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Multifunctional GelMA platforms with nanomaterials for advanced tissue therapeutics

Bioactive Materials 2022年第2期7卷 267-295页

作者： Amal George Kurian Rajendra KSingh kapil dpatel Jung-Hwan Lee Hae-Won Kim Institute of Tissue Regeneration Engineering(ITREN) Dankook UniversityCheonan31116Republic of Korea Department of Nanobiomedical Science&BK21 NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonan31116Republic of Korea Biomaterials and Tissue Engineering UCL Eastman Dental InstituteLondonWC1X8LDUK Department of Biomaterials Science School of DentistryDankook UniversityCheonan31116Republic of Korea UCL Eastman-Korea Dental Medicine Innovation Centre Dankook UniversityCheonan31116Republic of Korea Cell&Matter Institute Dankook UniversityCheonan31116Republic of Korea Department of Regenerative Dental Medicine College of DentistryDankook UniversityCheonan31116Republic of Korea Mechanobiology Dental Medicine Research Center Dankook UniversityCheonan31116Republic of Korea

Polymeric hydrogels are fascinating platforms as 3D scaffolds for tissue repair and delivery systems of therapeutic molecules and *** others,methacrylated gelatin(GelMA)has become a representative hydrogel formulation,finding various biomedical *** efforts on GelMA-based hydrogels have been devoted to combining them with bioactive and functional nanomaterials,aiming to provide enhanced physicochemical and biological properties to *** benefits of this approach are multiple:i)reinforcing mechanical properties,ii)modulating viscoelastic property to allow 3D printability of bio-inks,iii)rendering electrical/magnetic property to produce electro-/magneto-active hydrogels for the repair of specific tissues(e.g.,muscle,nerve),iv)providing stimuli-responsiveness to actively deliver therapeutic molecules,and v)endowing therapeutic capacity in tissue repair process(e.g.,antioxidant effects).The nanomaterial-combined GelMA systems have shown significantly enhanced and extraordinary behaviors in various tissues(bone,skin,cardiac,and nerve)that are rarely observable with *** we systematically review these recent efforts in nanomaterials-combined GelMA hydrogels that are considered as next-generation multifunctional platforms for tissue *** approaches used in GelMA can also apply to other existing polymeric hydrogel systems.

关键词： GelMA hydrogel Nanomaterials Multifunctional Therapeutics Tissue repair

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Double hits with bioactive nanozyme based on cobalt-doped nanoglass for acute and diabetic wound therapies through anti-inflammatory and pro-angiogenic functions

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Bioactive Materials 2024年第1期31卷 298-311页

作者： Nandin Mandakhbayar YunSeong Ji Ahmed El-Fiqi kapil dpatel Dong Suk Yoon Khandmaa Dashnyam Oyunchimeg Bayaraa Gangshi Jin Khaliunsarnai Tsogtbaatar Tae-Hyun Kim Jung-Hwan Lee Hae-Won Kim Institute of Tissue Regeneration Engineering(ITREN) Dankook UniversityCheonan31116Republic of Korea Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonan31116Republic of Korea Glass Research Department National Research CentreCairo12622Egypt School of Cellular and Molecular Medicine(CMM) University of BristolBristolBS81TD United Kingdom Department of Biomedical Science Hwasung Medi-Science UniversityHwaseong-Si 18274Gyeonggi-DoRepublic of Korea Drug Research Institute Mongolian University of Pharmaceutical SciencesUlaanbaatar 14250Mongolia R&D Center TE BiosOsongRepublic of Korea Department of Biomaterials Science School of DentistryDankook UniversityCheonan31116Republic of Korea Mechanobiology Dental Medicine Research Center Dankook UniversityCheonan31116Republic of Korea UCL Eastman-Korea Dental Medicine Innovation Centre Dankook UniversityCheonan31116Republic of Korea Cell&Matter Institute Dankook UniversityCheonan 31116Republic of Korea

