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Prospective cohort study on facial profile changes in infants with Robin sequence and healthy controls

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World Journal of Pediatrics 2024年第6期20卷 581-589页

作者： Cornelia Wiechers Julian Sowula karen Kreutzer Christoph E.Schwarz Christina Weismann Michael Krimmel Christian F.Poets bernd Koos Department of Neonatology Tuebingen University HospitalCalwerstrasse 772076 TuebingenGermany Center for Cleft Lip Palate and Craniofacial MalformationsTuebingen University HospitalTuebingenGermany Department of Orthodontics Tuebingen University HospitalTuebingenGermany Department of Oral and Maxillofacial Surgery Tuebingen University HospitalTuebingenGermany

background Various conservative and surgical approaches exist to treat Robin sequence(RS),but their effects on facial profile and mandibular catch-up growth are unclear.A functional treatment concept,used in our centre for 25 years,includes an individualized palatal plate with a velo-pharyngeal extension and intensive feeding *** We performed a prospective study to objectively describe facial profiles in infants with RS treated with the above *** with isolated RS were admitted to our tertiary perinatal and national referral centre for craniofacial malformations between May 2018 and Nov *** with RS received 3D-photographs during clinically indicated *** controls were recruited from Dec 2018 to Sep 2019 and received 3D-photographs every 3 *** digitally measured jaw index(JI),defined as alveolar overjet(O)x maxillary arch(U)/mandibular arch(L),and the soft tissue reference points A’-point,Nasion’,b’-point angle(ANb’),describing the relative position of maxilla to mandible,were *** mixed models were used to examine time trajectories in JI and ANb’.Results A total of 2073D images,obtained in 19 infants with RS and 32 controls,were *** and ANb’decreased over time in both groups[for JI−0.18(95%CI−0.25 to−0.10);for ANb’:−0.40°per month[(95%CI−0.48 to−0.32)]]but remained lower in controls[for JI−2.5(95%CI−3.2 to−1.8);for ANb’-1.7°(95%CI−2.4 to−1.0)].Also,the ANb’model showed a significant effect of the interaction term diagnosis x *** based on longitudinal 3D images,we describe changes in objective parameters of facial profile in infants with and without RS during the first year of *** findings indicate catch-up growth in infants treated for RS.

关键词： Infant Mandibular catch-up growth Pre-epiglottic baton Plate Robin sequence Three-dimensional photography

Impact of exercise on markers of b cell-related immunity:A systematic review

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Journal of Sport and Health Science 2024年第3期13卷 339-352,I0002页

作者： David Walzik Sergen belen karen Wilisch Marie Kupjetz Silvana Kirschke Tobias Esser Niklas Joisten Alexander Schenk Sebastian Proschinger Philipp Zimmer Division of Performance and Health(Sports Medicine) Institute for Sport and Sport ScienceTU Dortmund UniversityDortmund 44227Germany

background:b cells represent a crucial component of adaptive immunity that ensures long-term protection from infection by generating pathogen-specific *** alters b cell counts and immunoglobulin levels,but evidence-based conclusions on potential benefits for adaptive immunity are *** systematic review assessed current literatures on the impact of acute exercise and exercise training on b cells,immunoglobulins,and markers of secretory immunity in human ***:According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)guidelines,MEDLINE,Web of Science,and Embase were searched on March 8,***-randomized controlled trials and crossover trials investigating the impact of acute exercise or exercise training on b cell counts and proportions,immunoglobulin levels,salivary flow rate,or secretory immunoglobulin A secretion rate were *** and reporting of exercise training studies were assessed using the Tool for the Assessment of Study Quality and reporting in *** characteristics,outcome measures,and statistically significant changes were summarized ***:Of the 67 eligible studies,22 applied acute exercise and 45 applied exercise *** included outcomes revealed significant alterations over time in acute exercise and exercise training context,but only a few investigations showed significant differences compared to control *** and plasma immunoglobulin A levels were most consistently increased in response to exercise ***:b cell-related outcomes are altered by acute exercise and exercise training,but evidence-based conclusions cannot be drawn with high confidence due to the large heterogeneity in populations and exercise ***-designed trials with large sample sizes are needed to clarify how exercise shapes b cell-related immunity.

