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Pivotal role of long non-coding ribonucleic acid-X-inactive specific transcript in regulating immune checkpoint programmed death ligand 1 through a shared pathway between miR-194-5p and miR-155-5p in hepatocellular carcinoma

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World Journal of Hepatology 2020年第12期12卷 1211-1227页

作者： Sara m Atwa Heba Handoussa karim m hosny margarete Odenthal Hend m El Tayebi Pharmaceutical Biology Department German University in CairoCairo 11865Egypt Department of General Surgery Faculty of MedicineCairo UniversityCairo 11562Egypt Institute for Pathology University Hospital CologneCologne 50924Germany molecular Pharmacology Research Group Department of Pharmacology and ToxicologyFaculty of Pharmacy and BiotechnologyGerman University in CairoCairo 11835Egypt

BACKGROUND Anti-programmed death therapy has thrust immunotherapy into the ***,such therapy has a modest response in hepatocellular carcinoma(HCC).Epigenetic immunomodulation is a suggestive combinatorial therapy with immune checkpoint ***-coding ribonucleic acid(ncRNA)driven regulation is a major mechanism of epigenetic *** the wide range of ncRNAs that co-opt in programmed cell-death protein 1(PD-1)/programmed death ligand 1(PD-L1)regulation,and based on the literature,we hypothesized that miR-155-5p,miR-194-5p and long non-coding RNAs(lncRNAs)X-inactive specific transcript(XIST)and mALAT-1 are involved in a regulatory upstream pathway for PD-1/***,nutraceutical therapeutics in cancers have received increasing ***,it is interesting to study the impact of oleuropein on the respective study key *** To explore potential upstream regulatory ncRNAs for the immune checkpoint PD-1/*** Bioinformatics tools including *** and lnCeDB software were adopted to detect targeting of miR-155-5p,miR-194-5p and lncRNAs XIST and mALAT-1 to PD-L1 mRNA,*** addition,Diana tool was used to predict targeting of both aforementioned miRNAs to lncRNAs XIST and *** and normal tissue samples were collected for scanning of PD-L1,XIST and mALAT-1 *** study the interaction among miR-155-5p,miR-194-5p,lncRNAs XIST and mALAT-1,as well as PD-L1 mRNA,a series of transfections of the Huh-7 cell line was carried *** Bioinformatics software predicted that miR-155-5p and miR-194-5p can target PDL1,mALAT-1 and ***-1 and XIST were predicted to target PD-L1 ***-L1 and XIST were significantly upregulated in 23 HCC biopsies compared to healthy controls;however,mALAT-1 was barely ***-194 induced expression elevated the expression of PD-L1,XIST and ***,overexpression of miR-155-5p induced the upregulation of PD-L1 and XIST,while it had a negative impact on mA

关键词： Hepatocellular carcinoma X-inactive specific transcript miR-155-5p miR-194-5p Programmed cell-death protein 1/Programmed death ligand 1 Immune checkpoint

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Geochemistry of island arc assemblage in the Eastern Desert of Egypt and the role of Pan-African magmatism in crustal growth of the Arabian–Nubian Shield:A review

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Acta Geochimica 2024年第3期43卷 588-622页

作者： Abdel-Aal mAbdel-karim mohamed mHamdy Adel A.Surour Geology Department Faculty of ScienceZagazig UniversityZagazig 44519Egypt Geology Department Faculty of ScienceTanta UniversityTanta 31527Egypt Department of Geological Sciences Faculty of ScienceNew Galala City 43511Egypt Geology Department Faculty of ScienceCairo UniversityGiza 12613Egypt

Neoproterozoic island arc assemblage of the Arabian–Nubian Shield(ANS)in the Eastern Desert(ED)of Egypt comprises juvenile suites of metavolcanics(mV),large amounts of meta-sedimentary rocks(mS),and voluminous metagabbros-diorites(mGD)and syn-tectonic intrusions of older granitoids(OG).We report here the updates of these four rock units in terms of classification,distribution,chemical characteristics,geodynamic evolution,metamorphism,and *** addition,we discuss these integrated data to elucidate a reasonable and reliable model for crustal evolution in the *** main features of these rock units indicate their relation to each other and the geodynamic environment dominated by early immature oceanic island arcs to primitive continental *** information of the island arc metavolcanic and plutonic rocks(gabbros,diorites,tonalites,and granodiorites)furnish evidence of the genetic *** include proximity and a coeval nature in the field;all protolith magmas are subalkaline in nature following calc-alkaline series with minor tholeiitic affinities;common geochemical signature of the arc rocks and subduction-related magmatism;their similar enrichment in LREEs;and similar major element compositions with mafic melts derived from metasomatized mantle *** volcano-sedimentary and the OG rocks underwent multiphase deformation events whereas the mGD complexes deformed *** on the magmatic,sedimentological,and metamorphic evolutions constrained by geochronological data as well as the progressive evolutionary trend from extensional to compressional regimes,a possible gradual decrease in the subducted slab dip angle is the most infl uential in any geodynamic model for arc assemblage in the ED of Egypt.

