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世界核心医学期刊文摘（神经病学分册） 2005年第4期1卷 17-18页

作者： Tvedskov J.F. thomsen l.l. 黄卫东 University of Copenhagen Department of Neurology Glostrup University Hospital Glostrup Copenhagen 2600 Denmark Dr

Prophylactic drug trials in migraine are long- lasting and expensive and require long- term toxicology information. A human migraine model would therefore be helpful in testing new drugs. Immediate headache and delayed migraine after glyceryltrinitrate (GTN) has been well characterized. We have recently shown that sodium valproate has prophylactic effect in the GTN model. Here we report our experience with propranolol in this model. Nineteen subjects with migraine without aura and 16 sex- and aged- matched healthy subjects were included in a two- centre randomized double- blind cross- over study. Fourteen migraine subjects and 14 healthy subjects completed the study and results from comparison of the 28 subjects are reported. Randomly propranolol 160 mg or placebo were each given daily for 14 days to both migraine and healthy subjects. A 20- min intravenous infusion of GTN 0.25 μ g/kg per min was administered on a study day at the end of both pretreatment periods. Headache was registered for 12 h after GTN infusions. Its intensity was scored on a numerical verbal rating scale from 0 to 10. Fulfilment of International Headache Society (HIS) criteria was recorded for 24 h. Radial and superficial temporal artery diameters and blood velocity of both middle cerebral arteries were measured. All migraine subjects developed headache after GTN. No reduction of overall peak headache was found after propranolol (median 5, range 0- 7) compared with placebo (median 5, range 0- 10) (P = 0.441). Eight of the 14 completing migraine subject developed IHS 1.1 migraine after GTN, two subjects on both days, three subjects only after placebo, and three subjects only after propranolol. No reduction of GTN induced migraine was found after propranolol compared with placebo (5 vs. 5, P = 1.000). All healthy subjects developed headache after GTN. No reduction of overall peak headache was found after propranolol (median 2, range 1- 5) compared with placebo (median 1, range 1- 7) (P = 0.315).

关键词：普萘洛尔三基安慰剂药物预防病理生理机制毒理学研究戊酸交叉试验血流速度血管舒张

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河流作用研究的进展

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世界地质 1986年第2期 31-39页

作者： karen l.Prestegaard 刘祥

现今,关于非冲积河床控制和河流力学详细的野外调查,使我们对河流作用的研究前进了。河流河床地形的非冲积控制,包括诸如木质碎屑,基岩露头和静止的沉积物这样一些特点。河流河床的这些特点,以及流量和沉积物特征都是河系的独立变量。... 详细信息

现今,关于非冲积河床控制和河流力学详细的野外调查,使我们对河流作用的研究前进了。河流河床地形的非冲积控制,包括诸如木质碎屑,基岩露头和静止的沉积物这样一些特点。河流河床的这些特点,以及流量和沉积物特征都是河系的独立变量。非冲积特点,通过固定的水池位置和对其起作用的斜坡、阻力和沉积物的搬运来影响河床地形。在过去十年里,地貌学家、工程师和沉积学家一直进行河流作用,特殊沉积物的搬运和沉积的详细的野外研究。这些研究表明了河流作用的复杂性,并提供了砾石覆盖面形成、点砂坝形成力学、急流—水池序列维持和其他作用的新的观点。这个令人鼓舞的调查趋势可以证明,在今后几年内,会更富有成果。

关键词：冲积河床木质基岩底岩岩石河流作用碎屑冲积河流砾石坝砂坝水流阻力

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Maize Carbohydrate Partitioning Defective33 Encodes an MCTP Protein and Functions in Sucrose Export from leaves

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Molecular Plant 2019年第9期12卷 1278-1293页

作者： Thu M.Tran Tyler J.McCubbin Saadia Bihmidine Benjamin T.Julius R.Frank Baker Martin Schauflinger Clifford Weil Nathan Springer Paul Chomet Ruth Wagner Jeff Woessner karen Grote Jeanette Peevers Thomas l.Slewinski David M.Braun Division of Biological Sciences’Interdisciplinary Plant Group Missouri Maize CenterUniversity of MissouriColumbiaMO 65211USA Division of Plant Sciences University of MissouriColumbiaMO 65211USA Electron Microscopy Core Facility University of MissouriColumbiaMO 65211USA Department of Agronomy Purdue UniversityWest LafayetteIN 47907USA Department of Plant and Microbial Biology University of MinnesotaSaint PaulMN 55108USA NRGene Inc. 8910 University Center Lane\r\n S u ite 400San DiegoCA 92122USA Bayer Crop Science ChesterfieldMO 63017USA National Key laboratory for Plant Cell Technology Agricultural Genetics InstituteHanoiVietnam

