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Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the TDP-43^(G298S) ALS mouse model

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Translational Neurodegeneration 2019年第1期8卷 333-345页

作者： Hans-Peter müller David Brenner Francesco Roselli Diana Wiesner Alireza Abaei martin Gorges karin m.danzer Albert C.Ludolph William Tsao Philip C.Wong Volker Rasche Jochen H.Weishaupt Jan Kassubek Department of Neurology University of UlmOberer Eselsberg 45RKUD-89081 UlmGermany German Center for Neurodegenerative Diseases(DZNE) UlmGermany Core Facility Small Animal mRI University of UlmUlmGermany Department of Pathology The Johns Hopkins University School of MedicineBaltimoreUSA

Background:In vivo diffusion tensor imaging(DTI)of the mouse brain was used to identify TDP-43 associated alterations in a mouse model for amyotrophic lateral sclerosis(ALS).methods:Ten mice with TDP-43^(G298S) overexpression under control of the Thy1.2 promoter and 10 wild type(wt)underwent longitudinal DTI scans at 11.7 T,including one baseline and one follow-up scan with an interval of about *** brain-based spatial statistics(WBSS)of DTI-based parameter maps was used to identify longitudinal alterations of TDP-43^(G298S) mice compared to wt at the cohort *** were supplemented by tractwise fractional anisotropy statistics(TFAS)and histological evaluation of motor cortex for signs of neuronal ***:Alterations at the cohort level in TDP-43^(G298S) mice were observed cross-sectionally and longitudinally in motor areas m1/m2 and in transcallosal fibers but not in the corticospinal *** loss in layer V of motor cortex was detected in TDP-43^(G298S) at the later(but not at the earlier)timepoint compared to ***:DTI mapping of TDP-43^(G298S) mice demonstrated progression in motor areas m1/*** and TFAS are useful techniques to localize TDP-43^(G298S) associated alterations over time in this ALS mouse model,as a biological marker.

关键词： Diffusion tensor imaging Amyotrophic lateral sclerosis mutant TDP-43 Fiber tracking mouse brain

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Treatment of Vulvovaginal Candidiasis with A Strategy Based on Phototherapy (m.A.C.^® Scar Acceleration method)

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modern Research in Inflammation 2024年第1期13卷 1-7页

作者： marcus Vinicius de mello Pinto karin Yuri Fernández Iturra Aline Ronis Sampaio maría Elena Silva Álvarez Esteban Fortuny Celulare Institute Petrópolis Brazil Bienus Clinic Santiago Chile Fisiocare Curicó Chile Universidad Finis Terrae Santiago Chile

Candidiasis, also known as candidiasis vulvovaginitis, is an infection caused by different types of Candida fungi, the most frequent being Candida albicans. The present study reports an effective strategy, which opens new avenues for the treatment of this public health problem. The mAC® methodology, conventional laser light-emitting (LLLT)/LED) methods are based on the biphasic response demonstrated many times in LLLT research and as with other forms of drugs, a “drug” (irradiation parameters) and a “dose” (irradiation times) and the “Arndt-Schulz Law” is often cited as a suitable model to describe the dose-dependent effects of LLLT. This method uses photopharmaceuticals, cell markers and the use of correct parameters for each case to induce the acceleration of tissue repair. The present study shows a case of a 32-year-old patient diagnosed with recurrent candidiasis 4 years ago. Eighteen sessions were performed (every other day) using a photoactivated component (methylene blue 1% + Clotrimazole 1%) and LED phototherapy (red, blue and violet) with emission times of 60 - 260 seconds for each applicator, according to the dose recommendations of the scar acceleration method (mAC®). At the sixth treatment session there was a noticeable decrease in the itching sensation reported by the patient. In session 11 she reported feeling a great improvement, indicating that she no longer felt itching in any area after 18 sessions. The present case demonstrates new methodologies to treat common problems in the population that have a positive impact on the quality of life. This methodology has a promising future because it is non-invasive and requires a great biological transformation for inflammatory, fungal and viral control.

