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Evaluation of antitumour activity of Calotropis gigantea *** bark against Ehrlich ascites carcinoma in Swiss albino mice

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Asian Pacific Journal of Tropical Medicine 2011年第10期4卷 786-790页

作者： M Rowshahul Habib M Rezaul karim Department of Biochemistry and Molecular Biology Faculty of ScienceRajshahi UniversityRajshahi-6205Bangladesh

Objective:To investigate experimentally the possible antitumor effect of methanol extract(ME) of Calotropis gigantea L.(***) root bark and its petroleum ether(PEF) and chloroform(CF) soluble fractions against Ehrlich ascites carcinoma(EAC) in Swiss albino ***:The effects of ME(10 and 20 mg/kg),PEF(40 and 80 mg/kg) and CF(20 and 40 mg/kg) on the growth of EAC and life span of EAC bearing mice were *** profile and biochemical parameters(SAI.P,SGPT and SCOT) were also ***:Results of in vivo study showed a significant decrease in viable tumor cell count and a significant increase of life span in the ME and CF treated group compared to untreated *** life span of ME and CF treated animals was significandy(P<0.05) increased by 43.90%(20 mg ME/kg) and 57.07%(40 mg CF/kg).ME and CF brought back the hematological parameter more or less normal *** and CF also restored the altered levels of serum alkaline phosphatase(SALP) and serum glutamate oxaloacetate transaminase(SGOT).Conclusions:Methanol extract(ME) of *** root bark and its chloroform soluble fraction(CF) possesses significant antitumor activity.

关键词： Calotropis gigantea Antitumor Ehrlich ascites carcinoma Root bark

Isolating the female agency‑driven development factor in external sovereign emerging market debt

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Financial Innovation 2023年第1期9卷 3064-3080页

作者： karim Henide Zaryab Ahmar London School of Economics Houghton StLondon WC2A 2AEUK iBoxx Fixed Income Indices IHS MarkitTower 185 FriedrichEbert‑Anlage 353760327 Frankfurt am MainGermany

The underlying literature hypothesises and provides randomised evidence for the positive impact of promoting the broad-based inclusion,empowerment,and representation of women on regional *** study seeks to isolate a female agencydriven development factor in external sovereign emerging market debt and finds evidence for superior risk-adjusted returns from tilting towards female agency *** propose the female agency factor as an additional scope in the modern investor’s toolbox of holistic credit assessment,allowing investors to isolate the issuers which are the most effective sovereign transmission mechanisms of sustainable development *** contribution to the corpus supports the notion of integrating sustainability factors into portfolio construction and reinforces the argument for supporting femaleled development from a financial markets’perspective.

关键词： Sovereign Fixed income Emerging markets Sustainability Female agency

Watershed classification by remote sensing indices： A fuzzy c-means clustering approach

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Journal of Mountain Science 2017年第10期14卷 2053-2063页

作者： Bahram CHOUBIN karim SOLAIMANI Mahmoud HABIBNEJAD ROSHAN Arash MALEKIAN Department of Watershed Management Sari University of Agricultural Sciences and Natural Resources P.O. Box 737 Sari Iran Department of Reclamation of Arid and Mountainous Regions University of Tehran Karaj 31585-3314 Iran

Determining the relatively similar hydrological properties of the watersheds is very crucial in order to readily classify them for management practices such as flood and soil erosion control. This study aimed to identify homogeneous hydrological watersheds using remote sensing data in western Iran. To achieve this goal, remote sensing indices including SAVI, LAI, NDMI, NDVI and snow cover, were extracted from MODIS data over the period 2000 to 2015. Then, a fuzzy method was used to clustering the watersheds based on the extracted indices. A fuzzy c-mean(FCM) algorithm enabled to classify 38 watersheds in three homogeneous *** optimal number of clusters was determined through evaluation of partition coefficient, partition entropy function and trial and error. The results indicated three homogeneous regions identified by the fuzzy c-mean clustering and remote sensing product which are consistent with the variations of topography and climate of the study area. Inherently,the grouped watersheds have similar hydrological properties and are likely to need similar management considerations and measures.

关键词： Karkheh watershed Fuzzy c-means clustering Watershed classification Homogeneous sub-watersheds

Biodegradation of natural and synthetic estrogens in moving bed bioreactor

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Chinese Journal of Chemical Engineering 2018年第2期26卷 393-399页

作者： Mohammad Mehdi Amin Bijan Bina karim Ebrahim Zeynab Yavari Farzaneh Mohammadi Environment Research Center Research Institute for Primordial Prevention of Non-communicable Disease Isfahan University of Medical Sciences Department of Environmental Health Engineering School of Health Isfahan University of Medical Sciences Student Research Committee Isfahan University of Medical Sciences

Estrogen hormones as a group of endocrine disruptive compounds （EDC） can interfere with endocrine system in humans and animals. The goal of this study was to investigate the elimination rate of Estrone （El）, 17β-estradiol （E2） and 17α-ethinyl estradiol （EE2） in Moving Bed Bioreactor （MBBR）. These analytes extracted by Dispersive Liquid-Liquid Microextraction （DLLME） technique, followed by derivatization, and detected by GC/MS. Estrogen removal efficiency in MBBR improved at high solid retention times （SRTs）, which notion is owing to development ofnitrification. Estrogenspecificremovalratewasbetween 0,22-1.45μg.（gVSS） 1.d -1 for natural and synthetic hormones. The adsorption rate was 0.9%-3.2% 0-1.3%, and 0.7%-5.7% for E1, E2, and EE2, respectively. In addition, the biodegradation rates were more than 95% for these compounds. These results illustrated that in MBBR, the hiodegradation and the adsorption to biomass are considered as two significant routes for elimination of estrogenic compounds. As a whole, the deterioration rate of estrogens enhanced by MBBR compared to other biological wastewater treatment processes such as conventional activated sludge.

