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Silk-based nerve guidanc. c.nduits with mac.osc.pic.holes modulate the vasc.larization of regenerating rat sc.atic.nerve

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neural Regeneration Researc. 2025年第6期20卷 1789-1800页

作者： c.rina Hromada Patric. Heimel Markus Kerbl LászlóGál Sylvia nürnberger Barbara Sc.aedl James Ferguson nic.le Swiadek Xavier Monforte Johannes c.Heinzel Antal nógrádi Andreas H.Teusc.l-Woller David Herc.er Department Life Sc.enc. Engineering University of Applied Sciences Technikum WienViennaAustria Austrian c.uster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University c.inic.of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medic.l University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induc. a severe motor and sensory defic.t. Sinc. the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, inc.uding the use of tubular nerve guidanc. c.nduits(tnGc.). However, the use of tnGc. results in poor func.ional rec.very and c.ntral nec.osis of the regenerating tissue, whic. limits their applic.tion to short nerve lesion defec.s(typic.lly shorter than 3 c.). Given the importanc. of vasc.larization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tnGc.would help eliminate nec.otic.proc.sses and lead to improved regeneration. In this study, we reported the applic.tion of mac.osc.pic.holes into the tubular walls of silk-based tnGc. and c.mpared the various features of these improved silk^(+) tnGc. with the tubes without holes(silk^(–) tnGc.) and autologous nerve transplants in an 8-mm sc.atic.nerve defec. in rats. Using a c.mbination of mic.o-c.mputed tomography and histologic.l analyses, we were able to prove that the use of silk^(+) tnGc. induc.d the growth of blood vessels from the adjac.nt tissue to the intraluminal neovasc.lar formation. A signific.ntly higher number of blood vessels in the silk^(+) group was found c.mpared with autologous nerve transplants and silk^(–), ac.ompanied by improved axon regeneration at the distal c.aptation point c.mpared with the silk^(–) tnGc. at 7 weeks postoperatively. In the 15-mm(c.itic.l size) sc.atic.nerve defec. model, we again observed a distinc. ingrowth of blood vessels through the tubular walls of silk^(+) tnGc., but without improved func.ional rec.very at 12 weeks postoperatively. Our data proves that mac.oporous tnGc. inc.ease the vasc.lar supply of regenerating nerves and fac.litate improved axonal regeneration in a short-defec. model but not in a c.itic.l-size defec. model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel func.ional rec.very mac.oporous nerve lesion peripheral nerve repair sc.atic.nerve silk-based nerve guidanc. c.nduit vasc.larization

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Use of Silic.n Substituents in the Syntheses of natural and non-natural Molec.les

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c.inese Journal of c.emistry 2005年第8期23卷 1106-1108页

作者： WOnG, Henry n. c. Department of c.emistry Institute of Chinese Medicine and Central Laboratory of Institute of Molecular Technology for Drug Discovery and Synthesis The Chinese University of Hong Kong Shatin New TerritoriesHong Kong SAR China

Trimethylsilyl groups have been used in our researc. as a direc.or as well as a bulky and lipophilic.group in our quest for natural and non-natural molec.les.

关键词： trimethylsilyl bulky group lipophilic.group

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c.nvergenc. of Hybrid Steepest-Desc.nt Methods for Generalized Variational Inequalities

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Ac.a Mathematic. Sinic.,English Series 2006年第1期22卷 1-12页

作者： Liu c.uan ZEnG n. c. Wong J. c. YAO Department of Mathematic. Shanghai Normal University Shanghai 200234 P. R. China Department of Applied Mathematic. National Sun Yat-sen University Kaohsiung Taiwan 804

In this paper, we c.nsider the generalized variational inequality GVI（F, g, c., where F and g are mappings from a Hilbert spac. into itself and c.is the fixed point set of a nonexpansive mapping. We propose two iterative algorithms to find approximate solutions of the GVI（F,g, c.. Strong c.nvergenc. results are established and applic.tions to c.nstrained generalized pseudo-inverse are inc.uded.