关键词： Island arc assemblage magmatism Crustal growth Neoproterozoic Arabian–Nubian Shield Eastern Desert Egypt

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Langmuir-Schaefer Film Investigation and Density Functional Theory Band Gap Calculations of Calix[n]arene-Para-Aminobenzoic Acid for Drug Nanosensor Application

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Journal of Wuhan University of Technology(materials Science) 2024年第5期39卷 1311-1318页

作者： WONG Yeong Yi F L Supian A Radzwan m musa N F N Abd karim Department of Physics Sultan Idris Education UniversityTanjong Malim 35900Malaysia Department of Chemistry Sultan Idris Education UniversityTanjong Malim 35900Malaysia

Calix[n]arenes was utilized to detect PABA,the primary sunscreen *** study investigates the interaction of calix[4]arene(C4),calix[6]arene(C6),and PABA using the Langmuir method and first-principle density functional theory(DFT).Using the Langmuir-Schaefer(LS)technique,an ultrathin film composed of calix[n]arenes and their complexes with PABA was deposited on various *** on the Langmuir study,the PABA molecule was bonded to the lower rims of both C4 and C6 with the host-guest ratio of 1:*** of the LS films formed were then characterized by ultravioletvisible spectroscopy(UV-Vis),Fourier-transform infrared spectroscopy(FTIR)and carbon,hydrogen,nitrogen,sulfur elemental analyzer(CHNS).The band gap reduction obtained in the DFT study denotes the charge transfer interaction with promising reactivity between the calix[n]arenes and *** sensing of PABA by C4 and C6 is successful based on the formation of bonding between them due to the hosts’effective trapping *** outcomes of this study could be applied to drug delivery systems for future pharmaceutical and medical applications.

关键词： calix[n]arenes band gap density functional theory Langmuir-Schaefer PABA sensor

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Sustainable land management in mali

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Geography and Sustainability 2024年第3期5卷 382-391页

作者： karim Nchare marcel Vitouley Richard mbih Vanderbilt University USA African School of Economics Benin Pennsylvania State University USA

This study uses logistic and Poisson regression models to examine the factors influencing the adoption of sustain-able land management(SLm)practices in mali using two rounds of the nationally representative survey Enquête Agricole de Conjoncture Intégrée aux Conditions de Vie des mé*** SLms considered include the applica-tion of organic fertilizers,the application of inorganic fertilizers,the use of improved seeds,and the practice of *** average the application of organic fertilizers(39.2%),and inorganic fertilizers(28.7%)are the most frequent SLm practices among malian farmers,and between 2014 and 2017,we observe a decline in the practice of *** regression results show that farmers’adoption of different SLms is significantly associated with biophysical factors(average temperature,climate type,plot size,plot shape,and location),de-mographic factors(age,gender,education,household size),and socioeconomic factors(number of cultivated plots,livelihood diversification,type of crop grown,market access,credit access,economic shocks,and social capital).Our findings suggest that policymakers and agricultural development agencies in mali need to adopt a multidimensional policy framework to unlock the untapped potential of SLm practices in promoting sustainable agriculture and food security.

关键词： Sustainable land management Africa Logistic regression models Poisson regression model

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Correlation between platinum–aluminide coating features and tensile behavior of nickel-based superalloy Rene?80

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Rare metals 2024年第10期43卷 5391-5402页

作者： mohammad mehdi Barjesteh Seyed mehdi Abbasi karim Zangeneh madar Kourosh Shirvani metallic materials Research Center Malek Ashtar University of Technology (MUT) Department of Advanced materials and New Energies Iranian Research Organization for Science and Technology (IROST)

The effect of platinum （a rare metal）–aluminide coating parameters on the tensile properties of nickel-based superalloy Rene?80 was evaluated at 871。*** this purpose,initial layers of platinum with different thicknesses （2,4,6 and 8μm） were coated on tensile samples Then,low-temperature high-activity （LTHA） and hightemperature low-activity （HTLA） processes were used for *** of microstructural evaluations using scanning electron microscope （SEm） and phase analysis by X-ray diffraction （XRD） showed a three-layer structure coating for different platinum layer thicknesses and both aluminizing *** the thickness of the platinum layer from 2 to 8μm led to the improvement in the final coating thickness from 91.6 to 102.1μm in *** increase was from 128.1 to 148.6 μm in *** results of hot tensile tests at 871℃ showed a decrease in strength properties of the coated samples compared to the uncoated ***,HTLA and high thicknesses of the initial platinum layer showed an intense *** results of fractographic evaluations abou uncoated samples showed a ductile *** the other hand,coated samples showed a simultaneous ductile and brittle fracture failure *** the main fracture morphology was brittle cleavage fracture which was for the HTLA.