Regeneration of pathological wounds,such as diabetic ulcers,poses a significant challenge in clinical settings,despite the widespread use of *** overcome clinical side effects and complications,drug-free therapeutics need to be developed to promote angiogenesis while overcoming inflammation to restore regenerative *** study presents a novel bioactive nanozyme based on cobalt-doped nanoglass(namely,CoNZ),which exhibits high enzymatic/catalytic activity while releasing therapeutic *** oxide“Co3O4”tiny crystallites produced in situ through a chemical reaction with H2O2 within CoNZ nanoparticles play a crucial role in scavenging *** showed that CoNZ-treatment to full-thickness skin wounds in mice significantly accelerated the healing process,promoting neovascularization,matrix deposition,and epithelial lining while reducing pro-inflammatory ***,CoNZ was highly effective in treating pathological wounds(streptozotocin-induced diabetic wounds).Rapid scavenging of ROS by CoNZ and down-regulation of pro-inflammatory markers while up-regulating tissue healing signs with proliferative cells and activated angiogenic factors contributed to the observed healing *** vitro experiments involving CoNZ-cultures with macrophages and endothelial cells exposed to high glucose and ROS-generating conditions further confirmed the effectiveness of ***-promoted angiogenesis was attributed to the release of cobalt ions,as evidenced by the comparable effects of CoNZ-extracted ionic medium in enhancing endothelial migration and tubule formation via activated HIF-1α.Finally,we compared the in vivo efficacy of CoNZ with the clinically-available drug *** demonstrated that CoNZ was as effective as the drug in closing the diabetic wound,indicating the potential of CoNZ as a novel drug-free therapeutic approach.

关键词： Diabetic wound Nanozyme Anti-inflammation Angiogenesis Therapeutic materials

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Tailoring wind properties by various passive roughness elements in a bound- ary-layer wind tunnel

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Journal of Thermal Science 2012年第4期21卷 336-341页

作者： kapil Varshney Research Department Manager Taitem Engineering PC Ithaca

Boundary-layer wind tunnel provides a unique platform to reproduce urban, suburban and rural atmospheric boundary layer （ABL） by using roughness devices such as vortex generators, floor roughness, barrier wails, and slots in the extended test-section floor in the contraction cone. Each passive device impacts wind properties in a certain way. In this study, influence of various passive devices on wind properties has been investigated. Experi- ments using eighteen different configurations of the passive devices have been carried out to simulate urban, sub-urban, and rural climate conditions in a boundary-layer wind tunnel. The effect of each configuration on the wind characteristics is presented. It was found that higher barrier height and more number of roughness elements on the floor, generated higher turbulence and therefore higher model scale factors were obtained. However, in- creased slot width in the extended test-section floor in the contraction cone of the wind tunnel seemed to have a little effect on wind characteristics.

关键词： Atmospheric boundary layer wind tunnel wind properties roughness elements turbulence.

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Multi-Objective Optimization of Fused Deposition Modeling for Mechanical Properties of Biopolymer Parts Using the Grey-Taguchi Method

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Chinese Journal of Mechanical Engineering 2023年第1期36卷 51-64页

作者： kapil Kumar Hari Singh Department of Mechanical Engineering National Institute of TechnologyKurukshetra136119India

The urgent need to develop customized functional products only possible by 3D printing had realized when faced with the unavailability of medical devices like surgical instruments during the coronavirus-19 disease and the ondemand necessity to perform surgery during space *** have recently been the most appropriate option for fabricating surgical instruments via 3D printing in terms of cheaper and faster *** all 3D printing techniques,fused deposition modelling(FDM)is a low-cost and more rapid printing *** article proposes the fabrication of surgical instruments,namely,forceps and hemostat using the fused deposition modeling(FDM)*** mechanical properties are the only indicator to judge the quality of the functional *** mechanical properties of FDM-processed parts depend on various process *** parameters are layer height,infill pattern,top/bottom pattern,number of top/bottom layers,infill density,flow,number of shells,printing temperature,build plate temperature,printing speed,and fan *** strength and modulus of elasticity are chosen as evaluation indexes to ascertain the mechanical properties of polylactic acid(PLA)parts printed by *** experiments have performed through Taguchi’s L27orthogonal array(OA).Variance analysis(ANOVA)ascertains the significance of the process parameters and their percent contributions to the evaluation ***,as a multiobjective optimization technique,grey relational analysis(GRA)obtains an optimal set of FDM process parameters to fabricate the best parts with comprehensive mechanical *** electron microscopy(SEM)examines the types of defects and strong bonding between *** proposed research ensures the successful fabrication of functional surgical tools with substantial ultimate tensile strength(42.6 MPa)and modulus of elasticity(3274 MPa).