关键词： Antibody b-lymphocyte Exercise Humoral immunity Immune system

Confirmation of a Sub-Saturn-size Transiting Exoplanet Orbiting a G Dwarf:TOI-1194 b and a Very Low Mass Companion Star: TOI-1251 b from TESS

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Research in Astronomy and Astrophysics 2024年第3期24卷 129-143页

作者： Jia-Qi Wang Xiao-Jun Jiang Jie Zheng Hanna Kellermann Arno Riffeser Liang Wang karen A.Collins Allyson bieryla Lars A.buchhave Steve b.Howell Elise Furlan Eric Girardin Joao Gregorio Eric Jensen Felipe Murgas Mesut Yilmaz Sam Quinn Xing Gao Ruo-Yu Zhou Frank Grupp Hui-Juan Wang CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy Of SciencesBeijing 10010China University of Chinese Academy of Sciences Beijing 100049China University Observatory Munich Scheinertrsse 1.D-81679 MunichGemany Max Planck Institute for Extraterrestrial Physics Giessenbachstr.1D-85748 GarchingGermany National Astronomical Observatories/Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing210042China CAS Key Laboratory of Astronomical Optics&Technology Nanjing Institute of Astronomical Optics&TechnologyNanjing 210042China Center for Astrophysics Harvard&Smithsonian60 Garden Street.CambridgeMA 02138USA National Space Institute Technical University of DenmarkElektrovejDK-2800 KgsLyngbyDenmark NASA Ames Research Center Moffett FieldCA 94035USA NASA Exoplanet Science Institute Caltech/IPACMail Code 100-221200 E.California Blvd.PasadenaCA91125USA Grand Pra Observatory Switzerland Department of Physics Washington UniversitySt.LouisMO 63130.USA Department of Physics and Astronomy Swarthmore CollegeSwarthmorePA 19081USA Instituto de Astrofísica de Canarias(IAC) E-38205 La Laguna.TenerifeSpain Departamento de Astrofísica Universidad de La LagunaSpain Dept.of Astronomy and Space Sciences Ankara UniversityTandogan 06100AnkaraTurkey Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Urumqi No.1 Senior High School Urumqi 830002China Lijiang Gemini Observatory Lijiang 674199China

We report the confirmation of a sub-Saturn-size exoplanet,TOI-1194 b,with a mass of about 0.456+0.055-0.051M_(J),and a very low mass companion star with a mass of about 96.5±1.5 MJ,TOI-1251 *** candidates provided by the Transiting Exoplanet Survey Satellite(TESS)are suitable for further follow-up observations by ground-based telescopes with small and medium *** analysis is performed based on data from several telescopes worldwide,including telescopes in the Sino-German multiband photometric campaign,which aimed at confirming TESS Objects of Interest(TOIs)using ground-based small-aperture and medium-aperture telescopes,especially for long-period ***-1194 b is confirmed based on the consistent periodic transit depths from the multiband photometric *** measure an orbital period of 2.310644±0.000001 days,the radius is 0.767+0.045-0.041RJ and the amplitude of the RV curve is 69.4_(-7.3)^(+7.9)m s^(-1).TOI-1251 b is confirmed based on the multiband photometric and high-resolution spectroscopic data,whose orbital period is 5.963054+0.000002-0.000001days,radius is 0.947+0.035-0.033 R_(J) and amplitude of the RV curve is 9849_(-40)^(+42)ms^(-1).

