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Phagocytic and oxidative burst activity of neutrophils in the end stage of liver cirrhosis

World Journal of Gastroenterology 2005年第48期11卷 7661-7665页

作者： Anatol Panasiuk Jolanta Wysocka Elzbieta Maciorkowska Bozena Panasiuk Danuta Prokopowicz Janusz Zak karol Radomski Department of Infectious Diseases Department of Pediatrics Diagnostics Department of Pediatric Nursing

AIM：To evaluate the phagocytic activity and neutrophil oxidative burst in liver ***： In 45 patients with advanced postalcoholic liver cirrhosis （aged 45±14 years） and in 25 healthy volunteers （aged 38±5 years）, the percentage of phagocytizing cells after in vitro incubation with E. coli （Phagotest Kit）, phagocytic activity （mean intensity of fluorescence, MIF） and the percentage of neutrophil oxidative burst （Bursttest Kit）, and the level of free oxygen radical production （MIF of Rodamine 123） were analyzed by flow cytometry. The levels of soluble sICAM-1, sVCAM-1, sP-selectin, sE-selectin, sL-selectin, and TNF-α were determined in blood ***： The percentage of E. coli phagocytizing neutrophils in liver cirrhosis patients was comparable to that in healthy subjects. MIF of neutrophil - ingested E. coli was higher in patients with liver cirrhosis. The oxidative burst in E. coli phagocytizing neutrophils generated less amount of active oxygen compounds in liver cirrhosis pa- tients （MIF of R123：24.7±7.1 and 29.7±6.6 in healthy, P〈0.01）. Phorbol myristate acetate （PMA） - stimulated neutrophilsproduced less reactive oxidants in liver cirrhosis patients than in healthy subjects （MIF of R123： 42.7±14.6 vs 50.2±13.3, P〈0.01）. A negative correlation was observed between oxidative burst MIF of PMA-stimulated neutrophils and ALT and AST levels （r -0.35, P〈0.05; r-0.4, P〈0.03）. sVCAM-1, sICAM-1, sE-selectin concentrations correlated negatively with the oxygen free radical production （MIF of R123） in neutrophils after PMA stimulation in liver cirrhosis patients （r-0.45, P〈0.05, r-0.41, P〈0.05; r-0.39, P〈0.05, respectively）.CONCLUSION： Neutrophil metabolic activity diminishes together with the intensification of liver failure. The metabolic potential of phagocytizing neutrophils is significantly lower in liver cirrhosis patients, which can be one of the causes of immune mechanism damage. The evaluation of oxygen metabolism of E. coli-stimulated neutrophils

关键词： Neutrophil Phagocytosis Oxidative burst Liver cirrhosis Flow cytometry

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IRAK4 inhibition: a promising strategy for treating RA joint inflammation and bone erosion

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Cellular & Molecular Immunology 2021年第9期18卷 2199-2210页

作者： Sadiq Umar karol Palasiewicz Katrien Van Raemdonck Michael V.Volin Bianca Romay MAsif Amin Ryan K.Zomorrodi Shiva Arami Mark Gonzalez Vikram Rao Brian Zanotti David A.Fox Nadera Sweiss Shiva Shahrara Jesse Brown VA Medical Center ChicagoIL60612USA Department of Medicine Division of RheumatologyUniversity of Illinois at ChicagoChicagoIL60612USA Department of Microbiology and Immunology Midwestern UniversityDowners GroveIL60515USA Division of Rheumatology and Clinical Autoimmunity Center of Excellence University of MichiganAnn ArborMI481096USA Department of Orthopedic Surgery University of Illinois at ChicagoChicagoIL60612USA Pfizer Research CambridgeMA02139USA

