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Journal of Integrative Agriculture 2021年第1期20卷 159-167页

作者： leidy J.VAlENCIA-HERNANDEZ karina lóopez-lópez Eyder D.GÓMEZ-lÓpez liliana SERNACOCK Cristobal N.AGUIlAR Universidad Nacional de Colombia Palmira CampusValle 763533Colombia Food Research Department School of ChemistryAutonomous University of CoahuilaSaltillo CampusCoahuila 25280Mexico

The fungistatic activity of a lactic acid bacterium, which had been isolated from yellow pitahaya cultures, against fungi associated with basal rot(Fusarium oxysporum and Fusarium fujikuroi) was measured in the present study. Its activity was assessed in three fractions: fermented(S1), metabolic products(S2), and biomass(S3), using two fermentation substrates: Man Rogosa Sharpe agar(MRS) and potato dextrose agar(PDA). The bacterium was molecularly identified as lactobacillus plantarum. S3 reduced F. fujikuroi growth by 100% over 48 h of fermentation, which occurred during the stationary phase of bacterial growth. The three fractions' fungistatic activity against F. fujikuroi depended on the substrate employed. The fermentation kinetic parameters for l. plantarum indicated that its specific growth rate was 0.46 h^–1, with 93.63% substrate consumption, 0.045 kg kg^–1 cell yield, and 0.54 kg kg^–1 product yield. The kinetic parameters calculated will allow for bacteria production scaling. These in-vitro trials reveal l. plantarum's possible application as a biocontrol agent for diseases associated with Fusarium. However, further ex-vivo and in-vivo researches are required to demonstrate its behavior in crops.

关键词： lactic acid bacteria Fusarium fungistatic activity biomass yellow pitahaya

A Systematic Review on the Comparison between lumbar Disc Hernia Resection by Endoscopy and Microdiscectomy

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Open Journal of Modern Neurosurgery 2025年第1期15卷 29-36页

作者： Iván Ulises Sámano lópez Ernesto Eduardo Galván Hernández Rafael Avendaño Pradel José Armando Biebrich Murguía Emmanuel Cantú Chávez Thania karina Gutiérrez Anchondo Centro Mdico ABC Ciudad de Mxico Mxico

Background: Surgical treatment of lumbar disc herniation is a widely debated topic, with several techniques available. Percutaneous endoscopic discectomy (PElD) has gained popularity due to its lower invasiveness compared to conventional techniques such as microdiscectomy/open lumbar microdiscectomy (OlMD)/tubular microdiscectomy (TMD). However, evidence on the effectiveness, recovery time and complications of these techniques is not yet clearly established. This systematic review aims to compare the preoperative and postoperative outcomes of both techniques. Methods: A comprehensive search was performed in databases including PubMed and Cochrane, following strict inclusion and exclusion criteria. Comparative studies and narrative reviews on PElD and OlMD/TMD published between 2019 and 2024 were included. Key outcomes considered were pre- and postoperative Visual Analogue Scale (VAS), hospitalization time, time to return to work, and postoperative complications. Results: The reviewed studies indicated that PElD is associated with a greater reduction in postoperative pain compared to OlMD/TMD, with a significant decrease in VAS, according to the study by Priola et al. (2019). The hospital stay was also shorter for patients undergoing PElD, averaging 2 days compared to OlMD/TMD. Furthermore, PElD favored a faster return to work and had a lower rate of postoperative complications, such as dural tears and reoperations, compared to OlMD/TMD. Conclusions: PElD demonstrates clear advantages over OlMD/TMD in terms of pain reduction, shorter hospital stay, faster return to work, and fewer postoperative complications. However, the implementation of this technique requires a significant learning curve, suggesting that its effectiveness may vary depending on the surgeon’s experience. PElD should be considered a preferred option in the resection of lumbar disc herniations, especially in patients seeking a quick and less invasive recovery.

