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Prospe.tive.e.aluation of ^(18)F-FDG positron e.ission tomography in the.pre.pe.ative.staging of patie.ts with he.atic colore.tal me.astase.

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He.atobiliary Surge.y and Nutrition 2022年第4期11卷 539-554页

作者： Tim Akhurst Mithat Göne. Raymond e.Base. Lawre.ce.H.Schwartz Scott Tuorto Lynn A.Brody Anne.Cove. karen T.Brown Ste.e. M.Larson Yuman Fong De.artme.t of Radiology Memorial Sloan-Kettering Cancer CenterNew YorkNYUSA Pe.e. MacCallum Cance. Ce.tre VictoriaAustralia De.artme.t of e.ide.iology and Biostatistics Memorial Sloan-Kettering Cancer CenterNew YorkNYUSA De.artme.t of Surge.y Memorial Sloan-Kettering Cancer CenterNew YorkNYUSA

Background:De.pite.conside.able.advance. in pre.pe.ative.imaging,up to one.third of patie.ts ope.ative.y e.plore. for he.atic colore.tal me.astase. are.une.pe.te.ly found to harbor unre.e.table.intrahe.atic or e.trahe.atic ***:The.curre.t study is a prospe.tive.blinde. study comparing utility of[18F]2-fluoro-2-de.xyglucose.positron e.ission tomography(18F-FDG-Pe.)to compute. tomography(CT)and CT arte.ial portography(CTAP)as pre.pe.ative.***:The.125 planne. subje.ts we.e.*** se.n on FDG-Pe. alone.change. the.apy for 23 of 125 patie.ts(18%).FDG-Pe. confirme. othe. radiologic findings in 16 case.(13%),for an ove.all influe.ce.on the.apy in 39 case.(31%).FDG-Pe. was the.most se.sitive.diagnostic imaging te.t for e.trahe.atic cance.;it was 80-90%se.sitive.for e.trahe.atic cance. and 70-90%*** the.28 case. of unre.e.table.dise.se.due.to e.trahe.atic dise.se.FDG-Pe. findings sole.y change. the.apie. in 16 case.(57%)and influe.ce. the.apy in se.e. othe. case.(25%).Of the.21 unre.e.table.case. due.to e.te.t of intrahe.atic dise.se.FDG-Pe. did not sole.y change.the.apy in ***,FDG-Pe. had the.lowe.t se.sitivity for he.atic site. compare. with CT or *** particular,small(e. tumors we.e.particularly poorly de.e.te. by *** are. unde. the.re.e.ve. ope.ating characte.istic(ROC)curve.for small tumors was 0.58 and for patie.ts on che.othe.apy it was 0.66,a mode.t improve.e.t ove. no ***:FDG-Pe. is an important te.t for pre.pe.ative.staging of patie.ts with he.atic colore.tal me.astase.,affe.ting tre.tme.t de.isions in ne.rly one.third of *** high yie.d is due.mainly to de.e.tion of e.trahe.atic *** is the.e.ore.re.omme.de. in patie.ts with e.trahe.atic le.ions suspe.te. to be.disse.inate. cance. or those.with high risk for e.trahe.atic *** is not a good te.t for ide.tification of small tumors in the.live..

关键词： Positron e.ission tomography(Pe.) compute. tomography(CT) colore.tal he.atic me.astase. surge.y

Suppre.sion of oste.sarcoma progre.sion by e.gine.re. lymphocyte.de.ive. prote.me.

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Ge.e. & Dise.se. 2023年第4期10卷 1641-1656页

作者： Ke.in Li Xun Sun Hudie.Li Hailan Ma Me.g Zhou Kazumasa Minami Ke.suke.Tamari Kazuhiko Ogawa Pankita HPandya MRe.a Saadatzade. Me.issa AKace.a karen e.ollok Bai-Yan Li Hiroki Yokota De.artme.t of Pharmacology School of PharmacyHarbin Medical UniversityHarbinHeilongjiang 150081China De.artme.t of Biome.ical e.gine.ring Indiana University Purdue University IndianapolisIndianapolisIN 46202USA De.artme.t of Radiation Oncology Osaka University Graduate School of MedicineSuitaOsaka 565-0871Japan Simon Compre.e.sive.Cance. Ce.te. Indiana University School of MedicineIndianapolisIN 46202USA De.artme.t of Pe.iatrics Indiana University School of MedicineIndianapolisIN 46202USA De.artme.t of Orthopae.ic Surge.y Indiana University School of MedicineIndianapolisIN 46202USA Indiana Ce.te. for Musculoske.e.al He.lth Indiana University School of MedicineIndianapolisIN 46202USA

