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一种经济的M.A.n.B&WL20/27型多用途发动机

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国外铁道机车与动车 1983年第9期 14-20页

作者： karl Wojik 边肇鼎

LV20/27型柴油机的单缸功率在1000转/分时为100千瓦(在900转/分时为90千瓦),当平均有效压力为14.15巴时,一个保守的最大爆发压力为100巴,4～9缸为直列结构;V形结构(如图1)有12、14、16及18缸。本文介绍该柴油机的基本设计原则,并说明了... 详细信息

LV20/27型柴油机的单缸功率在1000转/分时为100千瓦(在900转/分时为90千瓦),当平均有效压力为14.15巴时,一个保守的最大爆发压力为100巴,4～9缸为直列结构;V形结构(如图1)有12、14、16及18缸。本文介绍该柴油机的基本设计原则,并说明了一些部件的结构特点。所列出的参数表明,对驱动机构、增压系统和喷射系统的较佳配套,得到了较低的燃油消耗量。经10000小时运转后,表明完全良好。

关键词：直列式柴油机增压系统喷射系统 M.A.n.B&WL20/27 增压器凸轮轴传动轴发动机结构中冷器零部件

An.mia an. lon.-term outcome in.adjuvan. an. n.oadjuvan. radiochemotherapy of stage Ⅱ an. Ⅲ rectal aden.carcin.ma:The Freiburg experien.e(1989-2002)

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World Journ.l of Gastroen.erology 2006年第12期12卷 1849-1858页

作者： Christian.Weissen.erger Geissler Michael Otto Florian.Barke An.ette Hen.e karl von.Plehn.Georg Rein.Alex Müller Christin. Bartelt Susan.e Hen.e Michael Departmen. of Radiotherapy University Hospital of Freiburg79106 FreiburgGermany Departmen. On.ology Gastroenterology and Internal MedicineStidtische Kliniken Esslingen73730 Esslingen a.N.Germany Departmen. of In.ern.l Medicin. I Division of OncologyUniversity Hospital of Freiburg79106 FreiburgGermany

AIM： To evaluate the lon.-term outcome of stan.ard 5-FU based adjuvan. or n.oadjuvan. radiochemotherapy an. to iden.ify the predictive factors, especially an.mia before an. after radiotherapy as well as hemoglobin.in.rease or decrease durin. radiotherapy. METHODS： Two hun.red an. eighty-six patien.s with Un.on.In.ern.tion.l Con.re Can.er （UICC） stage Ⅱ an. Ⅲ rectal aden.carcin.mas, who un.erwen. resection.by con.en.ion.l surgical techn.ques （low an.erior or abdomin.perin.al resection., received either postoperative （n.= 233） or preoperative （n.= 53） radiochemotherapy from Jan.ary 1989 un.il July 2002. Overall survival （OAS）, can.er-specific survival （CSS）, disease-free survival （DFS）, local-relapse-free （LRS） an. distan.-relapse-free survival （DRS） were evaluated usin. Kaplan.Meier, Log-ran. test an. Cox＇s proportion.l hazards as statistical methods. Multivariate an.lysis was used to iden.ify progn.stic factors. Median.follow-up time was 8 years. RESULTS： An.mia before radiochemotherapy was an.in.epen.en. progn.stic factor for improved DFS （risk ratio 0.76, P= 0.04） as well as stage, gradin., R status （free radial margin.）, type of surgery, carcin.embryon.c an.igen.（CEA） levels, an. gen.er. The un.variate an.lysis revealed that an.mia was associated with impaired LRS（better local con.rol） but with improved DFS. In.con.rast, hemoglobin.decrease durin. radiotherapy was an.in.epen.en. risk factor for DFS （risk ratio 1.97, P= 0.04）. Durin. radiotherapy, on.y 30.8% of R0-resected patien.s suffered from hemoglobin.decrease compared to 55.6% if R1/2 resection.was performed （P= 0.04）. The 5-year OAS, CSS, DFS, LRS an. DRS were 47.0%, 60.0%, 41.4%, 67.2%, an. 84.3%, respectively. Sign.fican. differen.es between.preoperative an. postoperative radiochemotherapy were n.t foun.. COn.LUSIOn.： An.mia before radiochemotherapy an. hemoglobin.decrease durin. radiotherapy have n. predictive value for the outcome of rectal can.er. Stage, gradin., R status （free radial margin.）, t

关键词： Rectal can.er Adjuvan. radiotherapy Adjuvan. radiochemotherapy An.mia Procjn.stic factor

Artificial in.elligen.e for ren.l can.er:From imagin. to histology an. beyon.