关键词： Percutaneous Endoscopic Discectomy (PElD) Microdiscectomy/Open lumbar Microdiscectomy (OlMD)/Tubular Microdiscectomy (TMD) lumbar Disc Herniation Minimally Invasive Surgery Postoperative Recovery Postoperative Complications

Return to Sports Activities after lumbar Disc Herniation Surgery: A Review

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Open Journal of Modern Neurosurgery 2025年第1期15卷 37-47页

作者： Iván Ulises Sámano lópez Ernesto Eduardo Galván Hernández Rafael Avendaño Pradel José Armando Biebrich Murguía Jorge Alberto Miranda Barrera Thania karina Gutiérrez Anchondo Enrique Rosales Betancourt Centro Mdico ABC Ciudad de Mxico Mxico

Background: lumbar disc herniation is a common injury among athletes, especially those who practice disciplines with repetitive flexion movements, twisting and axial loading on the spine, such as weightlifting, gymnastics, hockey and American football. In refractory cases to conservative treatment, microscopic discectomy or full endoscopic discectomy are used as surgical options to relieve pain and restore patient functionality. However, the ideal time for a return to sports activities remains a matter of debate due to variations in recovery times and risks of complications associated with each technique. Methods: A review was conducted, including articles published in the last 33 years (1991-2024), as it was the earliest date matching our search criteria. Clinical studies, systematic reviews, meta-analyses, and clinical guidelines were included. Results: The most common complications when returning to sport prematurely include recurrence of the hernia, persistent pain (VAS leg 7 or higher after surgery) and reduced physical performance. The return to full activity rate of patients who underwent microdiscectomy reaches up to 90%, while the endoscopic technique shows a success rate that reaches 99%. Return to play meantime was 5.19 months (range 1.00 - 8.7 months) and mean time of 4.6 months (range 2 - 8 months) with Microdiscectomy and full endoscopic discectomy respectively. Conclusions: There is no unanimous consensus on the exact timing of return to sport due to variability in recovery times and clinical outcomes. In both techniques, evidence highlights the need for a multidisciplinary approach that integrates surgeons, physical therapists and trainers to optimize recovery and ensure a safe return.

关键词： lumbar Disc Herniation Microdiscectomy lumbar Endoscopy Return to Sport Sports Injuries Sports Rehabilitation

Influence of phytoplankton,bacteria and viruses on nutrient supply in tropical waters

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Journal of Environmental Sciences 2025年第5期151卷 174-186页

作者： Zhi Yang Sim Kwan Chien Goh Nur Hanisah binte Sukarji Feijian Mao Yiliang He karina Yew-Hoong Gin National University of Singapore Environmental Research Institute National University of Singapore1 Create Way#15-02Singapore 138602Singapore Institute of Tibetan Plateau Research Chinese Academy of Sciences(CAS)Beijing 100101China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Civil and Environmental Engineering National University of SingaporeBlk E1A-07-031 Engineering Drive 2Singapore 117576Singapore

Diel investigations of water environments are one means to holistically understand the dynamics and functional roles of phytoplankton,bacteria and viruses in these *** have the potential to substantially impact carbon(C),nitrogen(N)and phosphorus(P)biogeochemistry through their respective *** study characterizes the phytoplankton,bacteria and virus communities and the elemental composition of various C,N and P nutrients flow over three diel cycles in tropical urban *** results show that ratios of C:N:P fluctuated strongly from the lack of dissolved organic phosphorus(DOP)and PO_(4).Specifically,green algae peaked during day time and exudate dissolved organic matter(DOM)that strongly modulate dissolved organic carbon(DOC):DOP ratio to diel DOP *** linear regression and Stella modelling emphasize the roles of viruses together with Synechococcus as important nutrient recyclers of NH_(4)and PO_(4)in nutrients-limited *** normalised surface PO_(4)and combined surface and bottom NH_(4)concentration selected both viruses and Synechococcus as important *** model of N and P biogeochemical cycles can achieve 69%and 57%similar to observed concentration of NH_(4)and PO_(4),respectively.A short latent period of 9 hr was calculated,in addition to the calibrated high infectivity of viruses to *** together,the rapid turn-over between Synechococcus and viruses has biogeochemical significance,where the rapid recycling of essential nutrients allows for shortcuts in the N and P cycle,supporting a wide range of microbes.

