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TEACHING VISUAL SCRIPTING IN BIm:A CASE STUDY USING A PANEL CONTROLLED BY SOLAR ANGLES

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Journal of Green Building 2018年第1期13卷 115-137页

作者： karen m.Kensek University of Southern California School of Architecture Watt Hall#204Los AngelesCA 90089-029

Programming and scripting can be used to activate a 3D parametric model to create a more intelligent and flexible building information model. There has been a trend in the building industry towards the use of visual scripting that allow users to create customized, flexible, and powerful programs without having to first learn how to write traditional code. Using visual scripting, users graphically interact with program elements instead of typing lines of text-based code. Nodes are created and virtually wired together;they can be numbers, sliders for adjusting values, operators and functions, list manipulation tools, graphic creators, and other types. Text based coding programs such as Python can also be used for the creation of custom nodes when greater flexibility is desired. Examples from professional firms include scripts that help automate work in the office to increase efficiency and accuracy (e.g. create escape routes, renumber rooms by levels, create documentation), assist in form generation (e.g. parametric design of metal panels, rebar generation, coordination between Revit and Rhino), analyze BIm files (e.g. terminal airflow, visual loads and capacity), and provide analysis results (e.g. daylighting, thermal comfort, window optimization). One can learn the basic steps of learning a visual programming language through the use of Dynamo within Autodesk Revit. The example used is for a façade component that changes based on the sun’s altitude.

关键词： BIm building information modeling visual programming scripting Revit Dynamo teaching

Regulation ofβ2-adrenoceptors in brain glia:implications for neuroinflammatory and degenerative disorders

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Neural Regeneration Research 2020年第11期15卷 2035-2036页

作者： karen m.Ryan Andrew Harkin Trinity College Institute of Neuroscience Trinity College Dublin Neuropsychopharmacology Research Group School of Pharmacy and Pharmaceutical Sciences&Trinity College Institute of NeuroscienceTrinity College DublinDublinIreland

Noradrenaline:Within the central nervous system(CNS),the primary source of the catecholamine neurotransmitter noradrenaline is the locus coeruleus(LC)in the pontine tegmentum,with LC neurons projecting to almost all regions of the brain and spinal *** its release from LC neurons,noradrenaline has wide ranging *** example,noradrenaline is the endogenous agonist for G-coupledα-andβ-adrenoceptors that are expressed on many cell types,including neurons and glia,in both the peripheral nervous system and *** is via these receptors that noradrenaline exerts its anti-inflammatory and neurotrophic effects in the *** additionally has adrenoceptor-independent neuroprotective actions,and as such plays a role in free radical scavenging and reducing oxidative stress(Feinstein et al.,2016).

关键词： adrenoceptor protective endogenous

Vitamin D improves inflammatory bowel disease outcomes:Basic science and clinical review

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World Journal of Gastroenterology 2014年第17期20卷 4934-4947页

作者： Krista m Reich Richard N Fedorak karen madsen karen I Kroeker Division of Gastroenterology University of AlbertaEdmontonAlberta T6G 2X8Canada

Vitamin D deficiency is commonly diagnosed among patients with inflammatory bowel disease (IBD). Patients with IBD are at risk of low bone density and increased fractures due to low vitamin D levels, long standing disease, and frequent steroid exposures; as a result, it is well established that vitamin D supplementation in this population is important. There is increasing support for the role of vitamin D in strengthening the innate immune system by acting as an immunomodulator and reducing inflammation in experimental and human IBD. The active form of vitamin D, 1,25(OH)D3, acts on T cells to promote T helper (Th)2/regulatory T responses over Th1/Th17 responses; suppresses dendritic cell inflammatory activity; induces antibacterial activity; and regulates cytokine production in favor of an anti-inflammatory response. murine and human IBD studies support a therapeutic role of vitamin D in IBD. Risk factors for vitamin D deficiency in this population include decreased sunlight exposure, disease duration, smoking, and genetics. Vitamin D normalization is associated with reduced risk of relapse, reduced risk of IBD-related surgeries, and improvement in quality of life. Vitamin D is an inexpensive supplement which has been shown to improve IBD outcomes. However, further research is required to determine optimal serum vitamin D levels which will achieve beneficial immune effects, and stronger evidence is needed to support the role of vitamin D in inducing disease response and remission, as well as maintaining this improvement in patients’ disease states.