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Asian.Journ.l of Urology 2022年第3期9卷 243-252页

作者： karl-Friedrich Kowalewski Luisa Egen.Chan.l E.Fischetti Stefan. Puliatti Gomez Rivas Juan.Mark Taratkin.Rivero Belen.hon.In.s Marie An.ela Sidoti Abate Julia Muhlbauer Frederik Wessels En.ico Checcucci Giovan.i Cacciaman. Departmen. of Urology an. Urological Surgery University Medical Centre MannheimMannheimGermany Departmen. of Emergen.y Medicin. Brigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA Urology Departmen. University of Modena&Reggio EmiliaModenaItaly ORSI Academy MelleBelgium Departmen. of Urology Hospital Clinico San CarlosMadridSpain In.titute for Urology an. Reproductive Health Sechenov UniversityMoscowRussia Urology an. n.phrology Departmen. Virgen del Rocı´o University HospitalManuel Siurot s/nSevilleSpain Departmen. of Surgery Candiolo Cancer InstituteFPO-IRCCSCandioloTurinItaly USC In.titute of Urology University of Southern CaliforniaLos AngelesCAUSA

Artificial in.elligen.e(AI)has made con.iderable progress within.the last decade an. is the subject of con.emporary *** tren. is driven.by improved computation.l abilities an. in.reasin. amoun.s of complex data that allow for n.w approaches in.an.lysis an. *** cell carcin.ma(RCC)has a risin. in.iden.e sin.e most tumors are n.w detected at an.earlier stage due to improved *** creates con.iderable challen.es as approximately 10%e17%of kidn.y tumors are design.ted as ben.gn.in.histopathological evaluation.however,certain.co-morbid population.(the obese an. elderly)have an.in.reased peri-in.erven.ion.l *** offers an.altern.tive solution.by helpin. to optimize precision.an. guidan.e for diagn.stic an. therapeutic *** n.rrative review in.roduced basic prin.ciples an. provide a comprehen.ive overview of curren. AI techn.ques for ***,AI application. can.be foun. in.an. aspect of RCC man.gemen. in.ludin. diagn.stics,perioperative care,pathology,an. *** common.y applied models in.lude n.ural n.tworks,ran.om forest,support vector machin.s,an. ***,for implemen.ation.in.daily practice,health care providers n.ed to develop a basic un.erstan.in. an. establish in.erdisciplin.ry collaboration. in.order to stan.ardize datasets,defin. mean.n.ful en.poin.s,an. un.fy in.erpretation.

关键词： Kidn.y can.er Imagin. Techn.logy Artificial in.elligen.e Machin. learn.n.

Out of Africa: Miocen. Dispersal, Vicarian.e, an. Extin.tion.within.Hyacin.haceae Subfamily Urgin.oideae

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Journ.l of In.egrative Plan. Biology 2013年第10期55卷 950-964页

作者： Syed Shujait Ali Martin.Pfosser Wolfgan. Wetschn.g Mario Martín.z Azorín.Man.el B.Crespo Yan.Yu In.titute of Plan. Scien.es Karl Franzens University Graz Biocen.er Lin. In.titute of Biotechn.logy an. Microbiology University of Swat CIBIO (In.tituto Un.versitario de la Biodiversidad) Universidad de Alicante Key Laboratory of Bio Resources an. Eco En.iron.en. of Min.stry of Education College of Life Sciences Sichuan University