To sustain plant growth,development,and crop yield,sucrose must be transported from leaves to distant parts of the plant,such as seeds and *** identify genes that regulate sucrose accumulation and transport in maize(Zea mays),we isolated carbo/iydrafe part/f/ofi/ngf defecf/Ve33(cpd33),a recessive mutant that accumulated excess starch and soluble sugars in mature *** cpd33 mutants also exhibited chlorosis in the leaf blades,greatly diminished plant growth,and reduced ***33 encodes a protein containing multiple C2 domains and transmembrane *** localization experiments showed the CPD33 protein localized to plasmodesmata(PD),the plasma membrane,and the endoplasmic *** also found that a loss-of-function mutant of the CPD33 homolog in Arabidopsis,QUIRKY,had a similar carbohydrate hyperaccumulation *** labeled sucrose transport assays showed that sucrose export was significantly lower in cpd33 mutant leaves relative to wild-type ***,PD transport in the adaxial-abaxial direction was unaffected in cpd33 mutant ***,transmission electron microscopy revealed fewer PD at the companion cell-sieve element interface in mutant phloem tissue,providing a possible explanation for the reduced sucrose export in mutant ***,our results suggest that CPD33 functions to promote symplastic transport into sieve elements.

关键词： carbohydrate accumulation companion cells phloem, plasmodesmata sieve elements symplastictransport

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Registered Dietitian Wellness Insurance Benefit Makes a Difference in Adult Weight Management: A Pre-Post Study

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Food and Nutrition Sciences 2011年第10期2卷 1043-1047页

作者： linda Snetselaar karen l. Smith Donna Hollinger Esther Myers Gwen Murphy laura Goettinger Qualls 不详

Registered Dietitian (RD) services as part of insurance wellness programs offer a promising potential venue for improving public health. This study was conducted to evaluate the effectiveness of RD nutrition counseling services provided as part of an insurance benefit on body weight and associated health parameters. Eligible members could enroll to receive 6 RDs visits a year for assistance with weight management. The study RDs were randomized into either Usual Care (UC) or lifestyle Case Management (lCM) groups. Body weight, waist circumference, and systolic and diastolic blood pressure measurements of program enrollees were evaluated for between group as well as start and end program comparisons. There was a statistically significant difference in the number of RD follow-up visits between the two groups as lCM patients had more RD contact than UC patients. Weight and waist circumference changes from baseline to end of study show statistically significant changes with a trend for improvement in systolic blood pressure. Additionally, a clinically significant reduction in weight was achieved in a quarter of program enrollees. In conclusion this study shows that through a coordinated health promotion program RDs’ services are of value to an insured population.

关键词： RD Nutrition Counseling Insurance Benefit Weight loss Blood Pressure

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The Study of Patients Mental State by Color Diagnostic Method

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Psychology Research 2013年第6期3卷 350-357页

作者： Kristina karen Vardanyan Gayane Albert Ghazaryan Yerevan State Medical University Yerevan Republic of Armenia

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质量、安全、效益:中美农村学校合并绕不开的议题

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教育与考试 2017年第6期 87-92页

作者：彭拥军 karen l.Biraimah 湖南科技大学教育学院中佛罗里达大学教育与人类行为学院

农村学校合并在中美两国一定发展阶段大量出现是某些内外部共同因素作用的结果。农业生产力水平提高和农村人口因流动而骤减共同加速了农村人口特别是适龄教育人口的快速下降,形成了农村学校合并的外部压力;人们对农村教育质量提高和孩... 详细信息

