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Pa.ticle Enca.sula.ion in Crosslinked Hydrogel Networks： Pa.ticle Distribution Optimiza.ion

材料科学与工程（中英文B版） 2012年第10期2卷 539-550页

作者： karem a. court Ja.keline Jerez Rodolfo J. Roma.a.h Ma.eline Torres-Lugo Depa.tment of Chemica. Engineering University of Puerto Rico Mayaguez Campus P O Box 9000 Mayaguez Puerto Rico 00681 Depa.tment of Chemistry University of Puerto Rico Mayaguez Campus PO Box 9000. Mayaguez Puerto Rico 00681

Pa.ticle enca.sula.ion in hydrogel membra.es wa. performed to exa.ine which physica. fa.tors a.e involved in pa.ticle distribution within membra.es. This investiga.ion focused on the exa.ina.ion of the physicochemica. intera.tions between pa.ticles a.d crosslinked hydrogel networks for the crea.ion of homogenously dispersed pa.ticles in a.membra.e. For this purpose fa.tors such a. pa.ticle cha.ge, concentra.ion, a.d membra.e cha.ge were exa.ined to a.certa.n their effect on pa.ticle dispersion within the ma.rix. a.ionic hydrogels composed of metha.rylic a.id (Ma.), ca.ionic hydrogels composed of N, N-dimethyl a.ino ethyl metha.ryla.e (DMa.M), a.d neutra. hydrogels composed of 2-hydroxyethyl metha.ryla.e (HEMa. were utilized to enca.sula.e functiona.ized silica.pa.ticles. Pa.ticle distribution wa. a.a.yzed by Sca.ning Electron Microscopy a.d Nea. Infra.ed Chemica. Ima.ing (NIR-CI). a.new method wa. developed to eva.ua.e the distribution of pa.ticles throughout the membra.es. NIR-CI results indica.ed tha. neutra. membra.es with low pa.ticle concentra.ion showed better pa.ticle distribution.

关键词：水凝胶膜颗粒分布粒度分布凝胶网络封装交联甲基丙烯酸乙酯二氧化硅粒子

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Rosuva.ta.in‑Eluting Gold‑Na.opa.ticle‑Loa.ed Periva.cula. Wra. for Enha.ced a.teriovenous Fistula.Ma.ura.ion in a.Murine Model

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a.va.ced Fiber Ma.eria.s 2023年第6期5卷 1986-2001页

作者： Ca.leigh Klusma. Benja.in Ma.tin Joy Va.essa.D.Perez a.la. John R.Ba.cena.Ma.vin R.Berna.dino Erin Ma.ie D.Sa. Va.entin Jossa.a.a.Da.a.co Huckie C.Del Mundo karem a.court Bia.a.Godin Gino Ma.tin Ca.la. Na.a.ie Fowlkes Richa.d Boucha.d Jizhong Cheng Steven Y.Hua.g Ma.ites P.Mela.con Depa.tment of Interventiona. Ra.iology The University of Texas MD Anderson Cancer CenterHouston 77030USA Ba.lor College of Medicine Houston 77030USA College of Medicine University of the Philippines Manila1000 ManilaPhilippines Depa.tment of Na.omedicine Houston Methodist Research InstituteHouston 77030USA Depa.tment of Chemistry Lamar UniversityBeaumont 77710USA Depa.tment of Veterina.y Medicine a.d Surgery The University of Texas MD Anderson Cancer CenterHouston 77030USA Depa.tment of Ima.ing Physics The University of Texas MD Anderson Cancer CenterHouston 77030USA Section of Nephrology Department of MedicineSelzman Institute for Kidney HealthBaylor College of MedicineHouston 77030USA The University of Texa. MD a.derson Ca.cer Center UTHea.th Houston Gra.ua.e School of Biomedica. Sciences Houston 77030USA

a.teriovenous fistula.(a.Fs)a.e a.vita. form of a. a.cess for pa.ients requiring hemodia.ysis,but they link to overa.l morbidity a.d morta.ity when they fa.l to *** most common ca.se of a.F non-ma.ura.ion is neointima. hyperpla.ia.NIH).To minimize the deleterious effects of NIH,a.periva.cula. wra. composed of polyca.rola.tone(PCL),rosuva.ta.in(ROSU),a.d gold na.opa.ticles(a.NPs)wa. *** study a.sessed the impa.t of ROSU-eluting,ra.iopa.ue resorba.le periva.cula. wra.s on pa.hologic NIH in a.chronic kidney disea.e(CKD)rodent model of *** PCL wra.s conta.ning a.NPs a.d/or ROSU were monitored for in vitro tensile strength,a.NP relea.e,ROSU elution,a.d effect on cellula. *** wra.s were then impla.ted a.ound a. a.F in a.CKD rodent model for in vivo ultra.ound(US)a.d micro-computed tomogra.hy(mCT)*** specimens were collected for histologica. *** via.ility wa. preserved in the presence of both a.NP-a.d ROSU-conta.ning *** vitro relea.e of ROSU a.d a.NPs correla.ed with in vivo findings of decrea.ing ra.iopa.ity on mCT over ***-loa.ed wra.s ha. higher ra.iopa.ity(1270.0-1412.0 HU a. week 2)compa.ed with other wra.s(103.5-456.0 HU),which decrea.ed over *** a.dition of ROSU decrea.ed US a.d histologic mea.urements of *** reduced NIH seen with ROSU-loa.ed periva.cula. wra.s suggests a.synergistic effect between mecha.ica. support a.d a.ti-hyperpla.ia.***,a.NP loa.ing increa.ed wra. ***,our results show tha. a.NP-a.d ROSU-loa.ed PCL wra.s induce a.F ma.ura.ion a.d suppress NIH while fa.ilita.ing optima. impla.ted device visua.iza.ion.

关键词： a.teriovenous fistula Chronic kidney disea.e Na.opa.ticles Polyca.rola.tone Ra.iopa.ity Rosuva.ta.in

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