关键词： Diel Phytoplankton Bacteria Virus Nutrients Element ratios

Association between Helicobacter *** and hepatobiliary malignancies:A review

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World Journal of Gastroenterology 2015年第5期21卷 1414-1423页

作者： Fany karina Segura-lópez Alfredo Güitrón-Cantú Javier Torres Hospital de Especialidades UMAE No 71 Instituto Mexicano del Seguro SocialTorreónCoahuila 27000México Departamento de Endoscopia Gastrointestinal Hospital de Especialidades UMAE No 71Instituto Mexicano del Seguro SocialTorreónCoahuila 2700México Unidad de Investigación en Enfermedades Infecciosas y Parasitarias Hospital de Pediatría UMAECentro Médico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMéxico CP 06720DFMéxico

Hepatobiliary cancers are highly lethal cancers that comprise a spectrum of invasive carcinomas originating in the liver hepatocellular carcinoma,the bile ducts intrahepatic cholangiocarcinoma and extrahepaticcholangiocarcinoma,the gallbladder and the ampulla of Vater(collectively known as biliary tract cancers).These tumors account for approximately 13% of all annual cancer-related deaths worldwide and for 10%-20% of deaths from hepatobiliary ***(CCA) is a devastating disease that displays a poor survival rate for which few therapeutic options are *** genetics,geographical and environmental factors,cholelithiasis,obesity,parity,and endemic infection with liver flukes have been identified as risk factors that influence the development of biliary tract *** important factors affecting the carcinogenesis of these tumors include chronic inflammation,obstruction of the bile ducts,and impaired bile *** has been suggested that CCA is caused by infection with Helicobacter species,such as Helicobacter bilis and Helicobacter hepaticus,in a manner that is similar to the reported role of Helicobacter pylori in distal gastric *** to the difficulty in culturing these Helicobacter species,molecular methods,such as polymerase chain reaction and sequencing,or immunologic assays have become the methods of choice for ***,clinical studies of benign or malignant biliary tract diseases revealed remarkable variability in the methods and the findings,and the use of uniform and validated techniques is needed.

关键词： Helicobacter bilis Helicobacter hepaticus Helicoba

Hepatitis C virus resistance to new specifically-targeted antiviral therapy: A public health perspective

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World Journal of Virology 2013年第1期2卷 6-15页

作者： karina Salvatierra Sabrina Fareleski Alicia Forcada F Xavier lópez-labrador Joint Unit in Genomics and Health Centre for Public Health Research Public Health Department Generalitat Valenciana/Institut Cavanilles University of Valencia Instituto de Biomedicina de Valencia-Consejo Superior de Investigaciones Científicas CIBER in Epidemiology and Public Health(CIBER-ESP) Instituto de Salud Carlos Ⅲ Department of Microbiology Medical School University of Valencia

Until very recently, treatment for chronic hepatitis C virus(HCV) infection has been based on the combination of two non-viral specific drugs: pegylated interferon-α and ribavirin, which is effective in, overall, about 40%-50% of cases. To improve the response to treatment, novel drugs have been designed to specifically block viral proteins. Multiple compounds are under development, and the approval for clinical use of the first of such direct-acting antivirals in 2011(Telaprevir and Boceprevir), represents a milestone in HCV treatment. HCV therapeutics is entering a new expanding era, and a highly-effective cure is envisioned for the first timesince the discovery of the virus in 1989. However, any antiviral treatment may be limited by the capacity of the virus to overcome the selective pressure of new drugs, generating antiviral resistance. Here, we try to provide a basic overview of new treatments, HCV resistance to new antivirals and some considerations derived from a Public Health perspective, using HCV resistance to protease and polymerase inhibitors as examples.

关键词： Specifically-targeted antiviral therapy Direct-acting antiviral Protease inhibitors Polymerase inhibitors Viral resistance

Development of gemcitabine-resistant patient-derived xenograft models of pancreatic ductal adenocarcinoma

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Cancer Drug Resistance 2020年第3期3卷 572-585页

作者： Aubrey l.Miller Patrick l.Garcia Tracy l.Gamblin Rebecca B.Vance karina J.Yoon Department of Pharmacology and Toxicology University of Alabama at BirminghamBirminghamAL 35294 USA.

