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Correlations between skin lesions induced by anti-tumor necrosis factor-α and selected cytokines in Crohn's disease patients

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World Journal of Gastroenterology 2014年第22期20卷 7019-7026页

作者： Marcin Wodarczyk Aleksandra Sobolewska Bartosz Wójcik karolina loga Jakub Fichna Maria Wisniewska-Jarosińska Department of Gastroenterology Medical University of Lodz90-647 LodzPoland Jakub Fichna Department of Biochemistry Medical University of Lodz 92-215 Lodz Poland

AIM:To investigate the correlation between the appearance of skin lesions and concentration of interleukin(IL)-17A,IL-23 and interferon-γ(IFN-γ)in Crohn’s disease(CD)patients during anti-tumor necrosis factor-α(TNF-α)therapy METHODS:A prospective study included 30 adult patients with CD of Caucasian origin(19 men and 11women;mean age±SD 32.0±8.6 years)during biological therapy with anti-TNF-αantibodies from January2012 to March *** patients were treated with infliximab,seven with adalimumab and five *** criteria were exacerbation of the underlying disease,Crohn’s Disease Activity Index over 300 and the ineffectiveness of previously used non-biological *** with a history of psoriasis,atopic dermatitis and other autoimmune skin lesions were excluded from the *** control group consisted of 12 healthy subjects.A diagnostic survey was carried out,blood tests and careful skin examination were performed,and the serum levels of IL-17,IL-23 and IFN-γwere measured using an enzyme-linked immunosorbent assays *** that have developed in the course of biological therapy in patients who had no pre-existing skin lesions of similar character were qualified as skin lesions induced by antiTNF-α***:Skin manifestations occurred in 18 of CD patients during the anti-TNF-αtherapy(60%),in the average time of 10.16±3.42 mo following the beginning of the 52-wk treatment *** lesions observed in CD patients during biological therapy included psoriasiform lesions(44.4%),and eczema forms lesions(22.2%).In CD patients with drug induced skin lesions significantly higher levels of hemoglobin(13.3±1.5 g/dL vs 10.8±1.9 g/dL,P=0.018)and hematocrit(39.9%±4.5%vs 34.3%±5.4%,P=0.01),as well as a significantly lower level of platelets(268±62×103/μL vs 408±239×103/μL,P=0.046)was observed compared with CD patients without skin *** concentrations of IL-17A and IL-23in CD patients with skin lesions developed

关键词： Biological therapy Crohn's disease Inter-leukin 17A Interleukin 23 Interferon γ Tumor necrosis factor-α

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