关键词： planets and satellites fundamental parameters-planets and satellites gaseous planets-stars fundamental parameters-stars low-mass-methods data analysis-techniques photometric-techniques spectroscopic

Right time, right place: The dynamic role of hormones in rhizobial infection and nodulation of legumes

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Plant Communications 2022年第5期3卷 5-18页

作者： karen Velandia James b.Reid Eloise Foo Discipline of biological Sciences School of Natural SciencesUniversity of TasmaniaPrivate Bag 55HobartTAS 7001Australia

Many legume plants form beneficial associations with rhizobial bacteria that are hosted in new plant rootorgans, nodules, in which atmospheric nitrogen is fixed. This association requires the precise coordinationof two separate programs, infection in the epidermis and nodule organogenesis in the cortex. There isextensive literature indicating key roles for plant hormones during nodulation, but a detailed analysis ofthe spatial and temporal roles of plant hormones during the different stages of nodulation is *** review analyses the current literature on hormone regulation of infection and organogenesis to revealthe differential roles and interactions of auxin, cytokinin, brassinosteroids, ethylene, and gibberellins during epidermal infection and cortical nodule initiation, development, and function. With the exception ofauxin, all of these hormones suppress infection events. by contrast, there is evidence that all of these hormones promote nodule organogenesis, except ethylene, which suppresses nodule initiation. This differential role for many of the hormones between the epidermal and cortical programs is striking. Future work isrequired to fully examine hormone interactions and create a robust model that integrates this knowledgeinto our understanding of nodulation pathways.

关键词： auxin brassinosteroids cytokinin ethylene gibberellin nodulation

Type 2 autoimmune pancreatitis associated with severe ulcerative colitis: Three case reports

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World Journal of Clinical Cases 2022年第24期10卷 8788-8796页

作者： Mark Ghali karen bensted David b Williams Simon Ghaly Department of Gastroenterology St Vincent's HospitalDarlinghurst 2010NSWAustralia School of Clinical Medicine Faculty of Medicine and HealthThe University of New South WalesSydney 1466NSWAustralia

bACKGROUND Type two autoimmune pancreatitis is a rare and difficult to diagnose,steroid responsive non-IgG4 inflammatory pancreatopathy that can be associated with inflammatory bowel *** SUMMARY This case series describes three cases with varied clinical presentations and representations of autoimmune pancreatitis,and all associated with an aggressive course of ulcerative *** pancreatopathy was independent of bowel disease activity and developed in one case following *** Clinician awareness about this condition is important to allow early diagnosis,treatment and avoid unnecessary pancreatic surgery.

关键词： Autoimmune pancreatitis Inflammatory bowel disease Ulcerative colitis Colectomy Case report

Inoculation with native grassland soils improves native plant species germination in highly disturbed soil

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Grassland Research 2022年第2期1卷 75-83页

作者： Eric b.Duell karen R.Hickman Gail W.T.Wilson Department of Natural Resource Ecology and Management Oklahoma State UniversityStillwaterOklahomaUSA Kansas biological Survey University of KansasLawrenceKSUSA Environmental Science Program Oklahoma State UniversityStillwaterOKUSA

background:Grasslands are globally imperiled,facing continued threats from anthropogenic *** remains a common grassland restoration method,and yet,is typically met with limited success,partially because soils of degraded systems inhibit the germination of native ***:We assessed the germination success of 16 native grassland species sown in soils collected from a degraded grassland converted into a nonnative warm‐season perennial grass,bothriochloa ischaemum,and areas previously subjected to the eradication of this nonnative *** objectives were as follows:(1)determine native seed germination in soils collected from *** or eradication control sites,compared to germination in native grassland soil,and(2)assess if native soil inoculation improves germination,compared to germination in degraded soils without ***:Germination of native species was exceedingly low when seeded into soil dominated by ***,or in soil previously treated with combinations of herbicide and prescribed fire,relative to native grassland ***,amendments with native grassland soil resulted in germination equivalent to native grasslands,alleviating the negative influences of degraded ***:Our results highlight the role of native soil in improving the germination of desirable plant species following intensive management and soil *** research may improve restoration outcomes for managers focused on the conservation and restoration of grasslands.

