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Acetylsalicylic Acid Administered in Patients with Type 2 Diabetes Mellitus and Its Effect on the Antioxidant Enzyme System

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Journal of Diabetes Mellitus 2022年第4期12卷 252-262页

作者： Sara Pascoe-González karina Celia Morgado-Castillo Maria guadalupe Ramos-Zavala Ernesto Germán Cardona-Muñoz Fernando Grover-Paez María Claudia Espinel-Bermúdez Sandra Ofelia Hernández-González Instituto de Terapéutica Experimental y Clínica (INTEC) Departamento de Fisiología Centro Universitario de Ciencias de la Salud Universidad de Guadalajara Guadalajara México Unidad de Investigación Biomédica 02 Unidad Médica de Alta Especialidad Hospital de Especialidades Centro Médico Nacional de Occidente del Instituto Mexicano del Seguro Social Guadalajara México

Type 2 diabetes mellitus and its complications are associated with oxidative stress and the depletion of antioxidant defenses. The influence of acetylsalicylic acid on reversing the decrease in antioxidants, insulin resistance, glucose homeostasis, and inflammatory cascade can help prevent diabetes complications. Purpose: The aim of the study was to evaluate the effect of acetylsalicylic acid on the antioxidant enzymatic system in patients with diabetes. Methods: A randomized, double-blind, placebo-controlled clinical trial was carried out in 21 patients of both sexes with Type 2 diabetes for less than five years at the time of diagnosis, without pharmacological treatment, and randomly selected. Acetylsalicylic acid (300 mg) was administered orally for three months to the study group (n = 11) compared to the placebo control group (n = 10). Before and after the intervention, anthropometric and metabolic measurements were taken, fasting plasma glucose, glycated hemoglobin A1c, lipid profile panel, glutathione peroxidase, superoxide dismutase, catalase, and antioxidant capacity/activity were determined;values are presented as mean ± standard deviation. Intra- and intergroup differences were tested by Wilcoxon signed rank and Mann-Whitney U test, respectively;p-value ≤ 0.05 was considered statistically significant. Results: The acetylsalicylic acid group showed a decrease in weight (85.6 ± 19.3 vs. 84.1 ± 19.0 kg p = 0.01), cholesterol (205.9 ± 16.6 vs. 186.0 ± 23.2 mg/dL p = 0.02), and glycated hemoglobin A1c (7.8% ± 0.9% vs. 7.0% ± 0.7% p = 0.02). The placebo group exhibited reduction in weight (76.1 ± 14.9 vs. 74.9 ± 15.0 kg p = 0.04), glycated hemoglobin A1c (6.9% ± 0.6% vs. 6.2% ± 0.4% p = 0.004), and total antioxidant capacity (4.1 ± 0.5 vs. 4.8 ± 0.3 mmol/L p = 0.002). Conclusion: The administration of acetylsalicylic acid did not modify the antioxidant enzyme system.

关键词： Type 2 Diabetes Mellitus Acetylsalicylic Acid Oxidative Stress Glucose Glycated Hemoglobin A1c

Gut microbiota in a population highly affected by obesity and type 2 diabetes and susceptibility to COVID-19

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World Journal of Gastroenterology 2021年第41期27卷 7065-7079页

作者： Jaime García-Mena karina Corona-Cervantes Daniel Cuervo-Zanatta Tizziani Benitez-Guerrero JuanManuel Vélez-Ixta Norma Gabriela Zavala-Torres Loan Edel Villalobos-Flores Fernando Hernández-Quiroz Claudia Perez-Cruz Selvasankar Murugesan Fernando guadalupe Bastida-González Paola Berenice Zárate-Segura Departamento de Genética y Biología Molecular Centro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMexico City 07360CDMXMexico Departamento de Genética y Biología Molecular and Departamento de Farmacología Centro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMexico City 07360CDMXMexico Departamento de Farmacología Centro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMexico City 07360CDMXMexico Department of Mother and Child Health SIDRA MedicineDoha 26999Qatar Laboratorio Estatal de Salud Pública del Estado de México ISEMToluca de Lerdo 50180Estado de MéxicoMexico Escuela Superior de Medicina Instituto Politécnico NacionalMexico City 11340CDMXMexico

