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Anti-inflammatory effects of Lacto-Wolfberry in a mouse model of experimental colitis

World Journal of Gastroenterology 2012年第38期18卷 5351-5359页

作者： David Philippe Viral Brahmbhatt Francis Foata Yen Saudan Patrick Serrant Stephanie Blum Jalil Benyacoub karine vidal Department of Nutrition and Health Nestlé Research CenterCH-1000 Lausanne Switzerland

AIM: To investigate the anti-inflammatory properties of Lacto-Wolfberry (LWB), bothin vitro and using a mouse model of experimental colitis. METHODS: The effects of LWB on lipopolysaccharide (LPS)-induced reactive oxygen species (ROS) and interleukin (IL)-6 secretion were assessed in a murine macrophage cell line. in vitro assessment also included characterizing the effects of LWB on the activation of NF-E2 related 2 pathway and inhibition of tumor necrosis factor-α (TNF-α)-induced nuclear factor-κB (NFκB) activation, utilizing reporter cell lines. Following the in vitro assessment, the anti-inflammatory efficacy of an oral intervention with LWB was tested in vivo using a preclinical model of intestinal inflammation. Multiple outcomes including body weight, intestinal histology, colonic cytokine levels and anti-oxidative measures were ***: LWB reduced the LPS-mediated inductionof ROS production [+LPS vs 1% LWB + LPS, 1590 ± 188.5 relative luminescence units (RLU) vs 389 ± 5.9 RLU, P < 0.001]. LWB was more effective than wolfberry alone in reducing LPS-induced IL-6 secretion in vitro (wolfberry vs 0.5% LWB, 15% ± 7.8% vs 64% ± 5%, P < 0.001). In addition, LWB increased reporter gene expression via the anti-oxidant response element activation (wolfberry vs LWB, 73% ± 6.9% vs 148% ± 28.3%, P < 0.001) and inhibited the TNF-α-induced activation of the NF-κB pathway (milk vs LWB, 10% ± 6.7% vs 35% ± 3.3%, P < 0.05). Furthermore, oral supplementation with LWB resulted in a reduction of macroscopic (-LWB vs +LWB, 5.39 ± 0.61 vs 3.66 ± 0.59, P = 0.0445) and histological scores (-LWB vs +LWB, 5.44 ± 0.32 vs 3.66 ± 0.59, P = 0.0087) in colitic mice. These effects were associated with a significant decrease in levels of inflammatory cytokines such as IL-1β (-LWB vs +LWB, 570 ± 245 μg/L vs 89 ± 38 μg/L, P = 0.0106), keratinocyte-derived chemokine/growth regulated protein-α (-LWB vs +LWB, 184 ± 49 μg/Lvs 75 ± 20 μg/L,P = 0.0244), IL-6 (-LWBvs +LWB, 318 ± 99 μg/L

关键词： Lacto-Wolfberry Colitis Nutrition Inflammation Wolfberry Inflammatory bowel disease Crohn's disease

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Bifidobacterium lactis attenuates onset of inflammation in a murine model of colitis

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World Journal of Gastroenterology 2011年第4期17卷 459-469页

作者： David Philippe Laurent Favre Francis Foata Oskar Adolfsson Genevieve Perruisseau-Carrier karine vidal Gloria Reuteler Johanna Dayer-Schneider Christoph Mueller Stéphanie Blum Department of Nutrition and Health Nestlé Research Centre Department of Pathology University of Bern

AIM: To assess the anti-inflammatory effect of the probiotic Bifidobacterium lactis (B. lactis) in an adoptive transfer model of colitis. METHODS: Donor and recipient mice received either B. lactis or bacterial culture medium as control (deMan Rogosa Sharpe) in drinking water for one week prior to transfer of a mix of naive and regulatory T cells until sacrifice. RESULTS: All recipient mice developed signs of colonic inflammation, but a significant reduction of weight loss was observed in B. lactis-fed recipient mice compared to control mice. Moreover, a trend toward a diminution of mucosal thickness and attenuated epithelial damage was revealed. Colonic expression of pro-inflammatory and T cell markers was significantly reduced in B. lactis-fed recipient mice compared to controls. Concomitantly, forkhead box protein 3, a marker of regulatory T cells, was significantly up-regulated by B. lactis. CONCLUSION: Daily oral administration of B. lactis was able to reduce inflammatory and T cells mediators and to promote regulatory T cells specific markers in a mouse model of colitis.

