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Associations between the physical environment and park-based physical activity:A systematic review

Journal of Sport and Health Science 2019年第5期8卷 412-421页

作者： Ru Zhang Hagen Wulff Yanping Duan Petra wagner Department of Sport and Physical Education Faculty of Social SciencesHong Kong Baptist UniversityHong Kong 999077China Institute of Exercise and Public Health Faculty of Sport SciencesUniversity of LeipzigLeipzig 04109Germany

Background:With an increase in the evidence for the associations between park-based physical activity(PA)and physical environments(especially park and neighborhood environments),researchers face an important challenge in interpreting and summarizing the evidence to develop environ?mental change *** updated review is needed to better inform policymaking and environmental *** current study aimed to systematically review the research on the associations of park-based PA with park and neighborhood environmental ***:We targeted English peer-reviewed articles from 5 electronic databases using keywords related to park-based PA,park environments,and neighborhood *** the 4071 identified papers,25 studies published between 2008 and 2016 met all the eligibility criteria and were included in this ***:The characteristics of physical environment that received consistent support included paths/trails,lighting,and incivilities(e.g.,broken glasses and litter).Mixed findings were revealed for 6 park environmental factors(unspecified active facilities,playgrounds and skating areas,fit?ness stations,picnic areas,greenness,and park size)and 2 neighborhood environmental factors(park density and park proximity).Conclusion:It can be concluded that paths/trails,lighting,and incivilities are 3 key physical environmental attributes of park-based *** the inconsistent findings on park and neighborhood environmental factors,more robust designs such as prospective investigation are required.

关键词： Neighborhood Park-based physical activity Park environment Physical environment Systematic review

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Ultrasound enhanced friction stir welding of aluminum and steel： Process and properties of EN AW 6061/DC04-Joints

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Journal of Materials Science & Technology 2018年第1期34卷 163-172页

作者： Marco Thoma Guntram wagner Benjamin Straβ Bernd Wolter Sigrid Benferc Wolfram Furbeth Chair of Composites and Material Compounds Chemnitz University of Technology Chemnitz 09125 Germany Fraunhofer Institute for Nondestructive Testing IZFP Saarbrucken 66123 Germany DECHEMA-Forschungsinstitut Frankfurt am Main 60486 Germany

In this work, the joining of aluminum to steel was conducted by ultrasound enhanced friction stir weld- ing （USE-FSW）. The power ultrasound was introduced into one of the metal sheets by an ultrasonic roll seam module synchronously to the FSW-process. The effect of the ultrasound on the resulting welds, their microstructure and their corrosion properties was investigated by light and scanning electron microscopy and corrosion investigations. The USE-FSW-joints showed less and smaller steel particles in the nugget zone as well as a thinner continuous intermetallic phase of FeAl3 at the interface. The nondestructive testing method of computed laminography proved the observations made by optic microscopy due to non-porous joints for both techniques. Corrosion investigations showed only low corrosion current densities and no enhanced galvanic corrosion for the EN AW-6061/DC04-hybrid joints in sodium chloride solution.

关键词： Friction stir welding Ultrasound enhancement Dissimilar joints Corrosion

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Systems-based approaches to study immunometabolism

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Cellular & Molecular Immunology 2022年第3期19卷 409-420页

作者： Vinee Purohit Allon wagner Nir Yosef Vijay K.Kuchroo Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases Brigham and Women’s HospitalHarvard Medical SchoolBostonMA02115USA Broad Institute of MIT and Harvard CambridgeMA02141USA Department of Electrical Engineering and Computer Science University of CaliforniaBerkeleyCA94720USA Center for Computational Biology University of CaliforniaBerkeleyCA94720USA

Technical advances at the interface of biology and computation,such as single-cell RNA-sequencing(scRNA-seq),reveal new layers of complexity in cellular *** emerging area of investigation using the systems biology approach is the study of the metabolism of immune *** diverse spectra of immune cell phenotypes,sparsity of immune cell numbers in vivo,limitations in the number of metabolites identified,dynamic nature of cellular metabolism and metabolic fluxes,tissue specificity,and high dependence on the local milieu make investigations in immunometabolism challenging,especially at the single-cell *** this review,we define the systemic nature of immunometabolism,summarize cell-and system-based approaches,and introduce mathematical modeling approaches for systems interrogation of metabolic changes in immune *** close the review by discussing the applications and shortcomings of metabolic modeling *** systems-oriented studies of metabolism expected to become a mainstay of immunological research,an understanding of current approaches toward systems immunometabolism will help investigators make the best use of current resources and push the boundaries of the discipline.

