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Do patients with gastroesophageal reflux disease and somatoform tendencies benefit from antireflux surgery?

World Journal of Gastroenterology 2019年第3期25卷 388-397页

作者： Hans Friedrich fuchs Benjamin Babic karl-hermann fuchs Wolfram Breithaupt Gabor Varga Frauke Musial Department of General Surgery University of Cologne Department of General Surgery University of Mainz Department of Surgery University of California San Diego Department of Surgery Goethe University Frankfurt National Research Center in Complementary and Alternative Medicine NAFKAM Department of Community Medicine UiT The Arctic University of Norway

BACKGROUND The clinical presentation of gastroesophageal reflux disease(GERD) shows a large symptom variation also in different intensities among patients. As several studies have shown, there is a large overlap in the symptomatic spectrum between proven GERD and other disorders such as dyspepsia, functional heartburn and/or somatoform *** To prospectively evaluate the GERD patients with and without somatoform disorders before and after laparoscopic antireflux *** In a tertiary referral center for foregut surgery over a period of 3 years patients with GERD, qualifying for the indication of laparoscopic antireflux surgery, were investigated prospectively regarding their symptomatic spectrum in order to identify GERD and associated somatoform disorders. Assessment of symptoms was performed by an instrument for the evaluation of somatoform disorders[Somatoform Symptom Index(SSI) > 17]. Quality of life was evaluated by Gastrointestinal Quality of Life Index(GIQLI).RESULTS In 123 patients an indication for laparoscopic antireflux surgery was established and in 43 patients further medical therapy was suggested. The portion of somatoform tendencies in the total patient population was 20.48%(34 patients).Patients with a positive SSI had a preoperative GIQLI of 77(32-111). Patients with a normal SSI had a GIQLI of 105(29-140)(P < 0.0001). In patients with GERD the quality of life could be normalized from preoperative reduced values of GIQLI102(47-140) to postoperative values of 117(44-144). In patients with GERD and somatoform disorders, the GIQLI was improved from preoperative GIQLI 75(47-111) to postoperative 95(44-122)(P < 0.0043).CONCLUSION Patients with GERD and associated somatoform disorders have significantly worse levels of quality of life. The latter patients can also benefit from laparoscopic fundoplication, however they will not reach a normal level.

关键词： Gastroesophageal reflux disease Antireflux surgery Laparoscopic fundoplication Somatization Gastroesophageal reflux disease symptoms

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Microglia:a promising therapeutic target in spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 454-463页

作者： Xiaowei Zha Guoli Zheng Thomas Skutella karl Kiening Andreas Unterberg Alexander Younsi Department of Neurosurgery Heidelberg University HospitalHeidelbergGermany Department of Neuroanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal *** a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal *** this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor *** a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive *** review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.

关键词： astrocytes cytokines functional recovery immune regulation M1/M2 activation macrophages microglia neuroinflammation spinal cord injury therapy

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Sedimentation acceleration of remanent iron oxide by magnetic flocculation

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China Particuology 2007年第1期5卷 145-150页

作者： Mathias Stolarski Christian Eichholz Benjamin fuchs hermann Nirschl Institute of Mechanical Process Engineering and Mechanics (MVM) University of Karlsruhe 76131 Karlsruhe Germany DuPont Experimental Station Building E304 Wilmington DE 19880 USA

Sedimentation based processes are widely used in industry to separate particles from a liquid phase. Since the advent of the ＂Nanoworld＂ the demand for effective separation technologies has rapidly risen, calling for the development of new separation concepts, one of which lies in hybrid separation using the superposition of a magnetic field for magnetic particles. Possible product portfolio of such separation consists of pigment production, nanomagnetics production for electronics and bio separation, A promising step in that direction is magnetic field enhanced cake filtration, which has by now progressed from batch to continuous ooeration. In sedimentation processes in a mass force field the settling behaviour of particles strongly depends on physico-chemical properties, concentration and size distribution of the particles. By adjusting the pH, the interparticle forces, in particular the electrostatic repulsion, can be manipulated. For remanent magnetic particles such as magnetite, pre-treatment in a magnetic field could lead to a change of interparticle interactions. By magnetizing the particles apart from van der Waals attraction and electrostatic repulsion, an additional potential is induced, the magnetic attraction, which could easily dominate the other potentials and result in agglomeration in the primary minimum. By sedimentation analysis, a wide spectrum of parameters like pH, magnetic field strength and concentration have been investigated. The results show a strong increase of sedimentation velocity by magnetic flocculation of the raw suspension. This leads to a rise in throughput due to the acceleration of sedimentation kinetics by imparting a non-chemical interaction to the physico-chemical properties in the feed stream of the separation apparatus.

