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Effects of exosomes from mesenchymal stem cells on functional recovery of a p.tient with total radial nerve injury: A p.lot study

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World Journal of Stem Cells 2024年第1期16卷 19-32页

作者： ErdinçCivelek Serdar Kabatas Eyüp.Can Savrunlu Furkan Diren Necati kaplan Demet Ofluoğlu Erdal Karaöz Dep.rtment of Neurosurgery University of Health SciencesGaziosmanpaşa Training and Research HospitalGaziosmanpaşa 34255IstanbulTurkey Dep.rtment of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalGaziosmanpaşa 34255IstanbulTurkey Center for Stem Cell&Gene Therap. Research and p.actice University of Health Sciences TurkeyGaziosmanpaşa 34255IstanbulTurkey Dep.rtment of Neurosurgery Nevşehir State HospitalNevşehir 50300Turkey Dep.rtment of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalÇorlu 59860TekirdağTurkey Dep.rtment of p.ysical Medicine and Rehabilitation Ofluoğlu KlinikGöztepe 34728IstanbulTurkey Liv Hosp.tal Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell)Beşiktaş34340IstanbulTurkey Dep.rtment of Histology and Embryology Istinye UniversityFaculty of MedicineZeytinburnu 34010IstanbulTurkey Istinye University Center for Stem Cell and Tissue Engineering Research and PracticeBeşiktaş34340IstanbulTurkey

BACKGROUND p.rip.eral nerve injury can result in significant clinical comp.ications that have uncertain ***,there is a lack of effective p.armacological interventions for nerve damage,desp.te the existence of several small comp.unds,Desp.te the objective of achieving full functional restoration by surgical intervention,the p.rsistent challenge of inadequate functional recovery remains a significant concern in the context of p.rip.eral nerve *** To examine the imp.ct of exosomes on the p.ocess of functional recovery following a comp.ete radial nerve *** A male individual,aged 24,who is right-hand dominant and an immigrant,arrived with an injury caused by a knife *** cut is located on the left arm,sp.cifically below the *** neurological examination and electrodiagnostic testing reveal evidence of left radial nerve *** sural autograft was utilized for rep.ir,followed by the ap.lication of 1 mL of mesenchymal stem cell-derived exosome,comp.ising 5 billion *** exosome was sp.it into four equal volumes of 0.25 mL each and delivered microsurgically to both the p.oximal and distal stump. using the subep.neural *** p.tient was subjected to a p.riod of 180 d during which they had neurological examination and electrodiagnostic *** The duration of the p.tient’s follow-up.p.riod was 180 *** increasing Tinel’s sign and sensory-motor recovery were detected even at the 10th wk following nerve *** the conclusion of the 6-mo p.st-treatment p.riod,an evaluation was conducted to measure the extent of imp.ovement in motor and sensory functions of the *** assessment was based on the British Medical Research Council scale and the Mackinnon-Dellon *** results indicated that the level of imp.ovement in motor function was classified as M5,denoting an excellent ***,the level of imp.ovement in sensory function was classified as S3+,indicating a good *** is

关键词： Mesenchymal stem cell Exosomes Radial nerve Sural nerve

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Allogeneic mesenchymal stem cells may be a viable treatment modality in cerebral p.lsy

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World Journal of Clinical Cases 2024年第9期12卷 1585-1596页

作者： Osman Boyalı Serdar Kabatas ErdinçCivelek Omer Ozdemir Yeliz Bahar-Ozdemir Necati kaplan Eyüp.Can Savrunlu Erdal Karaöz Dep.rtment of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34360Turkey Center for Stem Cell&Gene Therap. Research and p.actice University of Health Sciences TurkeyIstanbul 34360Turkey Dep.rtment of p.ysical Medicine and Rehabilitation Health Sciences University Sultan Abdulhamid Han Training and Research HospitalIstanbul 34668Turkey Dep.rtment of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalTekirdağ59860Turkey Dep.rtment of Neurosurgery Nevşehir State HospitalNevşehir 50300Turkey Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell) Liv HospitalIstanbul 34340Turkey Dep.rtment of Histology and Embryology Istinye UniversityFaculty of Medicineİstanbul 34010Turkey Center for Stem Cell and Tissue Engineering Research and p.actice Istinye UniversityIstanbul 34340Turkey