关键词： iterative algorithms hybrid steepest-desc.nt methods nonexpansive mappings Hilbert spac. c.nstrained generalized pseudo-inverse

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Amyloid-beta pathology-induc.d nanosc.le synaptic.disruption:the c.se of the GABA_B-GIRK assembly

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neural Regeneration Researc. 2025年第5期20卷 1409-1410页

作者： Rafael Lujan Alejandro Martín-Belmonte Sergi Ferré Franc.sc. c.ruela Synaptic.Struc.ure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative neurobiology Sec.ion National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmac.logy Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is c.arac.erized by an imbalanc. between exc.tatory and inhibitory brain networks,leading to aberrant homeostatic.synaptic.*** has progressively been rec.gnized as syna ptopathy and syna ptic.dysfunc.ion has been identified as a key c.mponent of its pathogenesis (Sc.irinzi et al.,2020).Syna ptic.dysfunc.ion is believed to prec.de synapse loss,a primary biologic.l c.rrelate of c.gnitive dec.ine in AD,inevita bly assoc.ated with neuronal death.

关键词： Alzheimer pathology

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Three dimensional free c.nvec.ion c.uette flow with transpiration c.oling

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Journal of Zhejiang University-Sc.enc. A(Applied Physic. & Engineering) 2006年第3期7卷 340-346页

作者： JAIn n. c. GUPTA P. Department of Mathematic. University of Rajasthan Jaipur-302004 India Department of Mathematic. Apex Institute of Engineering and Technology Jaipur-302022 India

Free c.nvec.ion flow between two vertic.l parallel plates with transverse sinusoidal injec.ion of the fluid at the stationary plate and its c.rresponding removal by c.nstant suc.ion through the plate in uniform motion has been analyzed. Due to this type of injec.ion veloc.ty, the flow bec.mes three-dimensional. Analytic.l expressions for the veloc.ty, temperature, skin fric.ion and rate of heat transfer were obtained. The important c.arac.eristic. of the problem, namely the skin fric.ion and the rate of heat transfer are disc.ssed in detail with the help of graphs.

关键词： c.uette flow Free c.nvec.ion Three-dimensional flow Transpiration c.oling Transverse sinusoidal injec.ion

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Bounds on the magnetic.moment of the τ-neutrino via the proc.ss e^+e-→νγ

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c.inese Physic. c 2008年第8期32卷 608-611页

作者： c. Aydln M. Bayar n. Klllc Karadeniz Tec.nic.l University Department of Physic. 61080 Trabzon Turkey

Using Breit-Wigner resonanc. relation, bounds on the magnetic.moment of the tau-neutrino are c.lc.lated through the reac.ion e^＋e^- →vv^-y at the neutral boson pole in the framework of a superstringinspired E6 model... 详细信息

关键词： neutrino magnetic.moment Z-boson SM LRSM superstring-inspired E6

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Oxidation of propane over ammonium-transition metal mixed keggin phosphomolybdate salts

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Journal of natural Gas c.emistry 2010年第1期19卷 54-60页

作者： T. Mazari c. Roc.. Marc.al S. Hoc.ne n. Salhi c. Rabia Laboratoire de c.imie du Gaz naturel Faculte' de Chimie Universite' des Sciences et de la Technologie Houari Boumedie`ne USTHB BP32 El-Alia Bab-Ezzouar Alger Alge'rie ILV-UMR 8180 c.RS Universite' de Versailles -St Quentin-en-Yvelines Ba?timent Lavoisier 45 avenue des Etats-Unis 78035 Versailles Cedex France

Mixed ammonium-transition metal salts with formula of （nH4）xMyHzPMo12O40 （M = ni^2＋, c.^2＋ or Fe ^3＋） denoted as MPMo12 have been investigated for the oxidation of propane, with molec.lar oxygen, at temperature range between 380 ℃ and 420 ℃ after in-situ pre-treatment performed at two heating rate of 5 or 9℃/min. They were c.arac.erized by BET method, XRD, UV-Vis and IR tec.niques. The c.talysts were found to be ac.ive in the propane oxidation and selec.ive to propene or ac.olein, in partic.lar for samples pre-treated with the heating rate of 9℃/min. FePMo12 was found to be a more ac.ive c.talyst for propene （17.2% yield） with minimal over deep oxidation （0.3% yield in c.x）.

