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Safety and efficacy outcomes of the Xen45 Gel Stent use for refractory glaucoma:a surgery series from surgeon trainees at a tertiary teaching hospital

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Eye and Vision 2020年第1期7卷 47-57页

作者： karen Hong John Lind Arsham Sheybani Department of Ophthalmology and Visual Sciences Washington University School of MedicineSt.LouisMOUSA Barnes-Jewish Center for Outpatient Health 4901 Forest Park AvenueSt LouisMO 63110USA

Background:To study the effect of an ab interno gelatin stent(XEN45 Gel Stent,Allergan Inc.,Irvine,California,USA)on intraocular pressure(IOP)as placed by glaucoma fellowship trainees in eyes with refractory ***:A prospective noncomparative study at a tertiary training center on 28 unique eyes undergoing ab interno gelatin stent implantation by glaucoma fellowship *** was collected at baseline and postoperatively at day 1,week 1,and months 1,3,5,and *** outcome was mean IOP *** outcomes included change in number of glaucoma medication classes and visual *** outcomes included needling *** success was defined by achieving≥20%reduction in IOP with the same or fewer classes of antiglaucoma medications from baseline without the need for secondary surgical intervention and/or stent ***:At baseline,28.6%(8/28)of the subjects had prior failed incisional glaucoma surgery in a study population that was 54%African-American,with 78%with severe glaucoma(average mean deviation of−14.58 dB).Thirteen subjects terminated their clinic visits before their 12-month postoperative visit,leaving 15 subjects for end point *** IOP went from 21.6 mmHg(range 12.0–31.0,SD 6.6)at baseline to 12.5 mmHg(range 7.0–19.0,SD 3.6),a 42.1%reduction(p<0.007).All subjects decreased the number of medication classes they were taking with an average reduction of 3.8(range 2–5,SD 0.9)to 1.3(range 0–3,SD 1.0)classes,or a 65.8%decrease(p<0.006).Crude surgical success was 80.0%for the 15 subjects that followed up at 12 *** Kaplan-Meier cumulative probability of success for all 28 subjects at 12 months was 70.4%(95%CI:44.7–85.8%).Regardless of the length of follow-up,21.4%(6/28)met failure criteria:3 subjects failed because they required secondary surgical intervention,and the other 3 did not have adequate IOP *** bleb needling rate was 28.6%(8/28)and repeat was 17.9%(5/28).Conclusions:Compared to the re

关键词： XEN Investigational devices Glaucoma Gelatin stent Ab interno surgery Minimally invasive glaucoma surgery Subconjunctival drainage Gelatin microstent

Solvent-Less Vapor-Phase Fabrication of Membranes for Sustainable Separation Processes

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Engineering 2020年第12期6卷 1432-1442页

作者： Junjie Zhao karen K.Gleason State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China Institute of Zhejiang University–Quzhou Quzhou 324000China Department of Chemical Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA

Sustainable processes for purifying water,capturing carbon,producing biofuels,operating fuel cells,and performing energy-efficient industrial separations will require next-generation ***-less fabrication for membranes not only eliminates potential environmental issues with organic solvents,but also solves the swelling problems that occur with delicate polymer ***,the activation procedures often required for synthesizing microporous materials such as metal–organic frameworks(MOFs)can be reduced when solvent-less vapor-phase approaches are *** perspective covers several vacuum deposition processes,including initiated chemical vapor deposition(iCVD),initiated plasma-enhanced chemical vapor deposition(iPECVD),solvent-less vapor deposition followed by in situ polymerization(SLIP),atomic layer deposition(ALD),and molecular layer deposition(MLD).These solvent-less vapor-phase methods are powerful in creating ultrathin selective layers for thin-film composite membranes and advantageous in conformally coating nanoscale pores for the precise modification of pore size and internal *** resulting membranes have shown promising performance for gas separation,nanofiltration,desalination,and water/oil *** development of novel membrane materials and the scaling up of high-throughput reactors for solvent-less vapor-phase processes are necessary in order to make a real impact on the chemical industry in the future.

关键词： Membrane separation Chemical vapor deposition Atomic layer deposition Molecular layer deposition Thin films Metal-organic frameworks Polymers Advanced manufacturing

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论触感——无情故我在

国际社会科学杂志（中文版） 2024年第2期41卷 46-56,5,9页

作者：凯伦·巴拉德丹琼(译) 加州大学圣克鲁斯分校

触摸行为发生在物理物质、理论研究以及两者无法区分的生产空间中。作者探讨了女性主义理论如何触及科学,并将触觉解读为一种揭示他者中的自我和自我中的他者的行为。文章提供了量子场论的教程,让读者为触摸话题的意外对话者一电子一做... 详细信息