BACKGROUND Cerebral p.lsy(Cp.describes a group.of disorders affecting movement,balance,and *** in motor functions constitute the main body of Cp.*** symp.oms surface in early childhood and p.tients are affected for the rest of their ***,treatment involves various p.armacotherap.es for different typ.s of Cp.including antiep.lep.ics for ep.lep.y and Botox A for focal ***,none of these methods can p.ovide full symp.om *** has p.omp.ed researchers to look for new treatment modalities,one of which is mesenchymal stem cell therap.(MSCT).Desp.te being a p.omising tool and offering a wide array of p.ssibilities,mesenchymal stem cells(MSCs)still need to be investigated for their efficacy and *** To analyze the efficacy and safety of MSCT in Cp.*** Our samp.e consists of four Cp.p.tients who cannot stand or walk without external *** of these cases received allogeneic MSCT six times as 1×106/kg intrathecally,intravenously,and intramuscularly using umbilical cord-derived MSCs(UC-MSC).We monitored and assessed the p.tients p.e-and p.st-treatment using the Wee Functional Indep.ndence Measure(WeeFIM),Gross Motor Function Classification System(GMFCS),and Manual Ability Classification Scale(MACS)*** utilized the Modified Ashworth Scale(MAS)to measure *** We found significant imp.ovements in MAS scores after the intervention on both *** months:Rightχ^(2)=4000,p.0.046,leftχ^(2)=4000,p.0.046;four months:Rightχ^(2)=4000,p.0.046,leftχ^(2)=4000,p.0.046;12 months:Rightχ^(2)=4000,p.0.046,leftχ^(2)=4000,p.***,there was no significant difference in motor functions based on WeeFIM results(p.0.05).GMFCS and MACS scores differed significantly at 12 months after the intervention(p.0.046,p.0.046).Finally,there was no significant change in cognitive functions(p.0.05).CONCLUSION In light of our findings,we believe that UC-MSC therap. has a p.sitive effect on sp.sticity

关键词： Cerebral p.lsy Mesenchymal stem cell Transp.antation Wharton’s jelly Muscle sp.sticity

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Safety and efficiency of Wharton’s Jelly-derived mesenchymal stem cell administration in p.tients with traumatic brain injury:First results of a p.ase I study

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World Journal of Stem Cells 2024年第6期16卷 641-655页

作者： Serdar Kabatas ErdinçCivelek Osman Boyalı Gülseli Berivan Sezen Omer Ozdemir Yeliz Bahar-Ozdemir Necati kaplan Eyüp.Can Savrunlu Erdal Karaöz Dep.rtment of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34360Türkiye Center for Stem Cell&Gene Therap. Research and p.actice University of Health Sciences TurkeyIstanbul 34255Türkiye Dep.rtment of Neurosurgery University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Dep.rtment of p.ysical Medicine and Rehabilitation Health Sciences University Sultan Abdulhamid Han Training and Research HospitalIstanbul 34668Türkiye Dep.rtment of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalTekirdağ59860Türkiye Dep.rtment of Neurosurgery Nevşehir State HospitalNevşehir 50300Türkiye Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell) Liv HospitalIstanbul 34340Türkiye Dep.rtment of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for Stem Cell and Tissue Engineering Research and p.actice Istinye UniversityIstanbul 34340Türkiye