Cance. ce.ls te.d to de.e.op re.istance.to che.othe.apy and e.hance.aggre.sive.ne.s.A counte.intuitive.approach is to tame.aggre.sive.e.s by an age.t that acts opposite.to che.othe.ape.tic *** on this strate.y,induce. tumor-suppre.sing ce.ls(iTSCs)have.be.n ge.e.ate. from tumor ce.ls and me.e.chymal ste. ***,we.e.amine. the.possi-bility of ge.e.ating iTSCs from lymphocyte. by activating PKA signaling for suppre.sing the.pro-gre.sion of oste.sarcoma(OS).While.lymphocyte.de.ive. CM did not pre.e.t anti-tumor capabilitie.,the.activation of PKA conve.te. the. into *** PKA conve.se.y ge.e.-ate. tumor-promotive.*** a mouse.mode.,PKA-activate. CM suppre.se. tumorinduce. bone.*** analysis re.e.le. that moe.in(MSN)and calre.iculin(Calr),which are.highly e.pre.se. intrace.lular prote.ns in many cance.s,we.e.e.riche. in PKA-activate. CM,and the. acte. as e.trace.lular tumor suppre.sors through CD44,CD47,and *** study pre.e.te. a unique.option for cance. tre.tme.t by ge.e.ating iTSCs that se.re. tumor-suppre.sive.prote.ns such as MSN and *** e.vision that ide.tifying the.e.tu-mor suppre.sors and pre.icting the.r binding partne.s such as CD44,which is an FDA-approve. oncoge.ic targe. to be.inhibite.,may contribute.to de.e.oping targe.e. prote.n the.apy.

关键词： Calre.iculin Lymphocyte. Moe.in Oste.sarcoma PKA Prote.me

e.ide.ce.of bisphosphonate.conjugate. sitafloxacin e.adication of e.tablishe. me.hicillin-re.istant *** infe.tion with osse.inte.ration in murine.mode.s of implant-associate. oste.mye.itis

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Bone.Re.e.rch 2023年第4期11卷 751-763页

作者： Youliang Re. Jason We.ks Thomas Xue.Joshua Rainbolt karen L.de.Me.y Be.tle. Ye.Shu Yuting Liu e.ysia Maste.s Philip Che.ian Charle. e.McKe.na Je.fre. Ne.ghbors Frank H.e.e.ino e.ward M.Schwarz Shuting Sun Chao Xie Ce.te. for Musculoske.e.al Re.e.rch University of Rochester Medical CenterRochesterNY 14642USA De.artme.t of Orthopae.ics University of Rochester Medical CenterRochesterNY 14642USA De.artme.t of Pathology and Ce.te. for Advance. Re.e.rch Te.hnologie. University of Rochester Medical CenterRochesterNY 14642USA BioVinc LLCPasadenaCA 91107USA De.artme.t of Che.istry University of Southern CaliforniaLos AngelesCA 90089USA De.artme.t of Pharmacology Pennsylvania State UniversityHersheyPA 17033USA De.artme.t of Che.istry University of RochesterRoche

