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Prospective cohort study on facial profile changes in infants with Robin sequence and healthy controls

World Journal of Pediatrics 2024年第6期20卷 581-589页

作者： Cornelia Wiechers Julian Sowula karen Kreutzer Christoph E.Schwarz Christina Weismann Michael Krimmel Christian f.Poets Bernd Koos Department of Neonatology Tuebingen University HospitalCalwerstrasse 772076 TuebingenGermany Center for Cleft Lip Palate and Craniofacial MalformationsTuebingen University HospitalTuebingenGermany Department of Orthodontics Tuebingen University HospitalTuebingenGermany Department of Oral and Maxillofacial Surgery Tuebingen University HospitalTuebingenGermany

Background Various conservative and surgical approaches exist to treat Robin sequence(RS),but their effects on facial profile and mandibular catch-up growth are unclear.A functional treatment concept,used in our centre for 25 years,includes an individualized palatal plate with a velo-pharyngeal extension and intensive feeding *** We performed a prospective study to objectively describe facial profiles in infants with RS treated with the above *** with isolated RS were admitted to our tertiary perinatal and national referral centre for craniofacial malformations between May 2018 and Nov *** with RS received 3D-photographs during clinically indicated *** controls were recruited from Dec 2018 to Sep 2019 and received 3D-photographs every 3 *** digitally measured jaw index(JI),defined as alveolar overjet(O)x maxillary arch(U)/mandibular arch(L),and the soft tissue reference points A’-point,Nasion’,B’-point angle(ANB’),describing the relative position of maxilla to mandible,were *** mixed models were used to examine time trajectories in JI and ANB’.Results A total of 2073D images,obtained in 19 infants with RS and 32 controls,were *** and ANB’decreased over time in both groups[for JI−0.18(95%CI−0.25 to−0.10);for ANB’:−0.40°per month[(95%CI−0.48 to−0.32)]]but remained lower in controls[for JI−2.5(95%CI−3.2 to−1.8);for ANB’-1.7°(95%CI−2.4 to−1.0)].Also,the ANB’model showed a significant effect of the interaction term diagnosis x *** Based on longitudinal 3D images,we describe changes in objective parameters of facial profile in infants with and without RS during the first year of *** findings indicate catch-up growth in infants treated for RS.

关键词： Infant Mandibular catch-up growth Pre-epiglottic Baton Plate Robin sequence Three-dimensional photography

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12周的来迪派韦/索磷布韦用于3至<6岁的慢性丙型肝炎病毒儿童感染患者时安全有效

12周的来迪派韦/索磷布韦用于3至<6岁的慢性丙型肝炎病毒儿童感染...

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第十届全国疑难及重症肝病大会

作者： Kathleen B.Schwarz Philip Rosenthal karen f.murray Jonathan Robert Honegger Winita Hardikar Rosemary Hague Naveen Mittal Benedetta Massetto Diana Brainard Rebecca Begley Bandita Parhy Jiang Shao Michael R.Narkewicz Girish S.Rao Suzanne Whitworth Sanjay Bansal William f.Balistreri Johns Hopkins Hospital University of California San francisco University of Washington School of Medicine and Seattle Children's Hospital The Ohio State University Medical Center The Royal Children's Hospital

背景基于索磷布韦的治疗方案已被批准用于12至<18岁的青少年患者,但对于年龄更小的儿童患者而言,标准治疗方案仍然是长达48周的聚乙二醇化干扰素+利巴韦林。之前,我们报告了有关12周或24周的来迪派韦/索磷布韦固定剂量组合(LDV/SOf fDC...

背景基于索磷布韦的治疗方案已被批准用于12至f fDC)用于6至f fDC疗法用于3至<6岁

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Reproductive patterns in Araucaria araucana forests in the Andean range, Chile

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Ecological Processes 2024年第1期13卷 252-261页

作者： Sergio Donoso karen Pe?a-Rojas Claudia Espinoza Carolain Badaracco Rómulo Santelices-Moya Antonio Cabrera-Ariza Mediterranean forests Laboratory Faculty of Forestry and Nature Conservation Centro Secano Faculty of Agricultural and Forestry Sciences Universidad Católica del Maule Maule Advanced Studies Research Center Vice-Rector's Office for Research and Postgraduate Studies Catholic University of Maule

