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Factors Predicting Transformation of Non-Severe Pre-Eclampsia into Pre-Eclampsia with Severe Features

Open Journal of Obstetrics and Gynecology 2023年第2期13卷 153-165页

作者： mohammed Mahmoud Samy Ahmed Nagy Abdul-Rahman Younis karim mohammed labib Departmenrt of Obstetrics and Gynecology Faculty of Medicine Ain Shams University Cairo Egypt Ain Shams University Cairo Egypt

Background: Pre-eclampsia (PE), a complex, multisystem, pregnancy-associated hypertensive disorder, typically developing after the 20th week of gestation, that complicates 2% - 8% of pregnancies, is a leading cause of neonatal and maternal mortality and morbidity. Aim of the Work: To identify different factors predicting transformation of non-severe pre-eclampsia in to pre-eclampsia with severe features. Patients and Methods: This prospective cohort study was conducted at tertiary care hospital at Ain Shams University hospitals from June 2021 till January 2022 and performed on total of 100 patients who diagnosed as non-severe pre-eclampsia after exclusion of severity features. Results: The current study revealed that transformation to severe pre-eclampsia occurred in 33% of the studied cases. Body mass index (BMI), past and family histories of preeclampsia statistically were significantly higher in cases transformed into preeclampsia with severe features. Admission blood pressure, albumin dipstick, Oligohydramnios and IUGR statistically were significantly higher in cases with transformation from non-severe pre-eclampsia into pre-eclampsia with severe features. Platelet count statistically was significantly lower in cases with transformation from non-severe pre-eclampsia into pre-eclampsia with severe features Conclusion: Our study results identified the most important clinical risk factors for transformation to severe features of pre-eclampsia from non-severe features and provided new information on the level of risk associated with specific combinations of risk factors (BMI ≥ 35.4, admission systolic blood pressure, admission diastolic blood pressure, albumin dipstick 4+ and platelets count) with low significant diagnostic performance in predicting transformation from non-severe pre-eclampsia into pre-eclampsia with severe features.

关键词： Pre-Eclampsia Blood Pressure Body Mass Index Platelet Count

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A New Scheme of the ARA Transform for Solving Fractional-Order Waves-Like Equations Involving Variable Coefficients

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工程与科学中的计算机建模(英文) 2024年第1期138卷 761-791页

作者： Yu-Ming Chu Sobia Sultana Shazia karim Saima Rashid mohammed Shaaf Alharthi Department of Mathematics Huzhou UniversityHuzhou313000China Department of Mathematics Imam Mohammad Ibn Saud Islamic UniversityRiyadh11461Saudi Arabia Department of Basic Sciences and Humanities UET LahoreFaisalabad Campus54800Pakistan Department of Mathematics Government College UniversityFaisalabad38000Pakistan Department of Mathematics and Statistics College of ScienceTaif UniversityP.O.Box 11099Taif21944Saudi Arabia

The goal of this research is to develop a new,simplified analytical method known as the ARA-residue power series method for obtaining exact-approximate solutions employing Caputo type fractional partial differential equations(PDEs)with variable ***-transform is a robust and highly flexible generalization that unifies several existing *** key concept behind this method is to create approximate series outcomes by implementing the ARA-transform and Taylor’s *** process of finding approximations for dynamical fractional-order PDEs is challenging,but the ARA-residual power series technique magnifies this challenge by articulating the solution in a series pattern and then determining the series coefficients by employing the residual component and the limit at infinity *** approach is effective and useful for solving a massive class of fractional-order *** appealing implementations are taken into consideration to demonstrate the effectiveness of the projected technique in creating solitary series findings for the governing equations with variable ***,several visualizations are drawn for different fractional-order *** that,the estimated findings by the proposed technique are in close agreement with the exact ***,statistical analyses further validate the efficacy,dependability and steady interconnectivity of the suggested ARA-residue power series approach.

关键词： ARA-transform Caputo fractional derivative residue-power seriesmethod analytical solutions statistical analysis

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A comparative in vitro study on the effect of SGLT2 inhibitors on chemosensitivity to doxorubicin in MCF-7 breast cancer cells

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Oncology Research 2024年第5期32卷 817-830页

作者： SHAHID karim ALANOUD NAHER ALGHANMI MAHA JAMAL HUDA ALKREATHY ALAM JAMAL HIND A.ALKHATABI mohammed BAZUHAIR AFTAB AHMAD Department of Clinical Pharmacology Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Department of Biochemistry Faculty of ScienceKing Abdulaziz UniversityJeddahSaudi Arabia Department of Biochemistry College of ScienceUniversity of JeddahJeddah21959Saudi Arabia Health Information Technology Department The Applied CollegeKing Abdulaziz UniversityJeddahSaudi Arabia Pharmacovigilance and Medication Safety Unit Center of Research Excellence for Drug Research and Pharmaceutical IndustriesKing Abdulaziz UniversityJeddahSaudi Arabia