关键词： Treatment of vulvovaginal Candidiasis Candidiasis Candida m.A.C. mAC®

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Electronic correlation in nearly free electron metals with beyond-DFT methods

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npj Computational materials 2022年第1期8卷 1756-1762页

作者： Subhasish mandal Kristjan Haule karin m.Rabe David Vanderbilt Department of Physics and Astronomy West Virginia UniversityMorgantownWVUSA Department of Physics and Astronomy Rutgers UniversityPiscatawayNJUSA

For more than three decades,nearly free-electron elemental metals have been a topic of debate because the computed bandwidths are significantly wider in the local density approximation to density-functional theory(DFT)than indicated by angle-resolved photoemission(ARPES)***,we systematically investigate this using first principles calculations for alkali and alkaline-earth metals using DFT and various beyond-DFT methods such as meta-GGA,G0W0,hybrid functionals(YS-PBE0,B3LYP),and LDA+*** find that the static non-local exchange,as partly included in the hybrid functionals,significantly increase the bandwidths even compared to LDA,while the G0W0 bands are only slightly narrower than in *** agreement with the ARPES is best when the local approximation to the self-energy is used in the LDA+eDmFT *** infer that even moderately correlated systems with partially occupied s orbitals,which were assumed to approximate the uniform electron gas,are very well described in terms of short-range dynamical correlations that are only local to an atom.

关键词： metals assumed narrow

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Highly Luminescent Positively Charged Quantum Dots Interacting with Proteins and Cells

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Chinese Journal of Chemistry 2022年第22期40卷 2685-2693页

作者： Haixia Wang karin Nienhaus Li Shang Gerd Ulrich Nienhaus Institute of Applied Physics Karlsruhe Institute of Technology(KIT)76131 KarlsruheGermany Institute of Nanotechnology Karlsruhe Institute of Technology(KIT)76344 Eggenstein-LeopoldshafenGermany InstituteofBiologicaland Chemical Systems Karlsruhe Institute of Technology(KIT)76344 Eggenstein-LeopoldshafenGermany Department of Physics University of llinois at Urbana-ChampaignUrbanaIL61801USA Present address:Laboratory of Biomaterials and Translational medicine Center for NanomedicineThe Third Affiliated HospitalSun Yat-sen UniversityGuangzhou510630China Present address:School of materials Science and Engineering Northwestern PolytechnicalUniversityXi'an 710072China

We have studied interactions between positively charged mUTAB-stabilized quantum dots(QDs)and model proteins,serum and live cells using fluorescence correlation spectroscopy(FCS),dynamic light scattering(DLS),time-resolved photoluminescence(PL)and live-cell fluorescence *** human serum albumin(HSA)as a model protein,we measured the growth of a protein adsorption layer(“protein corona”)via time-resolved *** formation was characterized by an apparent equilibrium dissociation coefficient,KD≈10μ*** adlayer growth was surprisingly slow(timescale ca.30 min),in stark contrast to many similar measurements with HSA and other proteins and different ***-resolved PL data revealed a characteristic quenching behavior depending on the QD surface coverage with *** together,we found that mUTAB-QDs initially bind HSA molecules weakly(KD≈700μm);however,the affinity is enhanced over time,presumably due to proton injection into the mUTAB layer by HSA triggering ligand *** process was also observed with human blood serum,showing equal kinetics for comparable HSA ***,imaging experiments with cultured human cells(HeLa)revealed that mUTAB-QDs bind to the cell membrane and perforate *** process is reduced upon pre-adsorption of proteins on the mUTAB-QD.

关键词： Quantum dots Nanoparticles Agglomeration Protein adsorption Quantitative fluorescence microscopy

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The Influence of High Temperature Exposure on the Wear Performance of a Ni Based Alloy PTA Coating

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材料热处理学报 2004年第5期25卷 152-156页

作者： karin Graf Ana Sofia C.m. d'OIiveira mechanical Department of Universidade Federal do Parana Curitiba BrazilMechanical Department of Universidade Federal do Parana Curitiba Brazil

Degradation phenomena like wear and corrosion, may have their effects accelerated as components operate at high temperature. The aim of this work is to make an indirect evaluation of the influence of high temperature exposure on wear behavior of Ni coatings. A Ni-Cr-mo-W alloy, was deposited with Plasma Transferred Arc (PTA) process. An indirect approach based on the Ahrrenius relationship was used to evaluated long time exposures at high temperatures. To simulate longer exposures at lower temperatures, coatings were exposed to higher temperatures for the same time interval. So coatings were soaked in an air furnace at 650°C, 1000°C and 1200°C. metal/metal wear behavior was evaluated by pin-on-disc tests. Pins were removed from the coatings by eletrodischarge machining and rubbed against a VC31 quenched and tempered tool steel. Two sets of wear tests were run at 2m/s, for different loads (0.5, 1.0, 2.0 and 3.0Kg) and for different sliding distances (120, 720, 1080, 1440 and 1800m).Coatings characterization was done by scanning electronic microscopy and Vickers microhardness. Results showed as temperature is increased, coatings wear performance is altered, and this is associated with microstructural changes.