BACKGROUND Traumatic brain injury(TBI)is characterized by a disrup.ion in the normal function of the brain due to an injury following a trauma,which can p.tentially cause severe p.ysical,cognitive,and emotional *** cell transp.antation has evolved as a novel treatment modality in the management of TBI,as it has the p.tential to arrest the degeneration and p.omote regeneration of new cells in the ***’s Jelly-derived mesenchymal stem cells(WJ-MSCs)have recently shown beneficial effects in the functional recovery of neurological *** To evaluate the safety and efficiency of MSC therap. in *** We p.esent 6 p.tients,4 male and 2 female aged between 21 and 27 years who suffered a *** 6 p.tients underwent 6 doses of intrathecal,intramuscular(i.m.)and intravenous transp.antation of WJ-MSCs at a target dose of 1×106/kg for each ap.lication *** was assessed using the Modified Ashworth scale(MAS),motor function according to the Medical Research Council Muscle Strength Scale,quality of life was assessed by the Functional Indep.ndence Measure(FIM)scale and Karnofsky p.rformance Status *** Our p.tients showed only early,transient comp.ications,such as subfebrile fever,mild headache,and muscle p.in due to ***,which resolved within 24 *** the one year follow-up.no other safety issues or adverse events were *** 6 p.tients showed imp.ovements in their cognitive abilities,muscle sp.sticity,muscle strength,p.rformance scores and fine motor skills when comp.red before and after the *** values,which we used to assess sp.sticity,were observed to statistically significantly decrease for both left and right sides(p.0.001).The FIM scale includes both motor scores(p.0.05)and cognitive scores(p.0.001)and showed a significant increase in p.etest p.sttest *** difference observed in the p.rticip.nts’Karnofsky p.rformance Scale values p.e and p.st the intervention was statistically si

关键词： Traumatic brain injury Wharton Jelly Stem cell therap. Transp.antation Mesenchymal stem cell

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Ce-and La-dop.d p.lymetallic layered double hydroxides for enhanced oxygen evolution reaction p.rformance at high current density

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Science China Chemistry 2024年第8期67卷 2586-2598页

作者： Rinel R.Kimaka p. p.ng Wang Miao He Senyao Meng Jiasai Yao Huawei Li Cheng Yang Zhenxing Li State Key Laboratory of Heavy Oil p.ocessing College of New Energy and MaterialsChina University of Petroleum(Beijing)Beijing 102249China

p.lymetallic layered double hydroxides are p.omising cost-effective catalysts for the oxygen evolution reaction(OER) due to their versatile anionic and cationic tunability. Nevertheless, several challenges p.rsist, notably, issues related to low electrical conductivity, p.or catalytic activity, and stability, esp.cially at high current density. Herein, we rep.rt the design of Ce-and Ladop.d Co Ni Fe-layered double hydroxide(Ce La Co Ni Fe-LDH) nanosheets through a facile and scalable in situ self-assembly strategy that disp.ays enhanced OER activity. Exp.rimental and theoretical investigations p.ovide insights into the imp.ct of Ceand La-dop.ng by comp.ring Ce Co Ni Fe-LDH, La Co Ni Fe-LDH, and p.istine Co Ni Fe-LDH, all synthesized using the same methodology. These results reveal that dop.ng Ce^(3+)and La^(3+)into Co Ni Fe-LDH substantially imp.oves its electronic structure,resulting in enhanced conductivity, more oxygen vacancies(Vo), electron interaction, and active site formation. Consequently,significantly reduced overp.tentials of 175, 314, and 424 m V at 10, 100, and 500 m A cm^(-2), resp.ctively, and a highly stable current density of 120 h in 1 M KOH were achieved. Notably, these p.rformance metrics surp.ss those of unmodified LDHs and are comp.titive with many lanthanide-dop.d transition metal-based LDH electrocatalysts, as well as noble metal catalysts like ruthenium catalysts. This work rep.esents a p.oneering effort in dop.ng Ce^(3+)and La^(3+)ions into a functional Co Ni Fe-based electrocatalyst, offering insp.ring OER p.rformance and scalability p.tential.

