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Stable ischemic heart disease in the older adults

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Journal of Geriatric Cardiology 2016年第2期13卷 109-114页

作者： Xuming DAI Jan Busby-Whitehead Daniel E Forman karen p alexander Division of Cardiology University of North Carolina at Chapel Hill Chapel Hill North Carolina USA Division of Geriatric Medicine Center for Aging and Health University of North Carolina at Chapel Hill North Carolina USA Section of Geriatric Cardiology University of Pittsburgh Medical Center Geriatrics Research Education and Clinical Center VA Pittsburgh Healthcare System Pittsburgh PA USA Division of Cardiology Duke University Medical Center Durham North Carolina USA

1 Introduction Ischemic heart disease is caused by atherosclerotic and/or thrombotic obstruction of coronary arteries. Clinical spec- trum of ischemic heart disease expands from asymptomatic atherosclerosis of coronary arteries to acute coronary syn- dromes （ACS） including unstable angina, acute myocardial infarction （non-ST elevation myocardial infarction and ST elevation myocardial infarction）. Stable ischemic heart dis- ease （SIHD） refers to patients with known or suspected SIHD who have no recent or acute changes in their symp- tomatic status, suggesting no active thrombotic process is underway.

关键词： Aging Coronary artery disease Older adults Risk assessment Stable ischemic heart disease

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili patricia Graham Adriana Brooks Risset Silvera alexander J.p.Goldschmidt Damien D.pearse W.Dalton Dietrich Allan D.Levi James D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami project to Cure paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

ON STABILITY BOUNDARY OF LINEAR MULTI-pARAMETER HAMILTONIAN SYSTEMS

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Acta Mechanica Sinica 2002年第6期18卷 661-670页

作者：齐朝晖 alexander p. Seyranian State Key Laboratory of Structure and Industrial Equipments Department of Engineering Mechanics Dalian University of Technology Dalian China 116023 Institute of Mechanics Moscow State Lomonosov University Moscow 117192 Russia

In this paper an approximate equation is derived to describe smooth parts of the stability boundary for linear Hamiltonian systems, depending on arbitrary number of parameters. With this equation, we can obtain parameters corresponding to the stability boundary, as well as to the stability and instability domains, provided that one point on the stability boundary is known. Then differential equations describing the evolution of eigenvalues and eigenvectors along a curve on the stability boundary surface are derived. These equations also allow us to obtain curves belonging to the stability boundary. Applications to linear gyroscopic systems are considered and studied with examples.

关键词： stability boundary Hamiltonian systems eigenvalues perturbation methods

Effects of historic wildfire and prescribed fire on site occupancy of bats in Shenandoah National park,Virginia,USA

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Journal of Forestry Research 2020年第4期31卷 1255-1270页

作者： Lauren V.Austin alexander Silvis W.Mark Ford karen E.powers Department of Fish and Wildlife Conservation Virginia TechBlacksburgVA 24061USA Resource Environmental Solutions WarrentonVA 20187USA U.S.Geological Survey Virginia Cooperative Fish and Wildlife Research UnitBlacksburgVA 24061USA Biology Department Radford UniversityRadfordVA 24141USA

Given the likelihood of regional extirpation of several once-common bat species in eastern North America from white-nose syndrome,it is critical that the impacts of forest management activities,such as prescribed fire,are known in order to minimize potentially additive negative effects on bat *** wildfires may offer a suitable surrogate to assess long-term burn impacts on bats for planning,implementing and assessing burn *** examine the effects of historic fire on bats,we sampled bat activities at 24 transect locations in burned and unburned forest stands in the central Appalachian Mountains of Shenandoah National park(SNp),Virginia,*** was limited evidence of positive fire effects over time on hoary bats(Lasiurus cinereus Beauvois)and big brown bats(Eptesicus fuscus Beauvois)***,there were few or mostly equivocal relationships of bat occupancy relative to burn conditions or time since fire in SNp across species using a false-positive occupancy *** results suggest that fire does not strongly affect bat site occupancy short-or long-term in the central Appalachians.

关键词： Appalachian mountains Bats False-positive occupancy prescribed fire Wildfire

ON THE STABILITY BOUNDARY OF HAMILTONIAN SYSTEMS

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Applied Mathematics and Mechanics(English Edition) 2002年第2期23卷 187-193页

作者：齐朝晖 alexander p.Seyranian Department of Mcchanics Dalian University of TechnologyDalian116023P Rchina Institute of Mechanics Moscow State Lomonosov UniversityMoscow117192Russia

The criterion for the points in the parameter space being on the stability boundary of linear Hamiltonian system depending on arbitrary numbers of parameters was given, through the sensitivity analysis of eigenvalues and eigenvectors. The results show that multiple eigenvalues with Jordan chain take a very important role in the stability of Hamiltonian systems.