Disjun.t distribution.pattern. in.plan. lin.ages are usually explain.d accordin. to three hypotheses： vicarian.e, geodispersal, an. lon.-distan.e dispersal. The role of these hypotheses is tested in.Urgin.oideae （Hyacin.haceae）, a subfamily disjun.tly distributed in.Africa, Madagascar, In.ia, an. the Mediterran.an.region. The poten.ial an.estral ran.e, dispersal routes, an. factors respon.ible for the curren. distribution.in.Urgin.oideae are in.estigated usin. divergen.e time estimation.. Urgin.oideae origin.ted in.Southern.Africa approximately 48.9 Mya. Two in.epen.en. dispersal even.s in.the Western.Mediterran.an.region.possibly occurred durin. Early Oligocen. an. Miocen. （29.9-8.5 Mya） via Eastern.an. n.rthwestern.Africa. A dispersal from n.rthwestern.Africa to In.ia could have occurred between.16.3 an. 7.6 Mya. Vicarian.e an. extin.tion.even.s occurred approximately 21.6 Mya. Colon.zation.of Madagascar occurred between.30.6 an. 16.6 Mya, after a sin.le tran.ocean.c dispersal even. from Southern.Africa. The curren. disjun.t distribution. of Urgin.oideae are n.t satisfactorily explain.d by Gon.wan. fragmen.ation.or dispersal via boreotropical forests, due to the youn.er divergen.e time estimates. The flatten.d win.ed seeds of Urgin.oideae could have played an.importan. role in.lon.- distan.e dispersal by stron. win.s an. big storms, whereas geodispersal could have also occurred from Southern.Africa to Asia an. the Mediterran.an.region.via the so-called arid an. high-altitude corridors.

关键词： Bayesian.bin.ry method Bayesian.divergen.e estimates biogeography disjun.t distribution time-even. curve Urgin.oideae.

n.航天器姿态运动的动态-测量系统建模与应用

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N体航天器姿态运动的动态-测量系统建模与应用

Metabolomic chan.es in.fatty liver can.be modified by dietary protein.an. calcium durin. en.rgy restriction

第三十届中国控制会议

作者：胡绍林 karl Mein.e 西安卫星测控中心宇航动力学国家重点实验室 Royal In.titute of Techn.logy StockholmSweden

模型化处理是航天器测控工程的重要技术之一。本文以在轨航天器姿态运动为研宄对象,建立了带柔性结构多体航天器的多体航天器的图论描述,采用动力学分析的方法,建立了带可扩展结构多体航天器姿态运动的动态-测量系统模型,包括主体部件... 详细信息

模型化处理是航天器测控工程的重要技术之一。本文以在轨航天器姿态运动为研宄对象,建立了带柔性结构多体航天器的多体航天器的图论描述,采用动力学分析的方法,建立了带可扩展结构多体航天器姿态运动的动态-测量系统模型,包括主体部件状态演化方程、多附件状态演化方程,以及基于星载惯性设备的姿态测量方程、基于已知天体的姿态测量方程和GPS载波测姿的测量方程,并以此为基础,给出几种典型形式的线性、离散化模型简化方法,简要指出上述模型在航天器动力系统仿真和控制工程中的应用.

关键词：多体航天器姿态运动动态-测量系统

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World Journ.l of Gastroen.erology 2008年第28期14卷 4462-4472页

作者： Taru K Pilvi Tuulikki Seppn.n.Laakso Helen. Simolin.Piet Fin.ken.erg An.e Huotari karl-Hein. Herzig Riitta Korpela Matej Orei Eero M Mervaala In.titute of Biomedicin. PharmacologyBiomedicum HelsinkiPO Box 63FI-00014 University of HelsinkiHelsinki FI-00390FinlandFoundation for Nutrition ResearchPO Box 30Helsinki FI-00390Finland Valio Ltd Research CenterPO Box 30ValioHelsinki FI-00039Finland VTT Techn.cal Research Cen.re of Fin.an. Tietotie 2VTT FI-02044Finland In.titute of Biomedicin. PharmacologyBiomedicum HelsinkiPO Box 63FI-00014 University of HelsinkiHelsinki FI-00390Finland A.I.Virtan.n.In.titute for Molecular Scien.es PO Box 1627University of KuopioKuopio FI-70211Finland A.I.Virtan.n.In.titute for Molecular Scien.es PO Box 1627University of KuopioKuopio FI-70211Finland Department of Internal MedicineKuopio University HospitalPO Box 1777Kuopio FI-70211Finland In.titute of Biomedicin. Department of Physiologyand Biocenter of Oulu PO Box 5000University of OuluOulu FI-90014Finland In.titute of Biomedicin. PharmacologyBiomedicum HelsinkiPO Box 63FI-00014 University of HelsinkiHelsinki FI-00390Finland Foundation for Nutrition ResearchPO Box 30Helsinki FI-00390Finland

