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Open Journal of Pediatrics 2020年第1期10卷 131-136页

作者： Djénèba Konaté Coulibaly Yacaria Doumbia Abdoul karim Doumbia Aliou Amadou Issa Oumar M. Coulibaly Traoré Fousseyni K. Traoré Kamaté Bénoi Djiré Mamadou Kassoum Coulibaly Youssouf Traoré Abdramane Togo Pierre Koné Oumou Togo Boubacar Service of Pediatrics Teaching Hospital Gabriel Touré Bamako Mali Service of Pediatric Surgery Teaching Hospital Gabriel Touré Bamako Mali National Public Health Research Institute Bamako Mali

Introduction:?The factors of nephroblastomas’ relapse are a set of elements playing a role in the reappearance of cancer cells in the same place of the kidney or in other regions of the body after a 5-year remission.?Objectives:?To determine the frequency and the factors of nephroblastomas’ relapse in the pediatric oncology unit and pediatric surgery of the academic hospital Gabriel Touré. Materials and methods:?This was a retrospective study carried out from January 1, 2005 to December 31, 2019 in all children treated for nephroblastoma relapses in the pediatric oncology unit and in the pediatric surgery service.?Results:?In 15 years, we have managed 182 cases of nephroblastoma, of which 128 cases were declared in complete remission after 5 years and 12 cases presented a recurrence. The relapses factors were: capsular break, intraoperative tumor rupture, presence of an associated malformation, surgery without neoadjuvant chemotherapy and tumor surgical stage (p??0.05). Patients’ age at diagnosis, sex, number of neoadjuvant and adjuvant chemotherapy sessions and histological type were not decisive (p?> 0.05).?Conclusion:?Relapses are more and more frequent in cases of nephroblastoma. The correct use of the protocol would avoid these recurrences.

关键词： Nephroblastoma Relapse Factors Children Mali

Giant Cervical Kystic Lymphangioma in Children: Surgical Management of a Case

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International Journal of Otolaryngology and Head & Neck Surgery 2019年第1期8卷 1-6页

作者： Youssouf Sidibé Abdoulaye Kanté Amady Coulibaly Rokia Koné Mamadou Koné Fatoumata Léonie Franç ois Diakité Drissa Ouattara Abdoul Wahab Haidara Boubacar Sanogo Sidiki Dao N’faly Konate Kadiatou Singaré Doumbia Samba karim Timbo Mohamed Keita Alhousseini Ag Mohamed ENT and Head and Neck Surgery Department CHU Mother-Child “Luxembourg” Bamako Mali ENT and Head and Neck Surgery Department CHU Gabriel Touré Bamako Mali Faculty of Medicine and Odontostomatology Bamako Mali Service of Surgery “B” CHU Point G Bamako Mali Department of Stomatology and Maxillofacial Surgery CHU-CNOS Bamako Mali Dermatology Department of the National Center for Disease Control Support (CNAM) Bamako Mali Service of Paediatrics CHU Gabriel Touré Bamako Mali

Introduction: Cervical cystic lymphangiomas are rare benign dysembryoplastic tumors of lymphatic origin. Its severity in the child is due on one hand to their fast evolution and the compression of the way aerodigestive and on the other hand, by the classical difficulty of their excision. The purpose of this work was to report a case of giant cervical cystic lymphangioma in a child to discuss the difficulties associated with its management in our context. Observation: This was a 3-year-old female child who was admitted to the ENT department of CHU “Luxembourg” for right lateral cervical swelling. The clinical examination had noted a large anterior-latero cervical swelling of soft, renitent, painless palpation, movable in relation to the superficial and deep plane, measuring about 20 cm × 17 cm, the skin was healthy. It wasn’t particularity to the rest of the physical examination. The diagnosis of giant cervical cystic lymphangioma was discussed. Thorough excision of the swelling by right lateral cervicotomy was performed. Anatomopathological examination of the operative specimen confirmed the diagnosis. The postoperative course was simple and the evolution was favorable. Conclusion: Cervical cystic lymphangiomas are rare. Their management involves surgery, with short and long-term post-operative outcomes are often excellent.