关键词： Immunometabolism Metabolic techniques GSMM Metabolic modeling Systems biology

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TIC-Tox: A preliminary discussion on identifying the forcing agents of DBP-mediated toxicity of disinfected water

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Journal of Environmental Sciences 2017年第8期29卷 208-216页

作者： Michael J.Plewa Elizabeth D.wagner Susan D.Richardson Safe Global Water Institute and the Department of Crop Sciences University of Illinois at Urbana-Champaign Department of Chemistry and Biochemistry University of South Carolina

The disinfection of drinking water is a major public health achievement; however, an unintended consequence of disinfection is the generation of disinfection by-products（DBPs）. Many of the identified DBPs exhibit in vitro and in vivo toxicity, generate a diversity of adverse biological effects, and may be hazards to the public health and the *** a few DBPs are regulated by several national and international agencies and it is not clear if these regulated DBPs are the forcing agents that drive the observed toxicity and their associated health effects. In this study, we combine analytical chemical and biological data to resolve the forcing agents associated with mammalian cell cytotoxicity of drinking water samples from three cities. These data suggest that the trihalomethanes（THMs） and haloacetic acids may be a small component of the overall cytotoxicity of the organic material isolated from disinfected drinking water. Chemical classes of nitrogen-containing DBPs, such as the haloacetonitriles and haloacetamides, appear to be the major forcing agents of toxicity in these samples. These findings may have important implications for the design of epidemiological studies that primarily rely on the levels of THMs to define DBP exposure among populations. The TIC-Tox approach constitutes a beginning step in the process of identifying the forcing agents of toxicity in disinfected water.

关键词： DBPs CHO cell cytotoxicity Toxicity Additivity

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Designing the new generation of intelligent biocompatible carriers for protein and peptide delivery

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Acta Pharmaceutica Sinica B 2018年第2期8卷 147-164页

作者： Angela M.wagner Margaret P.Gran Nicholas A.Peppas McKetta Department of Chemical Engineering The University of Texas at Austin Institute for Biomaterials Drug Delivery and Regenerative Medicine The University of Texas at Austin Department of Biomedical Engineering The University of Texas at Austin Department of Pediatrics Dell Medical School The University of Texas at Austin Department of Surgery and Perioperative Care Dell Medical School The University of Texas at Austin Division of Pharmaceutics College of Pharmacy The University of Texas at Austin

Therapeutic proteins and peptides have revolutionized treatment for a number of diseases, and the expected increase in macromolecule-based therapies brings a new set of challenges for the pharmaceutics field. Due to their poor stability, large molecular weight, and poor transport properties,therapeutic proteins and peptides are predominantly limited to parenteral administration. The short serum half-lives typically require frequent injections to maintain an effective dose, and patient compliance is a growing issue as therapeutic protein treatments become more widely available. A number of studies have underscored the relationship of subcutaneous injections with patient non-adherence, estimating that over half of insulin-dependent adults intentionally skip injections. The development of oral formulations has the potential to address some issues associated with non-adherence including the interference with daily activities, embarrassment, and injection pain. Oral delivery can also help to eliminate the adverse effects and scar tissue buildup associated with repeated injections. However, there are several major challenges associated with oral delivery of proteins and peptides, such as the instability in the gastrointestinal(GI)tract, low permeability, and a narrow absorption window in the intestine. This review provides a detailed overview of the oral delivery route and associated challenges. Recent advances in formulation and drugdelivery technologies to enhance bioavailability are discussed, including the co-administration of compounds to alter conditions in the GI tract, the modification of the macromolecule physicochemical properties, and the use of improved targeted and controlled release carriers.

