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engineering for Inclusion:empowering Individuals with Physical and Neurological Differences through engineering Invention,Research,and Development

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engineering 2021年第2期7卷 141-143页

作者： Peter T.Cummings Philippe M.Fauchet Michael Goldfarb Martha W.M.Jones Maithilee Kunda Jonathan B.Perlin Nilanjan Sarkar Keivan G.Stassun Zachary e.Warren karl e.zelik Department of Chemical and Biomolecular engineering Vanderbilt UniversityNashvilleTN 37235-1604USA Department of electrical engineering and Computer Science Vanderbilt UniversityNashvilleTN 37235-1826USA Department of Mechanical engineering Vanderbilt UniversityNashvilleTN 37235-1592USA Department of Medicine Healthand SocietyVanderbilt UniversityNashvilleTN 37235-1665USA The Frist Center for Autism and Innovation Vanderbilt UniversityNashvilleTN 37212USA Department of Physics and Astronomy Vanderbilt UniversityNashvilleTN 37235-1807USA Department of Biomedical engineering Vanderbilt UniversityNashvilleTN 37235-1631USA HCA Healthcare NashvilleTN 37203USA Department of Pediatrics Vanderbilt University Medical CenterNashvilleTN 37232USA Treatment and Research Institute for Autism Spectrum Disorders Vanderbilt Kennedy CenterNashvilleTN 37203USA Department of Physical Medicine and Rehabilitation Vanderbilt University Medical CenterNashvilleTN 37212USA

*** The use of engineering tools,design,research,and thinking to create environments and capabilities whereby individuals who are currently under-employed or unemployed due to a physical disability(e.g.,amputation or spinal cord injury)or neurological difference(e.g.,autism)are enabled to become fully productive and employed members of society has been the implicit goal of decades of research at Vanderbilt University and *** Vanderbilt University,progress in these areas has been greatly facilitated by the proximity of the School of engineering to the world-class Vanderbilt University Medical Center and the resulting close collaboration between engineering and medical researchers.

关键词： has environments power

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Microglia:a promising therapeutic target in spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 454-463页

作者： Xiaowei Zha Guoli Zheng Thomas Skutella karl Kiening Andreas Unterberg Alexander Younsi Department of Neurosurgery Heidelberg University HospitalHeidelbergGermany Department of Neuroanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal *** a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal *** this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor *** a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive *** review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.

关键词： astrocytes cytokines functional recovery immune regulation M1/M2 activation macrophages microglia neuroinflammation spinal cord injury therapy

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Dedicated to Professor Dr.-Ing. ***.h.c. Jurgen Zierep for his 80^(th) birthday Pattern Formation in Rotating Fluids

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Journal of Thermal Science 2009年第2期18卷 109-118页

作者： karl Bühler Department of Mechanical and Process engineering University of Applied Sciences

Flows in nature and technology are often associated with specific structures and pattern. This paper deals with thedevelopment and behaviour of such flow pattern. Flow structures are important for the mass, momentum and energytransport. The behaviour of different flow pattern is used by engineers to obtain an efficient mass and energyconsumption. Mechanical power is transmitted via the momentum of rotating machine parts. Therefore thephysical and mathematical knowledge of these basic concepts is important. Theoretical and experimental investigationsof principle experiments are described in the following. We start with the classical problem of the flowbetween two concentric cylinders where the inner cylinder rotates. Periodic instabilities occur which are calledTaylor vortices. The analogy between the cylindrical gap flow, the heat transfer in a horizontal fluid layer exposedto the gravity field and the boundary layer flow along concave boundaries concerning their stability behaviour isaddressed. The vortex breakdown phenomenon in a cylinder with rotating cover is also described. A generalizationto spherical sectors leads then to investigations with different boundary conditions. The spherical gap flowexhibits interesting phenomena concerning the nonlinear character of the Navier-Stokes equations. Multiple solutionsin the nonlinear regime give rise to different routes during the laminar-turbulent transition. The interactionof two rotating spheres results in flow structures with separation and stagnation lines. experimental results areconfirmed by numerical simulations.

