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Allium sativum Flavor Compounds as an Indicator for Garlic Identity and Quality Determination

Journal of Food Science and Engineering 2013年第5期3卷 226-234页

作者： Ruta Galoburda karina Bodniece Thierry Talou Department of Food Technology Latvia University of Agriculture Jelgava L V 3001 Latvia Laboratoire de Chimie Agro-industrielle Universite de Toulouse INP-ENSIACET Toulouse 31030 France

The objective of the study was to research the aroma profile of volatile compounds in garlic subspecies originating from Latvia, and compare them with the aroma composition of garlic grown in the region of Midi-Pyrenees （France）. It was established that hard-neck garlic tends to contain more diallyl disulfide （DADS）, the main decomposition product of allicin. Compared to the hard-neck subspecies, the content of allyl mercaptan, one of the major compounds producing the strong odor detectable after ingestion of garlic, was significantly lower in the soft-neck garlic clones. The amount of cyclic compound 3-vinyl-1,2-dithiin differed considerably with higher contents in the soft-neck subspecies. The results also demonstrate the soft-neck garlic as a more suitable subspecies for long-term storage. In general, the results show no significant difference in the content of DADS and the total content of other flavor compounds between hard-neck and soft-neck garlic grown in the region of Midi-Pyrenees and Latvia. However, comparing garlic subspecies originating from France and Latvia by the content of allyl mercaptan, 1,2-dithiolane and 3-vinyl-1,2-dithiin, a considerable proportional difference of these volatiles was determined. Also, a significant difference was established in the content of DADS between the white garlic variety ＂Blanc de Lomagne＂（France, region of Midi-Pyrenees） and white garlic grown in other countries. The results of this study suggest the suitability of solid phase microextraction （SPME） and gas chromatography （GC） methods for quality control of garlic originating from France.

关键词： Allium sativum diallyl disulfide flavor garlic identity

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Psychiatric Sequelae of Chronic Pruritic Dermatoses

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Open Journal of Medical Psychology（医学心理学） 2024年第2期 25页

作者： Kelly Frasier Vivian Li Kathleen Click Christina Dudzik Michelle Sobotka Evadne Rodriguez karina Stech

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The Impact of Psychosocial Influences on Chronic Wound Healing

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Open Journal of Medical Psychology（医学心理学） 2024年第3期 39页

作者： Kelly Frasier Vivian Li Sara Christoforides Kathleen Daly Alexandra Loperfito karina Stech Milena Dragovic

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Phylogenetic Analysis of RhoGAP Domain-Containing Proteins

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Genomics, Proteomics & Bioinformatics 2006年第3期4卷 182-188页

作者： Marcelo M. Brando karina L. Silva-Brando Fernando F. Costa Sara T.O. Saad Hematology and Hemotherapy Center State University of Campinas 13083-970 Campinas SP Brazil Department of Zoology Institute of Biology State University of Campinas 13083-970 Campinas SP Brazil.

Proteins containing an Rho GTPase-activating protein （RhoGAP） domain work as molecular switches involved in the regulation of diverse cellular functions. The ability of these GTPases to regulate a wide number of cellular processes comes from their interactions with multiple effectors and inhibitors, including the RhoGAP family, which stimulates their intrinsic GTPase activity. Here, a phylogenetic approach was applied to study the evolutionary relationship among 59 RhoGAP domain-containing proteins. The sequences were aligned by their RhoGAP domains and the phylogenetic hypotheses were generated using Maximum Parsimony and Bayesian analyses. The character tracing of two traits, GTPase activity and presence of other domains, indicated a significant phylogenetic signal for both of them.

关键词： Bayesian analysis character tracing parsimony phylogenomics protein domain,RhoGAP

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The Relationship between Understaffing of Nurses and Patient Safety in Hospitals—A Literature Review with Thematic Analysis

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Open Journal of Nursing 2017年第12期7卷 1387-1429页

作者： Malin Knutsen Glette karina Aase Siri Wiig Department of Health Western Norway University of Applied Sciences Haugesund Norway Faculty of health Sciences University of Stavanger Stavanger Norway

Introduction: Patient safety and the occurrence of adverse events in hospitals is a topic which has been widely addressed over the last decades. In that respect, there has been an increasing interest in the effect of working conditions on patient safety, and whether understaffing and adverse events are correlated. This paper therefore reports results from a study of under- staffing of nurses understood as a lack of nurses available to conduct the tasks required of them. This implies that nurses are forced to ignore or postpone important tasks, thereby compromising patient safety. Purpose: The purpose of the study is to increase the knowledge of understaffing of hospital nurses, and the consequences that understaffing may have on patient safety. Methods: A literature search of the databases Chinal, Medline, Cochrane library, Isi Web of Science and Academic Search premiere was conducted in the period January 2014 to February, 2016. Results: Results are categorized into two main themes and four subthemes. The first main theme describes the direct relationship between understaffing and patient safety. Poor staffing increases the risk of mortality, and adverse conditions such as pressure ulcers, deep vein thrombosis and hospital-related infections. The second main theme relates to the indirect implications of understaffing for patient safety. These implications pertain to the lack of time that nurses could give each patient, limitations in the quality of nursing, and challenges in safe medication administration. Conclusions: The study documents the relationship between understaffing of nurses and adverse events in hospitals, revealingthat understaffing of nurses is a risk factor for hospitalized patients.