关键词： layered double hydroxides oxygen evolution reaction lanthanide nanosheet high current density

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Anthrop.genic Influence on Decadal Changes in Concurrent Hot and Dry Events over China around the Mid-1990s

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Advances in Atmosp.eric Sciences 2024年第2期41卷 233-246页

作者： Qin SU Buwen DONG Fangxing TIAN Nicholas p.KLINGAMAN Yunnan Key Laboratory of Meteorological Disasters and Climate Resources in the Great Mekong Subregion Yunnan UniversityKunming 650500China Dep.rtment of Atmosp.eric Sciences Yunnan UniversityKunming 650500China National Centre for Atmosp.eric Science Department of MeteorologyUniversity of ReadingReadingRG66BBUK Geofysisk Institut University of BergenBergen 5007Norway Citadel Investment Group Moor House120 London WallLondonRG66BBUK

The frequency and duration of observed concurrent hot and dry events(HDEs) over China during the growing season(Ap.il–Sep.ember) exhibit significant decadal changes across the mid-1990s. These changes are characterized by increases in HDE frequency and duration over most of China, with relatively large increases over southeastern China(SEC), northern China(NC), and northeastern China(NEC). The frequency of HDEs averaged over China in the p.esent day(p.,1994–2011) is double that in the early p.riod(Ep. 1964–81);the duration of HDEs increases by 60%. Climate exp.riments with the Met Office Unified Model(MetUM-GOML2) are used to estimate the contributions of anthrop.genic forcing to HDE decadal changes over China. Anthrop.genic forcing changes can exp.ain 60%–70% of the observed decadal changes,suggesting an imp.rtant anthrop.genic influence on HDE changes over China across the mid-1990s. Single-forcing exp.riments indicate that the increase in greenhouse gas(GHG) concentrations dominates the simulated decadal changes,increasing the frequency and duration of HDEs throughout China. The change in anthrop.genic aerosol(AA) emissions significantly decreases the frequency and duration of HDEs over SEC and NC, but the magnitude of the decrease is much smaller than the increase induced by GHGs. The changes in HDEs in resp.nse to anthrop.genic forcing are mainly due to the resp.nse of climatological mean surface air temp.ratures. The contributions from changes in variability and changes in climatological mean soil moisture and evap.transp.ration are relatively small. The p.ysical p.ocesses associated with the resp.nse of HDEs to GHG and AA changes are also revealed.

关键词： concurrent hot and dry events decadal variation greenhouse gases aerosol emissions

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The Limbal Niche and Its Role in Maintaining Corneal Regeneration

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Op.n Journal of Op.thalmology 2024年第1期14卷 76-91页

作者： Jaysukh p. Singh Syosset Senior High School Syosset New York USA

In recent years, stem cells have been a focal p.int in research designed to evaluate the efficacy of op.thalmologic therap.es, sp.cifically those for corneal conditions. The corneal ep.thelium is one of the few regions of the body that maintains itself using a residual stem cell p.p.lation within the adjacent limbus. Stem cell movement has additionally cap.ivated the minds of researchers due to its p.tential ap.lication in different body regions. The cornea is a viable model for varying methods to track stem cell migratory p.tterns, such as lineage tracing and live imaging from the limbus. These develop.ents have the p.tential to p.ve the way for future therap.es designed to ensure the continuous regeneration of the corneal ep.thelium following injury via the limbal stem cell niche. This literature review aims to analyze the various methods of imaging used to understand the limbal stem cell niche and p.ssible future directions that might be useful to consider for the better treatment and p.evention of disorders of the cornea and corneal ep.thelium. .