农村学校合并在中美两国一定发展阶段大量出现是某些内外部共同因素作用的结果。农业生产力水平提高和农村人口因流动而骤减共同加速了农村人口特别是适龄教育人口的快速下降,形成了农村学校合并的外部压力;人们对农村教育质量提高和孩子受教育程度提升的追求、实现农村学校办学经济效率和社会效益优化的愿望则是推动大规模农村学校合并的直接动因。然而,中美两国尽管都对农村学校合并中的教育质量提高、效益优化和学生安全等重要事项予以积极关注,但由于管理体制不同、教育理念差异等多方面原因的叠加,二者在教育资源动员策略与方式的选择、在解决方案选取规则的澄清和农村学校合并最终格局的呈现等方面则存在较大差异,这些差异其实也是文化差异、治理结构差异乃至教育哲学差异对教育行为产生潜在或显在影响的反映。

关键词：农村学校合并质量安全效益

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Evidence for the involvement of infectious agents in the pathogenesis of Crohn's disease

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World Journal of Gastroenterology 2008年第6期14卷 845-852页

作者： Gert De Hertogh Jeroen Aerssens karen P Geboes Karel Geboes Karel Geboes Department of Pathology University Hospitals KULeuven Minderbroedersstraat 12 Leuven 3000 Belgium Tibotec bvba Generaal De Wittelaan L 11B 3 Mechelen 2800 Belgium Department of Gastroenterology University Hospitals KULeuven Herestraat 49 Leuven 3000 Belgium

Many advances have been made in the understanding of Crohn’s disease (CD) pathogenesis during the last decade. CD is currently seen as a predominantly T-lym-phocyte-driven disease characterized by the presence of a complex cocktail of interacting cytokines, chemokines and other mediators produced by a variety of cell types. Prevailing theories of CD pathogenesis suggest that patients’ T-lymphocytes are inappropriately activated in the setting of an immune imbalance, which is itself caused by an unfortunate confluence of genetic and en- vironmental factors. The T-cell response then leads to the chronic inflammation characteristic for the disease. Various environmental factors may play a role in the development of CD, but microbes are most consistently implied. This theory is based on epidemiological, clinico- pathological, genetic and experimental evidence. Despite the abundance of arguments for the implication of bac-teria in the aetiopathogenesis of CD, the precise role of bacteria in this disease still remains elusive. Three not necessarily mutually exclusive theories have been pro- posed: (1) an unidentified persistent pathogen; (2) an abnormally permeable mucosal barrier leading to exces-sive bacterial translocation; and (3) a breakdown in the balance between putative "protective" versus "harmful" intestinal bacteria ("dysbiosis"). At present, one cannot exclude with certainty any of these three proposed hy-potheses; they may all apply to CD to a certain extent.

关键词： Crohn's disease Etiology Microbiology

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lactobacilli,bifi dobacteria and *** nissle induce pro-and anti-inflammatory cytokines in peripheral blood mononuclear cells

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World Journal of Gastroenterology 2006年第37期12卷 5978-5986页

作者： Ulf Helwig karen M lammers Fernando Rizzello Patricia Brigidi Verena Rohleder Elisabetta Caramelli Paolo Giochetti Juergen Schrezenmeir Ulrich R Foelsch Stefan Schreiber Massimo Campieri University Hospital Schleswig-Holstein Campus Kiel 1~(st) Medical Department Schittenhelmstr.12 24105 Kiel Germany University of Bologna Department of Internal Medicine and Gastroenterology Policlinico S. Orsola Via Massarenti 9 40138 Bologna Italy University of Bologna Department of Internal Medicine and Gastroenterology Policlinico S. Orsola Via Massarenti 9 40138 Bologna Italy University of Bologna Institute for Microbiology Via Bellmeloro 9 40138 Bologna Italy University Hospital Schleswig-Holstein Campus Kiel 1~(st) Medical Department Schittenhelmstr.12 24105 Kiel Germany University of Bologna Histology and General Embryology and Pharmaceutical Science Via Bellmeloro 9 40138 Bologna Italy Federal Research Center for Nutrition and Food Location Kiel Institute for Physiology and Bioche- mistry of Nurtition Hermann-Weigmann-Str.1 24103 Kiel Germany