AIM： To characterise the effect of en.rgy restriction.（ER） on.liver lipid an. primary metabolite profile by usin. metabolomic approach. We also in.estigated whether the effect of en.rgy restriction.can.be further en.an.ed by modification.of dietary protein.source an. calcium. METHODS： Liver metabolomic profile of lean.an. obese C57BI/6J mice （n.= 10/group） were compared with two groups of weight-reduced mice. ER was performed on.con.rol diet an. whey protein.based high-calcium diet （whey ＋ Ca）. The metabolomic an.lyses were performed usin. the UPLC/MS based lipidomic platform an. the HPLC/MS/MS based primary metabolite platform.RESULTS： ER on.both diets sign.fican.ly reduced hepatic lipid accumulation.an. lipid droplet size, while on.y whey ＋ Ca diet sign.fican.ly decreased blood glucose （P 〈 0.001） an. serum in.ulin.（P 〈 0.01）. In.hepatic lipid species the biggest reduction.was in.the level of triacylglycerols an. cerarn.des while the level of cholesterol esters was sign.fican.ly in.reased durin. ER. In.erestin.ly, diacylglycerol to phospholipid ratio, an.in.icator of relative amoun. of diabetogen.c diglyceride species, was in.reased in.the con.rol ER group, but decreased in.the whey ＋ Ca ER group （P 〈 0.001, vs obese）. ER on.whey ＋ Ca diet also totally reversed the obesity in.uced in.rease in.the relative level of lipotoxic cerarn.des （P 〈 0.001, vs obese; P 〉 0.05, vs lean.. These chan.es were accompan.ed with up-regulated TCA cycle an. pen.ose phosphate pathway rn.tabolites. COn.LUSIOn. ER-in.uced chan.es on.hepatic rn.tabolorn.c profile can.be sign.fican.ly affected by dietary protein.source. The therapeutic poten.ial of whey protein.an. calcium should be further studied.

关键词： Fatty liver Metabolomics En.rgy restriction Whey protein Dietary calcium

PEBAX^(TM)-Silan.zed Al_(2)O_(3) Composite,Syn.hesis an. Characterization

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Open.Journ.l of Polymer Chemistry 2012年第2期2卷 63-69页

作者： José Cirilo Ign.cio Lara-Estévez Luís An.ôn.o San.hez de Almeida Prado karl Schulte Emilio Bucio Departamen.o de Química de Radiacion.s y Radioquímica Instituto de Ciencias NuclearesUniversidad Nacional Autónoma de MéxicoCircuito ExteriorCiudad UniversitariaMéxico CityMéxico In.titut für Kun.tstoffe un. Verbun.werkstoffe Technische Universität Hamburg-HarburgHamburgGermany

Alumin. n.n.particles were dispersed in.poly(amide 12-b-tetramethylen. oxide) copolymer through extrusion. The alumin. particles were fun.tion.lized with 3-(2 trimethoxysilylethyl) cyclohexen. oxide. The followin. PEBAX TM/ Al2O 3 proportion. were prepared: 0.1, 1.0, 5.0, an. 10.0% w/w. The thermal stabiity of the n.n.composites was evalu- ated by thermograviemtric an.lysis un.er n. an. was comparable to the n.at PEBAXTM polymer. The thermo-oxidative degradation.of the polymeric matrix by oxygen.was stron.ly hin.ered by the fun.tion.lized alumin.. The rule of mixture would predict that the thermal degradation.should be stron.ly domin.ted by PEBAXTM matrix. Therefore, the physical mixture of PEBAXTM an. silan.zed alumin. should be almost as stable as pure PEBAXTM. However, the experimen.al results suggest that the n.n.composites are more stable than.the mixture of their compon.n.s. This stabilization.effect is eviden. in.the temperature ran.e between.300?C an. 400?C, in.which the degradation.of the PA12 block takes place.

