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International Journal of Otolaryngology and Head & Neck Surgery 2020年第4期9卷 141-148页

作者： Divya Mishra Ravinder Singh Nagi karan sharma Department of ENT & Head Neck Surgery GMC Amritsar Punjab India

Aim: Chronic otitis media (COM) is chronic muco purulent discharge through a perforated tympanic membrane. Theossicular chain damage is found in both mucosal and squamosal types of COM. We aim to evaluate relationship between preoperative otologic features, pure tone audiometric findings and intraoperative ossicular chain status in patients with chronic otitis media. Material and Methods: 100 patients of either sex aged between 12 to 60 years operated for active or inactive, squamosal or mucosal chronic otitis media attending Ram Lal Eye and ENT Hospital, Government Medical College Amritsar were taken. The preoperative ossicular chain status based on set parameters was compared with the intraoperative ossicular chain status. Results: The ossicular chain integrity is more commonly compromised in squamosal COM and the most common ossicle eroded is Incus. Pure tone audiogram has got a very important role in determining the ossicular chain integrity preoperatively and must be done in all cases with accuracy. Conclusion: It is concluded that on the basis of otoscopic examination and pure tone audiometry values, we can accurately classify the COM as mucosal or squamosal type and get an idea of the ossicular chain integrity preoperatively hence planning the extent of surgery.

关键词： Otoscopy Pure Tone Audiometry Ossicular Chain Status

Targeting brain tumors with innovative nanocarriers:bridging the gap through the blood-brain barrier

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Oncology Research 2024年第5期32卷 877-897页

作者： karan WADHWA PAYAL CHAUHAN SHOBHIT KUMAR RAKESH PAHWA RAVINDER VERMA RAJAT GOYAL GOVIND SINGH ARCHANA sharma NEHA RAO DEEPAK KAUSHIK Department of Pharmaceutical Sciences Maharshi Dayanand UniversityRohtak124001India Department of Pharmaceutical Technology Meerut Institute of Engineering and Technology(MIET)NH-58Delhi-Roorkee HighwayMeerut250005India Institute of Pharmaceutical Sciences Kurukshetra UniversityKurukshetra136119India Department of Pharmaceutical Sciences Chaudhary Bansi Lal UniversityBhiwani127021India MM College of Pharmacy Maharishi Markandeshwar(Deemed to be University)Mullana-AmbalaHaryana133207India Delhi Pharmaceutical Sciences and Research University(DIPSAR) Delhi Pharmaceutical Sciences and Research UniversityNew Delhi110017India

Background:Glioblastoma multiforme(GBM)is recognized as the most lethal and most highly invasive *** high likelihood of treatment failure arises fromthe presence of the blood-brain barrier(BBB)and stemcells around GBM,which avert the entry of chemotherapeutic drugs into the ***:Recently,several researchers have designed novel nanocarrier systems like liposomes,dendrimers,metallic nanoparticles,nanodiamonds,and nanorobot approaches,allowing drugs to infiltrate the BBB more efficiently,opening up innovative avenues to prevail over therapy problems and radiation ***:Relevant literature for this manuscript has been collected from a comprehensive and systematic search of databases,for example,PubMed,Science Direct,Google Scholar,and others,using specific keyword combinations,including“glioblastoma,”“brain tumor,”“nanocarriers,”and several ***:This review also provides deep insights into recent advancements in nanocarrier-based formulations and technologies for GBM *** of various scientific advances in conjunction with encouraging findings concerning the future perspectives and challenges of nanocarriers for effective brain tumor management has also been discussed.

关键词： Glioblastoma Brain tumor Blood-brain barrier Liposomes Metallic nanoparticles Nanocarriers

Development of prosthetic arm using body actioned SEMG signals

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Journal of Innovative Optical Health Sciences 2016年第6期9卷 58-65页

作者： karan Veer Tanu sharma Amod Kumar EIED Department Thapar UniversityPatialaIndia CSED Department Global College of EngineeringKhanpur KuiIndia Chief Scientist CSIO-CSIRChandigarhIndia

People's working capability is badly affected when they sufer an amputated *** replacements with prosthetic devices to get a satisfactory level of performance for essential functions with the currently available prosthetic technology are very *** arm prostheses are becoming popular because they are operated by a natural contraction of intact ***,SEMG based artifdal arm was *** system cousists of diferent electronic and mechanical assemblies for operation of hand utilizing microcontroller in order to have minimum signal loss during its *** the hep of relay switching connected to low power DC motor,system is capable of opening and closing of grip according to individual wish.

关键词： SEMG electrodes variable gripping myoelectric controls electronic interface signals processing.

