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Immune-mediated liver injury following COVID-19 vaccination

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World Journal of Virology 2023年第2期12卷 100-108页

作者： Georgios Schinas Eleni Polyzou Vasiliki Dimakopoulou Stamatia Tsoupra Charalambos Gogos karolina akinosoglou Department of Medicine University of PatrasPatras 26504Greece Department of Internal Medicine University of PatrasPatras 26504Greece

Liver injury secondary to vaccination is a rare adverse event that has recently come under attention thanks to the continuous pharmacovigilance following the widespread implementation of coronavirus disease 2019(COVID-19)vaccination *** three most widely distributed severe acute respiratory syndrome coronavirus 2 vaccine formulations,e.g.,BNT162b2,mRNA-1273,and ChAdOx1-S,can induce liver injury that may involve immune-mediated pathways and result in autoimmune hepatitis-like presentation that may require therapeutic intervention in the form of corticosteroid *** mechanisms have been proposed in an attempt to highlight immune checkpoint inhibition and thus establish causality with *** autoimmune features of such a reaction also prompt an in-depth investigation of the newly employed vaccine *** vaccine delivery platforms,e.g.,mRNA-containing lipid nanoparticles and adenoviral vectors,contribute to the inflammatory background that leads to an exaggerated immune response,while patterns of molecular mimicry between the spike(S)protein and prominent liver antigens may account for the autoimmune *** mediators triggered by vaccination or vaccine ingredients per se,including autoreactive antibodies,cytokines,and cytotoxic T-cell populations,may inflict hepatocellular damage through wellestablished *** aim to review available data associated with immunemediated liver injury associated with COVID-19 vaccination and elucidate potential mechanisms underlying its pathogenesis.

关键词： Adverse effects COVID-19 vaccines mRNA vaccine Autoimmune Hepatitis Chemical and Drug Induced Liver Injury Autoimmunity

Immune-modulating therapy in acute pancreatitis:Fact or fiction

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World Journal of Gastroenterology 2014年第41期20卷 15200-15215页

作者： karolina akinosoglou Charalambos Gogos Department of Internal Medicine and Infectious Diseases University General Hospital of Patras

Acute pancreatitis(AP) is one of the most common diseases of the gastrointestinal tract,bearing significant morbidity and mortality *** treatment of AP remains unspecific and supportive and is mainly targeted to aggressively prevent systemic complications and organ failure by intensive *** acute pancreatitis shares an indistinguishable profile of inflammation with sepsis,therapeutic approaches have turned towards modulating the systemic inflammatory ***,among others,have included pro- and antiinflammatory modulators,cytokines,chemokines,immune cells,adhesive molecules and *** though,initial results in experimental models have been encouraging,clinical implementation of immuneregulating therapies in acute pancreatitis has had a slow *** reasons include difficulty in clinical translation of experimental data,poor understanding of inflammatory response time-course,flaws in experimental designs,need for multimodal approaches and commercial *** immune-modulation in acute pancreatitis remains a fact or just fiction remains to be seen in the future.

关键词： Acute pancreatitis Immune-modulation Systemic infl

Modern approaches for detection of volatile organic compounds in metabolic studies focusing on pathogenic bacteria:Current state of the art

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Journal of Pharmaceutical Analysis 2024年第4期14卷 483-505页

作者： karolina Zuchowska Wojciech Filipiak Department of Pharmacodynamics and Molecular Pharmacology Faculty of PharmacyCollegium Medicum in BydgoszczNicolaus Copernicus University in Torun85-089 BydgoszczPoland

Pathogenic microorganisms produce numerous metabolites,including volatile organic compounds(VOCs).Monitoring these metabolites in biological matrices(e.g.,urine,blood,or breath)can reveal the presence of specific microorganisms,enabling the early diagnosis of infections and the timely implementation of tar-geted ***,complex matrices only contain trace levels of VOCs,and their constituent com-ponents can hinder determination of these ***,modern analytical techniques enabling the non-invasive identification and precise quantification of microbial VOCs are *** this paper,we discuss bacterial VOC analysis under in vitro conditions,in animal models and disease diagnosis in humans,including techniques for offline and online analysis in clinical *** also consider the advantages and limitations of novel microextraction techniques used to prepare biological samples for VOC analysis,in addition to reviewing current clinical studies on bacterial volatilomes that address inter-species in-teractions,the kinetics of VOC metabolism,and species-and drug-resistance specificity.

