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A systematic review of metabolism of methionine sources in animals:One parameter does not convey a comprehensive story

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Animal Nutrition 2023年第2期13卷 31-49页

作者： Philippe Becquet Mercedes Vazquez-Anon Yves Mercier karen wedekind Tahir Mahmood Dolores I.Batonon-Alavo Frances Yan International Methionine Analogue Association Regus Brussels City CentreStephanie SquareAvenue Louise65B-1050 BrusselsBelgium Novus International Inc. 20 Research Park DriveSaint CharlesMissouri 63304USA Adisseo France SAS Antony Parc II10 Place Du General de GaulleAntony 92160France

The goal of this review article,based on a systematic literature search,is to critically assess the state of knowledge and experimental methodologies used to delineate the conversion and metabolism of the 2 methionine(Met)sources DL-methionine(DL-Met)and DL-2-hydroxy-4-(methylthio)butanoic acid(HMTBa).The difference in the chemical structures of HMTBa and DL-Met indicates that these molecules are absorbed and metabolized differently in *** review explores the methodologies used to describe the 2-step enzymatic conversion of the 3 enantiomers(D-HMTBa,L-HMTBa and D-Met)to L-Met,as well as the site of conversion at the organ and tissue *** work was published documenting the conversion of HMTBa and D-Met into L-Met and,consequently,the incorporation into protein using a variety of in vitro techniques,such as tissue homogenates,cell lines,primary cell lines,and everted gut sacs of individual *** studies illustrated the role of the liver,kidney,and intestine in the con-version of Met precursors into L-Met.A combination of in vivo studies using stable isotopes and infusions provided evidence of the wide conversion of HMTBa to L-Met by all tissues and how some tissues are net users of HMTBa,whereas others are net secreters of L-Met derived from *** of D-Met to L-Met in organs other than the liver and kidney is poorly *** methodology cited in the literature to determine conversion efficiency ranged from measurements of urinary,fecal,and respiratory excretion to plasma concentration and tissue incorporation of isotopes after intraperitoneal and oral *** observed between these methodologies reflect differences in the metabolism of Met sources rather than differences in conversion *** factors affecting conversion efficiency are explored in this paper and are mostly associated with extreme dietary conditions,such as noncommercial crystalline diets that are very deficient in total sulfur amino a

关键词： DL-Methionine Hydroxy-analog of methionine 2-Hydroxy-4-(methylthio)butanoic acid Conversion Metabolism Methodology

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Absorption of methionine sources in animals-is there more to know?

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Animal Nutrition 2023年第1期12卷 159-170页

作者： Philippe Becquet Mercedes Vazquez-Anon Yves Mercier Dolores I.Batonon-Alavo Frances Yan karen wedekind Tahir Mahmood IMAA BrusselsBelgium Novus International Saint CharlesMissouriUSA Adisseo France SAS AntonyFrance

This literature review evaluates the absorption of methionine (Met) sources such as 2-hydroxy-4-methylthiobutyric acid (HMTBa), its calcium salts (HMTBa-Ca), and DL-methionine (DL-Met) by focusing on the state of knowledge regarding the absorption mechanism, experimental methodology, and factors affecting their absorption. The 2 Met sources differ in mechanism and site of absorption due to differences in their chemical characteristics and enzymatic conversion. This review addresses diffusion- and transport-mediated absorption systems for amino acids and carboxylic compounds, best elucidated by in vitro, ex vivo, and in vivo experimental models. Opportunities and limitations in the use of radioisotopes to depict absorption sites as well as host and microbial metabolism are described. Physiological and environmental conditions that lead to changes in gut absorptive capacity and the impact of Met source absorption are also evaluated. This review concludes that any comparison between HMTBa and DL-Met should consider their different behaviors during the absorption phase. Hence, the chemical characteristics of these 2 molecules entail different absorption sites and mechanisms, from passive absorption in the case of HMTBa and HMTBa-Ca to active transporters for DL-Met, HMTBa, and HMTBa-Ca. In addition, the different conversion modes of these 2 molecules further differentiate their absorption modes. Considering these important differences, it is easier to understand the apparent divergence between the conclusions of existing publications. When comparing these 2 molecules, it is recommended to properly adapt to the conditions under which the absorption of Met sources is evaluated.

