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Aminothiols exchange in coronavirus disease 2019

Frigid Zone Medicine 2023年第1期3卷 37-41页

作者： Fefelova Elena Viktorovna karavaeva tatyana mikhailovna Parshina Anastasia Anatolyevna Ma Van De Vasilina Denisovna Tereshkov Pavel Petrovich Department of Pathological Physiology Chita State Medical AcademyChita 672090Russia Department of Chemistry and Biochemistry Chita State Medical AcademyChita 672090Russia Department of Faculty Therapy Chita State Medical AcademyChita 672090Russia Laboratory of Experimental and Clinical Biochemistry and Immunology Chita State Medical AcademyChita 672090Russia

Objective:Clinical manifestation of the inflammatory process in its relation to biochemical markers(total cysteine[Cys],cysteine-glycine[CysGly],glutathione[GSH],glutamate-cysteine[Glu-Cys],homocysteine[Hcy],the ratio of reduced to oxidized glutathione[GSH/GSSG],the ratio of reduced to oxidized cysteine[CySH/CySS],malondialdehyde-oxidized low-density lipoproteins[MDA-oxLDL])has been studied in patients with coronavirus disease 2019(COVID-19).Material and methods:48 patients with mild to severe COVID-19 and 20 healthy volunteers were included in our *** participants were divided into 4 experimental groups according to inflammation intensity estimated based on the serum levels of interleukin 6(IL-6).Results:All 4 groups showed the prevalence of male patients and elevated serum levels of IL-6(by 54.6%).There was no comorbidity in patients with mild COVID-19(nasopharyngitis symptoms)and in healthy control subjects.50%of patients with lung damage had accompanying *** of aminoethyl metabolism were detected in COVID-19 patients:as reflected by the decreased levels of Cys,CysGly,and Glu-Cys and the increased levels of GSH as compared to the control ***:Elevation of IL-6 over 7.5 pg/mL was associated with decreased GSH/GSSG and CySH/CySS ratios indicating enhanced oxidative stress and was followed by protein oxidation,specifically MDA-oxLDL.

关键词： coronavirus disease 2019 aminothiols oxidative stress interleukin-6 oxidized lipoproteins

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