关键词： stability boundary Hamiltonian system sensitivity analysis perturbation method

Evidence for the involvement of infectious agents in the pathogenesis of Crohn's disease

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World Journal of Gastroenterology 2008年第6期14卷 845-852页

作者： Gert De Hertogh Jeroen Aerssens karen p Geboes Karel Geboes Karel Geboes Department of Pathology University Hospitals KULeuven Minderbroedersstraat 12 Leuven 3000 Belgium Tibotec bvba Generaal De Wittelaan L 11B 3 Mechelen 2800 Belgium Department of Gastroenterology University Hospitals KULeuven Herestraat 49 Leuven 3000 Belgium

Many advances have been made in the understanding of Crohn’s disease (CD) pathogenesis during the last decade. CD is currently seen as a predominantly T-lym-phocyte-driven disease characterized by the presence of a complex cocktail of interacting cytokines, chemokines and other mediators produced by a variety of cell types. prevailing theories of CD pathogenesis suggest that patients’ T-lymphocytes are inappropriately activated in the setting of an immune imbalance, which is itself caused by an unfortunate confluence of genetic and en- vironmental factors. The T-cell response then leads to the chronic inflammation characteristic for the disease. Various environmental factors may play a role in the development of CD, but microbes are most consistently implied. This theory is based on epidemiological, clinico- pathological, genetic and experimental evidence. Despite the abundance of arguments for the implication of bac-teria in the aetiopathogenesis of CD, the precise role of bacteria in this disease still remains elusive. Three not necessarily mutually exclusive theories have been pro- posed: (1) an unidentified persistent pathogen; (2) an abnormally permeable mucosal barrier leading to exces-sive bacterial translocation; and (3) a breakdown in the balance between putative "protective" versus "harmful" intestinal bacteria ("dysbiosis"). At present, one cannot exclude with certainty any of these three proposed hy-potheses; they may all apply to CD to a certain extent.

关键词： Crohn's disease Etiology Microbiology

Compact stars admitting Finch-Skea symmetry in the presence of various matter fields

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Chinese physics C 2023年第1期47卷 234-251页

作者： Oleksii Sokoliuk alexander Baransky p.K.Sahoo Main Astronomical Observatory of the NAS of Ukraine(MAO NASU) Kyiv03143Ukraine Astronomical Observatory Taras Shevchenko National University of Kyiv3 Observatorna St.04053 KyivUkraine Department of Mathematics Birla Institute of Technology and Science-PilaniHyderabad CampusHyderabad-500078India

In the present study,we investigate the anisotropic stellar solutions admitting Finch-Skea symmetry(viable and non-singular metric potentials)in the presence of some exotic matter fields,such as Bose-Einstein Condensate(BEC)dark matter,the Kalb-Ramond fully anisotropic rank-2 tensor field from the low-energy string theory effective action,and the gauge field imposing U(1)*** spacetime is matched with both Schwarzchild and Reissner-N?rdstrom vacuum spacetimes for BEC,KB,and gauge *** addition,we study the energy conditions,Equation of State(EoS),radial derivatives of energy density and anisotropic pressures,Tolman-OppenheimerVolkoff equilibrium condition,relativistic adiabatic index,sound speed,and surface *** of the aforementioned conditions are ***,the solutions derived in the current study lie in the physically acceptable regime.

关键词： compact stars Finch-Skea symmetry energy conditions Tolman-Oppenheimer-Volkoff equilibrium condition sound speed

The effect of self-focusing on laser space-debris cleaning

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Light(Science & Applications) 2014年第1期3卷 250-255页

作者： alexander M Rubenchik Michail p Fedoruk Sergei K Turitsyn Lawrence Livermore National Laboratory LivermoreCA 94550USA Institute of Computational Technologies Siberian Branch of the Russian Academy of SciencesNovosibirsk 630090Russia Novosibirsk State University Novosibirsk 630090Russia Aston Institute of photonic Technologies School of Engineering and Applied ScienceAston UniversityBirmingham B47ETUK

A ground-based laser system for space-debris cleaning will use powerful laser pulses that can self-focus while propagating through the *** demonstrate that for the relevant laser parameters,this self-focusing can noticeably decrease the laser intensity on the *** show that the detrimental effect can be,to a great extent,compensated for by applying the optimal initial beam *** effect of laser elevation on the system performance is discussed.

关键词： laser self-focusing space debris

Social cliques in male northern muriquis Brachyteles hypoxanthus

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Current Zoology 2012年第2期58卷 342-352页

作者： Marcos TOKUDA Jean p. BOUBLI patricia IZAR karen B. STRIER Department of Experimental psychology University of S~io Paulo Av. Prof. Mello Moraes 1721 CEP 05508-030 Sao Paulo Brazil Wildlife Conservation Society Rio de Janeiro Brazil Department of Anthropology University of Wisconsin-Madison USA

Analyses of spatial relationships and social interactions provide insights into the social structure of animal societies and the ways in which social preferences among and between dyads affect higher order social relationships. In this paper we de- scribe the patterns of spatial associations and social interactions among adult male northern muriquis in order to evaluate the dy- namics of their social networks above the dyadic levels. Systematic observations were made on the 17 adult males present in a multi-male/multi-female group from April 2004 through February 2005, and in July 2005. Analyses of their spatial relationships identified two distinct male cliques; some adult males （called ＂N＂ males） were more connected to the females and immatures than other adult males （＂MU＂ males）, which were more connected to one another. Affiliative interactions were significantly higher among dyads belonging to the same clique than to different cliques. Although frequencies of dyadic agonistic interactions were similarly low among individuals within and between cliques, MU males appeared to be subordinate to N males. Nonetheless, there were no significant differences in the copulation rates estimated for MU males and N males. Mutual benefits of cooperation between MU and N cliques in intergroup encounters might explain their ongoing associations in the same mixed-sex group

关键词： Brachyteles hypoxanthus Male northern muriquis Social relationship Social clique Social network analysis