关键词： Fused deposition modeling Mechanical properties Taguchi method ANOVA Grey relational analysis SEM

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On dry machining of AZ31B magnesium alloy using textured cutting tool inserts

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Journal of Magnesium and Alloys 2024年第4期12卷 1608-1618页

作者： Shailendra Pawanr kapil Gupta Department of Mechanical and Industrial Engineering Technology University of JohannesburgDoornfontein CampusJohannesburg 2028 South Africa

Magnesium alloys have many advantages as lightweight materials for engineering applications,especially in the fields of automotive and *** undergo extensive cutting or machining while making products out of *** cutting,a sustainable machining method,causes more friction and adhesion at the tool-chip *** of the promising solutions to this problem is cutting tool surface texturing,which can reduce tool wear and friction in dry cutting and improve machining *** paper aims to investigate the impact of dimple textures(made on the flank face of cutting inserts)on tool wear and chip morphology in the dry machining of AZ31B magnesium *** results show that the cutting speed was the most significant factor affecting tool flank wear,followed by feed rate and cutting *** tool wear mechanism was examined using scanning electron microscope(SEM)images and energy dispersive X-ray spectroscopy(EDS)analysis reports,which showed that at low cutting speed,the main wear mechanism was abrasion,while at high speed,it was *** chips are discontinuous at low cutting speeds,while continuous at high cutting *** dimple textured flank face cutting tools facilitate the dry machining of AZ31B magnesium alloy and contribute to ecological benefits.

关键词： Magnesium alloy Dry machining Textured tools Flank wear Sustainability

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Salmonella Typhimurium infection disrupts but continuous feeding of Bacillus based probiotic restores gut microbiota in infected hens

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Journal of Animal Science and Biotechnology 2020年第3期11卷 789-804页

作者： Samiullah Khan kapil K.Chousalkar School of Animal and Veterinary Sciences The University of AdelaideRoseworthySouth Australia 5371Australia

Background:The gut microbiota plays an important role in the colonisation resistance and invasion of *** Typhimurium has the potential to establish a niche by displacing the microbiota in the chicken gut causing continuous faecal shedding that can result in contaminated eggs or egg *** the current study,we investigated the dynamics of gut microbiota in laying chickens during Salmonella Typhimurium *** optimisation of the use of an infeed probiotic supplement for restoration of gut microbial balance and reduction of Salmonella Typhimurium load was also ***:Salmonella infection caused dysbiosis by decreasing(FDR0.05)by Salmonella challenge and the butyrate level was increased by the continuous feeding of the *** supplementation in Salmonella challenged chickens resulted in higher level of *** probiotic supplementation decreased(P<0

关键词： 16S rRNA sequencing Chicken gut microbiota Gut metabolites Salmonella Typhimurium Strategic feeding of probiotic

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Squeeze casting for metal alloys and composites:An overview of influence of process parameters on mechanical properties and microstructure

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China Foundry 2023年第2期20卷 148-158页

作者： Osarue Osaruene Edosa Francis Kunzi Tekweme kapil Gupta Department of Mechanical and Industrial Engineering Technology University of JohannesburgJohannesburgRepublic of South Africa Department of Mechanical Engineering College of Engineering and TechnologyWilliam V.S.Tubman UniversityHarperMaryland CountyRepublic of Liberia

Squeeze casting is a well-established and reliable process for fabricating high-integrity metallic alloys,bimetals,and *** quality and high performance of squeeze cast components are dependent on optimum casting *** selection of parameter values may adversely affect the quality of the *** squeeze cast components are generally subjected to secondary processing such as heat treatment,extrusion,and other bulk deformation processes to improve the microstructural features and mechanical *** treatment further refines the grains and reduces porosity,consequently improving tensile strength,and hardness;however,ductility *** paper provides a comprehensive review on studies concerning the influence of processing parameters on porosity,density,percentage elongation,strength,hardness,wear,and fracture of squeeze casting alloys,aiming to provide sufficient information on the squeeze casting process and the effects of processing parameters on product quality.

关键词： composites microstructure optimization porosity solidification squeeze casting

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Synthesis and Characterization of CdO–SnO_2 Nanocomposites Prepared by Hydrothermal Method

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Acta Metallurgica Sinica(English Letters) 2018年第3期31卷 254-262页

作者： kapil Sirohi Suresh Kumar Virender Singh Anil Vohra Department of Electronic Science Kurukshetra University