关键词： Estrogen hormones Adsorption Biodegradation Nitrification

Prediction of Uncertainty Estimation and Confidence Calibration Using Fully Convolutional Neural Network

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Computers, Materials & Continua 2023年第5期75卷 2557-2573页

作者： karim Gasmi Lassaad Ben Ammar Hmoud Elshammari Fadwa Yahya Department of Computer Science College of Arts and Sciences at TabarjalJouf UniversityJoufSaudi Arabia College of Sciences and Humanities Prince Sattam Bin Abdulaziz UniversityAl-KharjSaudi Arabia University of Sfax SfaxTunisia Department of Information Systems College of Computer and Information SciencesJouf UniversityJoufSaudi Arabia

Convolution neural networks(CNNs)have proven to be effective clinical *** study highlighted some of the key issues within these *** is difficult to train these systems in a limited clinical image databases,and many publications present strategies including such learning ***,these patterns are known formaking a highly reliable *** addition,normalization of volume and losses of dice have been used effectively to accelerate and stabilize the ***,these systems are improperly regulated,resulting in more confident ratings for correct and incorrect classification,which are inaccurate and difficult to *** study examines the risk assessment of Fully Convolutional Neural Networks(FCNNs)for clinical image *** contributions have been made to this planned work:1)dice loss and cross-entropy loss are compared on the basis of segment quality and uncertain assessment of FCNNs;2)proposal for a group model for assurance measurement of full convolutional neural networks trained with dice loss and group normalization;And 3)the ability of the measured FCNs to evaluate the segment quality of the structures and to identify test examples outside the *** evaluate the study’s contributions,it conducted a series of tests in three clinical image division applications such as heart,brain and *** findings of the study provide significant insights into the predictive ambiguity assessment and a practical strategies for outside-distribution identification and reliable measurement in the clinical image *** approaches presented in this research significantly enhance the reliability and accuracy rating of CNNbased clinical imaging methods.

关键词： Medical image segmentation confidence calibration uncertainty estimation fully convolutional neural network

Polysaccharide isolated from wax apple suppresses ethyl carbamate-induced oxidative damage in human hepatocytes

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第7期24卷 574-586页

作者： Tao BAO Naymul karim Huihui KE Jitbanjong TANGPONG Wei CHEN Department of Traditional Chinese Medicine Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016China Department of Food Science and Nutrition Zhejiang UniversityHangzhou 310058China Biomedical Sciences School of Allied Health SciencesWalailak UniversityNakhon Si Thammarat 80161Thailand Ningbo Innovation Center Zhejiang UniversityNingbo 315100China

Wax apple(Syzygium samarangense)has received growing research interest for its high nutritional and medicinal value due to its constituents such as polysaccharide,organic acids,flavonoids,minerals,and other *** this study,wax apple polysaccharide(WAP)was isolated from this plant and its protective effect against ethyl carbamate(EC)-induced oxidative damage was evaluated in human hepatocytes(L02 cells).Firstly,a series of analyses such as high-performance liquid chromatography(HPLC),high-performance gel permeation chromatography(HPGPC),Fourier transform infrared spectroscopy(FT-IR),gas chromatography/mass spectrometry(GC/MS),and 1H and 13C nuclear magnetic resonance(NMR)were conducted to identify the structure of,in vitro cell experiments were performed to verify the protective effects of WAP against EC-induced cytotoxicity,genotoxicity,and oxidative damage in L02 *** results revealed that WAP is composed of mannose,rhamnose,glucuronic acid,galacturonic acid,glucose,galactose,arabinose,and fucose in a molar ratio of 2.20:3.94:4.45:8.56:8.86:30.82:39.78:*** a combination of methylation and NMR spectroscopic analysis,the primary structure of WAP was identified as Araf-(1→,Glcp-(1→,→2)-Araf-(1→,→3)-Galp-(1→,→3)-Araf-(1→,and→6)-Galp-(1→.Cell experiments indicated that WAP exhibited significant protective effects on EC-treated L02 cells via suppressing cytotoxicity and genotoxicity,reducing reactive oxygen species(ROS)and O2?-formation,as well as improving mitochondrial membrane potential(MMP)and glutathione(GSH).In a nutshell,WAP has the potential as an important therapeutic agent or supplement for hepatic oxidative ***,further studies are needed to prove the above effects in vivo at the biological and clinical levels.