A neural network-based electromyography motion classifier for upper limb activities

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Journal of Innovative Optical Health Sciences 2016年第6期9卷 77-84页

作者： karan Veer Tanu sharma Ravinder Agarwal Electrical and Instrumentation Engineering Department Thapar University Computer Science Engineering Department GCET Ropar 174001India

The objective of the work is to investigate the classifcation of different movements based on the surface electromyogram(SEMG)pattern recognition *** testing was conducted for four arm movements using several experiments with artificial neural network class fication *** time domain features were extracted and consequently dlassification was implemented using back propagation neural dassifier(BPNC).Further,the realization of projected network was verified using cross validation(CV)process;hence ANOVA algorithm was carried *** of the network is analyzed by considering mean square error(MSE)value.A comparison was performed between the extracted feat ures and back propagation network results reported in the *** concurrent result indicates the significance of proposed network with classification accuracy(CA)of 100%recorded from two channels,while analysis of variance technique helps in investigating the effectiveness of classified sigmal for recognition tasks.

关键词： ANN SEMG arm recognition statistics classification RMS upper arm activities

A Novel Hybrid Clustering Based Transmission Protocol for Wireless Body Area Networks

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Computers, Materials & Continua 2021年第11期69卷 2459-2473页

作者： Neelam sharma Harshita Chadha karan Singh B.M.Singh Nitish Pathak Research Scholar Computer Science and EngineeringUttarakhand Technical University(UTU)DehradunIndia Computer Science and Engineering Maharaja Agrasen Institute of TechnologyNew DelhiIndia School of Computer&Systems Sciences Jawaharlal Nehru University(JNU)DelhiIndia College of Engineering Roorkee UTUDehradunIndia Department of Information Technology KIET Group of InstitutionsGhaziabadIndia

Wireless sensor networks are a collection of intelligent sensor devices that are connected to one another and have the capability to exchange information packets amongst *** recent years,this field of research has become increasingly popular due to the host of useful applications it can potentially serve.A deep analysis of the concepts associated with this domain reveals that the two main problems that are to be tackled here are throughput enhancement and network security *** present article takes on one of these two issues namely the throughput *** the purpose of improving network productivity,a hybrid clustering based packet propagation protocol has been *** protocol makes use of not only clustering mechanisms of machine learning but also utilizes the traditional forwarding function approach to arrive at an optimum *** result of the simulation is a novel transmission protocol which significantly enhances network productivity and increases throughput value.

关键词： Forwarding function wireless sensor networks WSNs WBANs energy characteristics clustering hybrid mechanism dissipated energy network stability

Comprehensive geochemical/hydrochemical and geo-thermometry analysis of Unai geothermal field, Gujarat, India

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Acta Geochimica 2019年第1期38卷 145-158页

作者： Manan Shah Anirbid Sircar Nahid Shaikh karan Patel Darshan sharma Dwijen Vaidya School of Petroleum Technology Pandit Deendayal Petroleum University Wipro Limited Centre of Excellence for Geothermal Energy Pandit Deendayal Petroleum University

The knowledge of water temperature produced from a geothermal reservoir and its composition is of utmost importance in designing utilization strategies, the surface production facilities and in selecting the material to be used. Unai hot springs are located in the southern part of Gujarat, India with discharge temperatures varying from 51 to 56 ℃. With the aim of developing Unai as a potential geothermal field and exploiting it in the future, geochemical and geothermometrical study was undertaken. The samples were collected from various Unai geothermal location and analysis of chemical composition of water obtained from different wells was done. The concentration of Silica, carbonate and ions like Na and Cl have been analyzed to delineate the path of water movement in the subsurface and classify the reservoir based on the *** ratio of the concentration of ions like Na^+ and K^+ and the relative proportions of various sets of ions were also used to characterize the geothermal reservoir and the reservoir fluid by the use of ternary diagrams. Na–K–Ca,Chalcedony, quartz, and Silica geo-thermometers have been studied. The present study also envisages the importance of graphical representations like Piper diagram,Scholler etc. to determine variation in hydrochemical facies and to understand the evolution of hydrochemical processes in the Unai geothermal field respectively. The study yields the conclusion that the reservoir under consideration is a low enthalpy reservoir with temperature ranging from 60 to 80 ℃.

关键词： Geothermal energy Hydrochemical Geochemical Geothermometery Renewable energy

Capacity Based Multicast Channel Assignment in Wireless Mesh Network

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Communications and Network 2013年第3期5卷 671-677页

作者： Anju Singh karan Singh Sandeep sharma School of Information and Communication Technology Gautam Buddha University Greater Noida India

Wireless mesh networking (WMN) is an emerging technology that enables multihop wireless connectivity to areas where wiring or installing cables is difficult or expensive. Multicast is a form of communication that delivers information from a source to a group of destinations. In a single-channel WMN, all nodes share and communicate with each other via the same channel. In such a network, the throughput capacity of multicast degrades significantly as the network size increases. A critical factor that contributes to this rapid degradation is the co-channel interference in single-channel WMNs. The major advantage of WMN is that power is not the major issue as compare to other wireless network like MANET, Sensor etc. Hence Power can be optimally utilized in WMN to increase throughput and total network efficiency. In this paper, we propose a channel assignment algorithm for multicast based on high channel capacity with minimum interference. This scheme usesall overlapping and non overlapping channel for the channel assignment. By this scheme we provide better performance in terms of average packet delivery ratio, average throughput and average end to end delay with respect to multichannel multicast channel assignment schemes.