关键词： Kystic Lymphangioma Cervical Child Bamako

Association between Polymorphisms of Glutathione S-Transferase and Progression to Cervical Cancer in Women from Burkina Faso and Mali

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Journal of Biosciences and Medicines 2020年第4期8卷 12-25页

作者： Teega-Wendé Clarisse Ouedraogo Florencia Wendkuuni Djigma Théodora Mahoukèdè Zohoncon Boureima Idani Abdoul karim Ouattara Pegdwendé Abel Sorgho Dorcas Obiri-Yeboah Prosper Bado Mah Alima Esther Traore Birama Diarra Albert Théophane Yonli Charlemagne Ouedraogo Jacques Simpore Laboratory of Molecular Biology and Genetics (LABIOGENE) University Joseph Ki-Zerbo Ouagadougou Burkina Faso Pietro Annigoni Biomolecular Research Centre (CERBA) Ouagadougou Burkina Faso University Saint Thomas d’Aquin Faculty of Medicine Ouagadougou Burkina Faso Department of Microbiology and Immunology School of Medical Sciences University of Cape Coast PMB Cape Coast Ghana University Joseph Ki-Zerbo UFR/SDS Ouagadougou Burkina Faso

Although persistence of high-risk human papillomavirus infection is the main risk factor, Glutathione S-Transferase highly polymorphic enzyme involved in the metabolism of xenobiotics, is a good candidate gene. The objective of this study was to compare the polymorphisms of Glutathione S-Transferase M1-null in women with cancerous lesions and without lesions. This study consisted of 322 uterine cervix samples of women from Mali and Burkina Faso with Cervical Intra-epithelial Neoplasia 2 and 3, adenocarcinoma and squamous cell carcinoma and 100 women with no lesions. Human Papillomavirus genotyping was performed by Real-time multiplex Polymerase Chain Reaction. Glutathione S-Transferase gene polymorphisms were determined using conventional Polymerase Chain Reaction followed by migration on agarose gel. A statistically significant association with high relative risks of 10.77 for the development of High grade Superficial or Squamous Intra-epithelial Lesion (95% CI = 5.59 - 20.72;p < 0.001), and 13.20 for cancer development (95% CI = 6.79 - 25.63;p < 0.001) was found in women with the null genotype of Glutathione S-Transferase M1 in the study population. In Burkina Faso and Mali, Glutathione S-Transferase M1-null presented relative risks of 9 and 11.05 for high-grade lesions, 15 and 11.40 for cancer. Similarly, significant results had been observed in women with human papillomavirus positive and human papillomavirus negative. The results of the present study support the idea that the deletion of Glutathione S-Transferase M1 plays a crucial role in the progression of high-grade lesions and cervical cancer.

关键词： Glutathione S-Transferase M1-Null Cervical Cancer Burkina Faso Mali

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叶面施肥对提高库尔勒香梨抗寒相关性的研究

新疆农业科学 2012年第8期49卷 1401-1407页

作者：何香克热木.伊力买合木提.卡热新疆农业大学林学与园艺学院乌鲁木齐830052

【目的】采用库尔勒香梨叶片为材料,进行叶面喷肥处理,研究其与提高香梨抗寒性的关系。【方法】通过磷钾肥、氮肥和硼肥进行3次6个不同浓度处理,在人工低温胁迫处理下测定枝条抗寒指标。【结果】各处理之间存在着极显著差异,其中PK2、N1... 详细信息

【目的】采用库尔勒香梨叶片为材料,进行叶面喷肥处理,研究其与提高香梨抗寒性的关系。【方法】通过磷钾肥、氮肥和硼肥进行3次6个不同浓度处理,在人工低温胁迫处理下测定枝条抗寒指标。【结果】各处理之间存在着极显著差异,其中PK2、N1、N2处理抗寒效果好,各项指标含量均较高。整体分析各项抗寒指标来看,高浓度处理比低浓度处理效果好,硼肥处理没有明显效果。【结论】叶面喷肥处理浓度为0.3%的磷钾肥和0.2%、0.3%的氮肥处理效果较好,尤其是0.3%的磷钾肥在3个抗寒指标中含量均最高,且显著高于对照和其他处理区。各项指标普遍在低温胁迫-28℃时,各处理区处理的抗寒效果不明显。硼肥不能作为提高香梨树抗寒性的叶面肥使用。