Cancer frequently develops resistance to the majority of chemotherapy *** study aimed to examine the synergistic cytotoxic and antitumor effects of SGLT2 inhibitors,specifically Canagliflozin(CAN),Dapagliflozin(DAP),Empagliflozin(EMP),and Doxorubicin(DOX),using in vitro *** precise combination of CAN+DOX has been found to greatly enhance the cytotoxic effects of doxorubicin(DOX)in MCF-7 ***,it was shown that cancer cells exhibit an increased demand for glucose and ATP in order to support their ***,when these medications were combined with DOX,there was a considerable inhibition of glucose consumption,as well as reductions in intracellular ATP and lactate ***,this effect was found to be dependent on the dosages of the *** addition to effectively inhibiting the cell cycle,the combination of CAN+DOX induces substantial modifications in both cell cycle and apoptotic gene *** work represents the initial report on the beneficial impact of SGLT2 inhibitor medications,namely CAN,DAP,and EMP,on the responsiveness to the anticancer properties of *** underlying molecular mechanisms potentially involve the suppression of the function of SGLT2.

关键词： SGLT2 Cancer Cytotoxicity ATP Cell cycle

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Factors Predicting Transformation of Non-Severe Pre-Eclampsia into Pre-Eclampsia with Severe Features

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Open Journal of Obstetrics and Gynecology（妇产科期刊） 2023年第2期

作者： mohammed Mahmoud Samy Ahmed Nagy Abdul-Rahman Younis karim mohammed labib

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DNA Barcoding of Insects and Its Direct Application for Plant Protection

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Open Journal of Applied Sciences 2024年第3期14卷 676-686页

作者： Peter Quandahor Iddrisu Yahaya Francis Kusi Issah Sugri Julius Yirzagla Abdul karim Alhassan Jerry A. Nboyine George Y. Mahama Godwin Opoku mohammed Mujitaba Dawuda Asieku Yahaya Theophilus Kwabla Tengey Rofela Combey John Abraham CSIR-Savanna Agricultural Research Institute Tamale Ghana Faculty of Agriculture Food and Consumer Science University for Development Studies Tamale Ghan Department of Conservational Biology and Entomology School of Biological Sciences University of Cape Coast Ghana

The introduction of invasive insect pests across national borders has become a major concern in crop production. Accordingly, national plant protection organizations are challenge to reinforce their monitoring strategies, which are hampered by the weight and size of inspection equipment, as well as the taxonomic extensiveness of interrupted species. Moreover, some insect pests that impede farmer productivity and profitability are difficult for researchers to address on time due to a lack of appropriate plant protection measures. Farmers’ reliance on synthetic pesticides and biocontrol agents has resulted in major economic and environmental ramifications. DNA barcoding is a novel technology that has the potential to improve Integrated Pest Management decision-making, which is dependent on the ability to correctly identify pest and beneficial organisms. This is due to some natural traits such as phenology or pesticide susceptibility browbeaten by IPM strategies to avert pest establishment. Specifically, Deoxyribonucleic acid (DNA) sequence information was applied effectively for the identification of some micro-organisms. This technology, DNA barcoding, allows for the identification of insect species by using short, standardized gene sequences. DNA barcoding is basically based on repeatable and accessible technique that allows for the mechanisation or automation of species discrimination. This technique bridges the taxonomic bio-security gap and meets the International Plant Protection Convention diagnostic standards for insect identification. This review therefore discusses DNA barcoding as a technique for insect pests’ identification and its potential application for crop protection.

关键词： DNA Barcoding Integrated Pest Management Taxonomy Biosecurity Crop Protection

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Autophagy as a targeted therapeutic approach for skin cancer:Evaluating natural and synthetic molecular interventions

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Cancer Pathogenesis and Therapy 2024年第4期2卷 231-245页

作者： Md.Liakot Ali Amdad Hossain Roky S.M.Asadul karim Azad Abdul Halim Shaikat Jannatul Naima Meem Emtiajul Hoque Abu mohammed Fuad Ahasan mohammed Murshedul Islam Md.Saifur Rahaman Arif Md.Saqline Mostaq Md.Zihad Mahmud Mohammad Nurul Amin MdAshiq Mahmud Department of Pharmacy University of ChittagongChattogram 4331Bangladesh Pratyasha Health Biomedical Research Center Dhaka 1230Bangladesh Department of Pharmacy International Islamic University ChittagongChattogram 4318Bangladesh Department of Pharmacy Daffodil International UniversityDhaka 1216Bangladesh Department of Pharmacy BGC Trust University BangladeshChattogram 4381Bangladesh School of Basic Pharmaceutical and Toxicological Sciences College of PharmacyUniversity of Louisiana at MonroeMonroeLA 71209-0497USA Pioneer Dental College and Hospital Dhaka 1229Bangladesh