e.adication of MRSA oste.mye.itis re.uire. e.imination of distinct *** ove.come.this,we.de.e.ope. bisphosphonate.onjugate. sitafloxacin(BCS,BV600072)and hydroxybisphosphonate.conjugate.sitafloxacin(HBCS,BV63072),which achie.e.targe.-and-re.e.se.drug de.ive.y proximal to the.bone.infe.tion and have.prophylactic e.ficacy against MRSA static biofilm in vitro and in *** we.e.aluate. the.r the.ape.tic e.ficacy in a murine.1-stage.e.change.fe.oral plate.mode. with biolumine.ce.t MRSA(USA300LAC::lux).Oste.mye.itis was confirme. by CFU on the.e.plants and longitudinal biolumine.ce.t imaging(BLI)afte. de.ride.e.t and implant e.change.surge.y on day 7,and mice.we.e.randomize. into se.e. groups:1)Base.ine.harve.te. at day7,no tre.tme.t);2)HPBP(bisphosphonate.control for BCS)+vancomycin;3)HPHBP(hydroxybisphosphonate.control for HBCS)+vancomycin;4)vancomycin;5)sitafloxacin;6)BCS+vancomycin;and 7)HBCS+*** confirme. infe.tion pe.siste. in all groups e.ce.t for mice.tre.te. with BCS or HBCS+*** re.e.le. catastrophic fe.ur fracture. in all groups e.ce.t mice.tre.te. with BCS or HBCS+vancomycin,which also displaye. de.re.se. in pe.i-implant bone.loss,oste.clast numbe.s,and *** confirm this,we.asse.se. the.e.ficacy of vancomycin,sitafloxacin,and HBCS monothe.apy in a transtibial implant *** re.ults showe. comple.e.lack of vancomycin e.ficacy while.all mice.tre.te. with HBCS had e.ide.ce.of infe.tion control,and some.had e.ide.ce.of osse.us inte.rate. se.tic implants,sugge.tive.of biofilm *** toge.he. the.e.studie. de.onstrate.that HBCS adjuvant with standard of care.de.ride.e.t and vancomycin the.apy has the.pote.tial to e.adicate.MRSA oste.mye.itis.

关键词： implant infe.tion ove.come

Nove. mate.ial tailoring me.hod for inte.nally pre.surize. FG sphe.ical and cylindrical ve.se.s

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Acta Me.hanica Sinica 2018年第5期34卷 936-948页

作者： Fayyaz Nosouhi De.navi Ali Parvizi karen Abrinia School of Me.hanical e.gine.ring College of EngineeringUniversity of TehranTehranIran

A ne. mate.ial tailoring me.hod for sphe.ical and cylindrical ve.se.s made.of functionally grade. mate.ials (FGMs) is *** is assume. that the.FG mate.ial is compose. of an A1-SiC me.allic-matrix composite.A uniform ratio of inplane.she.r stre.s to yie.d stre.gth [φ(r)] is use. as the.de.ign crite.ion to utilize.the.maximum capacity of the.*** aim is to find a distribution of SiC particle. in the.radial dire.tion,i.e.,f(r),that achie.e. a uniform inde. φ(r) =const,through the.wall thickne.s of the.inte.nally pre.surize. sphe.ical or cylindrical *** the.Mori-Tanaka and rule.of-mixture. homoge.ization sche.e. are.use. to e.pre.s the.e.fe.tive.e.astic module.and Poisson's ***,the.stre.gth of the.composite.is e.pre.se. base. on the.rule.of ***,finite.e.e.e.t simulation is carrie. out to ve.ify the.accuracy of the.analytical *** e.fe.ts of input parame.e.s such as the.inte.nal pre.sure.stre.gth of the.SiC particle.,ratio of in-plane.she.r stre.s to e.fe.tive.yie.d stre.gth,and choice.of homoge.ization sche.e.on the.tailore. distribution of the.SiC volume.fraction in the.radial dire.tion are.also inve.tigate..

关键词： Mate.ial tailoring Sphe.e Cylinde. FGM Mori-Tanaka Rule of mixture.

Gastric Be.oar afte. Ve.tical Bande. Gastroplasty: A Case.Re.ort and Re.ie. of the.Lite.ature

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Surgical Scie.ce 2011年第5期2卷 242-245页

作者： Abdul S. Bangura Ste.in Johnson karen e. Gibbs 不详

Gastric be.oars are.uncommon in the.bariatric surge.y population. Though popular in e.rlie. de.ade., the.Ve.tical Bande. Gastroplasty (VBG) is no longe. a staple.proce.ure.in the.Unite. State.. It has be.n supplante. by the.Roux-e.-Y gastric bypass (RYGBP) and the.laparoscopic adjustable.gastric band (LAGB) as the.most commonly pe.forme. bariatric proce.ure.. Howe.e., the.e.are.many patie.ts who have.pre.iously unde.gone.VBGs, and may pre.e.t with associate. complications. We.pre.e.t a case.of a gastric obstruction cause. by a be.oar in a patie.t who had a VBG fifte.n ye.rs prior to pre.e.tation.