关键词： Volatile organic compounds Pathogenic bacteria metabolites Metabolomics Microextraction techniques Gas chromatography-mass spectrometry In vivo breath analysis In vitro model

Coronary atherosclerosis burden is not advanced in patients with β-thalassemia despite premature extracardiac atherosclerosis： a coronary artery calcium score and carotid intima-media thickness study

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Journal of Geriatric Cardiology 2016年第2期13卷 158-162页

作者： George Hahalis Evangelia Zacharioglou Ioanna Xanthopoulou Ioanna Koniari Chistina Kalogeropoulou Irene Tsota Aspasia Rigopoulou Athanasios Diamantopoulos Vasilios Gkizas Periklis Davlouros karolina akinosoglou Marianna Leopoulou Charalampos Gogos Dimitrios Alexopoulos Cardiology Department of Patras University Hospital Patras Greece Radiology Department of Patras University Hospital Patras Greece Internal Medicine Department of Patras University Hospital Patras Greece

BackgroundThalassemic 病人表明 extracardiac 的增加的率脉管的复杂并发症和增加的颈动脉墙 intima 媒介厚度(cIMT ) ，而是冠的动脉疾病(CAD ) 的很低的流行。我们由估计冠的动脉钙(CAC ) 调查了粉瘤负担，在这些 *** 的 cIMT 与 &#x... 详细信息

BackgroundThalassemic 病人表明 extracardiac 的增加的率脉管的复杂并发症和增加的颈动脉墙 intima 媒介厚度(cIMT ) ，而是冠的动脉疾病(CAD ) 的很低的流行。我们由估计冠的动脉钙(CAC ) 调查了粉瘤负担，在这些 *** 的 cIMT 与 β 检查了 37 个病人； -thalassemia 和 150 健康控制与多察觉者计算机断层摄影术(CT ) 和 ultrasonography 自愿决定 CAC 分数和 cIMT， *** 分数匹配(C 统计数值：0.88；95% CI：0.83-0.93 ) 导致了 27 个病人；严重 CAC 在 2 被观察(7.4%) 并且 0 β； -thalassemia 病人和健康志愿者分别地(P = 0.5 ) 。中部的钙分数是 0 (0-0 ) 在 β； -thalassemia 病人并且 0 (0-4 ) 在健康志愿者(P = 0.8 ) 。中部的 intima 媒介厚度在 β 是更高的；与控制相比的 -thalassemia 病人组织[0.45 (0.06-0.65 ) 对 0.062 (0.054-0.086 ) ；P = 0.04 ] 有 β 的 .ConclusionsPatients；与健康控制比较的 -thalassemia 使展览遭到类似的 CAC 分数和增加的 cIMT。我们的调查结果显示动脉粥样硬化在之间的前进的迥异的率冠并且在把支持借给流行病学的证据的这些病人的 extracardiac 动脉。

关键词：冠状动脉粥样硬化地中海贫血颈动脉膜厚度患者评分钙化计算机断层扫描

Short neuropeptide F in integrated insect physiology

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第5期25卷 389-409页

作者： Marcin CHOLEWINSKI Szymon CHOWANSKI Jan LUBAWY Arkadiusz URBANSKI karolina WALKOWIAK-NOWICKA Paweł MARCINIAK Department of Animal Physiology and Developmental Biology Adam Mickiewicz UniversityPoznan 61-614Poland

The short neuropeptide F(sNPF)family of peptides is a multifunctional group of neurohormones involved in the regulation of various physiological processes in *** have been found in a broad spectrum of species,but the number of isoforms in the precursor molecule varies from one to *** receptor for sNPF(sNPFR),which belongs to the G protein-coupled receptor family,has been characterized in various insect orders and was shown to be an ortholog of the mammalian prolactin-releasing peptide receptor(PrPR).The sNPF signaling pathway interacts with other neurohormones such as insulin-like peptides,SIFamide,and pigment-dispersing factors(PDFs)to regulate various *** main physiological function of sNPF seems to be involved in the regulation of feeding,but the observed effects are *** is also connected with the regulation of foraging behavior and the olfactory *** influence of sNPF on feeding and thus energy metabolism may also indirectly affect other vital processes,such as reproduction and *** addition,these neurohormones are involved in the regulation of locomotor activity and circadian rhythm in *** review summarizes the current state of knowledge about the sNPF system in insects.