Background Araucaria araucana is a mast species that presents a high variability in annual cone production. Researchers have recorded synchronization events in cone production in different populations, which allows the seed production to be concentrated, reducing the percentage of seeds consumed by different animal *** We sampled three populations located in the Andes Mountains, Araucanía Region, Chile. In 2004 we began the collection of data on cone production, for which we installed permanent plots（1200 m2each） at each location. We identified and labeled each female tree in each plot to monitor its cone production. In 2012 we selected a total of 30 trees near the plots to evaluate the number of seeds per cone. In each february from 2012 to 2014 we selected two mature cones and covered them with a porous mesh for subsequent collection and storage in March. At the beginning of June, we counted and weighed the seeds, determining the average weight, the number of seeds per cone, the germination capacity（GC）, and the germination speed（GS）.Results Cone production was synchronous across the three locations. We observed significant differences among the locations and years evaluated. The cones had fewer seeds in 2013（high production） compared to those in 2012（low production）, but their weights were similar. In 2014 the cones produced smaller seeds in fewer quantities. The difference between the years 2013 and 2014 resulted from the high-energy expenditure in 2013. Regarding GC and GS, there were significant differences among the three locations（GC: f = 45.41, p f = 96.08, p f cones produced in a given year. These annual fluctuations in seed production are determining factors in the population dynamics of forest species. Our results allow a better understanding of the reproductive phenology of A. araucana and could hel

关键词： Seed weight Germination potential Masting species Sustainable use Dioecious species

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12周或24周的索磷布韦+利巴韦林用于3至<12岁的基因2型或基因3型慢性丙型肝炎的儿童感染患者时安全有效

12周或24周的索磷布韦+利巴韦林用于3至<12岁的基因2型或基因3型...

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第十届全国疑难及重症肝病大会

作者： Philip Rosenthal Kathleen B.Schwarz Regino P Gonzalez-Peralta Chuan-Hao Lin Deirdre A.Kelly Scott Nightingale William f.Balistreri Sanjay Bansal Maureen M.Jonas Benedetta Massetto Diana Brainard Rebecca Begley Jiang Shao Bandita Parhy Suzanne Davison Cornelia feiterna-Sperling Lynette A.Gillis Giuseppe Indolfi Etienne M.Sokal karen f.murray Stefan Wirth University of California San francisco Johns Hopkins Hospital Pediatric Hepatology and Liver Transplantation University of Florida Children's Hospital Los Angeles

背景基于索磷布韦的治疗方案已被批准用于12至<18岁的青少年患者,但对于年龄更小的儿童患者而言,标准治疗方案仍然是长达48周的聚乙二醇化干扰素+利巴韦林。本研究评估了索磷布韦(SOf)+利巴韦林(RBV)全口服疗法用于3至<12岁的儿童患者...

背景基于索磷布韦的治疗方案已被批准用于12至f)+利巴韦林(RBV)全口服疗法用于3至<12岁的儿童患者时的安全性和疗效。方法 3至<12岁的慢性HCVGT2或GT3儿童患者入组本项正在进行的开放标签研究,接受

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A novel diagnostic gene region for distinguishing between two pest fruit flies:Bactrocera tryoni(froggatt)and Bactrocera neohumeralis(Hardy)(Diptera:Tephritidae)

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Insect Science 2024年第4期31卷 1285-1295页

作者： Melissa L.Starkie Elizabeth V.fowler Alexander M.Piper Xiaocheng Zhu Pauline Wyatt David Gopurenko Matt N.Krosch francesca Strutt karen f.Armstrong Hamish Patrick Mark K.Schutze Mark J.Blacket Department of Agriculture and fisheries BiosecurityBrisbaneQueenslandAustralia Agriculture Victoria AgriBioBundooraVictoriaAustralia Department of Primary Industries Wagga Wagga Agricultural InstituteWagga WaggaNew South WalesAustralia forensic Services Group Queensland Police ServiceBrisbaneQueenslandAustralia Department of Pest-management and Conservation Lincoln UniversityLincolnNew Zealand Better Border Biosecurity(B3 B3nz.org.nz)LincolnNew Zealand