关键词： Rotating Fluids Stability Behaviour Bifurcation Vortices Laminar-turbulent Transition

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Land use change and its ecological effect in Qian’an County of Jilin Province

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Journal of Geographical Sciences 2003年第4期 41-46页

作者： karl e.Ryavec Department of Geography MN55455 USA University of Minnesota

Based on GIS and statistical methods, with the help of searching historical literatures andcalculating the landscape indices, the land use changes of Qian’an County in both spatial and temporalaspects from 1945 to 1996 has been analyzed in this paper. And the driving forces of land use changesand their ecological effects are discussed too. The main findings of this study are as follows:(1)Landuse changed greatly in Qian’an during 1945-1996, characterized by a decrease in grassland, wetlandand water bodies,and an increase in cultivated land, saline-alkali land, and the land for housing andother construction purposes. Grassland decreased by 175,828.66 ha, and cultivated land increased by

关键词： land use change ecological effect land degradation Qian’an County

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Investigation on the resonance phenomena of multi-solitons for the (3+1)-dimensional Kadomtsev-Petviashvili equation

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Chinese Physics B 2011年第1期20卷 473-478页

作者：石玉仁张娟杨红娟段文山 karl e.Lonngren College of Physics and electronic engineering Northwest Normal University Department of electrical and Computer engineering The University of IowaIowa CityIA 52242USA

In this paper, we theoretically investigate the four-soliton interaction and their resonance phenomena of the （3＋1）- dimensional Kadomtsev Petviashvili （KP） equation. We find that the maximum amplitude of the resonantly created soliton can be 16 times that of one of the four equi-amplitude initial interacting solitons. We also find that the maximum amplitude can only be 4 times the initial soliton amplitude when the resonance phenomena does not take place. The case of four solitons with different amplitudes also has been studied analytically. The results indicate that the resonance phenomena still exists in this case. Numerical results confirm the theoretical predictions.

关键词： Kadomtsev-Petviashvili equation soliton resonance

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Insect Science 2008年第4期15卷 369-374页

作者： karl Kral Institute of Zoology KarI-Franzens-University Graz A-8010 Graz Austria

The peering-jump behavior was studied for the common field grasshopper Chorthippus brunneus, the meadow grasshopper C. parallelus and the alpine grasshopper Miramella alpina （Orthoptera, Caelifera）. It was found that immediately before jumping M. alpina executes primarily unilateral object-related peering movements, with approximately twice the amplitude and velocity of the predominantly bilateral object-related peering movements of the other two species. Whereas M. alpina almost always jumped toward the black stripes in the experimental arena, the other species jumped toward both the black stripes and the white spaces between them. All three species preferred the same pattern of black stripes, which permitted them to view one black stripe frontally, with an additional black stripe to the left and right, in the lateral visual field. The similarities and differences in the peering-jump behavior of the three grasshopper species is discussed with regard to visual perception （parallax cues） and environmental adaptation.

关键词： Chorthippus environmental adaptation grasshopper jumping Miramella,peering phototaxis scototaxis

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A high-resolution history of vegetation and climate history on Sunda Shelf since the last glaciation

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Science China earth Sciences 2007年第1期50卷 75-80页

作者： karl STATTeGGeR Institute of Geosciences University of Kiel Olshausenstrasse 40 Kiel 24118 Germany

This paper presents 16500-year-long high-resolution pollen and spore records from sediments of core 18287 on the continental slope of the southern South China Sea. In the period of 16.5―13.9 ka B.P., the low-mountain rainforest dominated the continental slope of the South China Sea. And in the period of 13.9―10.2 ka B.P., the lowland rainforest and ferns expanded greatly, while the low-mountain rainforest shrank, which indicated a warming at the last deglaciation. Also during this period, the pollen sedi-mentation rates reduced sufficiently. This might imply a rise of the sea level and therefore the sub-mergence of the shelf, resulting in the broadening of the distance between the source area and the slope. After 10.2 ka B.P, decreasing of the fern indicates the early Holocene (10.2―7 ka B.P.) is a cold period, while the increasing of fern marks the rising temperature (7―3.6 ka B.P.).