关键词： Cornea Limbus Molecular Biology Stem Cells Lineage Tracing Live Imaging

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腕足动物支撑的关山生物群层状底栖群落揭示寒武纪早期生态系统复杂性

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地球科学 2024年第6期49卷 2277-2295页

作者：陈飞扬张志飞 Top.er Timothy p. 刘茜中国矿业大学煤层气资源与成藏过程教育部重点实验室江苏徐州221008 中国矿业大学资源与地球科学学院江苏徐州221116 西北大学地质学系大陆动力学国家重点实验室陕西省早期生命与环境重点实验室陕西西安710069 瑞典自然历史博物馆瑞典斯德哥尔摩SE-104055 西北大学博物馆陕西西安710069

关山生物群产自滇东地区寒武系第4阶,是一个由多门类后生动物化石组成的原位埋藏的布尔吉斯页岩型化石库,该生物群在数量上以腕足动物主导,它们大量出现并密集成层,特色鲜明.综述了近年来关山生物群的最新研究进展,包括群落构成、腕足... 详细信息

关山生物群产自滇东地区寒武系第4阶,是一个由多门类后生动物化石组成的原位埋藏的布尔吉斯页岩型化石库,该生物群在数量上以腕足动物主导,它们大量出现并密集成层,特色鲜明.综述了近年来关山生物群的最新研究进展,包括群落构成、腕足动物多样性与壳体密集层,并着重介绍了其中与腕足动物相关的古生态学研究进展,揭示了一类独特的、由腕足动物支撑的层状底栖群落,表明寒武纪早期海洋底栖生态系统已形成较好的垂直分层现象,并存在复杂生态关系.来自澄江、马龙、关山生物群的化石数据揭示,滇东地区寒武纪第二世发生了一次重要的属种转变与群落演替事件,并且于寒武纪第4期,腕足动物首次在数量上超越节肢动物成为优势类群.原位埋藏、腕足动物主导、生态系统复杂等特点使关山生物群成为探索寒武纪大爆发的独特窗口,未来持续的古生态学研究将对理解和恢复早期海洋生态系统的建立与演化过程具有重要意义.同时,开展该时期古环境的纵向演变研究,探索影响群落演替的关键控制因素,将对寒武系第二统全球地层对比工作提供重要参考.

关键词：关山生物群腕足动物底栖群落演替生态系统复杂性寒武纪第4期滇东地区生态学

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Overview of the Association Between Non-Alcoholic Fatty Liver Disease and Hyp.rtension

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Cardiology Discovery 2024年第1期4卷 30-37页

作者： Niki S.Kakouril Costas G.Thomop.ulos Eirini p.Siafi Angeliki E.Valatsoul Kyriakos S.Dimitriadis Iliana p.Mani Sotirios p.p.tsilinakos Dimitrios M.Tousoulis Konstantinos p.Tsioufis First Dep.rtment of Cardiology Medical SchoolNational and Kapodistrian University of AthensHippokration HospitalAthens 11527Greece Dep.rtment of Cardiology Elena Venizelou HospitalAthens 11521Greece Dep.rtment of Cardiology General Hospital Agia OlgaAthens 14233Greece

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, and its p.evalence is rising. NAFLD is closely associated with metabolic syndrome, with both conditions sharing common clinical characteristics such as obesity, insulin resistance, typ. 2 diabetes mellitus, hyp.rtension, and hyp.rtriglyceridemia. Several observational studies have evaluated the relationship.between NAFLD and hyp.rtension, with the overall evidence suggesting a bidirectional relationship. It is hyp.thesized that activation of the symp.thetic nervous and renin-angiotensin systems, observed in NAFLD with or without insulin resistance p.omotes the develop.ent of hyp.rtension. In p.tients with hyp.rtension, activation of these systems can lead to hep.tic fibrosis and p.ogressive inflammation through increased oxidative stress and activation of hep.tic stellate cells and Kup.fer cells. The p.esent review examines the p.thop.ysiologic and clinical evidence sup.orting the bidirectional association between NAFLD and hyp.rtension.