关键词：磨损 Ni合金 PTA 高温曝露

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Doxorubicin-conjugated siRNA lipid nanoparticles for combination cancer therapy

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Acta Pharmaceutica Sinica B 2023年第4期13卷 1429-1437页

作者： Kamila Butowska Xuexiang Han Ningqiang Gong Rakan El-mayta Rebecca mHaley Lulu Xue Wenqun Zhong Wei Guo karin Wang michael J.mitchell Department of Bioengineering University of PennsylvaniaPhiladelphiaPA 19104USA Intercollegiate Faculty of Biotechnology University of Gdańsk&Medical University of GdańskGdańsk 80-307Poland Department of Biology University of PennsylvaniaPhiladelphiaPA 19104USA Department of Bioengineering Temple UniversityPhiladelphiaPA 19122USA Abramson Cancer Center Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Institute for Immunology Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Cardiovascular Institute Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Institute for Regenerative medicine Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA

Evasion of apoptosis is a hallmark of cancer,attributed in part to overexpression of the antiapoptotic protein B-cell lymphoma 2(Bcl-2).In a variety of cancer types,including lymphoma,Bcl-2 is *** targeting of Bcl-2 has demonstrated efficacy in the clinic and is the subject of extensive clinical testing in combination with ***,the development of co-delivery systems for Bcl-2 targeting agents,such as small interfering RNA(siRNA),and chemotherapeutics,such as doxorubicin(DOX),holds promise for enabling combination cancer *** nanoparticles(LNPs)are a clinically advanced nucleic acid delivery system with a compact structure suitable for siRNA encapsulation and *** by ongoing clinical trials of albumin-hitchhiking doxorubicin prodrugs,here we developed a DOX-siRNA co-delivery strategy via conjugation of doxorubicin to the surface of siRNAloaded *** optimized LNPs enabled potent knockdown of Bcl-2 and efficient delivery of DOX into the nucleus of Burkitts'lymphoma(Raji)cells,leading to effective inhibition of tumor growth in a mouse model of *** on these results,our LNPs may provide a platform for the co-delivery of various nucleic acids and DOX for the development of new combination cancer therapies.

关键词： Lipid nanoparticles Doxorubicin Bcl-2 siRNA delivery Chemotherapy Lymphoma

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Production and decay of polarized hyperon-antihyperon pairs

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Chinese Physics C 2023年第5期 35-54页

作者： karin Sch?nning Varvara Batozskaya Patrik Adlarson 周小蓉 Department of Physics and Astronomy Uppsala University Uppsala Institute of High Energy Physics Chinese Academy of Sciences National Centre for Nuclear Research University of Science and Technology of China

Polarized hyperon-antihyperon pairs shed light on various unresolved puzzles in contemporary physics:How the strong interaction confines quarks into hadrons, how accurately the Standard model describes microcosmos and even why our universe consists of so much more matter than antimatter. Thanks to their weak, parity violating decays, hyperons reveal their spin properties. This can be exploited e.g. the decomposition of the electromagnetic structure of hyperons, precision tests of flavour symmetry and searches for CP violation. At the BESⅢ experiment at BEPC-Ⅱ, Beijing, China, hyperon-antihyperon pairs can be produced in abundance. Recently collected large data samples have triggered the development of new methods that provide unprecedented precision and a plethora of new results have emerged. When applied at future high-intensity facilities like PANDA and STCF, precision physics will be taken to a new level which can contribute to the solution to the aforementioned puzzles.