关键词： Aluminizing Fractography Platinum–aluminide Rene®80 Tensile properties

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Hydrometallurgy two stage process for preparation of (Nd,La,Ce)_(2)O_(3) from end-of-life NimH batteries

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Journal of Rare Earths 2024年第2期42卷 415-423,I0007页

作者： karim Tanji Khalid Ouzaouit mohamed Belghiti Isam Lamsayety Hakim Faqir Intissar Benzakour Centre de recherche REmINEX-Groupe mANAGEm MarrakechMorocco

The present work aims to investigate the recovery of light rare earth elements(LREEs) oxides from end-oflife NimH batteries using a hydro metallurgical process followed by effective *** operational leaching parameters such as phosphoric acid concentration,temperature,and the solid-liquid ratio were first optimized by Box-Behnken *** results reveal that under optimum conditions([H_(3)PO_(4)]=2 mol/L,T=80℃,and S/L=1:10 g/mL) the leaching efficiencies of Ni,Co reach 98.1% and99.3%.While La,Ce,and Nd elements remain in the leaching residue as(La,Ce,Nd)PO_(4) with yields of 98.2%,98.6%,and 99.6% for La,Ce,and Nd,***,the(La,Ce,Nd)PO_(4) is leached with HCl acid,then the rare earth oxalate was precipitated using oxalic acid at a pH of 1.8 and then the product was calcined at 800℃ for 2 h in order to synthesize the(Nd,La,Ce)_(2)O_(3).The analysis using scanning electron microscopy(SEm) coupled with energy dispersive X-ray spectroscopy(EDX) confirms the homogeneity of(Nd,La,Ce)_(2)O_(3) particles that have two morphologies,i.e.,flower and sticks with a particle size between 3and 6 μ*** unit cell parameters of(Nd,La,Ce)_(2)O_(3) were calculated after Rietveld refinement of the XRD patterns,in the space group of Fm-3m are a=b=c=0.57921 nm and the volume equal to 0.194322 nm^(3).

关键词： NimH batteries Hydrometallurgical process Leaching Phosphoric acid Box-Behnken Light rare earth oxides

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Facile formation of hierarchical magnesium silicate hydrate microspheres as an adsorbent for the textile dyes

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Particuology 2024年第10期93卷 99-110页

作者： Tin Kyawoo Naveed karim Chao Jiang Saeed Ahmed Weiliang Tian Huiyu Li Yongjun Feng State Key Laboratory of Chemical Resource Engineering Beijing Engineering Center for Hierarchical CatalystsBeijing University of Chemical TechnologyBeijing100029China Department of Chemistry The University of ChakwalChakwal48800Pakistan College of Chemistry and Chemical Engineering Tarim UniversityAlar843300China

Hierarchical porous magnesium silicate hydrate (mSH) microspheres composed of sheets are successfully developed under facile conditions using a hard template. The role of hexadecyltrimethylammonium bromide (CTAB) on the formation and adsorption behavior was also observed for the methyl orange and methylene blue. The formed mSH possesses a surface area of 453.24 m^(2)/g, an average pore size of 6.38 nm, and a pore volume of 0.75 cm^(3)/g without CTAB. Based on the role of CTAB and the change in the ratio of mg/Si, the mSH retained its sphere-like structure with a variation in pore parameters. The formed mSH was used as an adsorbent to remove methylene blue and methyl orange. The pseudo-second-order kinetic and Langmuir Isotherm models are well-fitted, with a 256.4 mg/g removal capacity and 84.2 mg/g for methylene blue and methyl orange, respectively. The modified mSH with CTAB played a positive role for the methyl orange and a negative role for the methylene blue regarding removal performance.

关键词： Adsorption Hierarchical microspheres magnesium silicate methyl orange methylene blue Surfacemodification

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Risk Factors Categorizations of Ischemic Heart Disease in South-Western Bangladesh

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Data Intelligence 2024年第3期6卷 834-868页

作者： m.Raihan Sami Azam Laboni Akter md.mehedi Hassan Ryana Quadir Asif karim Saikat mondal Arun more Department of Computer Science and Engineering North Western UniversityKhulna 9100Bangladesh Faculty of Science and Technology Charles Darwin UniversityNT 0909Australia Departmentof Biomedical Engineering Khulna University of Engineering&TechnologyKhulnaBangladeh Computer Science and Engineering Discipline Khulna UniversityKhulna 9208Bangladesh Department of Computer Science and Engineering Daffodil International University(DIU)Bangladesh Department of Cardiology Ter Institute of Rural Health and ResearchMurud-413510India