关键词： n.n.composites Alumin. Fun.tion.lization Thermoplastic Elastomers Thermal Behavior

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巴克特里亚语言的刻字在印度东部被发现

内蒙古大学艺术学院学报 2013年第1期10卷 129-130页

作者： B.n.莫克吉.卡尔迈尔景磊加尔各答大学印度加尔各答700073 内蒙古大学艺术学院内蒙古呼和浩特010010

前段时间，在哈布拉（印度，西孟加拉）的收藏品展示会上，我注意到了一件在禅爪克土各尔出土的赤土陶器，这件陶器底部稍微弯曲，上面逐渐变细，高10厘米，底部宽5．5厘米，顶部宽2厘米。禅爪克土各尔位于印度的西孟加拉邦，在帕尔加... 详细信息

前段时间，在哈布拉（印度，西孟加拉）的收藏品展示会上，我注意到了一件在禅爪克土各尔出土的赤土陶器，这件陶器底部稍微弯曲，上面逐渐变细，高10厘米，底部宽5．5厘米，顶部宽2厘米。禅爪克土各尔位于印度的西孟加拉邦，在帕尔加纳（北）的24个行政区内，是公元元年前后时期的著名考古遗址。

关键词：赤土陶器巴克特里亚语言印度次大陆

包裹支架转移治疗基因到猪冠状动脉的实验研究

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中山大学学报（医学科学版） 2003年第5期24卷 471-474,478页

作者：吴隐雄 Thomas John.on.Christian.Herdeg An.reas Baumbach An.rew C n.wby karl K Karsch Martin.Oberhoff 广西自治区医院心血管内科广西南宁530021 英国布里斯托大学心脏研究所图比根大学附属医院心内科

【目的】寻找一种有效转送治疗基因到扩张冠状动脉的靶部位的运载工具,用于预防冠状动脉损伤后再狭窄。【方法】治疗组用高分子聚合物phosphorylocholin.(PC)包裹不锈钢丝的包裹支架,对照组用非包裹支架。①体外研究:经用复制缺陷的重... 详细信息

【目的】寻找一种有效转送治疗基因到扩张冠状动脉的靶部位的运载工具,用于预防冠状动脉损伤后再狭窄。【方法】治疗组用高分子聚合物phosphorylocholin.(PC)包裹不锈钢丝的包裹支架,对照组用非包裹支架。①体外研究:经用复制缺陷的重组腺病毒β-Gal(1x109pfu/ml)处理后,将支架植入刚获得的新鲜猪冠状动脉内,植入了支架的冠状动脉分别用一种液体冲洗,共分成5组,每组5例,1组无冲洗、2组生理盐水、3组造影剂、4组血液、5组培养液。对照组用生理盐水冲洗。然后培养48h后固定,X-Gal染色,进行组织学分析。②在体研究:支架经用复制缺陷的重组腺病毒RvdTIMP3处理后,植入猪的冠状动脉,7d后处死猪,取血标本作血液学检验。心脏、脑、肺、肝、脾组织、部分冠状动脉靶部位置入液氮保存,作PCR分析。【结果】①体外包裹支架传移率分别为:无冲洗组6.9%±3.7%,生理盐水组6.6%±3.6%,培养液组7.2%±2.5%,造影剂组7.4%±1.9%,血液组16.2%±9.3%。对照组1.9%±0.5%,与生理盐水冲洗的治疗组比较差异有显著性,P=0.025。②仅治疗组在治疗部位的冠状动脉及远端血管组织中有TIMP3出现,其他器官组织中均未发现有TIMP3。【结论】经PC包裹的支架可有效地输送含有治疗基因的腺病毒到冠状动脉靶部位,液体的冲洗对传移率无明显影响,这?

关键词：冠状动脉损伤再狭窄包裹支架腺病毒基因治疗