Skin cancer,a prevalent malignancy worldwide,poses significant health concerns owing to its increasing ***,a natural cellular process,is a pivotal event in skin cancer and has advantageous and detrimental *** duality has prompted extensive investigations into medical interventions targeting autophagy modulation for their substantial therapeutic *** systematic review aimed to investigate the relationship between skin cancer and autophagy and the contribution and mechanism of autophagy modulators in skin *** outlined the effectiveness and safety of targeting autophagy as a promising therapeutic strategy for the treatment of skin *** comprehensive review identified a diverse array of autophagy modulators with promising potential for the treatment of skin *** of these compounds demonstrates efficacy through distinct physiological mechanisms that have been elucidated in ***,findings from a literature search indicated that none of the natural,synthetic,or semisynthetic compounds exhibited notable adverse effects in either human or animal ***,this review offers novel mechanistic and therapeutic perspectives on the targeted modulation of autophagy in skin cancer.

关键词： Autophagy Skin cancer Autophagy inducers Autophagy inhibitors Nature-derived compounds Synthetic compounds

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Delayed Grafting as a Valid Technique in Burn Management: Experience from a Burn Unit in Oman

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Modern Plastic Surgery 2024年第1期14卷 9-14页

作者： Taif Alsafy Joe Jacob Anish Thadathil Elias Ahmed Salah El Din Salim mohammed Ghawas Majid Tariq Saud Albusaidi Ahmed Al Jabri Al Anood Al Hadhrami Mutazz Obeid Al Khaldi Moath Abdelhamid Shummo karim Mohamed Haridi Aml Eid Saleh Said Al-Busaidi Department of Plastic and Reconstructive Surgery Sultan Qaboos Hospital Salalah Oman ENT Department Al Nahdha Hospital Muscat Oman Department of Plastic Reconstructive and Craniofacial Surgery Khoula Hospital Muscat Oman

Background: Early excision and grafting has been the preferred method of managing major burns around the world since 1970. Considering the advances in health care and the development of new antibiotics over the past 50 years, delayed grafting as a technique for the management of burns over 15%-20% of total body surface area (TBSA) could have comparable results to that of early excision. This study aims to highlight the outcomes of practicing delayed grafting in burn patients. Methods: A case series analysis was performed of 51 patients who were admitted to the burns unit in Sultan Qaboos Hospital Salalah with over 20% TBSA between January 2014 and December 2019. The patients received prophylactic antibiotics and silver sulphadiazine dressing until the burn eschar had completely separated, followed by grafting. Results: Two patients were lost during the entire duration of the study. The mortality rate was comparable to that of early excision, while the rate of hypertrophic scarring was lower than the range reported by other studies. Conclusion: In the management of patients with over 20% TBSA, delayed grafting after complete separation of eschar is still a valid technique.

关键词： Burns Burn Units Burn Management Delayed Grafting Major Burns Treatment Efficacy

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Performance Analysis of Multi-Channel CR Enabled IoT Network with Better Energy Harvesting

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Computers, Materials & Continua 2022年第4期71卷 183-197页

作者： Afiya Kiran Ahmad karim Yasser Obaid Alharbi Diaa mohammed Uliyan Department of Computer Science BZ UniversityMultan6000Pakistan Department of Information Technology BZ UniversityMultanPakistan College of Computer Science and Engineering University of Ha’ilHailSaudi Arabia

Wireless Sensor Networks(WSNs)can be termed as an autoconfigured and infrastructure-less wireless networks to monitor physical or environmental conditions,such as temperature,sound,vibration,pressure and motion *** may comprise thousands of Internet of Things(IoT)devices to sense and collect data from its surrounding,process the data and take an automated and mechanized *** the other side the proliferation of these devices will soon cause radio spectrum ***,to facilitate these networks,we integrate Cognitive Radio(CR)functionality in these *** can sense the unutilized spectrum of licensed users and then use these empty bands when *** order to keep the IoT nodes functional all time,continuous energy is *** this reason the energy harvested techniques are preferred in IoT *** it is preferred to harvest Radio Frequency(RF)energy in the *** this paper a region based multi-channel architecture is *** which the coverage area of primary node is divided as Energy Harvesting Region and Communication *** Secondary User(SU)that are the licensed user is IoT enabled with Cognitive Radio(CR)techniques so we call it CR-enabled IoT node/device and is encouraged to harvest energy by utilizing radio frequency *** harvest energy efficiently and to reduce the energy consumption during sensing,the concept of overlapping region is given that supports to sense multiple channels simultaneously and help the SU to find best channel for transmitting data or to harvest energy from the ideal *** the experimental analysis,it is proved that SU can harvest more energy in overlapping region and this architecture proves to consume less energy during data transmission as compared to single *** also show that channel load can be highly reduced and channel utilization is proved to be more ***,this proves the proposed architecture cost-effective and energy-efficient.