关键词：库尔勒香梨叶面肥抗寒性

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不同处理对扁桃种子发芽率及幼苗生长的影响

种子 2005年第12期24卷 4-5,9页

作者：侯江涛克热木.伊力高启明新疆农业大学园艺学院乌鲁木齐830052

以石头扁桃和桃扁桃为试材,研究了不同浓度的GA3和BA以及不同发芽床(沙床、毛巾和培养皿)对扁桃发芽率及幼苗生长的影响。结果发现:GA31.6 mg/L与BA 0.4 mg/L和0.8 mg/L对打破石头扁桃休眠效果明显,GA31.0 mg/L与BA 0.4 mg/L能明显提高... 详细信息

以石头扁桃和桃扁桃为试材,研究了不同浓度的GA3和BA以及不同发芽床(沙床、毛巾和培养皿)对扁桃发芽率及幼苗生长的影响。结果发现:GA31.6 mg/L与BA 0.4 mg/L和0.8 mg/L对打破石头扁桃休眠效果明显,GA31.0 mg/L与BA 0.4 mg/L能明显提高桃扁桃的发芽率。BA处理可使幼苗出现畸形,叶片卷曲,顶端呈莲座状,经营养液浇灌,症状没有缓解。

关键词：扁桃种子发芽率 GA3 BA 巴旦杏特征特性

Early Management of Nephroblastoma: A Single-Center Study in a Sub-Saharan African Country

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Open Journal of Pediatrics 2021年第4期11卷 797-803页

作者： Abdoul karim Doumbia Pierre Togo Mariam Maiga Mohamed Elmouloud Cissé Guédiouma Dembélé Oumar Coulibaly Karamoko Sacko Belco Maiga Djeneba Konaté Abdou Diarra Yakaria Coulibaly Fatoumata Léonie Diakité Abdoul Aziz Diakité Boubacar Togo Check Bougadary Traore Adama Bah Department of Pediatrics at CHU Gabriel Touré Bamako Mali Reference Health Center of the Municipality 6 Bamako Mali Pediatric Surgery Department of the Gabriel Touré CHU Bamako Mali Pathological Anatomy and Cytology Department of the “Point G” CHU Bamako Mali

Introduction: Nephroblastoma is the most common renal cancer in pediatrics. The aim of this study was to describe the epidemiological, clinical, histological characteristics and the immediate outcome of patients with nephroblastoma. Methodology: This was a cross-sectional study of 18 cases of unilateral nephroblastoma, carried out in the pediatric oncology unit (UOP) of the CHU Gabriel Touré from January 2015 to December 2016. Results: The mean age of the patients was 33 months old. The sex ratio was 0.63. The average consultation time was 3 months. A case of malformation syndrome (aniridia and mental retardation) had been observed. The main reason for consultation was abdominal mass (100%) associated with deterioration of general condition (44%), pain (44%) and fever (17%). Stage I accounted for 61% and stage II 39%. The postoperative histological classification made it possible to find the high-risk blastematous type (33%), the regressive type of intermediate risk (11%) and the stromal type of intermediate risk (45%). Toxicities (haematological and digestive) were minimal. The 3-year overall survival was 90%. Conclusion: This study is characterized by the predominance of stages I and II and the fairly large percentage of histology at intermediate risk. These results are above all the result of multidisciplinary collaboration.

关键词： Cancer Child Nephroblastoma Diagnosis Prognosis Mali

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首尔Amoje美食广场

现代装饰 2013年第10期 66-71页

作者： karim Rashid Juliette Hyunju Lee Alex Loyer Huges Kamala Hutauruk Mike Gibson Mana Mohammadkhani Lee Gyeon Bae 谢作标

一个国家的首都往往是视觉地标的聚集地，到处分布着广为人知的标志性场所，是人们聚会、开展社交活动甚至品尝各式美食的绝佳场地。本空间是一个美食广场，内部有机排列的“岛屿”不仅赋予空间十足的个性和当代美学品味，而且还成为附... 详细信息

