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Fatty acid changes help to better understand regression of nonalcoholic fatty liver disease

World Journal of Gastroenterology 2015年第1期21卷 301-310页

作者： Dominika Maciejewska Arleta Drozd Piotr Ossowski karina ryterska Dominika Jamio-Milc Marcin Banaszczak Joanna Raszeja-Wyszomirska Magorzata Kaczorowska Anna Sabinicz Ewa Stachowska Department of Biochemistry and Human Nutrition Pomeranian Medical University70-204 SzczecinPoland Department of General Transplant and Liver SurgeryMedical University of Warsaw02-672 WarsawPoland

AIM: To investigate whether liver steatosis reduction due to a six-month dietary intervention results in significant changes in the concentrations of fatty ***: A group of 35 Caucasian individuals diagnosed with different levels of steatosis were prospectively enrolled in the present *** of the fatty acid profiles was performed according to changes in liver steatosis(liver steatosis reduction by one or two degrees) after a six-month dietary *** diet helped reduce body mass in obese and overweight patients,and stabilize both glycemia and *** acids were extracted according to the Folch method and analyzed by gas ***: This study showed significant changes in fatty acid profiles in patients who had reduced liver steatosis by one as well as two degrees.A reduction in liver steatosis by one degree caused a significant increase in the level of the n-3 family: eicosapentaenoic acid(P < 0.055),docosapentaenoic acid-C 22:5(P < 0.05) and docosahexaenoic acid(P < 0.05).A reduction in liver steatosis by two degrees caused a significant decrease in serum palmitoleic acid-C 16:1(P < 0.05).CONCLUSION: Liver steatosis reduction is associated with changes in fatty acid profiles,and these changes may reflect an alteration in fatty acid synthesis and *** findings may help better understand regression of nonalcoholic fatty liver disease.

关键词： Nonalcoholic fatty liver disease Fatty acids Bioch

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