Flares of joint inflammation and resistance to currently available biologic therapeutics in rheumatoid arthritis(RA)patients could reflect activation of innate immune ***,we show that a TLR7 GU-rich endogenous ligand,miR-Let7b,potentiates synovitis by amplifying RA monocyte and fibroblast(FLS)***-Let7b ligation to TLR7 in macrophages(MΦs)and FLSs expanded the synovial inflammatory ***,secretion of M1 monokines triggered by miR-Let7b enhanced Th1/Th17 cell *** showed that IRAK4 inhibitor(i)therapy attenuated RA disease activity by blocking TLR7-induced M1 MΦor FLS activation,as well as monokine-modulated Th1/Th17 cell ***4i therapy also disrupted RA osteoclastogenesis,which was amplified by miR-Let7b ligation to joint myeloid ***,the effectiveness of IRAK4i was compared with that of a TNF inhibitor(i)or anti-IL-6R treatment in collagen-induced arthritis(CIA)and miR-Let7b-mediated *** found that TNF or IL-6R blocking therapies mitigated CIA by reducing the infiltration of joint F480+iNOS+MΦs,the expression of certain monokines,and Th1 cell ***,these biologic therapies were unable to alleviate miR-Let7b-induced *** superior efficacy of IRAK4i over anti-TNF or anti-IL-6R therapy in miR-Let7b-induced arthritis or CIA was due to the ability of IRAK4i therapy to restrain the migration of joint F480+iNOS+MΦs,vimentin+fibroblasts,and CD3+T cells,in addition to negating the expression of a wide range of monokines,including IL-12,MIP2,and IRF5 and Th1/Th17 *** conclusion,IRAK4i therapy may provide a promising strategy for RA therapy by disconnecting critical links between inflammatory joint cells.

关键词： TLR7 MΦs RA FLSs osteoclasts T cells IRAK4

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钢渣沥青混合料应用现状

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交通运输工程学报 2020年第2期20卷 15-33页

作者：何亮詹程阳吕松涛 GRENFELL James 高杰 KOWALSKI karol J VALENTIN Jan 谢君 REKLidija 凌天清重庆交通大学交通土建工程材料国家地方联合工程实验室重庆400074 长沙理工大学特殊环境道路工程湖南省重点实验室湖南长沙410114 ARRB集团有限公司维多利亚墨尔本VIC3207 华沙理工大学土木工程学院马佐夫舍华沙00-637 捷克理工大学土木工程学院布拉格16629 武汉理工大学硅酸盐建筑材料国家重点实验室湖北武汉430070 斯洛文尼亚国家建筑和土木工程研究院沥青与沥青基产物实验室卢布尔雅那SI1000

总结了钢渣的物理性质、化学成分及矿物相组成,分析了影响钢渣体积安定性的因素及其改善措施,探讨了钢渣沥青混合料的配合比设计方法,分析了钢渣沥青混合料的路用性能(高温稳定性、低温抗裂性、水稳定性、抗疲劳性、体积安定性、抗滑性... 详细信息

总结了钢渣的物理性质、化学成分及矿物相组成,分析了影响钢渣体积安定性的因素及其改善措施,探讨了钢渣沥青混合料的配合比设计方法,分析了钢渣沥青混合料的路用性能(高温稳定性、低温抗裂性、水稳定性、抗疲劳性、体积安定性、抗滑性)及其功能特性(导电性与微波加热),研究了钢渣沥青混合料的生态、社会及经济效益,介绍了国内外的工程应用。研究结果表明:钢渣可用于沥青混合料,且应为陈化半年以上的转炉钢渣或电炉钢渣,钢渣的物理力学性能优良,而化学成分及矿物相组成受炼钢工艺影响有所区别,钢渣体积安定性的不足可通过预处理或陈化处理得到较好的改善,钢渣沥青混合料的配合比设计要点包括钢渣替代传统集料的方式和比例、沥青混合料级配修正、有效相对密度测定以及最佳油石比的确定,钢渣沥青混合料的路用性能及功能特性优于天然集料沥青混合料,具有较好的环境影响性且综合经济效益更高,关于钢渣沥青混合料路用性能的研究较多,而作用机理方面相对缺乏,关键性的限制因素如密度较高、体积安定性不良、混合料沥青用量增加等仍未得到根本性解决,未来应重点研究钢渣沥青路面的长期性能及质量控制体系,并开展全寿命周期研究,以加快钢渣沥青路面的应用与推广。

关键词：路面工程钢渣沥青混合料特征参数配合比设计路用性能环境效益

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Advancement in “Direct Solid Sampling” Glow Discharge Mass Spectroscopy（GDMS） for Trace Analysis of Advanced Alloys,Engineering Coatings,Thin Films and Coarse Surfaces

Advancement in “Direct Solid Sampling” Glow Discharge Mass...

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“第十届中国钢铁年会”暨“第六届宝钢学术年会”

作者： Wang Xinwei Su Kenghsien Liu Yan PUTYERA karol EAG Inc.