关键词： bothriochloa ischaemum invasive species restoration soil inoculation

Insights into social relationships among female black howler monkeys Alouatta pigra at Palenque National Park, Mexico

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Current Zoology 2011年第1期57卷 1-7页

作者： Sarie VAN bELLE Alejandro ESTRADA karen b. STRIER Department of Zoology University of Wisconsin-Madison USA Estaclon de blologla Tropical Los Tuxtlas Instituto de Biologfa Universidad Nacional Autonoma de Mexico Mexico Department of Anthropology University of Wisconsin-Madison USA

We investigated the social relationships among adult females in two multimale-multifemale groups of black howler monkeysAlouatta pigraduring a 14-month study in Palenque National Park, Mexico. based on over 900 focal hours and over 5400 scan samples recording neighboring group members, we found that females very rarely engaged in agonistic interactions and no dominance hierarchy could be discerned. Relationships among resident females were primarily affiliative, but females of one study group spent a higher proportion of time in close proximity and engaged in affiliative interactions with one another at higher rates than females in the other study group. The strength of female relationships increased with the birth of an infant. Although no females immigrated during the study period, the temporary association of three extragroup females with our study groups implies that the social system of black howler monkeys is more dynamic than previously suggested. These findings suggest that female black howler monkeys behave more similarly to female red howler monkeysA. seniculusthan to female mantled howler monkeysA. palliata.

关键词：国家公园社会关系墨西哥雌性猴层次结构相互作用社会制度

Genomic instability as a major mechanism for acquired resistance to EGFR tyrosine kinase inhibitors in cancer

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Protein & Cell 2022年第2期13卷 82-89页

作者： bing Liu Daniela Duenas Li Zheng karen Reckamp binghui Shen Department of Cancer Genetics and Epigenetics Beckman Research Institute of City of Hope1500 East Duarte RoadDuarteCA 91010USA Division of Medical Oncology Cedars-Sinai Medical Center8700 Beverly BlvdWest HollywoodCA 90048USA

The mutation-mediated overexpression of epidermal growth factor receptor tyrosine kinase(EGFR TK)and its activation play an important role in the cellular proliferation and epithelial tumorigenesis.A series of inhibitors targeting the intracellular tyrosine kinase(TK)domain of EGFR have been developed and applied to clinical *** these inhibitors safely and effectively restrain tumor cell proliferation and prolong survival in some patients,acquired resistance ultimately *** mutations contribute to druginduced cancer-cell resistance.

关键词： cancer resistance clinical

De novo serine synthesis regulates chondrocyte proliferation during bone development and repair

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bone Research 2022年第2期10卷 274-285页

作者： Steve Stegen Shauni Loopmans Ingrid Stockmans karen Moermans Peter Carmeliet Geert Carmeliet Laboratory of Clinical and Experimental Endocrinology Department of Chronic Diseases and MetabolismKU Leuven3000 LeuvenBelgium Laboratory of Angiogenesis and Vascular Metabolism VIB Center for Cancer Biology3000 LeuvenBelgium Laboratory of Angiogenesis and Vascular Metabolism Department of Oncology and Leuven Cancer InstituteKU Leuven3000 LeuvenBelgium State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-Sen UniversityGuangzhou 510080China

The majority of the mammalian skeleton is formed through endochondral ossification starting from a cartilaginous *** cells, or chondrocytes, survive, proliferate and synthesize extracellular matrix in an avascular environment, but the metabolic requirements for these anabolic processes are not fully understood. Here, using metabolomics analysis and genetic in vivo models, we show that maintaining intracellular serine homeostasis is essential for chondrocyte function. De novo serine synthesis through phosphoglycerate dehydrogenase(PHGDH)-mediated glucose metabolism generates nucleotides that are necessary for chondrocyte proliferation and long bone growth. On the other hand, dietary serine is less crucial during endochondral bone formation, as serine-starved chondrocytes compensate by inducing PHGDH-mediated serine ***, this metabolic flexibility requires ATF4, a transcriptional regulator of amino acid metabolism and stress *** demonstrate that both serine deprivation and PHGDH inactivation enhance ATF4 signaling to stimulate de novo serine synthesis and serine uptake, respectively, and thereby prevent intracellular serine depletion and chondrocyte dysfunction. A similar metabolic adaptability between serine uptake and de novo synthesis is observed in the cartilage callus during fracture ***, the results of this study reveal a critical role for PHGDH-dependent serine synthesis in maintaining intracellular serine levels under physiological and serine-limited conditions, as adequate serine levels are necessary to support chondrocyte proliferation during endochondral ossification.

关键词： synthesis starting thereby