关键词： Oral delivery Hydrogels Protein delivery Peptide delivery Carbohydrates Mucoadhesion

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An evolutionary algorithm approach for the constrained multi-depot vehicle routing problem

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International Journal of Intelligent Computing and Cybernetics 2016年第1期9卷 2-22页

作者： Carin Lightner-Laws Vikas Agrawal Constance Lightner Neal wagner Clayton State University MorrowGeorgiaUSA Jacksonville University JacksonvilleFloridaUSA Fayetteville State University FayettevilleNorth CarolinaUSA MIT Lincoln Laboratory LexingtonMassachusettsUSA

Purpose-The purpose of this paper is to explore a real world vehicle routing problem(VRP)that has multi-depot subcontractors with a heterogeneous fleet of vehicles that are available to pickup/deliver jobs with varying time windows and *** the overall job completion time and number of drivers utilized are analyzed for the automated job allocations and manual job assignments from transportation field ***/methodology/approach-A nested genetic algorithm(GA)is used to automate the job allocation process and minimize the overall time to deliver all jobs,while utilizing the fewest number of drivers-as a secondary ***-Three different real world data sets were used to compare the results of the GA vs transportation field experts’manual *** job assignments from the GA improved the overall job completion time in 100 percent(30/30)of the cases and maintained the same or fewer drivers as BS Logistics(BSL)in 47 percent(14/30)of the ***/value-This paperprovidesa novel approach to solving a real world VRPthathasmultiple *** there have been numerous models to capture a select number of these variants,the value of this nested GA lies in its ability to incorporate multiple depots,a heterogeneous fleet of vehicles as well as varying pickup times,pickup locations,delivery times and delivery locations for each job into a single *** research does not provide models to collectively address all of these variants.

关键词： Genetic algorithms Evolutionary computation Vehicle routing Multiple depot transportation Hard/soft time windows

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Approaching the upper boundary of driver-response relationships:identifying factors using a novel framework integrating quantile regression with interpretable machine learning

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Frontiers of Environmental Science & Engineering 2023年第6期17卷 153-163页

作者： Zhongyao Liang Yaoyang Xu Gang Zhao Wentao Lu Zhenghui Fu Shuhang Wang Tyler wagner National Engineering Laboratory for Lake Pollution Control and Ecological Restoration State Environment Protection Key Laboratory for Lake Pollution ControlChinese Research Academy of Environmental SciencesBeijing 100012China Fujian Provincial Key Laboratory for Coastal Ecology and Environmental Studies Xiamen UniversityXiamen 361102China College of the Environment&Ecology Xiamen UniversityXiamen 361102China Key Laboratory of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Department of Global Ecology Carnegie Institution for ScienceStanfordCA 94305USA Institute of Strategic Planning Chinese Academy of Environmental PlanningBeijing 100012China The Center for Beautiful China Chinese Academy of Environmental PlanningBeijing 100012China U.S.Geological Survey Pennsylvania Cooperative Fish and Wildlife Research UnitPennsylvania State UniversityUniversity ParkPA 16802USA

The identification of factors that may be forcing ecological observations to approach the upper boundary provides insight into potential mechanisms affecting driver-response relationships,and can help inform ecosystem management,but has rarely been *** this study,we propose a novel framework integrating quantile regression with interpretable machine *** the first stage of the framework,we estimate the upper boundary of a driver-response relationship using quantile ***,we calculate“potentials”of the response variable depending on the driver,which are defined as vertical distances from the estimated upper boundary of the relationship to observations in the driver-response variable scatter ***,we identify key factors impacting the potential using a machine learning *** illustrate the necessary steps to implement the framework using the total phosphorus(TP)-Chlorophyll a(CHL)relationship in lakes across the continental *** found that the nitrogen to phosphorus ratio(N:P),annual average precipitation,total nitrogen(TN),and summer average air temperature were key factors impacting the potential of CHL depending on *** further revealed important implications of our findings for lake eutrophication *** important role of N:P and TN on the potential highlights the co-limitation of phosphorus and nitrogen and indicates the need for dual nutrient *** wetter and/or warmer climate scenarios can decrease the potential which may reduce the efficacy of lake eutrophication *** novel framework advances the application of quantile regression to identify factors driving observations to approach the upper boundary of driver-response relationships.

关键词： Driver-response Upper boundary of relationship Interpretable machine learning Quantile regression Total phosphorus Chlorophyll a

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Stochastic seismic inversion and Bayesian facies classification applied to porosity modeling and igneous rock identification

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Petroleum Science 2024年第2期21卷 918-935页

作者： Fábio Júnior Damasceno Fernandes Leonardo Teixeira Antonio Fernando Menezes Freire wagner Moreira Lupinacci Exploratory Interpretation and Reservoir Characterization Group(GIECAR) Department of Geology and GeophysicsFederal Fluminense UniversityNiter oiRJ24210-346Brazil Petrobras Rio de JaneiroRJ20231-030Brazil National Institute of Science and Technology of Petroleum Geophysics(INCT-GP/CNPQ) Niter oiRJ24210-346Brazil