Aim:Gemcitabine is a frontline agent for locally-advanced and metastatic pancreatic ductal adenocarcinoma(PDAC),but neither gemcitabine alone nor in combination produces durable remissions of this tumor *** developed three PDAC patient-derived xenograft(PDX)models with gemcitabine resistance(gemR)acquired in vivo,with which to identify mechanisms of resistance relevant to drug exposure in vivo and to evaluate novel ***:Mice bearing independently-derived PDXs received 100 mg/kg gemcitabine once or twice *** initially responded,but regrew on treatment and were designated *** used immunohistochemistry to compare expression of proteins previously associated with gemcitabine resistance[ribonucleotide reductase subunit M1(RRM1),RRM2,human concentrative nucleoside transporter 1(hCNT1),human equilibrative nucleoside transporter 1(hENT1),cytidine deaminase(CDA),and deoxycytidine kinase(dCK)]in gemR and respective gemcitabine-naïve parental ***:Parental and gemR tumors did not differ in tumor cell morphology,amount of tumor-associated stroma,or expression of stem cell *** consistent pattern of expression of the six gemR marker proteins was observed among the *** in RRM1 and CDA were consistent with in vitro-derived gemR ***,rather than the expected decreases of hCNT1,hENT1,and dCK,gemR tumors expressed no change in or higher levels of these gemR marker proteins than parental ***:These models are the first PDAC PDX models with gemcitabine resistance acquired in *** data indicate that mechanisms identified in models with resistance acquired in vitro are unlikely to be the predominant mechanisms when resistance is acquired in *** work focuses on characterizing unidentified mechanisms of gemR and on identifying agents with anti-tumor efficacy in these gemR models。

关键词： Gemcitabine resistance patient-derived xenograft ribonucleotide reductase subunit M1 ribonucleotide reductase subunit M2 human concentrative nucleoside transporter 1 human equilibrative nucleoside transporter 1 cytidine deaminase deoxycytidine kinase

Gender disparities and woman-specific trends in Barrett’s esophagus in the United States:An 11-year nationwide populationbased study

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World Journal of Methodology 2025年第1期15卷 60-71页

作者： karina Fatakhova Faisal Inayat Hassam Ali Pratik Patel Attiq Ur Rehman Arslan Afzal Muhammad Sarfraz Shiza Sarfraz Gul Nawaz Ahtshamullah Chaudhry Rubaid Dhillon Arthur Dilibe Benjamin Glazebnik lindsey Jones Emily Glazer Division of Gastroenterology and Hepatology Mather Hospital and Zucker School of Medicine at Hofstra UniversityPort JeffersonNY 11777United States Department of Internal Medicine Allama Iqbal Medical CollegeLahorePunjab 54550Pakistan Division of Gastroenterology and Hepatology East Carolina University Brody School of MedicineGreenvilleNC 27834United States Division of Gastroenterology and Hepatology Geisinger Wyoming Valley Medical CenterWilkes-BarrePA 18711United States Department of Internal Medicine East Carolina University Brody School of MedicineGreenvilleNC 27834United States Department of Internal Medicine St.Dominic's HospitalJacksonMS 39216United States Department of Gastroenterology Hepatologyand NutritionCleveland Clinic FoundationClevelandOH 44195United States Department of Internal Medicine Mather Hospital and Hofstra University ZuckerSchool of MedicinePort JeffersonNY 11777United States

BACKGROUND Barrett's esophagus(BE)is a known premalignant precursor to esophageal adenocarcinoma(EAC).The prevalence rates continue to rise in the United States,but many patients who are at risk of EAC are not *** practice guidelines include male gender as a predisposing factor for BE and *** population-based clinical evidence regarding female gender remains *** To study comparative trends of gender disparities in patients with BE in the United *** A nationwide retrospective study was conducted using the 2009-2019 National Inpatient Sample(NIS)*** with a primary or secondary diagnosis code of BE were *** major outcome of interest was determining the gender disparities in patients with *** analysis for respective outcomes for females was also reported to ascertain any time-based *** We identified 1204190 patients with BE for the study *** the included patients,717439(59.6%)were men and 486751(40.4%)were *** mean age was higher in women than in men(67.1±0.4 vs 66.6±0.3 years,Pl NIS hospitalizations for males increased from 144.6 in 2009 to 213.4 in 2019(Ples increased from 96.8 in 2009 to 148.7 in 2019(Plence among females increased from 12.3%in 2009 to 21.9%in 2019(Plower prevalence of smoking was noted in women than in men(20.8%vs 35.7%,Plysis showed an increasing prevalence of smoking among women,from 12.9%in 2009 to 30.7%in 2019(Plly,there was a lower prevalence of alcohol abuse,Helicobacter pylori(***),and diabetes mellitus among females than males(Plysis showed an increasing prevalence of alcohol use disorder and a decreasing prevalence of *** and diabetes mellitus among women(PlUSION The prevalence of BE among