关键词： DL-Methionine Hydroxy-analog of methionine 2-Hydroxy-4-methylthiobutyric acid AbsorptionM ethodology

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Superior growth performance in broiler chicks fed chelated compared to inorganic zinc in presence of elevated dietary copper

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Journal of Animal Science and Biotechnology 2016年第4期7卷 561-569页

作者： Junmei Zhao Robert B. Shirley Julia J. Dibner karen J. wedekind Frances Yan Paula Fisher Thomas R. Hampton Joseph L. Evans Mercedes Vazquez-Anon research and development novus international20 Research Park DriveSaint CharlesMO 63304USA current affiliation:poultry technical services adisseo usaAlpharettaGA 30022USA

Background： The goal of this study was to compare the antagonism of elevated dietary Cu （250 mg/kg） from CuS04 on three different Zn sources （ZnS04. H20; [Zn bis（-2-hydroxy-4-（methylthio）butanoic acid）], Zn（HMTBa）2 a chelated Zn methionine hydroxy analogue; and Zn-Methionine）, as measured using multiple indices of animal performance in ROSS 308 broilers. Methods： Three experiments were conducted in broiler chicks fed a semi-purified diet. All birds were fed a Zn-deficient diet （8.5 mg/kg diet） for 1 wk, and then provided with the experimental diets for 2 wks. Results： Experiment 1 was a 2 x 2 factorial design with two levels of Cu （8 vs. 250 mg/kg diet from CuSO4） and two Zn sources at 30 mg/kg [ZnSO4. H20 vs. Zn（HMTBa）2]. Elevated Cu impaired growth performance only in birds fed ZnSO4. Compared to ZnSO4. H20, Zn（HMTBa）2 improved feed intake （12 %; P 〈 0.001） and weight gain （12 %, P 〈 0.001） and the benefits were more pronounced in the presence of 250 mg/kg diet Cu. Experiment 2 was a dose titration of ZnSO4- H20 and Zn（HMTBa）2 at 30, 4,5, 60, and 75 mg/kg diet in the presence of 250 mg/kg CuSO4. Feed：gain was decreased and tibia Zn was increased with increasing Zn levels from 30 to 75 mg/kg. Birds fed Zn（HMTBa）2 consumed more food and gained more weight compared to birds fed ZnSO4, especially at lower supplementation levels （30 and 45 mg/kg; interaction P 〈 0,05）. Experiment 3 compared two organic Zn sources （Zn（HMTBa）2 vs. Zn-Methionine） at 30 mg/kg with or without 250 mg/kg CuSO4. No interactions were observed between Zn sources and Cu levels on performance or tissue mineral concentrations. High dietary Cu decreased weight gain （P 〈 0.01）. Tibia Cu and liver Cu were significantly increased with 250 mg/kg dietary Cu supplementation （P 〈 0.01）. No difference was observed between the two Zn sources. Conclusions： Dietary 250 mg/kg Cu significantly impaired feed intake and weight gain in birds fed ZnSO4. H20, but had less impact in birds fed Zn（HMTBa）2. No difference

关键词： Antagonism Broilers Chelates Growth MineraLs Organic Performance

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Absorption of methionine sources in animals-is there more to know?—— Clarification

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Animal Nutrition 2023年第3期14卷 69-69页

Our publication on absorption of methionine sources(Becquet et al.,2023a)is a thorough analysis of 129 references dealing with absorption of sources of methionine,with the objective to critically evaluate the methodologies used and their impact on the conclusions of the *** the focus of our publicationwas on the evaluation of absorption,efficacy studies and reports not having information on absorption were not considered(Elwert et al.,2008;Rychen et al.,2008).

关键词： absorption dealing conclusions

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