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Sea-blue histiocytes syndrome: Case report and review of literature

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Open Journal of Internal Medicine 2013年第1期3卷 19-21页

作者： Mounira El Euch Fatma Ben Fredj Ismail Amel Rezgui monia karmani Belgacen Mrad Hassen Hosi Mhiri Chedia Laouani Kechrid Department of Internal Medicine Sahloul Hospital Soussa Tunisia

A 57-year-old female was admitted with pancytopenia, and mild splenomegaly. The multiple myeloma diagnosis was wrongly made since the discovery of monoclonal peak to the protein electrophoresis. Further microscopic examination of bone marrow revealed the accumulation of sea-blue histiocytes. The evolution was stable and the patient did not receive any treatment due to the lack of nervous symptoms.

关键词： Syndrome of the Sea-Blue Histiocyte Pancytopenia Splenomegaly

Left intracardiac thrombosis: An exceptional complication revealing BehCet’s disease

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Open Journal of Internal Medicine 2013年第1期3卷 15-18页

作者： Mounira El Euch Ben Fredj Ismail Fatma Rezgui Amel karmani monia Derbali Fatma Amri Raja Laouani Kechrid Chedia Department of Internal Medicine Sahloul University Hospital Sousa Tunisia

Although cardiac involvement during Behcet syndrome is uncommon and intracardiac thrombosis is exceptional, it concerns the right ventricle much more than the left one. We report an illustrative case of left intracard... 详细信息

关键词： Behcet’s Disease Cardiac Involvement Thrombosis

The Role of the Spatial Network in Urban Disaster Risk Variations:Reimagining the Notion of Spatial Vulnerability at the Urban Scale

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International Journal of Disaster Risk Science 2024年第3期15卷 303-316页

作者： monia Del Pinto Ksenia Chmutina Falli Palaiologou Lee Bosher School of Architecture Building and Civil Engineering Loughborough University School of Business University of Leicester

The notion of “spatial vulnerability” is present in most disaster studies with a strong geographical connotation and accordingly is adopted at all scales, including the urban. While enabling mapping and visualizing risk patterns at macroscales, this geocentric foundation fails to capture disaster risk dynamics associated with the urban spatial network—an element that plays a significant role in the everyday and emergency functioning of cities, enabling users' movement and interaction. Yet,urban vulnerability assessment overlooks this aspect and thus leaves urban disaster risk mechanisms partially *** study investigated the role of the network of urban public open spaces(UPOS) in the creation and progression of urban disaster risk in earthquake-prone settlements. Through a multimethod approach that integrates quantitative and qualitative methods and explores spatial configuration, planning policies, and practices of use of UPOS in everyday and emergency scenarios, our study demonstrated that UPOS configuration plays an active role in urban disaster risk. Urban public open spaces impact risk by influencing the exposure of pedestrians and their capacity for self-protection. The study further reconceptualized spatial vulnerability at the urban scale, as the fraction of vulnerability associated to the spatial network, highlighting the interplay of planning policies and spatial practices in its production and progression. Our findings make the notion of spatial vulnerability less ambiguous at the urban scale, by viewing the variable as an imbalance in capacities and exposure that generates spatially unsafe conditions. This refined conceptualization of spatial vulnerability becomes a lens for a more granular approach to urban disaster risk reduction and city planning by identifying and integrating sociospatial considerations.

关键词： Central Italy Earthquakes Pedestrian evacuation Space syntax Spatial vulnerability Urban disaster risk

An Improved Deep Learning Framework for Automated Optic Disc Localization and Glaucoma Detection

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1429-1457页

作者： Hela Elmannai monia Hamdi Souham Meshoul Amel Ali Alhussan Manel Ayadi Amel Ksibi Department of Information Technology College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Information System College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia

Glaucoma disease causes irreversible damage to the optical nerve and it has the potential to cause permanent loss of *** ranks as the second most prevalent cause of permanent *** glaucoma diagnosis requires a highly experienced specialist,costly equipment,and a lengthy wait *** automatic glaucoma detection,state-of-the-art glaucoma detection methods include a segmentation-based method to calculate the cup-to-disc *** methods include multi-label segmentation networks and learning-based methods and rely on hand-crafted *** the optic disc(OD)is one of the key features in retinal images for detecting retinal diseases,especially for glaucoma disease *** approach presented in this study is based on deep classifiers for OD segmentation and glaucoma ***,the optic disc detection process is based on object detection using a Mask Region-Based Convolutional Neural Network(Mask-RCNN).The OD detection task was validated using the Dice score,intersection over union,and accuracy *** OD region is then fed into the second stage for glaucoma ***,considering only the OD area for glaucoma detection will reduce the number of classification artifacts by limiting the assessment to the optic disc *** this task,VGG-16(Visual Geometry Group),Resnet-18(Residual Network),and Inception-v3 were pre-trained and *** also used the Support Vector Machine *** feature-based method uses region content features obtained by Histogram of Oriented Gradients(HOG)and Gabor *** final decision is based on weighted fusion.A comparison of the obtained results from all classification approaches is *** metrics including accuracy and ROC curve are compared for each classification *** novelty of this research project is the integration of automatic OD detection and glaucoma diagnosis in a global ***,the fusion-based decision system uses the g