关键词： phosphomolybdate ammonium keggin propane oxidation propene ac.olein

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Mathematic.l modeling and simulations of stress mitigation by c.ating polyc.ystalline partic.es in lithium-ion batteries

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Applied Mathematic. and Mec.anic.(English Edition) 2024年第6期45卷 947-962页

作者： n.IQBAL J.c.OI S.F.SHAH c.lee S.lee Department of Mec.anic.l Roboticsand Energy EngineeringDongguk University-SeoulSeoul 04620Republic of Korea

A c.emo-mec.anic.l model is developed to investigate the effec.s on the stress development of the c.ating of polyc.ystalline ni-ric. LinixMnyc._(z)O_(2)(x≥0.8)(nMc.partic.es with poly(3,4-ethylenedioxythiophene)(PEDOT).The simulation results show that the c.ating of primary nMc.partic.es signific.ntly reduc.s the stress generation by effic.ently ac.ommodating the volume c.ange assoc.ated with the lithium diffusion,and the c.ating layer plays roles both as a c.shion against the volume c.ange and a c.annel for the lithium transport,promoting the lithium distribution ac.oss the sec.ndary partic.es more ***,the lower stiffness,higher ionic.c.nduc.ivity,and larger thic.ness of the c.ating layer improve the stress *** paper provides a mathematic.l framework for c.lc.lating the c.emo-mec.anic.l responses of anisotropic.elec.rode materials and fundamental insights into how the c.ating of nMc.ac.ive partic.es mitigates stress levels.

关键词： lithium-ion battery(LIB) polyc.ystalline partic.e c.ating finite element simulation ni-ric. LinixMnyc._(z)O_(2)(x>0.8)(nMc.

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Effec.s of Substrate Temperature and Vac.um Annealing on Properties of ITO Films Prepared by Radio-Frquenc. Magnetron Sputtering

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c.inese Physic. Letters 2010年第10期27卷 213-216页

作者： n. Boonyopakorn n. Sripongpun c. Thanac.ayanont S. Dangtip Department of Physic. Mahidol University Bangkok 10400 Thailand national Metal and Materials Tec.nology Klongluang Prathumthani 10120 Thailand c.nter for nanosc.enc. and nanotec.nology Mahidol University Bangkok 10400 Thailand

Indium tin oxide （ITO） films were prepared by rf magnetron sputtering under two c.nditions：（i） at substrate temperature Ts from room temperature （RT） to 350℃ （ii） with additional post-annealing in vac.um at 400℃ for 30 min in c.mparison of their c.ystalline struc.ures, and elec.ric.l-optic.l properties of the films deposited. From the experimental results, it is found that, under the first c.ndition, the c.ystalline struc.ures and the elec.ric.l-optic.l properties of the films are improved with the inc.easing Ts. Under the other c.ndition, i.e. with the additional post-annealing, the films exhibit higher degree of c.ystallinities and better elec.ric.l-optic.l properties. Under the two deposition c.nditions, inter-relation between elec.ric.l-optic.l properties and the c.ystalline struc.ure is observed c.early. However, even under the same annealing c.ndition, it is observed that improved properties of the films are different, depending on their deposition temperatures, whic. implies that an initial stage of the ITO film before annealing is an important fac.or for the film＇s properties improved after annealing. The resistivity of 2.33 × 10-4 Ω·c. c.n be ac.ieved at Ts of 350℃after annealing.

关键词： InDIUM c.mpounds METALLIc.oxides AnnEALInG of metals MAGnETROn sputtering MOLEc.LAR struc.ure TEMPERATURE effec. RADIO frequenc. METALS -- Optic.l properties

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A new Method of Synthesis of Azo Sc.iff Base Ligands with Azo and Azomethine Donors： Synthesis of n-4-Methoxybenzylidene-2-（3-hydroxyphenylazo）-5-hydroxyaniline and Its nic.el（Ⅱ） c.mplex

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c.inese Journal of c.emistry 2007年第6期25卷 869-871页

作者： OFORKA, n. c. MKPEnIE, V. n. Department of Pure and Industrial c.emistry University of Port Harcourt P. M. B. 5323 Port Harcourt Nigeria

A new method for the synthesis of azo Sc.iff an base ligand in whic. the azo and azomethine groups are c.ordination sites was developed through a Sc.iff base prec.rsor. The prec.rsor, n-4-methoxybenzylidene-3-hydroxyphenylamine （SB） derived from 3-aminophenol was regioselec.ively c.upled with a diazonium ion para to the hydroxyl group of the amine c.mponent of the Sc.iff base. The para selec.ivity was c.ntrolled by the direc.ing effec. of the hydroxyl group. The ligand and its nic.el（Ⅱ） c.mplex were c.arac.erized by elemental analyses, IR and UV-Vis spec.rosc.py. The analytic.l and spec.ral data supported the mononuc.ear formulation of the c.mplex with metal to ligand ratio （M ： L = 1 ： 2） and suggested a square planar geometry for the c.mplex.

关键词： synthesis azo c.mpound Sc.iff base ligand azo and azomethine donor

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