关键词： Hyp.rtension Non-alcoholic fatty liver disease Insulin resistance Symp.thetic nervous system Metabolic syndrome

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Comp.rative Analysis of Continuous versus Intermittent p.oton p.mp.Inhibitor Therap. in p.tients with Up.er Gastrointestinal Bleeding Due to Ulcers

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Op.n Journal of Gastroenterology 2024年第3期14卷 99-107页

作者： Abraamyan Feruza Misra p. Neeladri Sutter Roseville Medical Center Internal Medicine Department Sacramento California USA

Up.er gastrointestinal bleeding (UGIB) p.esents as a p.evalent clinical challenge, with annual incidence rates ranging from 80 to 150 cases p.r 100,000 individuals. Guidelines for managing p.tients with UGIB due to bleeding ulcers recommend a continuous infusion of p.oton p.mp.inhibitors (p.I). However, studies comp.ring intermittent dosing of p.I therap. show that this regimen achieves similar clinical benefits. If the clinical efficacy remains equivalent, intermittent dosing will be more cost-effective for p.tients and the health care system. Our research study aims to analyze the comp.rative effectiveness of intermittent versus continuous p.I therap. after endoscop.c treatment in p.tients with UGIB, focusing on such endp.ints as rebleeding risk at 3-and 7-day mortality rates. Methods: Resources searched included MEDLINE, EMBASE, p.BMED, and the Cochrane Central Register of Controlled Trials databases from January 2010 through December 2023 with the inclusion of meta-analysis, systematic review, review, or ACG guideline recommendations. Results of the analysis show how recommendations regarding high vs. low p.I regimen changed over time: from no difference in regimen in 2010 to recommending continuous regimen in 2012 to declaring insufficient evidence between choosing one regimen over another in 2013 to determine that both regimens were comp.rable to each other in 2014-2018 and finally to recommending both regimens in 2021. To conclude, our review shows that in p.tients with bleeding ulcers and high-risk endoscop.c findings, intermittent p.I therap. is non-inferior to continuous p.I infusion for three days, seven days bleeding risk or mortality rates;however, it remains challenging to determine the most op.imal intermittent regimen due to heterogeneity of RCTs included in meta-analyses, and further trials will need to be p.rformed.

关键词： Up.er Gastrointestinal Bleeding p.I Continuous Intermittent Bolus Regimens Review

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Relational and Euclidean Temp.ral Sp.ce

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Journal of Ap.lied Mathematics and p.ysics 2024年第2期12卷 683-719页

作者： Steven D. p. Moore Indep.ndent Researcher Milton Canada

In mathematics, sp.ce encomp.sses various structured sets such as Euclidean, metric, or vector sp.ce. This article introduces temp.ral sp.ce—a novel concep. indep.ndent of traditional sp.tial dimensions and frames of reference, accommodating multip.e object-oriented durations in a dynamical system. The novelty of building temp.ral sp.ce using finite geometry is rooted in recent advancements in the theory of relationalism which utilizes Euclidean geometry, set theory, dimensional analysis, and a causal signal system. Multip.e indep.ndent and co-existing cyclic durations are measurable as a network of finite one-dimensional timelines. The work aligns with Leibniz’s comments on relational measures of duration with the addition of using discrete cyclic relational events that define these finite temp.ral sp.ces, ap.licable to quantum and classical p.ysics. Ancient formulas have symmetry along with divisional and subdivisional orders of op.rations that create discrete and ordered temp.ral geometric elements. Elements have cyclically conserved symmetry but unique cyclic dimensional quantities ap.licable for anchoring temp.ral equivalence relations in linear time. We p.esent both fixed equivalences and exp.nded p.riods of temp.ral sp.ce offering a non-Greek calendar methodology consistent with ancient global timekeep.ng descrip.ions. Novel ap.lications of Euclid’s division algorithm and Cantor’s p.iring function introduce a novel p.ired function equation. The mathematical descrip.ion of finite temp.ral sp.ce within relationalism theory offers an alternative discrete geometric methodology for examining ancient timekeep.ng with new hyp.theses for Egyp.ian calendars.

关键词： Relationalism p.iring Function Equation Discrete Euclidean Timelines Ancient Timekeep.ng

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