关键词： Insect neuropeptide Invertebrate neurobiology Short neuropeptide F(sNPF) Feeding Neurohormone

昆虫生理中短神经肽F的功能研究进展（英文）

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第5期 389-410页

作者： Marcin CHOLEWI?SKI Szymon CHOWA?SKI Jan LUBAWY Arkadiusz URBA?SKI karolina WALKOWIAK-NOWICKA Pawe? MARCINIAK 亚当密茨凯维奇大学生物学院动物生理学和发育生物学系

短神经肽F(sNPF)肽家族是参与调控昆虫体内各种生理过程的多功能神经激素。它们广泛分布于生物体中，但前体分子中的异构体数量因物种而异，从一个到四个不等。sNPF受体（sNPFR）属于G蛋白偶联受体家族，在多种昆虫目中已有表征，并被... 详细信息

短神经肽F(sNPF)肽家族是参与调控昆虫体内各种生理过程的多功能神经激素。它们广泛分布于生物体中，但前体分子中的异构体数量因物种而异，从一个到四个不等。sNPF受体（sNPFR）属于G蛋白偶联受体家族，在多种昆虫目中已有表征，并被证明是哺乳动物泌乳素释放肽受体（PrPR）的同源物。sNPF信号通路通过与其他神经激素（例如类胰岛素肽、SIFamide和色素分散因子（PDFs））的相互作用以调控多种生理过程。其主要生理功能涉及摄食的调节，但观察到的效应因物种而异。sNPF还与觅食行为和嗅觉系统的调节相关。其对摄食及能量代谢的影响还可能间接影响其他重要过程，例如繁殖和发育。此外，这些神经激素还参与昆虫的运动活动和昼夜节律的调节。本文回顾并总结了昆虫中sNPF系统的现阶段研究进展。

关键词：昆虫神经肽无脊椎动物神经生物学短神经肽F(sNPF) 摄食神经激素

Positive health:An integrated quantitative approach in patients with chronic gastrointestinal and hepato-pancreatico-biliary disorders

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World Journal of Gastroenterology 2024年第28期30卷 3418-3427页

作者： Anja H W M Lemlijn-Slenter karolina AP Wijnands Gijs van der Hamsvoort Luuk P van Iperen Nico Wolter Angelique E de Rijk Ad AM Masclee Department of Social Medicine Faculty of HealthMedicine and Life sciencesCare and Public Health Research Institute Maastricht UniversityMaastricht 6200 MDLimburgNetherlands Division of Gastroenterology and Hepatology Department of Internal MedicineSchool of Nutrition and Translational Research in MetabolismMaastricht 6200 MDLimburgNetherlands Social Medical Affairs Employee Insurance Agency(UWV)Heerlen 6400 ACLimburgNetherlands Department of Research Academic Knowledge Center Work and Health South-East Netherlands(AKAG-ZON)Heerlen 6400 ACLimburgNetherlands

BACKGROUND The concept of positive health(PH)supports an integrated approach for patients by taking into account six dimensions of *** approach is especially relevant for patients with chronic *** gastrointestinal and hepatopancreatico-biliary(GI-HPB)disorders are among the top-6 of the most prevalent chronically affected organ *** impact of chronic GI-HPB disorders on individuals may be disproportionally high because:(1)The affected organ system frequently contributes to a malnourished state;and(2)persons with chronic GIHPB disorders are often younger than persons with chronic diseases in other organ *** To describe and quantify the dimensions of PH in patients with chronic GI-HPB *** Prospective,observational questionnaire study performed between 2019 and 2021 in 235 patients with a chronic GIHPB disorder attending the Outpatient Department of the Maastricht University Medical *** questionnaires and data from patient files were used to quantify the six dimensions of *** consistency was tested with McDonald’s ***-order Pearson correlations and t-tests were used to assess associations and differences.A P value<0.05 was considered *** The GI-HPB patients scored significantly worse in all dimensions of PH compared to control data or norm scores from the general *** quality of life,participation and daily functioning,GI-HPB patients scored in the same range as patients with chronic disorders in other organ systems,but depressive symptoms(in 35%)and malnutrition(in 45%)were more frequent in patients with chronic GI-HPB *** scores between the six dimensions were only very weak to weak,forcing us to quantify each domain *** All six dimensions of PH are impaired in the GI-HPB *** and depressive symptoms are more prevalent compared to patients with chronic disorders in other organ systems.