关键词： Ve.tical Bande. Gastroplasty Bariatric Surge.y Be.oar Obstruction

Mole.ular Characte.ization of the.Calvin Cycle.e.zyme.Phosphoribulokinase.in the.Strame.opile.Alga Vauche.ia litore. and the.Plastid Hosting Mollusc e.ysia chlorotica

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Mole.ular Plant 2009年第6期2卷 1384-1396页

作者： Mary e. Rumpho Sirisha Pochare.dy Jare. M. Worful e.izabe.h J. Summe. De.ashish Bhattacharya karen N. Pe.le.re.u Mary S. Tyle. Jungho Le. Jame. R. Manhart Kara M. Soule De.artme.t of Bioche.istry Microbiology and Molecular Biology 5735 Hitchner Halt University of Maine Orono ME 04469 USA De.artme.t of Biology Texas A&M University College Station TX 77843 USA De.artme.t of e.ology Evolution and Natural Resources Institute of Marine and Coastal Sciences Rutgers University New Brunswick NJ 08901 USA School of Biology and e.ology University of Maine Orono ME 04469 USA Gre.n Plant Institute #2-202 Bio Valley Seoul National University 103-2 Seodun Gwonseon Suwon Gyeonggi 441-853 Korea De.artme.t of Bioche.istry and Biophysics Texas A&M University College Station TX 77843 USA

Phosphoribulokinase.（PRK）, a nucle.r-e.code. plastid-localize. e.zyme.unique.to the.photosynthe.ic carbon re.uction （Calvin） cycle. was clone. and characte.ize. from the.strame.opile.alga Vauche.ia litore.. This alga is the.source.of plastids for the.mollusc （se. slug） e.ysia chlorotica which e.able.the.animal to survive.for months sole.y by photoautotrophic CO2 fixation. The.1633-bp V. litore. prk ge.e.was clone. and the.coding re.ion, found to be.inte.rupte. by four introns, e.code. a 405-amino acid prote.n. This prote.n contains the.typical bipartite.targe. se.ue.ce.e.pe.te. of nucle.re.code. prote.ns that are.dire.te. to comple. （i.e. four me.brane.bound） algal plastids. De.novo synthe.is of PRK and e.zyme.activity we.e.de.e.te. in e. chlorotica in spite.of having be.n starve. of V. litore. for se.e.al months. Unlike.the.algal e.zyme. PRK in the.se. slug did not e.hibit re.ox re.ulation. Two copie. of partial PRK-e.coding ge.e. we.e.isolate. from both se. slug and aposymbiotic se. slug e.g DNA using PCR. e.ch copy contains the.nucle.tide.re.ion spanning e.on 1 and part of e.on 2 of V litore. prk, including the.bipartite.targe.ing pe.tide. Howe.e., the.large. prk fragme.t also include. intron 1. The.e.on and intron se.ue.ce. of prk in e. chlorotica and V/itore. are.ne.rly ide.tical. The.e.data sugge.t that PRK is diffe.e.tially re.ulate. in V. litore. and e. chlorotica and at le.st a portion of the.V. litore. nucle.r PRK ge.e.is pre.e.t in se. slugs that have.be.n starve. for se.e.al months.

关键词： Alga Calvin cycle e.ysia chlorotica kle.toplast mollusc phosphoribulokinase photosynthe.is plastid re.ox re.ulation strame.opile symbiosis Vauche.ia litore..

Portugue.e.For Dummie. 2

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Insights into social re.ationships among fe.ale.black howle. monke.s Alouatta pigra at Pale.que.National Park, Me.ico

丛书名： --For dummie.

2013年

作者： karen Ke.le.

ISBN: (数字)9781118461266

ISBN: (纸本)1118399218;9781118399217

The.fast and e.sy way to le.rn to spe.k Brazilian Portugue.e.uick! What's the.most wide.y spoke. language.in South Ame.ica? That's right, Portugue.e. And what's the.faste.t, e.sie.t, most e.joyable.way to le.rn Portugue.e. Portugue.e.for Dummie., of course. This fun, frie.dly guide.he.ps you start spe.king Brazilian Portugue.e.imme.iate.y!Whe.he. you're.a stude.t, a trave.e., or you work in busine.s or gove.nme.t, you'll love.its practical le.sons, cultural facts, and handy re.e.e.ce.—including a Portugue.e.e.glish mini-dictionary, lists of vital ve.bs, and more.Have.e.e.yday conve.sations in Portugue.e.ake.se.se.of Portugue.e.grammarUse.idioms and popular e.pre.sionsImprove.your pronunciationGrasp ve.b conjugationsGe. around in Portugue.e.spe.king countrie.Portugue.e.For Dummie. come. comple.e.with a CD loade. with re.l-life.dialogue. that he.p you unde.stand and pronounce.this love.y, lyrical language.with ***-ROM/DVD and othe. supple.e.tary mate.ials are.not include. as part of the.e.book file. but are.available.for download afte. purchase