关键词： Vitamin D Inflammatory bowel disease Immune response Inflammation Cytokines Supplementation

Protein construct optimization:data sharing strategy

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Protein & Cell 2012年第5期3卷 321-322页

作者： karen m.Polizzi Rivka L.Isaacson Center for Synthetic Biology and Innovation Division of Molecular BiosciencesImperial College LondonLondon SW72AZUK Center for Structural Biology Division of Molecular BiosciencesImperial College LondonLondon SW72AZUK

The British medical Journal devoted its first issue of 2012 to the problem of unreported clinical trial data,highlighting the serious impact that incomplete information can have on world health(for an editorial summary see Lehman and Loder,2012).Adopted innovations in clinical intervention,inappro-priately based on only a subset of trial data,can,at best,prove uneconomical and,at worst,lead to large-scale patient *** its consequences may be most severe in medicine this problem applies to many scientific disciplines and we are now seeing a move towards greater transparency in data declaration.

关键词： subset consequences incomplete

Predicting phosphorus sorption isotherm parameters in soil using data of routine laboratory tests

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Pedosphere 2021年第5期31卷 694-704页

作者： Kathleen S.DUNNE Nicholas m.HOLDEN karen DALY Teagasc Johnstown CastleEnvironmental Research CentreCo.Wexford Y35TC97(Ireland) UCD School of Biosystems and Food Engineering University College DublinBelfieldDublin 4 D04VIW8(Ireland)

Knowledge of phosphorus(P)sorption dynamics across different soil types could direct agronomic and environmental management of *** objective of this study was to predict P isotherm parameters for a national soil population using data of routine laboratory *** and Freundlich sorption parameters were calculated from two different ranges(0-25 and 0-50 mg P L^(-1))using an archive of representative agricultural soil types from *** linear regression(mLR)identified labile forms of aluminium(Al)and iron(Fe),organic matter(Om),cation exchange capacity(CEC),and clay as significant *** and Freundlich sorption capacities,Freundlich affinity constant,and Langmuir buffer capacity were predicted reliably,with R^(2) of independent validation>*** isotherm parameters were predicted from P sorbed at a single concentration of 50 mg P L^(-1)(S_(50)).An mLR prediction of P sorption maximum in the 0-50 mg P L-1 range was achieved,to an accurate standard,using S_(50),Om,and mehlich-3 Fe(R^(2) of independent calibration and validation being 0.91 and 0.95,respectively).Using Giles’four shapes of isotherms(C,L,H,and S),L non-strict-and C-shaped isotherm curves accounted for 64% and 27% of the soils,*** clustering identified a separation of isotherm curves influenced by two ranges of mehlich-3 *** with a low range of mehlich-3 Al(2.5-698 mg kg^(-1))had no incidence of rapid sorption(C shape).Single point indices,Al,or available soil data make the regression approach a feasible way of predicting Langmuir parameters that could be included with standard agronomic soil P testing.

关键词： available phosphorus binding fertilizer soil test sorption maximum

Cx26 heterozygous mutations:role in hyperacusis and vulnerability to noise

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Signal Transduction and Targeted Therapy 2023年第8期8卷 3551-3552页

作者： karen Tawk mehdi Abouzari Department of Otolaryngology-Head and Neck Surgery University of CaliforniaIrvineCAUSA

In a recent study published in Science Advances,Liu et *** that heterozygous deletion of connexin 26(Cx26)in mice is not harmless as they lead to hyperacusis-like hearing *** authors also found that children who carry a single-point heterozygous mutation in the gap junction(GJ)gene Cx26(GJB2)are susceptible to noise,which eventually leads to hearing loss(HL).1 HL affects millions of people worldwide and is considered the most prevalent sensory disorder,encompassing a wide range of heterogeneous characteristics.