Bactrocera tryoni and Bactrocera neohumeralis are morphologically similar sibling pest fruit fly species that possess different biological attributes,geographic distributions,and host *** need to differentiate between the two species is critical for accurate pest status assessment,management,biosecurity,and maintenance of reference *** morphologically similar,adults may be separated based on subtle characters;however,some characters exhibit intraspecific variability,creating overlap between the two ***,there is currently no single molecular marker or rapid diagnostic assay that can reliably distinguish between *** and ***;therefore,ambiguous samples remain *** we report the first molecular marker that can consistently distinguish between *** and *** diagnostic region consists of two adjacent single nucleotide polymorphisms(SNPs)within the pangolin(pan)gene *** confirmed the genotypes of each species are consistent across their distributional range,then developed a tetra-primer amplification refractory mutation system(ARMS)PCR assay for rapid diagnosis of the *** assay utilizes four primers in multiplex,with two outer universal primers,and two internal primers:one designed to target two adjacent SNPs(AA)present in *** and the other targeting adjacent SNPs present in ***(GG).The assay accurately discriminates between the two species,but their SNP genotypes are shared with other nontarget tephritid fruit fly ***,this assay is most suited to adult diagnostics where species confirmation is necessary in determining ambiguous surveillance trap catches;maintaining pure colony lines;and in Sterile Insect Technique management responses.

关键词： ARMS-PCR colony molecular diagnostics pangolin tetra-primer

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2023年美国麻醉医师学会神经肌肉阻滞监测与拮抗实践指南:美国麻醉医师学会工作组关于神经肌肉阻滞的报告

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中华麻醉学杂志 2024年第5期44卷 518-542页

作者： Stephan R.Thilen Wade A.Weigel Michael M.Todd Richard P.Dutton Cynthia A.Lien Stuart A.Grant Joseph W.Szokol Lars I.Eriksson Myron Yaster Mark D.Grant Madhulika Agarkar Anne M.Marbella Jaime f.Blanck karen B.Domino 西雅图华盛顿州明尼阿波里斯明尼苏达州达拉斯得克萨斯州密尔沃基威斯康星州教堂山北卡罗来纳州洛杉矶加利福尼亚州斯德哥尔摩瑞典丹佛科罗拉多州绍姆堡伊利诺斯州巴尔的摩马里兰州

本实践指南基于证据提供了全身麻醉期间及术后神经肌肉功能监测与阻滞拮抗的管理推荐。主要关注神经肌肉功能监测的类型与部位及阻滞拮抗的过程,以减少肌肉松弛药残留阻滞。

关键词：神经肌肉阻滞肌肉松弛药神经肌肉功能监测舒更葡糖钠新斯的明

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Bio/hydrochar Sorbents for Environmental Remediation

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Energy & Environmental Materials 2020年第4期3卷 453-468页

作者： Xingguang Zhang Yang Wang Junmeng Cai karen Wilson Adam f.Lee College of Chemical Engineering Nanjing Forestry UniversityNanjing 210037China Department of Chemistry School of ScienceUniversity of Shanghai for Science and TechnologyShanghai 200093China Biomass Energy Engineering Research Center School of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China School of Science RMIT UniversityMelbourne VIC 3000Australia

A rising global population and aspirational higher living standards has driven a step change in resource utilization and concomitant anthropogenic pollution across the ***-cost and scalable technologies for environmental remediation are therefore urgently sought,with an emphasis on trash-to-treasure strategies that exploit abundant but underutilized waste by-products of existing *** are carbon-rich,porous solids produced by biomass pyrolysis under anaerobic or oxygen-scarce conditions at high temperature(350–700°C),while hydrochars are produced by hydrothermal biomass carbonization at lower temperature(130–250°C)and high autogenous pressures(0.3–4.0 MPa).Bio/hydrochars possess unique physicochemical properties,notably high surface areas(100–1500 m2 g-1)and porosity(0.25–2.5 cm^(3)g^(-1))and rich surface chemistry featuring carboxylic,phenolic,hydroxyl,and carbonyl functions,amenable to chemical,physical,or biochemical modification,rendering them ideal sorbents for pollutants such as heavy metals(*** and Cr),and toxic organic(e.g.,dyes and xenobiotics)and inorganic(e.g.,SO_(2))***/hydrochars are attractive for environmental remediation of pollutant mixtures by surface complexation,redox chemistry,electrostatic interactions/ion exchange,or *** review discusses recent opportunities and challenges in creating bio/hydrochar sorbents and their nanocomposites through grafting,doping,and chemical/physical activation,for the depollution of aquatic and atmospheric environments.