关键词： Wireless sensor network multi-channel sensing energy harvesting cognitive radio IoT network

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Obstetric Anesthesia Practice Significantly Evolved: A Field for Cesarean Delivery Parturient for the Provision of Safe Anesthesia in Urgent Circumstances

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Open Journal of Anesthesiology 2024年第3期14卷 66-92页

作者： Mustafa Zakaria Amal Haoudar Said Makani Mariame Kabbour Oumaima Taoussi karim Elaidaoui Yousra Rajaa Chafik El Kettani Adil Elghanmi Department of Anesthesia and Resuscitation Hospital ZNA Middelheim Antwerpen Belgium European Society of Anaesthesiology and Intensive Care Ghent Belgium Anesthesia and Resuscitation Services Mohammed VI University of Sciences and Health-UM6SS Casablanca Morocco Cardiologist Vascular Surgery Mohammed VI University of Sciences and Health-UM6SS Casablanca Morocco Faculty of Science and Technology Hassan II University of Casablanca Casablanca Morocco Departement of Services Cardiology Mohammed VI University of Sciences and Health-UM6SS Casablanca Morocco Department of Anesthesia and Resuscitation Mohammed VI University of Sciences and Health-UM6SS Casablanca Morocco Obstetrics and Gynecology Services Mohammed VI University of Sciences and Health-UM6SS Casablanca Morocco

General anesthesia and Obstetric Anesthesia is the gold standard for a cesarean section but there are some cases where general anesthesia is unavoidable. The use of general anesthesia for cesarean delivery has decreased in recent years due to the widespread use of neuraxial techniques. The choice of anesthesia techniques for cesarean delivery depends on several factors, including the patient’s psychology and the attending physician’s experience. It is chosen because of its safety profile and its benefits to the mother and fetus. It may be indicated due to emergency, maternal refusal of regional techniques, or regional contraindications. Major complications include failed intubation, gastric content aspiration, and increased bleeding risk. This study aims to evaluate the impact of a newly launched team on obstetric anesthesia practice.

关键词： General Anesthesia Cesarean Delivery Intubation Maternal Refusal Obstetric Anesthetists

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Histopathological,histochemical and biochemical postmortem changes in induced fatal hypothermia in rats

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Forensic Sciences Research 2022年第2期7卷 211-227页

作者： Mahrous Abdelbasset Ibrahim Sally Salem mohammed Hany Goda Tammam Rehab Ibrahim Abdel-karim Medhat mohammed Farag Forensic Medicine&Clinical Toxicology College of MedicineJouf UniversitySakakahSaudi Arabia Forensic Medicine&Clinical Toxicology Department Faculty of MedicineSuez Canal UniversityIsmailiaEgypt Histology and Cell Biology Department Faculty of MedicineSuez Canal UniversityIsmailiaEgypt Forensic Medicine and Clinical Toxicology Department Faculty of MedicineAl-Azhar UniversityCairoEgypt Medical biochemistry Department College of MedicineShaqra UniversityShaqraaSaudi Arabia Medical Biochemistry&Molecular Biology Department Faculty of MedicineBenha UniversityBenhaEgypt

Reaching a postmortem diagnosis of hypothermia is challenging in forensic ***,this study was conducted to detect the histopathological,histochemical and biochemical changes that occur in adult albino rats following exposure to induced fatal ***-four adult albino rats were divided into the negative control,moderate hypothermia,severe hypothermia and hypoxia *** in the control group were euthanized when those in the moderate hypothermic group *** samples were collected via heart puncture,and the cerebrum,heart,suprarenal gland,kidney,liver and skeletal muscle were removed to investigate the biochemical,histochemical and histopathological *** assessment depicted significant changes in lipid peroxidation,represented by increased malondialdehyde levels in the studied organs of the rats in hypothermic and hypoxia *** examination of the rats’organs revealed degeneration and necrosis in the hypothermia and hypoxia *** taken from the severe hypothermic rats revealed a loss of normal cardiac tissue architecture,necrotic changes in the pyramidal cells in the cerebral cortex,and massive necrosis,mainly in the tubules of the renal cortex and *** findings suggest that histological changes might be used as biochemical markers for postmortem diagnosing of fatal hypothermia,particularly in severe hypothermic conditions.

关键词： Forensic sciences forensic medicine legal medicine autopsy forensic pathology histochemical hypothermia

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