触摸行为发生在物理物质、理论研究以及两者无法区分的生产空间中。作者探讨了女性主义理论如何触及科学,并将触觉解读为一种揭示他者中的自我和自我中的他者的行为。文章提供了量子场论的教程,让读者为触摸话题的意外对话者一电子一做好准备。电子是如何困扰物理学家,以至于被“正常化”并称为“不道德”的,这些粒子抵制规范的物理接触概念;它们是反常的。在人类的尺度上,电子使原子之间的距离无法拉近,从而给触摸的概念带来了麻烦:触摸的感觉自相矛盾地依赖于相邻物体之间的电排斥力。在亚原子尺度上,每个电子都从与自身的接触中获取能量,就像与另一个电子进行交换一样。接触的存在不仅源于接触的不存在,而且电子本身的存在也依赖于容纳其虚拟对应物的虚空。在每一个层面上,人们都无法触及他人一一甚至是自身中的他人。这种微观尺度上的悖论构成了所有宏观尺度的物质,对身份的空间和时间固定性提出了质疑。统一、自主的自我概念不仅在个人层面上存在问题,在粒子层面上也是如此。

关键词：压力感左右手他者陌生者不可思议

Novel material tailoring method for internally pressurized FG spherical and cylindrical vessels

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Acta Mechanica Sinica 2018年第5期34卷 936-948页

作者： Fayyaz Nosouhi Dehnavi Ali Parvizi karen Abrinia School of Mechanical Engineering College of EngineeringUniversity of TehranTehranIran

A new material tailoring method for spherical and cylindrical vessels made of functionally graded materials (FGMs) is *** is assumed that the FG material is composed of an A1-SiC metallic-matrix composite.A uniform ratio of inplane shear stress to yield strength [φ(r)] is used as the design criterion to utilize the maximum capacity of the *** aim is to find a distribution of SiC particles in the radial direction,i.e.,f(r),that achieves a uniform index φ(r) =const,through the wall thickness of the internally pressurized spherical or cylindrical *** the Mori-Tanaka and rule-of-mixtures homogenization schemes are used to express the effective elastic module and Poisson's ***,the strength of the composite is expressed based on the rule of ***,finite element simulation is carried out to verify the accuracy of the analytical *** effects of input parameters such as the internal pressure,strength of the SiC particles,ratio of in-plane shear stress to effective yield strength,and choice of homogenization scheme on the tailored distribution of the SiC volume fraction in the radial direction are also investigated.

关键词： Material tailoring Sphere Cylinder FGM Mori-Tanaka Rule of mixtures

Cx26 heterozygous mutations:role in hyperacusis and vulnerability to noise

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Signal Transduction and Targeted Therapy 2023年第8期8卷 3551-3552页

作者： karen Tawk Mehdi Abouzari Department of Otolaryngology-Head and Neck Surgery University of CaliforniaIrvineCAUSA

In a recent study published in Science Advances,Liu et *** that heterozygous deletion of connexin 26(Cx26)in mice is not harmless as they lead to hyperacusis-like hearing *** authors also found that children who carry a single-point heterozygous mutation in the gap junction(GJ)gene Cx26(GJB2)are susceptible to noise,which eventually leads to hearing loss(HL).1 HL affects millions of people worldwide and is considered the most prevalent sensory disorder,encompassing a wide range of heterogeneous characteristics.

关键词： Cx26 noise

Understanding the health and social care needs of people living with IBD: A meta-synthesis of the evidence

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World Journal of Gastroenterology 2012年第43期18卷 6240-6249页

作者： karen Kemp Jane Griffiths Karina Lovell School of Nursing Midwifery and Social Work University of Manchester Manchester M13 9PL United Kingdom Department of Gastroenterology Manchester Royal Infirmary Manchester M13 9WL United Kingdom

AIM:To undertake a metasynthesis of qualitative studies to understand the health and social needs of people living with inflammatory bowel disease (IBD). METHODS:A systematic search strategy identified qualitative studies exploring the phenomenon of living with inflammatory bowel disease. Databases included MEDLINE, PsychInfo, EMBASE, CINAHL and the British Nursing Index via the OVID platform. Qualitative search filters were adapted from Hedges database (http://***/hslt/miner/ digital_library/tip_sheets/Cinahl_eb_***). Qualitative empirical studies exploring the health and social needs of people living with inflammatory bowel disease were selected. Study eligibility and data extraction were independently completed using the Critical Appraisal Skills Programme for qualitative studies. The studies were analysed and synthesised using metasynthesis methodology. The themes from the studies allowed for common translations into a new interpretation of the impact of living with inflammatory bowel disease. RESULTS:Of 1395 studies, six published studies and one unpublished thesis fulfilled the inclusion criteria. First iteration of synthesis identified 16 themes, 2nd iteration synthesised these into three main 2nd order constructs:"detained by the disease"; "living in a world of disease" and "wrestling with life". "Detained by the disease" is the fear of incontinence, the behaviour the patients display due to the fear, and the impact this has on the individual, such as social isolation and missing out on life events. All of these serve to "pull" the patient back from normal living. "Living in a world of disease" is the long term effects of living with a long term condition and the fear of these effects. "Wrestling with life" is the continued fight to thrive, the "push" to continue normal living. CONCLUSION:The metasynthesis provides a comprehensive representation of living with IBD. The unmistakeable burden of incontinence is exposed and its ongoing