Glow discharge mass spectroscopy（GDMS） is a direct solid sampling technique with growing importance for high sensitivity trace elemental analysis of advanced materials used in aerospace, semiconductor, energy and medical device industries. In this article, several case studies were given, covering the applications in quality control, production support and failure analysis. GDMS is the technique of choice for full survey analysis, in particular monitoring the critical bulk trace impurity in advanced alloys such as S, Se, Pb, etc., due to its exceptional long-term reproducibility（yearly measurement variation RSD ＜ 10%）. The GDMS equipped with a fast flow GD source is also a highly sensitive technique for depth profiling of trace impurities in engineering coatings（up to 100 s mm thick） in the direct current mode, and in thin metal oxide film（100s nm thick） in the modulated GD mode. We also demonstrated that this GDMS configuration is also an effective tool for near surface chemical analysis of coarse surfaces.

关键词： glow discharge mass spectroscopy trace analysis depth profile alloys engineering coatings

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Laboratory and Field Investigations of Polymer and Crumb Rubber Modified Bitumen

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Journal of Civil Engineering and Architecture 2014年第10期8卷 1327-1334页

作者： Jan B. Krol Piotr Radziszewski karol J. Kowalski Michal Samowski Pawel Czajkowski Faculty of Civil Engineering Warsaw University of Technology Warsaw 00-637 Poland Development and Technology Office LOTOS Asfalt Sp. z o.o. Gdahsk 80-718 Poland

In this paper, properties of new kind of modified bitumen are presented. Bituminous binder was modified with mix modification using polymer and additive of crumb rubber. Terminal blend process at the refinery was applied to produce the mixed modified binder. Laboratory tests were focused on the characterization of the properties of 45/80-55 CR binder with comparison to reference 50/70 and conventional polymer modified 45/80-55 bitumen. Based on conventional binder tests such as penetration, softening point and Fraass breaking point as well as BBR （bending beam rheometer） and DSR （dynamic shear rheometer） tests, rheological properties were investigated. For determination of stability of the polymer and crumb rubber, modified bitumen tube testing method was used. Based on the results analysis, improvement of the viscoelastic properties of polymer and crumb rubber modified bitumen was observed. Conventional properties and stability tests showed that it is possible to pass standard requirements for polymer modified bitumen. Mixed modification and terminal blend allow to use crumb rubber as a modifier with elimination of the separation of crumb rubber during transportation and storage at high temperature. In this paper, experience from filed sections with use of the asphalt mixture with new kind of modified bitumen is presented.

关键词： Polymer modified bitumen crumb rubber terminal blend.

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辐射防护与核安全的教育与培训:填补空白

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国际原子能机构通报 1994年第2期36卷 27-31页

作者： karol Skornik IAEA核安全处

在全世界的工业部门中,教育与培训对人力资源的开发来说是必不可少的。最近若干年,核工业方面的此类工作已得到加强。国际原子能机构(IAEA)在其到2000年的计划规划中,十分重视核与辐射安全方面的人力资源开发。

关键词：辐射防护核安全教育培训

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POLISH SEED INDUSTRY

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湖南林业科技 2001年第1期28卷 82-85页

作者： karolW.Duczmal PolandPoznanUniversityofAgriculture

介绍了波兰种子工业的发展历史及波兰农业的现状 ,对二战以后波兰种子立法方面情况作了详细论述。

关键词：波兰种子工业农作物育种种子法

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History, Present and Expected Future of Forests in Slovakia

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American Journal of Plant Sciences 2013年第3期4卷 711-716页

作者： Gubka Andrej Nikolov Christo Gubka karol Galko Juraj Vakula Jozef Kunca Andrej Leontovyc Roman National Forest Centre—Forest Ressearch Institute ZvolenSlovak Republic Faculty of Forestry Technical UniversityZvolenSlovak Republic

In this paper, we briefly summarize the problems that have been affecting Slovakian forestry in the past, in the present and are expected in the future. In the past, the forests in Central Europe were significantly harmed by the development of mining, metallurgy, wood processing industry, agriculture and grazing of sheep and cattle. Many areas have been completely deforested. Fundamental change occurred in the 18th Century, when the regulations about forest management, declared by Empress of the Austro-Hungarian monarchy Maria Therese, came into force. With the changing level of forest cover, there have been changing as well the problems in the forestry. Forests in Slovakia are nowadays dealing with the climate change, which is causing extreme weather fluctuations. It is connected with the emergence of abiotic disturbances after which usually occurs activation of biotic harmful agents. We expect that the most serious problem of forests in the future will be their state of health. We expect an increase representation of thermophilic tree species (beech and oak) at the expense of upland trees such as spruce. An important role will be played by the invasive species of plants, fungi and animals that can compete with native species and their habitats or in the situation of the absence of their reducents these can cause serious economic and environmental damage.