关键词： adsorption biochar environmental remediation hydrochar

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SO2、Hf对小麦、大麦产量及品质的联合影响

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环境科学与管理 1990年第3期 10-12页

作者： f.murray S.wilson 刘国振

本文研究了SO2、Hf对小麦、大麦的产量及品质的联合影响。SO2浓度为130和267μgm-3,Hf浓度为0.03和0.38μgm-3,实验在顶部开口的桶中进行,为期90天。在所用浓度下,SO2比Hf具有更大的影响。所有反应的一个显著特点是补偿效应。虽然SO2减... 详细信息

本文研究了SO2、Hf对小麦、大麦的产量及品质的联合影响。SO2浓度为130和267μgm-3,Hf浓度为0.03和0.38μgm-3,实验在顶部开口的桶中进行,为期90天。在所用浓度下,SO2比Hf具有更大的影响。所有反应的一个显著特点是补偿效应。虽然SO2减少了小麦地上部重量,但各处理对产量并无影响。SO2促进了大麦的生长,增加了产量,并且SO2和Hf都使籽粒蛋白含量增加。SO2和Hf混合物的效应较为复杂,但通常是对抗性的,加入Hf可以抵消SO2单独存在的影响。

关键词：大麦麦类作物小麦产量

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SO_2、Hf对小麦、大麦产量及品质的联合影响

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国外环境科学技术 1990年第3期 10-12页

作者： f.murray S.wilson 刘国振

本文研究了SO_2、Hf对小麦、大麦的产量及品质的联合影响。SO_2浓度为130和267μgm^(-3),Hf浓度为0.03和0.38μgm^(-3),实验在顶部开口的桶中进行,为期90天。在所用浓度下,SO_2比Hf具有更大的影响。所有反应的一个显著特点是补偿效应。... 详细信息

本文研究了SO_2、Hf对小麦、大麦的产量及品质的联合影响。SO_2浓度为130和267μgm^(-3),Hf浓度为0.03和0.38μgm^(-3),实验在顶部开口的桶中进行,为期90天。在所用浓度下,SO_2比Hf具有更大的影响。所有反应的一个显著特点是补偿效应。虽然SO_2减少了小麦地上部重量,但各处理对产量并无影响。SO_2促进了大麦的生长,增加了产量,并且SO_2和Hf都使籽粒蛋白含量增加。SO_2和Hf混合物的效应较为复杂,但通常是对抗性的,加入Hf可以抵消SO_2单独存在的影响。

关键词： SO2 Hf 小麦大麦产量品质

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耐药结核病:现实与潜在的威胁

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国际结核病与肺部疾病杂志 2010年第2期5卷 255-258页

作者： Series editor.John f.murray 赵津王雪静 Department of Pulmonology and Critical Care Nelson R Mandela School of MedicineUniversity of KwaZulu NatalDurbanSouth Africa

根据世界卫生组织估算:2008年全球新发结核病例890～990万例;在因结核病死亡的病例中,110～170万例未感染人免疫缺陷病毒(HIV),45～67万例感染了HIV。几年来,尽管做出了很大努力,但非洲国家仍然具有不成比例的全球结核病负担(人口占世界... 详细信息

根据世界卫生组织估算:2008年全球新发结核病例890～990万例;在因结核病死亡的病例中,110～170万例未感染人免疫缺陷病毒(HIV),45～67万例感染了HIV。几年来,尽管做出了很大努力,但非洲国家仍然具有不成比例的全球结核病负担(人口占世界的n % , 结核病患者例数却占全球的29 % )2 ' 在2007 年的结核病全球报告中, 报告了抗结核治疗成功率达到87 % , 第1 次实现了1991 年设定的治疗成功率85 % 的目标- ' 尽管成绩显著, 但随着H IV 的流行, 结核病仍然是全球公共卫生的主要威胁; 耐药结核病( 包括耐多药(MDR) 和广泛耐药( XDR) 发病率的升高加剧了这一威胁, 尤其是在发展中国家' 如果不花大力气! 有效而迅速的改变产生MDR 和XDR 结核病的状况, 那么泛耐药结核病( 即结核分枝杆菌对已知的全部抗结核药均耐药) 这个可怕的幽灵将到来。

关键词：耐药结核病 XDR TB HIV MDR 结核病患者耐多药抗结核药抗结核病药抗感染药结核病控制

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