关键词： Magnetic flocculation Field enhanced separation Cake filtration Magnetic structuring Magnetic separation

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Overview of Particles and Bubbles in Continuously Cast Steel

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Journal of Iron and Steel Research International 2011年第S2期18卷 211-219页

作者： karl-hermann TACKE AG der Dillinger Hüttenwerke P.O. Box 1580 D-66748 Dillingen/Saar Germany

This paper gives an overview of phenomena associated with particles and bubbles in continuously cast steel. During steel processing from deoxidation to solidification the inclusion population undergoes changes with opportunities of removal. Flotation is an important separation mechanism. Inclusion particles may accumulate in the solidifying strand, thus forming enriched bands, which depend on the type of casting machine. Bubbles are created during inert gas injection. They also change in size, can float out, but also form accumulation bands. The interaction of bubbles and particles is discussed. Internal structure that recently has been observed on the inner surface of bubbles will be reviewed.

关键词： continuous casting solidification inclusions particles agglomeration accumulation bands gas injection bubbles attachment flotation inner surface wave rings terraces

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CO_(2)capture costs of chemical looping combustion of biomass:A comparison of natural and synthetic oxygen carrier

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Journal of Energy Chemistry 2024年第5期92卷 296-310页

作者： Benjamin Fleiß Juraj Priscak Martin Hammerschmid Josef fuchs Stefan Müller hermann Hofbauer Institute of Chemical Environmental and Bioscience EngineeringTU WienVienna1060 ViennaAustria BEST–Bioenergy and Sustainable Technologies GmbH Graz8010 StyriaAustria

Chemical looping combustion has the potential to be an efficient and low-cost technology capable of contributing to the reduction of the atmospheric concentration of CO_(2) in order to reach the 1.5/2°C goal and mitigate climate *** this process,a metal oxide is used as oxygen carrier in a dual fluidized bed to generate clean CO_(2) via combustion of *** commonly,natural ores or synthetic materials are used as oxygen carrier whereas both must meet special requirements for the conversion of solid *** oxygen carriers are characterized by higher reactivity at the expense of higher costs versus the lower-cost natural *** determine the viability of both possibilities,a techno-economic comparison of a synthetic material based on manganese,iron,and copper to the natural ore ilmenite was *** synthetic oxygen carrier was characterized and tested in a pilot plant,where high combustion efficiencies up to 98.4%and carbon capture rates up to 98.5%were *** techno-economic assessment resulted in CO_(2) capture costs of 75 and 40€/tCO_(2) for the synthetic and natural ore route respectively,whereas a sensitivity analysis showed the high impact of production costs and attrition rates of the synthetic *** synthetic oxygen carrier could break even with the natural ore in case of lower production costs and attrition rates,which could be reached by adapting the production process and recycling *** comparison to state-of-the-art technologies,it is demonstrated that both routes are viable and the capture cost of CO_(2) could be reduced by implementing the chemical looping combustion technology.

关键词： Chemical looping combustion BECCS Techno-economic assessment CO_(2)capture costs Oxygen carrier development Synthetic materials Ilmenite

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Baby Porver

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疯狂英语(初中天地) 2010年第10期 66-67页

作者： karl fuchs

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Geoscience material structures prediction via CALYPSO methodology

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Chinese Physics B 2019年第10期28卷 38-49页

作者： Andreas hermann Centre for Science at Extreme Conditions and SUPA School of Physics and Astronomy The University of Edinburgh

Many properties of planets such as their interior structure and thermal evolution depend on the high-pressure properties of their constituent materials. This paper reviews how crystal structure prediction methodology can help shed light on the transformations materials undergo at the extreme conditions inside planets. The discussion focuses on three areas:(i) the propensity of iron to form compounds with volatile elements at planetary core conditions(important to understand the chemical makeup of Earth's inner core),(ii) the chemistry of mixtures of planetary ices(relevant for the mantle regions of giant icy planets), and(iii) examples of mantle minerals. In all cases the abilities and current limitations of crystal structure prediction are discussed across a range of example studies.

