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Hepatoprotective evaluation of Anogeissus latifolia:In vitro and in vivo studies

World Journal of Gastroenterology 2009年第38期15卷 4816-4822页

作者： Hulikere Ananth Pradeep Saleemullah Khan karamkonda ravikumar Mohammed Fazil Ahmed Meesala Srinivasa Rao Mandava Kiranmai Dachani Sudhershan Reddy Shaik Rasheed Ahamed Mohammed Ibrahim Department of Pharmacology and Biotechnology Nizam Institute of Pharmacy JSS College of Pharmacy OotyTamilnaduIndia and Manipal College of Pharmaceutical Sciences Centre for Liver Research and Diagno-stics Deccan College of Medical Sciences and Allied Hospitals

AIM:To evaluate the hepatoprotective activity of a hydroalcoholic extract of the bark of Anogeissus latifolia; in vitro in primary rat hepatocyte monolayer culture and in vivo in the liver of Wistar rats intoxicated by carbon tetrachloride (CCl4).METHODS: In the in vitro study, a primary hepatocyte monolayer culture was treated with CCl4 and extract of Anogeissus latifolia. Hepatoprotective activity was demonstrated in the CCl4 damaged primary monolayer culture. In the in vivo study, the hepatoprotective activity of a hydroalcoholic extract of Anogeissus latifolia was analyzed in liver injured CCl4-treated rats. Biochemical parameters including serum transaminases [aspartate aminotransferase (AST) and alanine aminotransferase (ALT)] and alkaline phosphatase (ALP) in serum were analyzed. The biochemical findings were supplemented with histopathological examination of rat liver ***: In vitro: primary hepatocyte monolayer cultures were treated with CCl4 and extract of Anogeissus latifolia. A protective activity could be demonstrated in the CCl4 damaged primary monolayer culture. In vivo : Hydroalcoholic extract of Anogeissus latifolia (300 mg/kg) was found to have protective activity in rats with CCl4-induced liver damage as judged from serum marker enzyme ***: The above findings lead to the conclusion that the hydroalcoholic extract of Anogeissus latifolia is hepatoprotective. Hence, we suggest that the inclusion of this plant in the management of liver disorders is justified.

关键词：体外培养肝细胞体内血清碱性磷酸酶评价丙氨酸转氨酶组织病理学检查单层培养

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