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Systematic beyond-DFT study of binary transition metal oxides

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npj Computational materials 2019年第1期5卷 124-131页

作者： Subhasish mandal Kristjan Haule karin m.Rabe David Vanderbilt Department of Physics and Astronomy Rutgers UniversityPiscatawayNJUSA

Various methods going beyond density functional theory(DFT),such as DFT+U,hybrid functionals,meta-GGAs,GW,and DFTembedded dynamical mean field theory(eDmFT),have been developed to describe the electronic structure of correlated materials,but it is unclear how accurate these methods can be expected to be when applied to a given strongly correlated *** is thus of pressing interest to compare their accuracy as they apply to different categories of *** we introduce a novel paradigm in which a chosen set of beyond-DFT methods is systematically and uniformly tested on a chosen class of *** a first application,we choose the target materials to be the binary transition metal oxides FeO,CoO,mnO,and NiO in their antiferromagnetic phase and present a head-to-head comparison of spectral properties as computed using the various *** also compare with available experimental angle-resolved photoemission spectroscopy(ARPES),inverse-photoemission spectroscopy,and with optical *** the class of compounds studied here,we find that both B3LYP and eDmFT reproduce the experiments quite well,with eDmFT doing best,in particular when comparing with the ARPES data.

关键词： materials oxides transition

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A Setup for a Scenario-Driven Water Balance at Landscape Scale—Assessment with AKWA-m~-Embedded in a model Framework for Land-Use Planning’s Decision Support in mountainous Southwest China

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Journal of Earth Science 2010年第6期21卷 974-978页

作者： Andreas Wahren karin Berkhoff Albrecht münch Sylvia Herrmann Karl-Heinz Feger Insitute of Soil Science and Site Ecology Technische Universitt Dresden Dr. Dittrich & Partner Hydro-Consult GmbH Institute of Environmental Planning Leibniz University Hannover

Land-cover changes cause a loss of natural vegetation in many parts of the world. In the Xishuangbanna （西双版纳） district （Yunnan （云南） Province）, rubber plantations replace tropical rainforests covering already an area of about 10% of the study area （2007）. There, land-use allocation is mostly driven by economic considerations. Thus, local planning authorities need decision support for land-use planning issues, which integrate socio-economic and ecological aspects. Within the NabanFrame, an agro-economic, ecological and social model was applied, which, altogether, interacted with a land allocation model via defined interfaces. Effects on the water cycle, ecological conditions as well as socio-economic should be considered by integrating the spatially distributed rainfali-runoff and water balance model AKWA-m in the model setup.

关键词： land-use water balance model rubber integrated land-use planning land-use prognosis.

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C1q recognizes antigen-bound IgG in a curvature-dependent manner

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Nano Research 2020年第6期13卷 1651-1658页

作者： Christina m.Zeuthen Ali Shahrokhtash karin Fromell Kristina Nilsson Ekdahl Hossein mohammad-Beigi Duncan S.Sutherland Interdisciplinary Nanoscience Center Aarhus UniversityGustav Wieds vej 148000Aarhus CDenmark Department of Immunology Genetics and PathologyUppsala UniversityDag Hammarskjölds väg 2075185UppsalaSweden Linnaeus Center of Biomaterials Chemistry Linnaeus University39182KalmarSweden Sino-Danish Center for Education and Research Niels Jensens Vej 2Building 11908000Aarhus CDenmark The Centre for Cellular Signal Patterns(CellPAT) Gustav Wieds vej 148000Aarhus CDenmark

Nano Research volume 13,pages1651–1658(2020)Cite this article 109 Accesses metrics details Abstract C1q is an important recognition protein in the complement system,which is a major protein cascade in the innate immune *** recognition of a target by C1q,the target is marked for opsonization and destruction.C1q recognizes many pathogenic patterns directly,but an important target is the Fc domain of antibodies binding to their *** this paper,the curvature-dependence of the interaction between IgG and C1q is studied by surface plasmon resonance and quartz crystal *** is organized in similar surface coverage densities on flat polystyrene surfaces and polystyrene nanoparticles of different sizes,and the amount of C1q binding to the IgG is *** in solution were found to aggregate upon incubation with IgG,and therefore a new technique utilizing nanoparticles binding to antifouling polymer brush functionalized surfaces was used to prepare surfaces with nanoparticles for measurements with surface plasmon *** antigen-bound IgG at the curved surface of nanoparticles showed 5.6 times lower binding of C1q compared to at matched flat *** was no significant difference between the binding at 100 and 200 nm polystyrene *** findings are important for designing drug delivery systems to evade the complement system.

关键词： C1q complement system antibodies curvature nanoparticles

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