关键词： crystal structure prediction core materials planetary ices hydrous minerals

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The World Stress Map

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Episodes 2007年第3期30卷 197-201页

作者： Heidbach, Oliver fuchs, karl Müller, Birgit Wenzel, Friedemann Reinecker, John Tingay, Mark Sperner, Blanka Geophysical Institute Karslruhe University 76187 Karlsruhe Hertzstr. 16 Germany Heidelberg Academy of Sciences and Humanities 69117 Heidelberg Karlst. 4 Germany Institute of Geosciences University of Tübingen 72076 Tübingen Sigwartstrasse 10 Germany School of Earth and Environmental Sciences University of Adelaide Adelaide SA 5005 DP313 Mawson Building Australia Geological Institute TU Bergakademie Freiberg 09599 Freiberg Bernhard-von-Cotta-Str. 2 Germany

Knowledge of the stress field in the Earth＇s crust is a key issue for the understanding of geodynamic processes, seismic hazard assessment, and stability of underground openings such as waste disposals, tunnels, mines or wells, and reservoir management. The World Stress Map project is a collaborative project of academia, industry and governmental organizations that aims to understand the states and sources of tectonic stresses in the Earth＇s crust. We present the World Stress Map at 1：46,000,000 scale as a result of more than two decades of international collaboration. The map reveals that the first-order pattern of stress is of plate-wide scale, indi- cating that plate boundary forces are the major control of the stress orientations and the tectonic regime.

关键词：世界应力地图合作计划政府组织构造

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On the genetic distinctiveness of tailorbirds(Cisticolidae:Orthotomus)from the South-east Asian mainland with the description of a new subspecies

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Avian Research 2018年第3期9卷 214-225页

作者： Jerome fuchs Dario Zuccon Institut de Systématique EvolutionBiodiversitéUMR7205 CNRS MNHN UPMC EPHESorbonne UniversitéMuséum National d’Histoire NaturelleCP 5157 rue Cuvier75231 Paris Cedex 05France

Background: The Cambodian Tailorbird(Orthotomus chaktomuk) was one of the most recent major ornithological discoveries in South-east Asia as it originated from lowland seasonally flooded scrub within the densely inhabited floodplain around the Tonle Sap, Mekong and Bassac rivers(Cambodia). The Cambodian Tailorbird is sister to the Dark-necked Tailorbird(O. atrogularis) with very limited genetics and biometric differentiation. Between 2004 and 2012, evidences of a new population of Ashy Tailorbird(O. ruficeps) in SE Cambodia/Vietnam accumulated but no museum specimens were ever reported. The Ashy Tailorbird currently consists of eight subspecies among which the closest geographical populations, O. r. cineraceus(SE Burma to Malay Peninsula, Sumatra, Bangka and Belitung) and O. r. borneoensis(Borneo), are allopatric. Subspecific identification of the Cambodian Ashy Tailorbirds individuals was not possible because of the limited differences in plumage among ***: We inspected the Orthotomus ruficeps specimens housed at the Museum National d'Histoire Naturelle(Paris) and discovered five specimens of O. ruficeps collected by Louis Rodolphe Germain in ‘Cochinchina'(corresponding to southern Vietnam) during the nineteenth century. We sequenced one mitochondrial locus and gathered biometric data from these specimens and compared them with other Orthotomus ***: The Ashy Tailord population from SE Cambodia and Vietnam is distinct from the two geographically close subspecies O. r. borneoensis(1.7%) and O. r. cineraceus(1.3%). O. chaktomuk is nested within O. atrogularis in the mitochondrial gene tree. The SE Cambodia/Vietnam population of O. ruficeps is distinct from the two other subspecies in bill ***: Our study described the biometric and molecular distinctiveness of a recently re-discovered population of Ashy Tailord in SE Cambodia and Vietnam and suggests that this population constitutes an independent evolutionary lineage that we de

关键词： Orthotomus Differentiation Subspecies Taxonomy

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A LIOUVILLE THEOREM FOR STATIONARY INCOMPRESSIBLE FLUIDS OF VON MISES TYPE

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Acta Mathematica Scientia 2019年第1期39卷 1-10页

作者： Martin fuchs Jan MüLLER Fachbereich 6.1 Mathematik Universit?t des Saarlandes

We consider entire solutions u of the equations describing the stationary flow of a generalized Newtonian fluid in 2 D concentrating on the question, if a Liouville-type result holds in the sense that the boundedness of u implies its constancy. A positive answer is true for p-fluids in the case p > 1(including the classical Navier-Stokes system for the choice p = 2), and recently we established this Liouville property for the Prandtl-Eyring fluid model,for which the dissipative potential has nearly linear growth. Here we finally discuss the case of perfectly plastic fluids whose flow is governed by a von Mises-type stress-strain relation formally corresponding to the case p = 1. It turns out that, for dissipative potentials of linear growth, the condition of μ-ellipticity with exponent μ < 2 is sufficient for proving the Liouville theorem.

关键词： generalized Newtonian fluids perfectly plastic fluids von Mises flow Liouville theorem

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