关键词： Wax apple polysaccharide Polysaccharide characterization Ethyl carbamate Hepatic oxidative stress

Two-dimensional selenium and its composites for device applications

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Nano Research 2022年第1期15卷 104-122页

作者： Zhe Shi Hongqiao Zhang karim Khan Rui Cao Kaikai Xu Han Zhang School of Physics&New Energy Xuzhou University of TechnologyXuzhou 221018China Shenzhen Engineering Laboratory of phosphorene and Optoelectronics Collaborative Innovation Center for Optoelectronic Science and Technology and Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong ProvinceShenzhen UniversityShenzhen 518060China State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of ChinaChengdu 610054China

Two-dimensional(2D)selenium was synthesized successfully in *** advanced properties,including size-dependent bandgap,excellent environmental robustness,strong photoluminescence effect,anisotropic thermal conductivity,and high photoconductivity,render it and selenium-based composites a promising candidate for various device *** include batteries,modulators,photodetectors,and photothermal effects in medical ***,compared to other commonly used 2D materials,such as graphene,transition metal dichalcogenides,and black phosphorus,2D Se is much less *** by the need to overcome this lack of knowledge,this article focuses on recent progress and elucidates the crystal structure,synthesis methods,physical properties,applications,challenges,and prospects of 2D Se nanoflakes.

关键词： two-dimensional materials selenium batteries photodetectors photothermal effect

Vapor intrusion in buildings: Development of semi-empirical models including lateral separation between the building and the pollution source

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Building Simulation 2022年第12期15卷 2031-2049页

作者： Juan Sebastian Rios Mora Thierno Diallo Bernard Collignan Marc Abadie karim Limam Centre Scientifique et Technique du Batiment Health and Comfort DepartmentSaint-Martin-d'HèresCO 38400France University of La Rochelle Laboratoire des Sciences de I'Ingénieur pour I'Environnement-LaSIE UMR CNRS 7356La RochelleCO 17042France

Future constructions in the context of the industrial wastelands reuse may be exposed to Vapor Intrusion(VI).VI can be evaluated by combining in-situ measures and analytical models to evaluate exposure risk in future indoor ***,the assumptions in the existing models may reduce their accuracy when they do not meet the characteristics of real *** estimations of indoor concentration levels may lead to inappropriate solutions against *** this context,new semi-empirical models(SEM)are proposed in order to better specify pollution scenarios and thus increase the accuracy of VI *** development is based on a parametric study(numerical CFD)and a dimensionless analysis combined to existing VI models that consider a continuous source distribution in the *** expressions allow to better take into account the source position in the soil(*** and lateral source/building separation),soil properties(air permeability,diffusion coefficient of the pollutant,…)and building features(building foundation,indoor pressure,air exchange rate,…)in the estimation of indoor concentration *** obtained results with the proposed SEM were compared with a numerical CFD model and available experimental data,showing good accuracy in the estimation of *** the advantages of these new models,they can provide better precision in the health risk assessments associated with ***,these expressions can be easily integrated into building ventilation codes allowing to consider air exchange rate and indoor pressure variations over time.

关键词： indoor air quality lateral source/building distance polluted soils semi-empirical models vapor intrusion

Hydrometallurgy two stage process for preparation of (Nd,La,Ce)_(2)O_(3) from end-of-life NiMH batteries

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Journal of Rare Earths 2024年第2期42卷 415-423,I0007页

作者： karim Tanji Khalid Ouzaouit Mohamed Belghiti Isam Lamsayety Hakim Faqir Intissar Benzakour Centre de recherche REMINEX-Groupe MANAGEM MarrakechMorocco

The present work aims to investigate the recovery of light rare earth elements(LREEs) oxides from end-oflife NiMH batteries using a hydro metallurgical process followed by effective *** operational leaching parameters such as phosphoric acid concentration,temperature,and the solid-liquid ratio were first optimized by Box-Behnken *** results reveal that under optimum conditions([H_(3)PO_(4)]=2 mol/L,T=80℃,and S/L=1:10 g/mL) the leaching efficiencies of Ni,Co reach 98.1% and99.3%.While La,Ce,and Nd elements remain in the leaching residue as(La,Ce,Nd)PO_(4) with yields of 98.2%,98.6%,and 99.6% for La,Ce,and Nd,***,the(La,Ce,Nd)PO_(4) is leached with HCl acid,then the rare earth oxalate was precipitated using oxalic acid at a pH of 1.8 and then the product was calcined at 800℃ for 2 h in order to synthesize the(Nd,La,Ce)_(2)O_(3).The analysis using scanning electron microscopy(SEM) coupled with energy dispersive X-ray spectroscopy(EDX) confirms the homogeneity of(Nd,La,Ce)_(2)O_(3) particles that have two morphologies,i.e.,flower and sticks with a particle size between 3and 6 μ*** unit cell parameters of(Nd,La,Ce)_(2)O_(3) were calculated after Rietveld refinement of the XRD patterns,in the space group of Fm-3m are a=b=c=0.57921 nm and the volume equal to 0.194322 nm^(3).

关键词： NiMH batteries Hydrometallurgical process Leaching Phosphoric acid Box-Behnken Light rare earth oxides