喷油器在各自适当的条件下均有NOx和碳烟减排效果。研究发现,低温燃烧可通过采用高的废气再循环率与晚喷相结合来实现。在传统的喷油定时下,高喷射压力明显减少了碳烟的排放。在推迟的喷射定时(即上止点后5°曲轴转角)下,喷射压力的影响不明显。研究发现,在相同的喷射条件下,与直孔喷嘴相比,收敛形喷嘴会产生更高的碳烟排放量。收敛形喷嘴对NOx排放和燃油消耗率的影响不明显。10孔喷油器中的小喷孔喷嘴可产生较小的燃油滴从而导致更好的雾化。10孔喷油器在宽广的运行条件下似乎具有更好的空气利用率从而有显著的NOx和碳烟减排作用。

关键词：柴油机 NOx 碳烟节能减排喷油器喷孔几何形状收敛形喷孔

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一级诊疗中新诊断的甲状腺功能亢进症

英国医学杂志中文版 2019年第11期22卷 679-682页

作者： Gabriella Bathgate Efthimia karra Bernard Khoo 夏心怡(译) 殷峻(译) Royal Free London NHS Trust LondonUK 上海交通大学第六医院内分泌科

一位36岁的妇女向她的全科医生主诉6周心悸、烦躁史,4个月内体重下降12kg。她最初认为她的症状是由于工作和近期搬家的压力所致。检查后发现促甲状腺激素(TSH)明显下降(<0.01 mU/L),游离甲状腺素为86.1 pmol/L.甲状腺功能亢进(简称甲亢... 详细信息

一位36岁的妇女向她的全科医生主诉6周心悸、烦躁史,4个月内体重下降12kg。她最初认为她的症状是由于工作和近期搬家的压力所致。检查后发现促甲状腺激素(TSH)明显下降(<0.01 mU/L),游离甲状腺素为86.1 pmol/L.甲状腺功能亢进(简称甲亢)指甲状腺产生过量激素,而甲状腺毒症是由于甲亢等各种原因引起的循环内甲状腺素过多而导致的临床状态(图1)。

关键词：甲状腺功能亢进症甲状腺毒症游离甲状腺素全科医生临床状态体重下降甲亢