关键词： dummie. lite.ature language portugue.e

来源：畅想之星图书光盘版（南... 评论

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Curre.t Zoology 2011年第1期57卷 1-7页

作者： Sarie.VAN Be.Le.Ale.andro e.TRADA karen B. STRIe. De.artme.t of Zoology University of Wisconsin-Madison USA e.taclon de.Blologla Tropical Los Tuxtlas Instituto de Biologfa Universidad Nacional Autonoma de Mexico Mexico De.artme.t of Anthropology University of Wisconsin-Madison USA

We.inve.tigate. the.social re.ationships among adult fe.ale. in two multimale.multife.ale.groups of black howle. monke.sAlouatta pigraduring a 14-month study in Pale.que.National Park, Me.ico. Base. on ove. 900 focal hours and ove. 5400 scan sample. re.ording ne.ghboring group me.be.s, we.found that fe.ale. ve.y rare.y e.gage. in agonistic inte.actions and no dominance.hie.archy could be.disce.ne.. Re.ationships among re.ide.t fe.ale. we.e.primarily affiliative. but fe.ale. of one.study group spe.t a highe. proportion of time.in close.proximity and e.gage. in affiliative.inte.actions with one.anothe. at highe. rate. than fe.ale. in the.othe. study group. The.stre.gth of fe.ale.re.ationships incre.se. with the.birth of an infant. Although no fe.ale. immigrate. during the.study pe.iod, the.te.porary association of thre. e.tragroup fe.ale. with our study groups implie. that the.social syste. of black howle. monke.s is more.dynamic than pre.iously sugge.te.. The.e.findings sugge.t that fe.ale.black howle. monke.s be.ave.more.similarly to fe.ale.re. howle. monke.sA. se.iculusthan to fe.ale.mantle. howle. monke.sA. palliata.

关键词：国家公园社会关系墨西哥雌性猴层次结构相互作用社会制度

Intrave.ous halope.idol for the.tre.tme.t of intractable.vomiting,cyclical vomiting,and gastropare.is

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World Journal of e.e.ge.cy Me.icine 2021年第3期12卷 228-231页

作者： Brad e.Schwartz karen Ke.le. Bake. Andre. J.Ble.nbe.ge. Amina Lle.hi Raul Cruz-Cano De.artme.t of e.e.ge.cy Me.icine University of Maryland Capital Region HealthUM Prince George’s Hospital CenterCheverly 20785USA Ross Unive.sity School of Me.icine.Bridge.own Bridgetown 11093Barbados De.artme.t of e.ide.iology and Biostatistics School of Public Health of the University of MarylandBaltimore 21201USA

De.r e.itor,The.incide.ce.of e.e.ge.cy de.artme.t(e.)visits from gastropare.is and cannabinoid hype.e.e.is syndrome.has incre.se. by two folds ove. the.past de.ade.[1-3]Roldan e. al[4]re.orte. that patie.ts with the.e.conditions ofte. have.prolonge. e. stays and are.like.y to be.hospitalize. be.ause.of the.dange. of de.ydration and challe.ge. inhe.e.t in re.ie.ing *** analge.ia is a particularly trouble.ome.tre.tme.t modality;the.e.conditions are.ofte. chronic with fre.ue.t re.urre.ce.,and re.e.te. opiate.the.apy can cause.opioid de.e.de.cy and narcotic bowe. syndrome.[5]Halope.idol(HP)and drope.idol,me.be.s of the.butyrophe.one.class,have.pote.t antidopamine.gic activity in the.che.ore.e.tor trigge. zone.[6,7]Intramuscular administration of HP is be.ng use. incre.singly in the.e. to tre.t nause.,vomiting se.ondary to gastropare.is,[6]intractable.vomiting,[8]and cyclical vomiting.

关键词： vomiting gastro tre.tme.t