关键词： Positive health Chronic gut disorders Gastrointestinal disorders Hepato-pancreatico-biliary disorders Integrated care

Knowledge,management,and complications of sepsis and septic shock:A significant therapeutic challenge in the intensive care unit

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Journal of Acute Disease 2024年第2期13卷 53-59页

作者： Jakub Mizera Adrian Bystroń karolina Matuszewska Justyna Pilch Ugo Giordano Wroclaw Medical University wyb.Ludwika Pasteura 150-367 WrocławPoland

Sepsis and septic shock are life-threatening conditions that are globally responsible for almost 20%of mortality,especially in low and middle-income *** review was conducted on PubMed and Google Scholar databases with keywords sepsis,septic shock,sepsis management,and sepsis *** published up to July 2023 in English were *** and management should be carried out without unnecessary *** between various medical specialties including intensive care doctors,neurologists,hepatologists,cardiologists,and pediatric doctors is needed if a child is *** strategies have to be implemented in low and middle-income countries to decrease the sepsis incidence and reduce mortality in the population.

关键词： Sepsis Septic shock Management Complications Diagnosis Review

Low-grade myofibrosarcoma of the maxillary sinus:Two case reports

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World Journal of Clinical Oncology 2024年第4期15卷 566-575页

作者： Anna Mydlak ŁukaszŚcibik Monika Durzynska Jakub Zwoliński karolina Buchajska Olga Lenartowicz Jakub Kucharz Department of Head and Neck Cancer Maria Sklodowska-Curie National Research Institute of OncologyWarsaw 02-781Poland Department of Otolaryngology and Head and Neck Oncological Surgery The 5th Military Clinical Hospital with PolyclinicKrakow 30-901Poland Department of Pathology Maria Sklodowska-Curie National Research Institute of OncologyWarsaw 02-781Poland Department of Genitourinary Oncology Maria Sklodowska-Curie National Research Institute of OncologyWarsaw 02-781Poland

BACKGROUND Low-grade myofibroblastic sarcoma(LGMS)is an extremely rare tumor characterized by the malignant proliferation of *** most commonly develops in adults,predominantly in males,in the head and neck region,oral cavity,especially on the tongue,mandible,and *** article presents 2 cases of LGMS localized to the maxillary sinus and provides an overview of the available *** SUMMARY Two patients with LGMS located in the maxillary sinus underwent surgery at the Department of Head and Neck *** 1:A 46-year-old patient was admitted to the clinic with suspected LGMS recurrence in the right maxillary sinus(rT4aN0M0),with symptoms of pain in the suborbital area,watering of the right eye,thick discharge from the right nostril,and augmented facial *** open biopsy-confirmed LGMS,the patient underwent expanded maxillectomy of the right side with immediate palate reconstruction using a microvascular skin flap harvested surgically from the middle *** patient qualified for adjuvant radiotherapy for the postoperative bed,with an additional ***,the patient is under 1.5 years of observation with no evidence of *** 2:A 45-year-old man was admitted to our clinic with facial asymmetry,strabismus,exophthalmos,and visual impairment in the right *** months earlier,the patient had undergone partial jaw resection at another hospital for fibromatosis.A contrast-enhanced computed tomography scan revealed a tumor mass in the postoperative log after an earlier *** open biopsy confirmed lowgrade fibrosarcoma(rT4aN0M0).The patient qualified for an extended total right maxillectomy with orbital excision and right hemimandibulectomy with immediate microvascular reconstruction using an anterolateral thigh *** patient subsequently underwent adjuvant radiotherapy to the postoperative *** 9 months,recurrence occurred in the right mandibular arch below the irradiated *** lesion infiltrated t

关键词： Head and neck cancer Paranasal sinuses Maxillary sinus Sarcoma Low-grade myofibroblastic sarcoma Case report