Ischemic heart disease(IHD)is one of the leading causes of death ***,different geographic regions show different variations of the risk factors of this disease based on the different lifestyles of *** study examines the current IHD condition in southern Bangladesh,a Southeast Asian middle-income *** main approach to this research is an Al-based proposal of a reduced set of the greatest impact clinical traits that may cause *** approach attempts to reduce IHD morbidity and mortality by early detection of risk factors using the reduced set of clinical ***,diagnostic,and symptomatic features were considered for analysing this clinical *** pre-processing utilizes several machine learning techniques to select significant features and make meaningful interpretations.A proposed voting mechanism ranked the selected 138 features by their impact *** this regard,diverse patterns in correlations with variables,including age,sex,career,family history,obesity,etc.,were calculated and explained in terms of voting *** the 138 risk factors,three labels were categorized:high-risk,medium-risk,and low-risk features;19 features were regarded as high,25 were medium,and 94 were considered low impactful *** research's technological methodology and practical goals provide an innovative and resilient framework for addressing IHD,especially in less developed cities and townships of Bangladesh,where the general population's socioeconomic conditions are often *** data collection,pre-processing,and use of this study's complete and comprehensive IHD patient dataset is another innovative *** believe that other relevant research initiatives will benefit from this work.

关键词： Ischemic heart disease machine learning CVD Data categorization medical data

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Cumulative Air Quality Impacts from Twenty-Two major Power Plants

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Journal of Environmental Science and Engineering(A) 2024年第1期13卷 1-14页

作者： md m.karim Navin Bindra Arub masud Environment Health and Safety DepartmentGEEC Ltd.108 Earlsbridge Blvd.BramptonOntarioL7A 3W7Canada Department of Health Science University of WaterlooWaterlooOntarioN2L 3G1Canada

Cumulative assessment is a tool for the project developer to try and take into consideration not only their contribution to cumulative impacts but also other projects and external factors that may place their developments at *** study assessed the cumulative impacts of air emissions from 22 major power plants in southeast Bangladesh planned to generate 21,550 mW of *** also includes anticipated growth in small to medium size industries,brickfields,highway traffic,inland water transport,transhippers,jetty,and vessel transports used for transporting fuel resources for these power plants.A 50 km by 50 km airshed is considered for air quality *** analysis indicates that predicted mGLCs(maximum Ground Level Concentrations)of NO2 and CO are complying with both Bangladesh NAAQS(National Ambient Air Quality Standards)and WBG(World Bank Group)*** daily average mGLC of Pm_(2.5)(62.45µg/m^(3))from all sources complies with NAAQS,however,exceeds the WBG *** Pm_(2.5) concentration(15.45µg/m^(3))exceeds NAAQS and WBG *** Pm10 concentration complies with the NAAQS for both 24-hour and annual averaging *** average concentration(23.12µg/m^(3))exceeds WBG *** average SO2 concentration(102.49µg/m^(3))complies with the NAAQS however,it exceeds the WBG guideline *** concentrations of Pm_(2.5) and SO2 are due to the contribution of transboundary emissions and secondary pollutants in the *** dispersion modeling outcome can be used by the policymakers for the pollution reduction strategy.

关键词： CIA(Cumulative Impact Assessment) dispersion modeling power generation Bangladesh.

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Recurrent acute pancreatitis as an initial presentation of primary hyperparathyroidism:A case report

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World Journal of Clinical Cases 2024年第29期12卷 6302-6306页

作者： masood m karim Hira Raza Om Parkash Department of medicine The Aga Khan University HospitalKarachi 74800SindhPakistan Department of Surgery Aga Khan University HospitalKarachi 74800SindhPakistan

BACKGROUND With 4.9 to 35 instances per 100000 cases,hyperparathyroidism is one of the rarest causes of acute *** major cause of primary hyperparathyroidism is a parathyroid adenoma,which can manifest clinically in various *** SUmmARY We discuss the unusual case of a 13-year-old boy with recurrent pancreatitis as the initial presentation of primary *** cause of his recurrent pancreatitis remained unknown,and the patient had multiple admissions with acute pancreatitis over 3 *** diagnosis was delayed due to the initial normal levels of parathyroid hormone,which were later reported elevated in a subsequent episode where ultrasound neck and thyroid scintigraphy revealed a parathyroid adenoma as the underlying *** the diagnosis was made,he underwent surgical resection of the *** This case study stresses the importance of considering uncommon causes for recurrent pancreatitis.

关键词： Recurrent pancreatitis Primary hyperparathyroidism Normal serum parathyroid hormone Parathyroid adenoma Case report

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