关键词： Understaffing Patient Safety Adverse Events Mortality Patient Harm

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DNA-repair ERCC1 Gene Polymorphisms in Epithelial Ovarian Cancer and Relation to Platinum Resistance and Survival

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Journal of Cancer Therapy 2011年第2期2卷 140-147页

作者： karina Dahl Steffensen Marianne Waldstrom Anders Jakobsen Department of Oncology Vejle HospitalVejleDenmark Institute of Regional Health Services Research University of Southern DenmarkOdense CDenmark Pathology Vejle HospitalVejleDenmark.

Objectives: Excision repair cross-complementation group 1 (ERCC1) is a key DNA repair gene in the nucleotide excision repair pathway which is activated in the repair of intra- and interstrand DNA crosslink caused by platinum-based treatment. Two single nucleotide polymorphisms (SNPs) of the ERCC1 gene, codon 118 C/T and C8092A, have been reported to be functional, but the influence on platinum resistance and survival is not yet clear. The primary aim of the present study was to investigate whether the two SNPs were associated with resistance to standard combination carboplatin and paclitaxel chemotherapy and the potential prognostic impact in newly diagnosed ovarian cancer patients. Methods: Serum samples from 202 patients with newly diagnosed ovarian cancer were assessed for ERCC1 SNP genotyping using real time PCR. All patients were treated with first line carboplatin/paclitaxel chemotherapy. Results: There were no correlation between the ERCC1 118 C/T and C8092A genotypes and platinum resistance (P = 0.79 and P = 0.36, respectively). Furthermore, the results showed no association to progression free survival (P = 0.18 and P = 0.16, respectively) or overall survival (P = 0.89 and P = 0.78, respectively) for the two SNPs. Conclusions: The ERCC1 118 C/T and C8092A polymorphisms did not have significant influence on clinical outcome defined as platinum resistance, PFS and OS.

关键词： Drug Resistance Ovarian Cancer Polymorphisms ERCC1 DNA Repair Predictive MARKEr

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负压封闭引流技术治疗难愈性创面的临床研究

负压封闭引流技术治疗难愈性创面的临床研究

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作者： karina Paramita Satyadi 苏州大学

学位级别：硕士

目的：探讨应用负压封闭引流技术治疗难愈性创面的临床效果。方法：40例难愈性创面患者,男23例,女17例,平均年龄41.13岁(17岁-78岁),致伤原因：交通事故、高处坠落伤、机械性损伤、褥疮、糖尿病足。随机分为2组。A组为治疗组,n=20,治... 详细信息

目的：探讨应用负压封闭引流技术治疗难愈性创面的临床效果。方法：40例难愈性创面患者,男23例,女17例,平均年龄41.13岁(17岁-78岁),致伤原因：交通事故、高处坠落伤、机械性损伤、褥疮、糖尿病足。随机分为2组。A组为治疗组,n=20,治疗中应用负压封闭引流技术;B组为对照组,n=20,治疗中应用传统的换药疗法。观察2组创面愈合时间,评价负压封闭引流技术疗难愈性创面的临床效果。结果：A组创面平均愈合时间是23.3±3.2天,B组创面平均愈合时间是32.3±5.1天,：A组平均愈合时间比B组明显加快,P<0.05。同时观察到A组创面能促进肉芽组织生长,加速坏死组织清除,提高植皮的成活率。结论：负压封闭引流术有助于改善创面微循环,引流坏死液化的组织和渗出液、有效减少各种有害代谢产物进入血循环,同时促进肉芽组织生长,促进创面愈合,缩短住院时间,降低患者住院费用,提高救治率,为临床提供了一种创面封闭或修复的简单、经济、安全有效的治疗方法,值得在临床上推广应用。

关键词：创面愈合难愈性创面创面负压治疗(NPWT) VSD负压引流

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Requirements in performance measurement systems of construction projects from the lean production perspective

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Frontiers of Engineering Management 2021年第3期8卷 442-455页

作者： karina B.BARTH Carlos T.FORMOSO Building Innovation Research Unit(NORIE) Universidade Federal do Rio Grande do SulPorto Alegre 90040-060Brazil