AIM： To investigate whether the stimulation of peripheral blood mononuclear cells （PBMNC） with the cell debris and cell extraction of different probiotic strains is similar or species specific. METHODS： Three strains of bifidobacteria, 4 strains of lactobacilli, and E. coli nissle were sonicated and centrifuged in order to divide them into cell extract and cell debris. PBMNC were separated by density gradient and incubated for 36 h with either the cell debris or the cell extract of single strains of probiotic bacteria in doses from 10^2 to 10^8 CFU/ml. Cell supernatants were taken and interleukin （Il）-10, Il-1β, and tumor necosis factor （TNF）-α were determined by ElISA. RESUlTS： Depending on the species super-family, the strains had different stimulation patterns. Except for both l. casei strains, the cell extract of bitTdobacteria and/actobacilli had less stimulating capacity than cell debris, whereas the cell extract of E. coli nissle had similar stimulating properties to that of the cell debris of the strain and significantly more stimulating capacity than that of bifidobacteria and lactobacilli. The cell debris of bifidobacteria stimulated more cytokine release than the cell debris of lactobacilli. The cell debris of lactobacilli did not have a stimulating capacity when lower concentrations were used. Neither cell extraction nor cell debris had an inhibitory effect on the production of the tested cytokines by stimulated PBMNC. CONClUSION： The incubation of probiotic strains, which have been used in clinical trials for inflammatory diseases, with immunocompetent cells leads to different species specific reactions. High Il-10 response to cell debris of bifidobacteria and E. coli nissle can be found. This corresponds to positive effects of bihdobacteria and E. coli nissle in clinical trials for inflammatory bowel disease compared to negative outcomes obtained with lactobacilli.

关键词： lactobacilli Bifidobacteria Probiotics Interleukin-l0 Tumor necrosis factor-α Interleukin-1β Peripheral blood mononuclear cells

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Anterior Cerebral Infarction by Fronto-Basal Meningioma

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Neuroscience & Medicine 2013年第4期4卷 277-289页

作者： Paul Macaire Ossou-Nguiet Dieu Donné Gnonlonfoun karen Obondzo-Aloba Hugues Brieux Ekouélé-Mbaki Gilbert Fabrice Otiobanda Department of Intensive Care University Hospital of Brazzaville Brazzaville Congo Department of Neurology University Hospital of Brazzaville Brazzaville Congo Department of Neurology University Hospital of Cotonou Cotonou Benin

The association between stroke and meningioma is rarely reported in the data. In most etiology classification, there is no compressive cause. The association between meningioma and stroke is increasingly reported. We report a case of 52-year-old woman, previously healthy, presented with sudden right hemiplegia with some transient mood disorders. The CT-scan revealed acute left anterior cerebral artery infarction associated with fronto-basale meningioma infiltrating both anterior cerebral arteries. She was treated by corticosteroid and rehabilitation, with partial recovery. No stroke prevention was used before surgical treatment.

关键词： Infarction Anterior Cerebral Artery Meningioma

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Stem and Progenitor Cell Expansionin Co-culture of Mobilized CD34^+ Cells and Osteopetrotic Mouse Stroma

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生物医学工程学杂志 2005年第S1期22卷 155-157页

作者： Na lI Pierre Feugier Deog-Yeon JO Jae Hung Shieh karen l.Mac Kenzie JF lesesve V latger-Cannard D Bensoussan Ronald G Crystal Shahin Rafii JF Stoltz Malcolm A.S.Moore Unitéde Thérapie Cellulaire et Banque de Tissus et UMR CNRS 7563 CHU et Facultéde Médecine de NancyFrance James Ewing laboratory of Developmental Hematopoiesis Memorial Sloan-Kettering Cancer CenterNew YorkNY 10021USA Hématologie Clinique NancyFrance Hématologie Biologique NancyFrance Division of Hematology-Oncology Weill Medical College of Cornell University-New York Presbyterian HospitalNew YorkNY 10021USA Institute of Genetic Medicine and Division of Pulmonary and Critical Care Medicine Weill Medical College of Cornell University-New York Presbyterian HospitalNew YorkNY 10021USA

1 IntroductionCulture systems capable of expanding and/or maintaining hematopoietic stem cells will not only facilitate our understanding of stem cell biology, but also broaden clinical applications. Among various in vitro hematopoietic culture systems, co-cultures of marrow or CD34+ cells with an adherent stromal layer that can produce cytokines and extracellular matrix components most effectively supports long-term hematopoiesis ( lTC ), mimicking the bone marrow micro-environment.

关键词： CD Cells and Osteopetrotic Mouse Stroma Stem and Progenitor Cell Expansionin Co-culture of Mobilized CD34

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