关键词： WMN Multicast Multi Interface Non Overlapping Channels Partially Overlapping Channels SNR

Conductivity Studies in Proton Irradiated AgI-Ag2O-V2O5-TeO2 Super-Ionic Glass System

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Materials Sciences and Applications 2010年第2期1卷 59-65页

作者： Poonam sharma Dinesh Kumar Kanchan Meenakshi Pant karan Pal Singh 不详

The electrical properties of proton ion beam irradiated glass samples are carried out by impedance spectroscopy in the frequency range from 10 Hz to 32 MHz. The ion beam of energy 3 MeV and fluence of of 1014 particles cm-2 was chosen for irradiation. The conductivity of the super ionic glass samples increases after irradiation and other electrical parameters like dielectric constant, dielectric loss and modulus of the proton irradiated glass samples as a function of glass composition and temperature are observed to change. The dielectric constant and the dielectric losses are increased after irradiation and the modulus parameters confirm the non-Debye nature for irradiated samples also.

关键词： Proton-Irradiated Glass DC Conductivity Silver-Ion Scaling Modulus

Anti-HBc screening in Indian blood donors:Still an unresolved issue

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World Journal of Gastroenterology 2008年第34期14卷 5327-5330页

作者： Hari Krishan Dhawan Neelam Marwaha Ratti Ram sharma Yogesh Chawla Beenu Thakral karan Saluja Sanjeev Kumar sharma Manish K Thakur Ashish Jain Department of Transfusion Medicine PGIMER Department of Hepatology PGIMER

AIM:To study the seroprevalence of antibody to hepatitis B core antigen (anti-HBc) in healthy blood donors negative for HBsAg and to evaluate whether anti-HBc detection could be adopted in India as a screening assay for HBV in addition to HBsAg. METHODS: A total of 1700 serum samples collected from HBsAg-negative healthy blood donors were tested for the presence of anti-HBc antibody (IgM + IgG). All samples reactive for anti-HBc antibody were then investigated for presence of anti-HBs and for liver function tests (LFTs). One hundred serum samples reactive for anti-HBc were tested for HBV DNA by PCR method. RESULTS: Out of 1700 samples tested, 142 (8.4%) blood samples were found to be reactive for anti-HBc. It was signif icantly lower in voluntary (6.9%) as compared to replacement donors (10.4%, P = 0.011). Seventy- two (50.7%) anti-HBc reactive samples were also reactive for anti-HBs with levels > 10 mIU/mL and 70 (49.3%) samples were non-reactive for anti-HBs, these units were labeled as anti-HBc-only. These 142 anti-HBc reactive units were also tested for liver function test. HBV DNA was detected in only 1 of 100 samples tested. CONCLUSION: Keeping in view that 8%-18% of donor population in India is anti-HBc reactive, inclusion of anti- HBc testing will lead to high discard rate. Anti-HBs as proposed previously does not seem to predict clearance of the virus. Cost effectiveness of introducing universalanti-HBc screening and discarding large number of blood units versus considering ID NAT (Individual donor nuclic acid testing) needs to be assessed.

关键词： Hepatitis B core antigen Hepatitis B surface antigen Hepatitis B virus Transfusion-associated hepatitis B virus Blood donors

A Study on the VLF/LF Long Term Amplitude Oscillations Associated with Frequencies 37.5 kHz and 45.9 kHz Received at Keil Longwave Monitor, Keil, Germany

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International Journal of Geosciences 2017年第9期8卷 1080-1090页

作者： Govinda sharma Keshav Prasad Kandel Balaram Khadka Peter Wilhelm Schnoor karan Bhatta Basu Dev Ghimire Aditya Singh Thapa St. Xavier’s College Kathmandu Nepal Nepalese Center for Research in Physical Sciences (NCRPS) Kathmandu Nepal Department of Physics St. Xavier’s College Kathmandu Nepal Keil Longwave Monitor Keil Germany

The middle and upper atmosphere of Earth displays many large-scale oscillations in several parameters. Of these oscillations, Atmospheric Oscillation (AO) and Semi-annual Oscillation (SAO) are prominent ones. In this work, we have analyzed the Very Low Frequency/Low Frequency (VLF/LF) data from two of the transmitters of frequency 45.9 kHz at NSY, Sicily, Italy and 37.5 kHz at Grindavik, Iceland. The selected Trasmitter-Receiver Great Circle Path (TRGCP) is middle latitude which is marine in case of Grindavik TRGCP and terrestrial in case of NSY TRGCP. The VLF/LF signals are bounced back and forth from D-layer of ionosphere (altitude at ~65 km during day and ~95 km during night) in Earth-ionospheric waveguide. This infers the presence of atmospheric oscillations as a consequence of change in ionization and recombination rates. Many works related to AO and SAO are mostly done only for equatorial region of the ionosphere and authors have reported the elegant dominancy of AO and SAO in the VLF/LF amplitude pattern over years. To our surprise, in our work it is seen that not only AO and SAO but also other oscillations are necessary to model the oscillation pattern of middle latitude ionosphere.

关键词： VLF/LF D-Layer SAO AO TRGCP NSY Grindavik