Performance measurement(PM)generates useful data for process control,facilitates communication between different sectors,and helps to align efforts on the most important aspects of the ***,PM plays a key role in the management of projects and *** is also important in the implementation of lean production principles and methods,such as reducing the share of nonvalue-adding activities,increasing process transparency,building continuous improvement into the process,and ***,the adoption of the lean production philosophy requires changes in *** its importance,limited studies have been conducted on the use of PM systems for assessing the impact of lean production programs in construction *** addition,studies on how lean companies(or projects)use performance measurement and to what extent the indicators adopted reflect the result of actions that have been undertaken are *** study proposes a set of requirements in PM systems of construction projects from the perspective of lean production and a taxonomy of performance metrics for lean production *** empirical studies have been carried out on construction companies from South America involved in the implementation of lean production *** scope of this investigation is limited to the construction projects as production systems rather than PM at the level of construction organizations.

关键词： performance measurement lean construction production management continuous improvement metrics

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Update on the Fungal Biofilm Drug Resistance and Its Alternative Treatment

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Journal of Biosciences and Medicines 2016年第5期4卷 37-47页

作者： karina Siow Yen Ng How Tseung Jingjun Zhao Department of Dermatology and Venereology Tongji Hospital Tongji University School of Medicine Shanghai China

Candida albicans (C. albicans) and Aspergillus fumigatus (A. fumigatus) are the two main pathogens in the clinical setting to cause serious, sometimes, lethal fungal infections. Immunocompromised patients fall victims to these fungi, with a mortality rate rising drastically over the past decades. This is in correlation with the fact that conventional antifungals are no longer capable of completely eradicating the disease, or if so, high doses are usually required to do so, leading to eventual resistance to those drugs and severe side effects. High drug resistance is in association with the discovery that these opportunistic pathogens have the ability to develop a multicellular complex, known as biofilm. Biofilms prevent drugs from reaching the fungal cells by sequestering them in their extracellular matrix. Other factors such as extracellular DNA, persister cells or heat shock protein 90 (Hsp90) also play a role in biofilm and contribute to drug recalcitrance. With the discovery of new antifungals lagging behind, scientists focused on other more profitable ways to counteract this phenomenon. Combination of two or more antifungals was found effective but came with serious drawbacks. Natural plant extracts, such as traditional Chinese medicine have also been demonstrated in vitro to possess antimicrobial actions. Great interest was directed towards their use with conventional antifungal agents with a possibility of lowering the necessary concentration required to inhibit the growth of fungi. This review aims in understanding the different factors contributing to clinical drug resistance and evaluating the effect of combination therapy and natural products on those cases difficult to treat.

关键词： Aspergillus fumigatus Candida albicans Biofilm Antifungal Resistance Combination Therapy Traditional Chinese Medicine

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Healthcare Staff Perceptions of Patient Safety Culture in Nursing Home Settings—A Cross-Sectional Study

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Open Journal of Nursing 2017年第9期7卷 1069-1085页

作者： Kathrine Cappelen Anette Harris Marianne Storm karina Aase Center for Care Research South Faculty of Health and Social Sciences University College of Southeast Norway Porsgrunn Norway Institute of Psychosocial Science Faculty of Psychology University of Bergen Bergen Norway Centre for Resilience in Healthcare Faculty of Health Sciences University of Stavanger Stavanger Norway

In nursing homes, knowledge about patient safety culture is still limited. This study investigates staff perceptions of patient safety culture in Norwegian nursing homes, measured with the Nursing Home Survey on Patient Safety Culture (NHSOPSC). 466 (69%) staff from 12 different nursing homes participated. The total percentages of positive responses for each patient safety culture dimension and differences in perceptions according to staff’s educational background and position were calculated. Multiple linear regression analysis was used to test if the NHSOPSC dimensions predicted participants’ ratings of the question “Please give this nursing home an overall rating on patient safety”. The proportion of positive responses was high, with six of ten dimensions having an average percentage above 70%. “Supervisor expectations and actions promoting patient safety” (88%), “feedback and communication about incidents” (87%), and a “non-punitive response to mistakes” (78%) had high average scores, while “staffing” (46%) and “training and skills” (56%) had the lowest average scores. Managers reported higher scores on all dimensions, except for “compliance with procedures” compared with other staff groups. Educational level had less influence on staff’s perceptions of patient safety culture than management position. The ten NHSOPSC dimensions explained 47.2% of the variance for the overall rating question “Please give this nursing home an overall rating on patient safety” (F [10, 384] = 34.39, p < 0.001). “Management and organizational learning” had the strongest unique contribution (28.1%). This study suggests that staff working at the bedside have confidence in their nursing managers’ attention to patient safety issues and that a non-punitive environment is prevalent in Norwegian nursing homes.

关键词： Patient Safety Safety Culture Nursing Home Perceptions Cross-Sectional Survey

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