关键词： Inflammatory bowel disease Metasynthesis Qualitative Incontinence

The enhanced element enrichment in the supercritical states of granite–pegmatite systems

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Acta Geochimica 2019年第3期38卷 335-349页

作者： Rainer Thomas Paul Davidson karen Appel Section 3.6.Chemistry and Physics of Earth Materials Helmholtz-Centre Potsdam German Research Centre for Geoscience – GFZ CODES Centre for Ore Deposit and Earth Sciences School of Natural Sciences University of Tasmania High Energy Density scientific instrument European X-Ray Free-Electron Laser Facility GmbH

In this paper, we show that supercritical fluids have a greater significance in the generation of pegmatites,and for ore-forming processes related to granites than is usually assumed. We show that the supercritical melt or fluid is a silicate phase in which volatiles; principally H_2O are completely miscible in all proportions at magmatic temperatures and pressures. This phase evolves from felsic melts and changes into hydrothermal fluids, and its unique properties are particularly important in sequestering and concentrating low abundance elements, such as metals. In our past research, we have focused on processes observed at upper crustal levels, however extensive work by us and other researchers have demonstrated that supercritical melt/fluids should be abundant in melting zones at deep-crustal levels too. We propose that these fluids may provide a connecting link between lower and upper crustal magmas,and a highly efficient transport mechanism for usually melt incompatible elements. In this paper, we explore the unique features of this fluid which allow the partitioning of variouselements and compounds, potentially up to extreme levels,and may explain various features both of mineralization and the magmas that produced them.

关键词： Granites Pegmatites Supercritical state Extreme element enrichment

Vitamin D improves inflammatory bowel disease outcomes:Basic science and clinical review

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World Journal of Gastroenterology 2014年第17期20卷 4934-4947页

作者： Krista M Reich Richard N Fedorak karen Madsen karen I Kroeker Division of Gastroenterology University of AlbertaEdmontonAlberta T6G 2X8Canada

Vitamin D deficiency is commonly diagnosed among patients with inflammatory bowel disease (IBD). Patients with IBD are at risk of low bone density and increased fractures due to low vitamin D levels, long standing disease, and frequent steroid exposures; as a result, it is well established that vitamin D supplementation in this population is important. There is increasing support for the role of vitamin D in strengthening the innate immune system by acting as an immunomodulator and reducing inflammation in experimental and human IBD. The active form of vitamin D, 1,25(OH)D3, acts on T cells to promote T helper (Th)2/regulatory T responses over Th1/Th17 responses; suppresses dendritic cell inflammatory activity; induces antibacterial activity; and regulates cytokine production in favor of an anti-inflammatory response. Murine and human IBD studies support a therapeutic role of vitamin D in IBD. Risk factors for vitamin D deficiency in this population include decreased sunlight exposure, disease duration, smoking, and genetics. Vitamin D normalization is associated with reduced risk of relapse, reduced risk of IBD-related surgeries, and improvement in quality of life. Vitamin D is an inexpensive supplement which has been shown to improve IBD outcomes. However, further research is required to determine optimal serum vitamin D levels which will achieve beneficial immune effects, and stronger evidence is needed to support the role of vitamin D in inducing disease response and remission, as well as maintaining this improvement in patients’ disease states.

关键词： Vitamin D Inflammatory bowel disease Immune response Inflammation Cytokines Supplementation

The molecular implications of a caspase-2-mediated site-specific tau cleavage in tauopathies

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Neural Regeneration Research 2021年第9期16卷 1774-1775页

作者： Peng Liu karen H.Ashe Department of Neurology University of MinnesotaMinneapolisMNUSA Department of Neuroscience University of MinnesotaMinneapolisMNUSA N.Bud Grossman Center for Memory Research and Care University of MinnesotaMinneapolisMNUSA Geriatric Research Educationand Clinical CentersVeterans Affairs Medical CenterMinneapolisMNUSA

A major focus of current experimental therapies for neurodegenerative diseases is on modulating post-translational modifications(PTMs)of the microtubule-associated protein *** is a highly soluble,neuronal protein that is comprised of four domains–the N-terminal projection domain,the proline-rich region,the microtubule-binding domain,and the C-terminal *** a scaffold protein,tau dynamically interacts with numerous structural and functional biomolecules,such as cytoskeleton and motor proteins,chaperones,enzymes,DNA,RNA,and *** a dozen types of PTMs,combined with alternative splicing,confer upon tau its enormous structural heterogeneity,which subserves its many(patho-)physiological functions.

关键词： tau structural cleavage