一个国家的首都往往是视觉地标的聚集地，到处分布着广为人知的标志性场所，是人们聚会、开展社交活动甚至品尝各式美食的绝佳场地。本空间是一个美食广场，内部有机排列的“岛屿”不仅赋予空间十足的个性和当代美学品味，而且还成为附近人们聚会的首选场所。自由形态的天花板为顾客开启了远眺和仰望的视觉空间，同时为正在用餐的顾客提供了隐匿的局部照明。这些“岛屿”呈离心式排列，吸引着顾客参与互动、交流以及各种社交活动，从而营造了一个生动活泼的氛围。

关键词：美食广场视觉空间首尔社交活动局部照明标志性顾客

Comparative Performance of Microscopy and Nested PCR for the Detection of Cryptosporidium Species in Patients Living with HIV/AIDS in Abidjan (Côte d’Ivoire)

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American Journal of Molecular Biology 2023年第1期13卷 18-31页

作者： N’Docho Assi Fiacre-Tanguy Gonédélé Bi Sery Ernest Tuo karim Bialé Marina Danielle Datcho-Gouenet Ayaud N’Guessan Tiacoh Landry Koffi Attoungbré Clément Koffi David Ako Ako Aristide Bérenger Vanga Bosson Abo Henriette Touré Offianan André Department of Parasitology Mycology Institut Pasteur Abidjan C&#244 te d’Ivoire Laboratory of Genetics and Species Improvement Félix Houphou&#235 t-Boigny University Abidjan C&#244 te d’Ivoire Department of Parasitology Mycology UFR Pharmaceutical and Biological Sciences Félix Houphou&#235 t-Boigny University Abidjan C&#244 te d’Ivoire

Cryptosporidium spp. infection is one of the causes of diarrhea in people living with HIV/AIDS. The objective of this study is to compare the sensitivity of microscopy and molecular biology to determine the prevalence of Cryptosporidium spp. in Patients Living With HIV (PLWH). This is a descriptive cross-sectional study conducted in three care centers for people living with HIV/AIDS in Abidjan. It took place from November 2018 to March 2020. Sociodemographic data were obtained via a questionnaire. Stool and blood samples were collected and analyzed for microscopy and Nested PCR detection of Cryptosporidium spp. Blood samples were analyzed for CD4+ count. A total of 363 stool samples were collected from the three sites. Individuals aged 40 - 50 years (36.52%) were most likely to participate in the study. HIV Type 1 accounted for 86.22% of the study population. The samples collected consisted of 47.65% diarrheal stool. Microscopic examination of the stool yielded a prevalence of 3.86% for Cryptosporidium spp. while the prevalence was 3.96% with molecular identification. No statistically significant difference was observed between these two prevalences (χ2 = 0.26;p = 0.609). CD4+ count was the factor associated with Cryptosporidium spp. infection for both microscopy (OR = 0.887, p = 0.001) and PCR (OR = 0.896, p = 0.001). This study demonstrated that Nested PCR improves the detection of Cryptosporidium spp. in patient diagnosis.

关键词： Cryptosporidium PCR Microscopy PLHIV Côte D’Ivoire

质量管理体系的确关注焦点——从合规性到产品

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中国认证认可 2012年第4期 13-16页

作者：卡瑞姆·洛卡斯（karim Lokas）刘健（译）

也许由于与科学技术发展的密切联系，人们一直把生命科学当成一个非常具有前瞻性的行业，总是处于或接近创新的前沿带头位置，并把它看成一种成长的动力。但很具有讽刺意味的是，这个行业对待质量管理体系的方式却远远地落在其他行业后... 详细信息

也许由于与科学技术发展的密切联系，人们一直把生命科学当成一个非常具有前瞻性的行业，总是处于或接近创新的前沿带头位置，并把它看成一种成长的动力。但很具有讽刺意味的是，这个行业对待质量管理体系的方式却远远地落在其他行业后边。在很大程度上，这种落后是因为这个行业最关注的是合规性而不是对提高质量的全部过程的重视。

关键词：质量管理体系产品焦点科学技术发展生命科学行业