关键词： Optic disc glaucoma fundus image deep learning

Fluctuating Asymmetry of Elopes lacerta (Valenciennes, 1847) Otoliths in the Western African Waters

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Open Journal of Marine Science 2024年第3期14卷 41-62页

作者： Madel Floriane Adjibayo Houeto Marwa Mejri Malek Tazarki Marius Sounouvou Nicolas Andrialovanirina Meriem Ben Ghorbel Pierre Dossou-Yovo Abdellah Chalh Pierre Quignard monia Trabelsi Kélig Mahé Laboratory of Ecology Biology and Physiology of Aquatic Organisms Faculty of Sciences of Tunis University of Tunis El Manar Tunis Tunisia Institute of Mathematics and Physical Sciences University of Abomey-Calavi (UAC) Abomey-Calavi Benin IFREMER Unit HMMN Halieutic Resources Laboratory Boulogne-sur-Mer France Laboratory for Research into the Processing and Conservation of Fishery Products (LAREPROH) University of Abomey-Calavi (UAC) Abomey-Calavi Benin Unit of Population Genetics and Biological Resources Faculty of Sciences of Tunis University of Tunis El Manar Tunis Tunisia Laboratoire dIchtyologie Universit Montpellier Montpellier France

The importance of this study lies in the in-depth exploration of the ecological diversity of otoliths in Elopes lacerta, based on the analysis of data from 260 individuals collected from various sites, including the Porto Novo lagoon, the Cotonou lagoon, Lake Nokou, and the Atlantic coast in southern Benin. The results highlight significant variations in otolith morphology, establishing relevant links with the biological parameters of the fish at each site. Exploration of the asymmetry between the right and left sides reveals notable distinctions between these two aspects. Analysis of otolith shape thus emerges as a valuable tool for discriminating between stocks and providing a better understanding of ecological variations. The local diversity observed highlights the crucial importance of implementing adaptive management strategies to ensure effective conservation of the species and its habitat.

关键词： Analysis Porto-Novo Lagoon Cotonou Lagoon Lake Nokoué Coast Atlantic

Two mitochondrial haplotypes in Pterochloroides persicae （Hemiptera： Aphididae： Lachninae） associated with different feeding sites

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Insect Science 2013年第5期20卷 637-642页

作者： Mdellel Lassaad David Martinez-Torres Ben Halima Kamel monia Hight Institute of Agronomy Chott Mariem 4042 Sousse Tunisia Institut Cavanilles de Biodiversitat i Biologia Evolutiva Universitat de Valencia Apdo. Correos 22085 46071 Valencia Spain

Pterochloroides persicae （Cholodkovsky） is an aphid species belonging to the subfamily Lachninae that uses different members of Rosaceae （specially Prunus spp.） as hosts. Partial sequences from the mitochondrial cytochrome c oxidase 1 （COI） and the nuclear long-wave opsin genes were obtained for approximately 100 P. persicae aphid individuals sampled from 34 colonies collected mainly in Tunisia and other Mediterranean locations. The variability found at the mitochondrial locus revealed the presence of two maternal haplotypes in the studied area that differed in a single nucleotide. The nuclear gene analyzed, however, failed to reveal any variability in this species. The variability found at the COI locus was related to the season of aphid sampling and with the site of feeding, with haplotype I mostly detected in samples collected in spring and summer on trunks and branches and haplotype II only detected in aphids collected in autumn on roots. The observed pattern of molecular variation suggests the presence of two clonal races of P. persicae coexisting in the studied area differentially adapted to conditions prevalent in the alternative seasons and/or to different feeding sites.

关键词： aphids COI Lachninae life cycle Pterochloroides variability

Theoretical and Experimental Study of the Reaction of 2-Guanidinobenzimidazole on a Series of meta-Substituted Benzaldehydes

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Chemical Research in Chinese Universities 2017年第5期33卷 765-772页

作者： monia Chebbi HAMMOUDA Chebbi HEDI M'rabet YOUS SEF Arfaoui Unit of Physical Chemistry of Condensed Materials Laboratory of Materials Crystallochemistry and Applied Thermodynamic Laboratory of Organic and Heterocyclic Synthesis Department of Chemistry Faculty of Sciences University of Tunis EI-Manar 2092 Tunisia

The syntheses of a variety of 1,3,5-triazinebenzimidazoles obtained by the cyclocondensafion reaction of 2-guanidinobenzimidazole with a series of meta-substituted benzaldehydes were reported. The prepared compounds were fully characterized by IR and NMR spectroscopies. Based on the density functional theory（DFT） calculations method, quantum chemical calculations were performed by Gaussian 09 set of programs. All possible transition states, reactants and products were fully optimized at the hybrid density functional B3LYP level using the 6-311＋G（d,p）. The geometries of five possible tautomers of 2-amino-4-aryl[1,3,5]triazino[1,2-a]benzimidazoles were optimized in ethanol, using conductor like polarizable confinuum（CPCM） in the gas phase. The energetic diagrams of tautomeric equilibrium showed that form A is the most stable tautomer which proved to be in accordance with the X-ray diffraction structure analysis. In order to interpret the reaction mechanism, the chemical reactivity was studied using local and global reactivity indexes.