关键词： Sunda Slope pollen and spores vegetation last deglaciation Holocene.

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Pattern Formation Around Interacting Bodies in Rotating Fluids

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Journal of Thermal Science 2006年第2期15卷 132-134页

作者： karl BHLeR University of Applied Sciences Badstrasse 24 D-77652 Offenburg Germany

The interaction of bodies like spheres and disks in rotating fluids leads to novel flow structures. The primary swirling flow in circumferential direction is superimposed by a secondary motion in the meridional plane. The flow is visualized by introducing ink through a hole in the center of the axes and distributed radially in the central plane between the interacting bodies. The flow structure depends on the shape of the bodies, their geometrical arrangement and the Reynolds number given by the rotational speed. The observed flow structures gave rise to further investigations with PIV-measurcments and numerical simulations.

关键词： Rotating fluids pattern formation recirculation zones interacting bodies flow visualization

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enhancing perianal disease management with integrated physical and psychological approaches

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World Journal of Clinical Cases 2025年第2期13卷 59-63页

作者： Uchenna e Okpete Haewon Byeon Department of Digital Anti-aging Healthcare(BK21) Inje UniversityGimhae 50834South Korea

This article provides a comprehensive analysis of the study by Hou et al,focusing on the complex interplay between psychological and physical factors in the postoperative recovery(POR)of patients with perianal *** study sheds light on how illness perception,anxiety,and depression significantly influence recovery *** et al developed a predictive model that demonstrated high accuracy in identifying patients at risk of poor *** article explores the critical role of pre-operative psychological assessment,highlighting the need for mental health support and personalized recovery plans in enhancing POR quality.A multidisciplinary approach,integrating mental health professionals with surgeons,anesthesiologists,and other specialists,is emphasized to ensure comprehensive care for *** study’s findings serve as a call to integrate psychological care into surgical practice to optimize outcomes for patients with perianal diseases.

关键词： Perianal disease Post-operative recovery Anxiety Depression Pain management emotional well-being Multidisciplinary approach

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Brain-derived neurotrophic factor alterations and cognitive decline in schizophrenia:Implications for early intervention

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World Journal of Psychiatry 2025年第1期15卷 189-193页

作者： Uchenna e Okpete Haewon Byeon Department of Digital Anti-aging Healthcare(BK21) Inje UniversityGimhae 50834South Korea

This manuscript explores the recent study by Cui et al which assessed the interplay between inflammatory cytokines and brain-derived neurotrophic factor(BDNF)levels in first-episode schizophrenia *** study revealed that higher levels of interleukin-6 and tumor necrosis factor-αcorrelated with reduced BDNF levels and poorer cognitive *** is a severe psy-chiatric disorder impacting approximately 1%of the global population,charac-terized by positive symptoms(hallucinations and delusions),negative symptoms(diminished motivation and cognitive impairments)and disorganized thoughts and *** research highlights the role of BDNF as a potential biomarker for early diagnosis and therapeutic *** findings from Cui et al’s study suggest that targeting neuroinflammation and enhancing BDNF levels may improve cognitive *** treatment approaches involve a com-bination of pharmacological and non-pharmacological interventions tailored to individual patient ***,monitoring cognitive and neuroinflammatory markers is essential for improving patient outcomes and quality of ***-quently,this manuscript highlights the need for an integrated approach to schizo-phrenia management,considering both clinical symptoms and underlying neuro-biological changes.

关键词： Schizophrenia Cognitive impairment Neuroinflammatory markers Brain-derived neurotrophic factor Interleukin Personalized treatment

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