We apply stochastic seismic inversion and Bayesian facies classification for porosity modeling and igneous rock identification in the presalt interval of the Santos Basin. This integration of seismic and well-derived information enhances reservoir characterization. Stochastic inversion and Bayesian classification are powerful tools because they permit addressing the uncertainties in the model. We used the ES-MDA algorithm to achieve the realizations equivalent to the percentiles P10, P50, and P90 of acoustic impedance, a novel method for acoustic inversion in presalt. The facies were divided into five: reservoir 1,reservoir 2, tight carbonates, clayey rocks, and igneous rocks. To deal with the overlaps in acoustic impedance values of facies, we included geological information using a priori probability, indicating that structural highs are reservoir-dominated. To illustrate our approach, we conducted porosity modeling using facies-related rock-physics models for rock-physics inversion in an area with a well drilled in a coquina bank and evaluated the thickness and extension of an igneous intrusion near the carbonate-salt interface. The modeled porosity and the classified seismic facies are in good agreement with the ones observed in the wells. Notably, the coquinas bank presents an improvement in the porosity towards the top. The a priori probability model was crucial for limiting the clayey rocks to the structural lows. In Well B, the hit rate of the igneous rock in the three scenarios is higher than 60%, showing an excellent thickness-prediction capability.

关键词： Stochastic inversion Bayesian classification Porosity modeling Carbonate reservoirs Igneous rocks

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National Cancer Institute’s early detection research network:a model organization for biomarker research

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Journal of the National Cancer Center 2023年第2期3卷 93-99页

作者： Paul D.wagner Sudhir Srivastava Cancer Biomarkers Research Group Division of Cancer PreventionNational Cancer InstituteBethesdaUSA

For many cancers a primary cause of poor survival is that they are detected at a late stage when therapies are less *** screening methods exist to detect some types of cancer at an early stage,there are currently no effective methods to screen for most types of *** have the potential to improve detection of early-stage cancers,risk stratification,and prediction of which pre-cancerous lesions are likely to progress and to make screening tests less *** thousands of research articles on biomarkers for early detection are published every year,few of these biomarkers have been validated and shown to be clinically *** reflects both the inherent difficulty in detecting early-stage cancers and a disconnect between the process of discovering biomarkers and their use in the *** overcome this limitation the US National Cancer Institute created the Early Detection Research *** is a highly collaborative program that brings together biomarker discoverers,assay developers,and *** provides an infrastructure that is essential for developing and validating biomarkers and imaging methods for early cancer detection and has successfully completed several multicenter validation studies.

关键词： Biomarkers Early detection Validation Collaboration Data sharing

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Geochemical Evaluation of the Permian Ecca Shale in Eastern Cape Province, South Africa:Implications for Shale Gas Potential

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Acta Geologica Sinica(English Edition) 2018年第3期92卷 1193-1217页

作者： Christopher BAIYEGUNHI Kuiwu LIU Nicola wagner Oswald GWAVAVA Temitope L.OLONINIYI Department of Geology University of Fort Hare Department of Geology University of Johannesburg

Shale gas has been the exploration focus for future energy supply in South Africa in recent time. Specifically, the Permian black shales of the Prince Albert, Whitehill, Collingham, Ripon and Fort Brown Formations are considered to be most prospective rocks for shale gas exploration. In this study,outcrop and core samples from the Ecca Group were analyzed to assess their total organic carbon(TOC), organic matter type, thermal maturity and hydrocarbon generation potential. These rocks have TOC ranging from 0.11 to 7.35 wt%. The genetic potential values vary from 0.09 to 0.53 mg HC/g,suggesting poor hydrocarbon generative potential. Most of the samples have Hydrogen Index(HI) values of less than 50 mg HC/g TOC, thus suggesting Type-Ⅳ kerogen. Tmax values range from 318℃ to601℃, perhaps indicating immature to over-maturity of the samples. The vitrinite reflectance values range from 2.22% to 3.93%, indicating over-maturity of samples. Binary plots of HI against Oxygen Index(OI), and HI versus Tmax show that the shales are of Type II and mixed Type Ⅱ-Ⅲ *** on the geochemical data, the potential source rocks are inferred as immature to over-matured and having present-day potential to produce gas.

关键词： geochemistry organic matter type thermal maturity hydrocarbons Ecca Group South Africa

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