关键词： 2-Amino-4-aryltriazino[1,2-a]benzimidazole 2-Guanidinobenzimidazole Density functional theory Tautomeric equilibrium Reaction mechanism X-Ray diffraction analysis

Effects of CXCL12 isoforms in a pancreatic pre-tumour cellular model:Microarray analysis

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World Journal of Gastroenterology 2021年第15期27卷 1616-1629页

作者： monia Cecati Matteo Giulietti Alessandra Righetti Berina Sabanovic Francesco Piva Department of Specialistic Clinical and Odontostomatological Sciences Polytechnic University of MarcheAncona 60126Italy

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is the fourth leading cause of death among cancers,it is characterized by poor prognosis and strong *** the PDAC microenvironment,stromal cells release different extracellular components,including *** CXCL12 is a chemokine promoting the communication between tumour and stromal *** different splicing isoforms of CXCL12 are known(α,β,γ,δ,ε,θ)but their role in PDAC has not yet been *** To investigate the specific role ofα,β,andγCXCL12 isoforms in PDAC *** We used hTERT-HPNE E6/E7/KRasG12D(Human Pancreatic Nestin-Expressing)cell line as a pancreatic pre-tumour model and exposed it to theα,β,andγCXCL12 *** altered expression profiles were assessed by microarray analyses and confirmed by Real-Time polymerase chain *** functional enrichment analyses have been performed by Enrichr tool to highlight Gene Ontology enriched *** addition,wound healing assays have been carried out to assess the phenotypic changes,in terms of migration ability,induced by theα,β,andγCXCL12 *** Microarray analysis of hTERT-HPNE cells treated with the three different CXCL12 isoforms highlighted that the expression of only a few genes was ***,theαandβisoforms showed an alteration in expression of different genes,whereasγisoform affected the expression of genes also common withαandβ***βisoform altered the expression of genes mainly involved in cell cycle *** addition,all isoforms affected the expression of genes assay confirmed that CXCL12 enhanced the migration ability of hTERT-HPNE *** the CXCL12 splicing isoforms,theγisoform showed higher induction of migration thanαandβ*** Our data suggests an involvement and different roles of CXCL12 isoforms in PDAC ***,more investigations are needed to confirm these preliminary observations.

关键词： CXCL12 Splicing isoforms Pancreatic cancer Microarray Migration Wound healing assay

An Efficient Three-Party Authenticated Key Exchange Procedure Using Chebyshev Chaotic Maps with Client Anonymity

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Computers, Materials & Continua 2023年第6期75卷 5337-5353页

作者： Akshaykumar Meshram monia Hadj Alouane-Turki N.M.Wazalwar Chandrashekhar Meshram Department of Applied Mathematics Yeshwantrao Chavan College of EngineeringNagpur441110MaharashtraIndia Department of Statistics Rashtrasant Tukadoji Maharaj Nagpur UniversityNagpur440033MaharashtraIndia Department of Computer Science College of Computer ScienceKing Khalid UniversityAbhaSaudi Arabia Department of Post Graduate Studies and Research in Mathematics Jaywanti Haksar Government Post-Graduate CollegeCollege of Chhindwara UniversityBetul460001Madhya PradeshIndia

Internet of Things(IoT)applications can be found in various industry areas,including critical infrastructure and healthcare,and IoT is one of several technological *** a result,tens of billions or possibly hundreds of billions of devices will be linked *** smart devices will be able to gather data,process it,and even come to decisions on their *** is the most essential thing in these *** IoT infrastructure,authenticated key exchange systems are crucial for preserving client and data privacy and guaranteeing the security of data-in-transit(e.g.,via client identification and provision of secure communication).It is still challenging to create secure,authenticated key exchange *** majority of the early authenticated key agreement procedure depended on computationally expensive and resource-intensive pairing,hashing,or modular exponentiation *** focus of this paper is to propose an efficient three-party authenticated key exchange procedure(AKEP)using Chebyshev chaotic maps with client anonymity that solves all the problems mentioned *** proposed three-party AKEP is protected from several *** proposed three-party AKEP can be used in practice for mobile communications and pervasive computing applications,according to statistical experiments and low processing *** protect client identification when transferring data over an insecure public network,our three-party AKEP may also offer client ***,the presented procedure offers better security features than the procedures currently available in the literature.

关键词： Client anonymity Chebyshev chaotic maps authenticated key exchange statistical experiment Galois fields