Coronavirus disease 2019(COVID-19)is a disease produced by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and it is currently causing a catastrophic pandemic affecting humans *** disease has been lethal for approximately 3.12 million people around the world since January ***,among the most affected countries,Mexico ranks third in deaths after the United States of America and *** the high number of deceased people might also be explained by social aspects and lifestyle customs in Mexico,there is a relationship between this high proportion of deaths and comorbidities such as high blood pressure(HBP),type 2 diabetes,obesity,and metabolic *** official epidemiological figures reported by the Mexican government have indicated that 18.4%of the population suffers from HBP,close to 10.3%of adults suffer from type 2 diabetes,and approximately 36.1%of the population suffers from *** in the gut microbiota(GM)have been associated with these diseases and with COVID-19 severity,presumably due to inflammatory *** data about the association between GM dysbiosis and metabolic diseases could suggest that the high levels of susceptibility to SARSCoV-2 infection and COVID-19 morbidity in the Mexican population are primarily due to the prevalence of type 2 diabetes,obesity,and metabolic syndrome.

关键词： SARS-CoV-2 COVID-19 High blood pressure Hypertension Type 2 diabetes Obesity Metabolic syndrome Gut microbiota Immunity

Synthesis and Characterization of GaN Rods Prepared by Ammono-Chemical Vapor Deposition

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Advances in Chemical Engineering and Science 2012年第2期2卷 292-299页

作者： Gregorio guadalupe Carbajal Arízaga karina Viridiana Chávez Hernández Nicolás Cayetano Castro Manuel Herrera Zaldivar Rafael García Gutiérrez Oscar Edel Contreras López Centro de Investigación en Física Universidad de Sonora Hermosillo México Centro de Nanociencias y Nanotecnología Universidad Nacional Autónoma de México Ensenada México Departamento de Química Universidad de Guadalajara Guadalajara México Instituto Potosino de Investigación Científica y Tecnológica (IPICYT) División de Materiales Avanzados (LINAN) San Luis Potosí México

GaN rods were deposited by chemical vapor deposition (CVD) onto sapphire (0 0 0 1) and amorphous quartz. The reactive Ga species in vapor the phase was formed with NH4Cl and gallium. The unidirectional growth was catalyzed with gold nanoparticles formed onto the substrate prior to the CVD reaction in order to induce a vapor-liquid-solid (VLS) mechanism. However, this method of synthesis seems to be influenced by other growth mechanisms which formed additional depositions of GaN with different morphology than the rods catalyzed by gold nanoparticles. The moieties of GaN that grew in the absence of gold formed branches in the rods or increased the lateral growth of rods resulting in larger diameters than the size of the gold particle that guided the growth.

关键词： Crystal Morphology Nanostructures Chemical Vapor Deposition Processes Semiconducting III-V Material

Performance Comparison among Trained Judges and Panels for the Evaluation of “Cuajada” Type Fresh Cheese in Two Regions from Oaxaca in México

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Food and Nutrition Sciences 2011年第10期2卷 1166-1179页

作者： Lorena guadalupe Ramón Canul Emmanuel de Jesús Ramírez Rivera Rodrigo Santiago Cabrera Fátima karina Delgado Vidal José Manuel Juárez Barrientos María Hernández Cervantes Juliana López Velázquez Tania Gómez Alvarado 不详

Four “cuajada” type fresh cheeses were evaluated by two trained panels in different regions from Oaxaca in Mexico (Instituto Tecnológico de Comitancillo (ITC) and Universidad del Mar (UMAR)). Each panel was integrated by six judges. Analysis of variance (ANOVA) in conjunction with principal component analysis (PCA) and the Rv coefficient were used to identify similarities and consensus among trained judges and panels. The ANOVA results revealed that the judges from ITC performed significantly better (P < 0.05) in discrimination and repetitivity, while both panels showed a similar effect in discrimination. The PCA determined some similarities in the position of cheeses in the sensory space, while Rv revealed that judges and panels were consensual. In conclusion, statistical resources determined that both panels were discriminating and that similarities in the positioning of cheeses in the sensory space were found.

关键词： AFM ANOVA Cuajada Type Fresh Cheese PCA Training Panelists