关键词： History of Forestry Forest Pests Climate Change Future of Forests Bark Beetles

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天然物质作为包衣材料对黄瓜种子发芽出苗及健康度的影响

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种子 2000年第5期19卷 10-12,50页

作者：常显民 karol W.Duczmal Krystyna Tylkowska Hanna Dorna 中国农业大学作物学院北京100094 南京农业大学南京210014 PoznanAgriculturalUniversity

本文以黄瓜为供试材料 ,采用不同的种子包衣材料 ,对黄瓜种子的室内发芽、田间出苗及种子健康度进行了测定。该实验采用的四种种子处理方法分别是 :裸种子 (不包衣 )、无活性物质包衣 (既无化学农药也无天然物质包衣 )、化学农药包衣和... 详细信息

本文以黄瓜为供试材料 ,采用不同的种子包衣材料 ,对黄瓜种子的室内发芽、田间出苗及种子健康度进行了测定。该实验采用的四种种子处理方法分别是 :裸种子 (不包衣 )、无活性物质包衣 (既无化学农药也无天然物质包衣 )、化学农药包衣和天然物质包衣。实验结果表明 ,合理的天然物质种子包衣材料配方将成为最有潜力的化学农药替代或部分替代品 ,以期解决由于化学农药给人、畜、自然环境。

关键词：黄瓜天然物质种子包衣室内发芽实验种子健康度检查田间出苗实验

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Prevalence, Grades and Management of Prostate Cancer among Men Attending Oncology Unit at Bugando Medical Centre Mwanza, Tanzania

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Open Journal of Epidemiology 2022年第2期12卷 146-157页

作者： Deogratias M. Katabalo Joyce Josephat Winfrida Minja Stanley Mwita karol J. Marwa Peter Rambau Department of Pharmaceutics and Pharmacy Practice School of Pharmacy Catholic University of Health and Allied Sciences Mwanza Tanzania Department of Pharmacology School of Medicine Catholic University of Health and Allied Sciences Mwanza Tanzania Department of Pathology School of Medicine Catholic University of Health and Allied Sciences Mwanza Tanzania

Background: Prostate cancer is the second most frequent cancer in men after lung cancer, it accounts for 3.8% of all deaths caused by cancer in men worldwide. This study aimed at determining the prevalence, grades and management of prostate cancer among male patients admitted with cancer at Oncology Department of Bugando Medical Centre. Methodology: This was a hospital-based retrospective cross-section study that retrieved data from 384 medical files of male patients admitted with cancer in Oncology wards at Bugando Medical Centre from January 2017 to December 2020. Results: The prevalence of prostate cancer was 39.84% (153 of 384 male patients). The mean age of patients with prostate cancer was 64.85 years ± 14.59 years. Two third of the patients’ prostate cancer were graded at presentation and of these, 52.58% (51 of 97) were having a high grade prostate cancer of Gleason scores 8, 9 or 10. Treatment involved hormonal therapy, chemotherapy and Radiotherapy whereby 49.48% (n = 190) were treated with hormonal therapy (Goserelin and Bicalutamide), 32.03% (n = 123) with combination of hormonal and chemotherapy, (Goserelin, bicalutamide and docetaxel or paclitaxel), 15.69% (n = 60) with combination of radiotherapy and hormonal therapy and 2.6% (n = 11) with chemotherapy alone (Docetaxel). Conclusion: The study found high prevalence of prostate cancer among male patients, majority with high grade form and limited options of treatment. Frequent screening and awareness programs should be conducted to enable early detection to reduce its morbidity and mortality. Patient on treatment should be followed up to determine their response to treatments.

关键词： Prostate Cancer Prevalence Management Tanzania

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