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Laser-Treated Surfaces for VADs:From Inert Titanium to Potential Biofunctional Materials

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Biomedical Engineering Frontiers 2022年第1期3卷 399-406页

作者： Eduardo Bock Wilhelm Pfleging Dayane Tada Erenilda Macedo Nathalia Premazzi Rosa Sá Juliana Solheid Heino besser Aron Andrade Laboratory of Bioengineering and Biomaterials Federal Institute of Technology in Sao Paulo(IFSP)Sao PauloBrazil Center of Engineering in Circulatory Assistance Institute Dante Pazzanese of Cardiology(IDPC)Sao PauloBrazil Institute for Applied Materials-Applied Materials Physics Karlsruhe Institute of Technology(KIT)KarlsruheGermany Federal University of Sao Paulo(UNIFESP) Sao Jose dos CamposBrazil National Institute for Space Research(INPE) Sao Jose dos CamposBrazil

***-treated surfaces for ventricular assist *** *** work has scientific impact since it proposes a biofunctional surface created with laser processing in bioinert *** diseases are the world’s leading cause of *** especially debilitating heart disease is congestive heart *** the possible therapies,heart transplantation and mechanical circulatory assistance are the main treatments for its severe form at a more advanced *** development of biomaterials for ventricular assist devices is still being carried *** polished titanium is currently employed in several devices,its performance could be improved by enhancing the bioactivity of its *** to improve the titanium without using coatings that can be detached,this work presents the formation of laser-induced periodic surface structures with a topology suitable for cell adhesion and neointimal tissue *** surface was modified by femtosecond laser ablation and cell adhesion was evaluated in vitro by using fibroblast *** results indicate the formation of the desired topology,since the cells showed the appropriate adhesion compared to the control *** electron microscopy showed several positive characteristics in the cells shape and their surface *** in vitro results obtained with different topologies point that the proposed LIPSS would provide enhanced cell adhesion and *** laser processes studied can create new interactions in biomaterials already known and improve the performance of biomaterials for use in ventricular assist devices.

关键词： titanium biomaterials Titanium

Antitumoral effects of cannabis in Notch1-mutated T-cell acute lymphoblastic leukemia

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Cancer Communications 2023年第6期43卷 711-715页

作者： Elazar besser Anat Gelfand Gil Moshe Lewitus Hila Novak-Kotzer Shiri Procaccia Paula Berman Igal Louria-Hayon Inbar Shreiber-Livne Yishai Ofran David Meiri The Laboratory of Cancer Biology and Cannabinoid Research Faculty of BiologyTechnion-Israel Institute of TechnologyHaifaIsrael Department of Hematology and Bone Marrow Transplantation Rambam Health Care CampusHaifaIsrael

Dear Editor,In T-cell acute lymphoblastic leukemia(T-ALL),an aggressive hematologic cancer with poor clinical outcomes,more than 50%of cases show NOTCH1-driven transformation[1].The NOTCH1 receptor signaling pathway is activated through a series of proteolytic cleavages,ultimately causing the release of the active intracellular domain(NICD),which translocates to the nucleus where it promotes transcription of target genes involved in cell *** importance of NOTCH1 mutations in T-ALL has generated great interest in the development of anti-NOTCH1 targeted therapies.A new and promising emerging field in cancer treatment is medical *** evidence suggests the direct effects of cannabis on tumor progression in cell lines and animal models[2].Cannabis,and its unique secondary metabolites,known as phytocannabinoids,directly affect the propagation of cancer cells by modulating key cellsignaling pathways[3].We have previously demonstrated that different cannabis extracts,each containing a unique composition of metabolites,selectively impaired the survival of cancer cell lines depending on amatch between the chemical composition of the extract and the characteristics of the specific cancer cell line[4].In the present work,we set out to investigate whether cannabis extracts with unique phytocannabinoid profiles can selectively facilitate antitumor effects in T-ALL cells that harbor a Notch1 mutation.

关键词： Notch1 impaired lymphoblastic

Petrology,Geochemistry and Economic Aspects of the Alkaline Dyke in Anta Gorda Region,Doutor Ulysses,Parana,Brazil

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Open Journal of Geology 2019年第7期9卷 378-394页

作者： Jose Augusto Simoes Neto Leonardo Fadel Cury Marcell Leonard besser Ariadne Borgo Salla Talvikki Eeva Departamento de Geologia Federal University of ParanáCuritibaBrazil Geologic Survey of Brazil(CPRM) CuritibaBrazil

The rock types of the alkaline dyke from Anta Gorda region, in the township of Doutor Ulysses (State of Paraná), encompass three lithological groups that have been individualized for their distinct textural, structural, mineralogical and/or geochemical characteristics: phonolites s.s., amygdaloidal phonolites and trachyphonolites. These are rocks with magmatic derivation, in which the most important differentiation processes interpreted were immiscibility and fractional crystallization from the ultrabasic mantellic source with primary magma. Fenite epidotes were also classified in the study area, probably product of fenitization of the granitic wall rock. Due to the geographical proximity, some similarities between the phonolites and the rocks from the Barra do Teixeira alkaline plug or the Banhadão Alkaline Complex were expected. However, the results of the petrographic and geochemical analysis point to major resemblance between the phonolites and the lithotypes of the Mato Preto Alkaline Complex. The studied rocks contain concentrations of economic interest of important chemicals elements, mainly Rare Earth Elements—REE, trace elements and mineral substances, such as zeolites and fluorites.

关键词： Phonolites Rare Earth Elements Epidote Mineralization

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1型糖尿病患儿的筛查值得深思和进一步研究

英国医学杂志中文版 2022年第5期25卷 244-245页

作者： R E J besser S M Ng E J Robertson 巴天皓(译) 任倩(校) Department of Paediatrics NIHR Oxford Biomedical Research CentreJohn Radcliffe HospitalOxfordUK Wellcome Centre for Human Genetics University of OxfordOxfordUK Department of Women′s and Children′s Health University of LiverpoolLiverpoolUK Department of Paediatrics Southport and Ormskirk NHS TrustSouthportUK Diabetes UK LondonUK 北京大学人民医院内分泌科

1921年胰岛素的发现,使糖尿病成为一种慢性疾病,患者不再被判"死刑"。100年后胰岛素仍然是1型糖尿病唯一的治疗手段。但是,新策略的出现正在为患儿的生活提供一条不同的道路。

关键词： 1型糖尿病慢性疾病胰岛素治疗手段新策略

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色彩（英文）

英语画刊(高中版) 2024年第15期 6页

作者： Rebecca T besser

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