In this work,（1-x）CdO-xSnO2 nanocomposites（≤0.15）have been synthesized via hydrothermal *** structural study reveals that CdO nanostructures possess crystalline phase and cubic *** CdO-SnO2 nanocomposites possess both cubic and orthorhombic structure with good *** crystallite size in the nanocomposites was found to be in the range of 9.6-19.6 *** emission scanning electronic microscopy and high-resolution tunnelling microscopy analysis confirm the presence of both cubic and orthorhombic structures which is also confirmed from X-ray diffraction *** transform infrared spectroscopy（FFIR）studies confirm that CdO-SnO2 nanocomposites possess the characteristics band of both CdO and SnO2 *** UV-visible absorption studies confirm that the optical absorption band in CdO-SnO2 nanocomposites possesses both blue and red shift as compared to that of CdO *** spectroscopy studies reveal the appearance of strong emission peak at 513,469 and 369 nm corresponding to green,blue and violet emission spectrum,respectively,in CdO-SnO2 *** FTIR studies confirm the presence of hydroxyl and water functional group due to atmospheric water vapours and chemical bonding in CdO and CdO-SnO2 *** spectroscopy confirms the presence of Raman bands of both CdO and SnO2 phases in the CdO-SnO2 nanocomposites.

关键词： Hydrothermal Nanocomposite CdO-SnO2 XRD FESEM HRTEM Optical properties

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Understanding the effects of intramuscular injection and feed withdrawal on Salmonella Typhimurium shedding and gut microbiota in pullets

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Journal of Animal Science and Biotechnology 2022年第1期13卷 123-137页

作者： Nitish Narendra Joat Samiullah Khan kapil Chousalkar School of Animal and Veterinary Sciences The University of AdelaideRoseworthySouth Australia 5371Australia

Background:Gut microbiota plays a key role in health,immunity,digestion,and production in *** such as environment,diet,diseases,stress,and flock management significantly affect gut microbiota;however,it is not known how potential stressors such as intramuscular injections or feed withdrawal alter the composition of gut microbiota that result in increased the shedding level of foodborne *** the current study,the effects of intramuscular corticosterone injection and feed withdrawal were evaluated to understand their role in Salmonella Typhimurium shedding and changes in the composition of gut microbiota in ***:Salmonella shedding was observed for 8 weeks *** was a significant increase in Salmonella Typhimurium count after intramuscular injection and feed *** Salmonella infected and the negative control groups showed significant differences in the abundance of different genera in gut microbiota at week 1 and up to week 7 post *** infected group showed a significant reduction in alpha diversity of gut *** reduced significantly(P<0.05)after intramuscular injection,while the feed withdrawal groups did not cause any significant changes in Proteobacteria-Firmicutes ***,intramuscular injection resulted in a significant change in alpha diversity of gut ***:Exposure of chicks to relatively low dose of Salmonella Typhimurium can lead to persistent shedding in *** Salmonella Typhimurium infection disrupted the gut microbiota composition immediately after *** potential stress of intramuscular injection and feed withdrawal significantly increased the Salmonella Typhimurium count in *** intramuscular injection also resulted in a significant alteration of the Proteobacteria-Firmicutes ratio,which could increase the risk of dysbiosis.

关键词： Corticosterone injection Feed withdrawal stress Gut microbiota composition Layer chicken Salmonella Typhimurium infection

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DeepWalk Based Influence Maximization (DWIM): Influence Maximization Using Deep Learning

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Intelligent Automation & Soft Computing 2023年第1期35卷 1087-1101页

作者： Sonia kapil Sharma Monika Bajaj Department of Information Technology Delhi Technological UniversityNew Delhi110039India Department of Computer Science University of DelhiNew Delhi110007India

Big Data and artificial intelligence are used to transform *** networking sites have given a new dimension to online *** media platforms help gather massive amounts of data to reach a wide variety of customers using influence maximization technique for innovative ideas,products and *** paper aims to develop a deep learning method that can identify the influential users in a *** method combines the various aspects of a user into a single *** a social network,the most influential user is the most trusted *** significant users are used for viral marketing as the seeds to influence other users in the *** proposed method combines both topical and topological aspects of a user in the network using *** proposed method is DeepWalk based Influence Maximization(DWIM).The proposed method was able tofind k influential nodes with computable time using the *** experiments are performed to assess the proposed algorithm,and centrality measures are used to compare the *** results reveal its performance that the proposed method canfind k influential nodes in computable *** can identify influential users,which helps viral marketing,outlier detection,and recommendations for different products and *** applying the proposed methodology,the set of seed nodes gives maximum influence measured with respect to different centrality measures in an increased computable time.

关键词： Deep learning inﬂuence maximization graph embedding deepwalk

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