关键词： Probiotics Bifidobacterium Colitis Adoptive transfer model Regulatory T cells Inflammation Mice

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枸杞粉改善老年人体质状态的随机双盲临床试验研究

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中国临床药理学杂志 2010年第10期26卷 729-732页

作者：高秋涛倪建俐曹金兰沈立松张力 karine vidal Peter BUCHELI 北京雀巢研发中心北京100095 上海交通大学附属新华医院中心实验室上海200092 思博灵(上海)咨询有限公司上海200021 Nestle Research Center Vers - Chez - Les - Blanc PO Box 44 CH - 1000 Lausanne 26 Switzerland

目的评价枸杞粉(滋补肝肾中药)对老年人体质状态的影响。方法用双盲、随机、安慰剂对照的临床试验设计,按年龄和性别进行分层。对健康老年人群(65～70岁,男女均衡)补充3个月枸杞粉前后中医证候的观察,给药组和对照组分别给予枸杞粉(每天... 详细信息

目的评价枸杞粉(滋补肝肾中药)对老年人体质状态的影响。方法用双盲、随机、安慰剂对照的临床试验设计,按年龄和性别进行分层。对健康老年人群(65～70岁,男女均衡)补充3个月枸杞粉前后中医证候的观察,给药组和对照组分别给予枸杞粉(每天13.7g)与安慰剂,每组75人。用中医诊断问卷,对补充枸杞3个月前后所有受试者的典型中医证候进行调查。结果和对照组相比,服用枸杞粉的老年人群的阴虚症状有明显改善,其中口干咽燥、心烦失眠和脉象3项指标均有显著性改善(P<0.01)。结论长期口服枸杞粉可使老龄人群的体质状况得到显著改善,这可能与枸杞中的抗氧化物质(玉米黄素)有关。

关键词：枸杞阴虚口干咽燥心烦失眠

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Should Empyema with or without Necrotizing Pneumonia in Children Be Managed Differently?

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Health 2017年第2期9卷 209-222页

作者： karine Anastaze Stelle Anne Mornand Nadia Bajwa Isabelle vidal Mehrak Anooshiravani Aikaterini Kanavaki Constance Barazzone Argiroffo Sylvain Blanchon Pediatric Pulmonology Unit Department of Pediatrics University Hospital Geneva Geneva Switzerland Division of General Pediatrics Department of Pediatrics University Hospital Geneva Geneva Switzerland Division of Pediatric Surgery Department of Pediatrics University Hospital Geneva Geneva Switzerland Pediatric Radiology Unit Department of Pediatrics University Hospital Geneva Geneva Switzerland

Background: Necrotizing pneumonia (NP) is an increasing lung infection mostly associated with pleural empyema. Objectives: We aimed to compare children with empyema with and without concomitant NP, in terms of risk factors, management and outcome. Methods: We retrospectively included children hospitalized between 2005-2014 with empyema to whom a computed tomography was performed. We recorded patient characteristics, clinical, biological (blood and pleural fluid) and radiological findings, medical and surgical treatments, and clinical, radiological and functional follow-up. Results: 35 children with empyema were included, including 25 with a concomitant NP. Patients with or without NP were undistinguishable, in terms of characteristics, symptoms at admission or detected pathogens. Pleural leucocytes were significantly higher in the empyema group (p = 0.0002) as pleural LDH (p = 0.002), and pleural/blood LDH ratio (p = 0.0005). Medical and surgical managements were similar between both groups. Complications occurred in 1/10 children with empyema alone (pneumatocele) and 5/25 with concomitant NP (bronchopleural fistula (n = 3), lobectomy, pneumothorax). The hospital length of stay and delay for chest X-ray normalization were similar in both groups. Conclusion: Except for minor biological parameters, the presence of concomitant NP in case of empyema does not change the presentation, clinical features, management and outcome, suggesting that the presence of additional NP to empyema should not be managed differently. Therefore, in case of empyema with suspected concomitant NP, chest CT should probably be restricted to abnormal worsening or when mandatory for surgical treatment.

关键词： Children Necrotizing Pneumonia Empyema

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