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Effect of Frey's procedure on islet cell function in patients with chronic calcific pancreatitis

Hepatobiliary & Pancreatic Diseases International 2018年第4期17卷 358-362页

作者： Ritesh Kumar Jaya prakash Sahoo Biju Pottakat Sadishkumar Kamalanathan Pazhanivel Mohan Vikram Kate Sitanshu Sekhar kar Jayakumar Selviambigapathya Department of Endocrinology Metabolism Jawaharlal Institute of Postgraduate Medical Education and Research(JIPMER)Pondicherry 605006India Department of Surgical Gastroenterology Jawaharlal Institute of Postgraduate Medical Education and Research(JIPMER)Pondicherry 605006India Department of Medical Gastroenterology Jawaharlal Institute of Postgraduate Medical Education and Research(JIPMER)Pondicherry 605006India Department of Surgery Jawaharlal Institute of Postgraduate Medical Education and Research(JIPMER)Pondicherry 605006India Department of Preventive and Social Medicine Jawaharlal Institute of Postgraduate Medical Education and Research(JIPMER)Pondicherry 605006India

Background: Frey’s procedure involves both drainage and resection of the pancreas in subjects with chronic calcific pancreatitis(CCP). The procedure may affect the pancreatic endocrine function after surgery. The present study was to evaluate the effect of Frey’s procedure on both beta and alpha cell function in CCP ***: Thirty CCP patients who underwent Frey’s procedure were included. According to the glycemic status, patients were divided into the diabetes mellitus(DM), prediabetes, and normal glucose tolerance(NGT) groups. Islet cell function was assessed before and 3 months after ***: At baseline, there was a significant difference in beta cell function among the three groups [NGT group 1.71(1.64–2.07) vs prediabetes group1.50(0.83–1.61) vs DM group 0.33(0.12–0.55), P < 0.0001], but the insulin resistance was not different among them. Post glucose hyperglucagonemia representing alphacell dysfunction during oral glucose tolerance test was present in all of them, but showed no significant difference [NGT group 0.15(0.06–0.31) vs prediabetes group 0.32(0.05–0.70) vs DM group 0.07(0.02–0.18), P = 0.20]. Frey’s procedure did not change beta cell function and insulin resistance. However, alphacell dysfunction deteriorated after surgery [0.10(0.03–0.27) vs 0.33(0.09–0.68), P = 0.004].Conclusions: Although Frey’s procedure does not affect the beta cell function and insulin resistance in CCP patients, the alpha-cell dysfunction deteriorates after surgery.

关键词： Beta-cell Diabetes mellitus Glucagon Insulin secretion sensitivity index Matsuda index

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Development of low power non-thermal plasma jet and optimization of operational parameters for treating dyes and emerging contaminants

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Plasma Science and Technology 2022年第10期24卷 86-97页

作者： Deepchandra JOSHI G Veda prakash Shaikh Ziauddin AHAMMAD Satyananda kar T R SREEKRISHNAN Department of Biochemical Engineering and Biotechnology Indian Institute of Technology DelhiNew Delhi 110016India Department of Energy Science and Engineering Indian Institute of Technology DelhiNew Delhi 110016India

Non-thermal plasma has emerged as an effective treatment system against the latest class of highly recalcitrant and toxic environmental pollutants termed emerging contaminants(ECs).In the present work,a detailed experimental study is carried out to evaluate the efficacy of a non-thermal plasma jet with two dyes,Rd.B and ***,as model *** plasma jet provided a complete dye decoloration in 30 min with an applied voltage of 6.5 kV_(p-p).·OH,having the highest oxidation potential,acts as the main reactive species,which with direct action on contaminants also acts indirectly by getting converted into H_(2)O_(2)and O_(3).Further,the effect of critical operational parameters viz,sample pH,applied voltage(4.5–6.5 kV_(p-p)),conductivity(5–20 mS cm^(-1)),and sample distance on plasma treatment efficacy was also *** of all the assessed parameters,the applied voltage and sample conductivity was found to be the most significant operating parameters.A high voltage and low conductivity favored the dye decoloration,while the pH effect was not that *** understand the influence of plasma discharge gas on treatment efficacy,all the experiments are conducted with argon and helium gases under the fixed geometrical *** the gases provided a similar dye decoloration *** DBD plasma system with complete dye removal also rendered maximum mineralization of 73%for Rd.B,and 60%for ***,the system's efficiency against the actual ECs(four pharmaceutical compounds,viz,metformin,atenolol,acetaminophen,and ranitidine)and microbial contaminant(***)was also *** system showed effectivity in the complete removal of targeted pharmaceuticals and a log2.5 *** *** present systematic characterization of dye degradation could be of interest to large communities working towards commercializing plasma treatment systems.

关键词： advanced oxidation processes(AOPs) non-thermal plasma dye-degradation ECs treatment reactive species quantification mineralization

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Cardioprotective effect of Urtica parviflora leaf extract against doxorubicin-induced cardiotoxicity in rats

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中国天然药物 2013年第1期11卷 38-42页

作者： N. R. Barman Prasanna K. kar prakash K. Hazam Himadri S. Pal Arvind Kumar Sanjib Bhattacharya Pallab K. Haldar Himalayan Pharmacy Institute Majhitar Rangpo East Sikkim 737136 India Bengal School of Technology Sugandha Hooghly West Bengal 712102 India Department of Pharmaceutical Technology Jadavpur University Kolkata 700032 India

瞄准评估的现在的学习对在老鼠的导致 doxorubicin 的 cardiotoxicity 的 Urtica parviflora 叶材料(EEUP ) 的 hydroethanol 摘录的 cardioprotective 性质。方法 Cardiotoxicity 被 doxorubicin 管理生产(15

关键词： Doxorubicin Cardioprotective Urtica parviflora Antioxidant Leaf material Serum biomarkers

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