关键词： Barrett’s esophagus Gender disparity Epidemiological trends Esophageal adenocarcinoma Screening endoscopy Female gender Risk factors

Physiological dormancy broken by endozoochory:Austral parakeets(Enicognathus ferrugineus)as legitimate dispersers of calafate(Berberis microphylla)in the Patagonian Andes

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Journal of Plant Ecology 2020年第5期13卷 538-544页

作者： Carolina Bravo Daniel Chamorro Fernando Hiraldo karina Speziale Sergio A.lambertucci Josél.Tella Guillermo Blanco Department of Evolutionary Ecology Museo Nacional de Ciencias NaturalesCSICJoséGutiérrez Abascal 228006 MadridSpain Centre d’Etudes Biologiques de Chizé UMR 7372CNRS and La Rochelle UniversitéF-79360 Beauvoir-sur-NiortFrance Departamento de Ciencias Ambientales Universidad de Castilla-La ManchaAv.Carlos III s/n45071 ToledoSpain Department of Conservation Biology Estación Biológica de DoñanaCSICAmérico Vespucio 2641092 SevillaSpain Grupo de Investigaciones en Biología de la Conservación Departamento de EcologíaINIBIOMA(CONICET-National University of Comahue)Pasaje Gutiérrez 11258400 BarilocheArgentina

Aims Seed dispersal by endozoochory is an important process in plant regeneration and the establishment of new *** with dormancy may especially benefit after disperser gut ***,the ways in which gut passage affect the germination of plant species with physiological dormancy remain ***,we experimentally assessed the mutualistic interaction between the Austral parakeet(Enicognathus ferrugineus)as a disperser of calafate(Berberis microphylla),a thorny bush inhabiting the understory of the Austral temperate forests of South America with seeds that are characterized by deep physiological *** Germination success and viability of calafate seeds obtained from faeces and from intact fruits were tested under four treatments:(i)digested seeds,(ii)digested seeds with faecal extract,(iii)intact seeds from fruit and(iv)intact seeds from fruit with *** Findings About 65%of the Austral parakeet droppings contained calafate *** of seeds did not differ between ***,germination was significantly higher in digested seeds than in intact seeds from fruits,while no difference was found between faecal and pulp *** faecal matter nor fruit pulp provided seeds with any ecological advantages derived from enhancing germinability,but did confer some disadvantage in germination *** matter is expected to be completely lacking around seeds after several months under snow before germinating in the following spring,given intense washing due to persistent rain and the spring thaw in the Patagonian *** higher germinability along with faster germination of digested seeds supports the hypothesis of a legitimate mutualistic interaction between Austral parakeets and *** hypothesized that the passage through the disperser digestive tract might break physiological dormancy as differences in germinability between ingested and non-ingested *** results highlight the relevant role of endoz

关键词： seed dispersal Austral forest mutualism gut passage viability germination success germinability

Isoform-and cell-state-specific APOE homeostasis and function

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Neural Regeneration Research 2024年第11期19卷 2456-2466页

作者： karina lindner Anne-Claude Gavin Department of Cell Physiology and Metabolism Faculty of MedicineUniversity of GenevaGenevaSwitzerland Diabetes Center Faculty of MedicineUniversity of GenevaGenevaSwitzerland

Apolipoprotein E is the major lipid transporter in the brain and an important player in neuron-astrocyte metabolic *** ensures the survival of neurons under stressful conditions and hyperactivity by nourishing and detoxifying *** E polymorphism,combined with environmental stresses and/or age-related alterations,influences the risk of developing late-onset Alzheimer’s *** this review,we discuss our current knowledge of how apolipoprotein E homeostasis,*** synthesis,secretion,degradation,and lipidation,is affected in Alzheimer’s disease.

关键词： Alzheimer’s disease apolipoprotein E autophagy cholesterol lipid detoxification lipid transport lysosomal failure metabolic impairment triacylglycerol