关键词： Cx26 noise

Improving the reaction mix of a Pichia pastoris cell-free system using a design of experiments approach to minimise experimental effort

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Synthetic and Systems Biotechnology 2020年第3期5卷 137-144页

作者： Alex J.Spice Rochelle Aw Daniel G.Bracewell karen m.Polizzi Department of Chemical Engineering Imperial College LondonLondonUK Imperial College Centre for Synthetic Biology Imperial College LondonUK Department of Biochemical Engineering University College LondonLondonUK

A renaissance in cell-free protein synthesis(CFPS)is underway,enabled by the acceleration and adoption of synthetic biology *** has emerged as a powerful platform technology for synthetic gene network design,biosensing and on-demand *** primarily of bacterial origin,cell-free extracts derived from a variety of host organisms have been explored,aiming to capitalise on cellular diversity and the advantageous properties associated with those ***,cell-free extracts produced from eukaryotes are often overlooked due to their relatively low yields,despite the potential for improved protein folding and posttranslational *** we describe further development of a Pichia pastoris cell-free platform,a widely used expression host in both academia and the biopharmaceutical *** a minimised Design of Experiments(DOE)approach,we were able to increase the productivity of the system by improving the composition of the complex reaction *** was achieved in a minimal number of experimental runs,within the constraints of the design and without the need for liquid-handling *** doing so,we were able to estimate the main effects impacting productivity in the system and increased the protein synthesis of firefly luciferase and the biopharmaceutical HSA by 4.8-fold and 3.5-fold,*** study highlights the ***-based cell-free system as a highly productive eukaryotic platform and displays the value of minimised DOE designs.

关键词： Cell-free protein synthesis Pichia pastoris Synthetic biology Design of experiments(DOE)

Safety effectiveness of roadway conversion with a two way left turn lane

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Journal of Traffic and Transportation Engineering(English Edition) 2018年第4期5卷 309-317页

作者： Subasish Das Xiaoduan Sun karen Dixon m.Ashifur Rahman Texas A&m Transportation Institute Texas A&M University College Station Department of Civil Engineering University of Louisiana at Lafayette

In urban or suburban areas with a large number of access points, four-lane undivided highways are prone to crashes due to left-turning and through movements in a single lane. many studies recommended expensive countermeasures like conversion from undivided to divided road with physical separation. One inexpensive alternative is reconfiguring the existing roadways by either increasing or decreasing the number of lanes. This study investigated the safety impact of converting four lane undivided roadways （4U） to five lane undivided roadways （ST） with a two way left turn lane （TIkrLTL）. This study used Empirical Bayes method to determine the safety impact of this inexpensive countermeasure. In this study, data from eight sites from Louisiana were collected for investigation, and site- specific crash modification factor （CmF） values were calculated. Although ST is usually not preferable due to its exposure of higher number of crashes in the existing literature, the findings of the current study indicated a positive safety impact. The benefit-cost ratio of this conversion ranges from 97 to 379. The current findings indicate that conversion of 4U to 5T is a feasible inexpensive solution for urban roadways with lower volume and a limited number of driveways.

关键词： Lane restriping Two way left turn lane Empirical Bayes Crash modification factor Benefit cost ratio

meat juice contributes to the stability of ethanol adaptation in Salmonella enterica serovar Enteritidis

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Food Quality and Safety 2021年第3期5卷 291-296页

作者： Shoukui He karen Fong Siyun Wang Xianming Shi mOST-USDA Joint Research Center for Food Safety School of Agriculture and BiologyState Key Lab of Microbial MetabolismShanghai Jiao Tong UniversityShanghaiChina Food Nutrition and HealthFaculty of Land and Food SystemsThe University of British ColumbiaVancouverBCCanada

Stability assessme nt of observed tolerance phe no types is integral in un dersta nding stress adaptati on in food-borne ***,the current work was carried out to determine whether ethanol adaptation induced by exposure to 5 percent ethanol for 60 min is a stable phenomenon in Salmonella enterica serovar *** capacity of Salmonella Enteritidis(***)to maintain the acquired ethanol adaptation in the absenee of sublethal ethanol stress was investigated at 37℃,25℃ or 4℃ in Luria-Bertani broth and two types of meat *** was found that ethanol adaptation was completely reversed within 40 min at 37℃ or within 60 min at 25℃,but was stable at 4℃ for at least 48 h in the broth *** adaptation was retained in chicken juice during 60-min incubation at 25℃ or 48h incubation at 4℃.moreover,exposure to pork juice stored at either 25℃ or 4℃ sigrdficantly(Pmeat juices should be take n into acco unt whe n con ducting a comprehensive risk analysis during food processing.

关键词： Salmonella Enteritidis ethanol adaptation stability temperature meat juice.