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Severity of ultrasonographic liver steatosis and metabolic syndrome in Korean men and women

World Journal of Gastroenterology 2005年第34期11卷 5314-5321页

作者： Hyeon Chang Kim Sung Hee Choi Hae Won Shin Jae Youn Cheong Kwan Woo Lee Hyun Chul Lee kap bum huh Dae Jung Kim Department of Preventive Medicine Yonsei University College of Medicine Seoul South Korea Department of Internal Medicine Seoul National University College of Medicine Seongnam South Korea Department of Public Health Graduate School of Yonsei University Seoul South Korea Department of Gastroenterology Ajou University School of Medicine Suwon South Korea Department of Endocrinology and Metabolism Ajou University School of Medicine Suwon South Korea Department of Internal Medicine Yonsei University College of Medicine Seoul South Korea huh's Diabetes Center and the 21~(st) Century Diabetes and Vascular Research Institute Seoul South Korea

AIM：To evaluate the association between the severity of liver steatosis and metabolic syndrome in apparently healthy Korean adults. METHODS： We examined 1022 men and women, aged 30-79 years, who participated in a health screening test. A standard interview, anthropometrics, biochemical studies, and abdominal ultrasonography were conducted for each participant. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel Ⅲ, with a modification for the waist circumference cut-off level. The severity of liver steatosis was evaluated using liver ultrasonography, and serum aspartate aminotransferase（AST）, alanine aminotransferase （ALT）, and γ-glutamyl transferase （γ-GT） levels were determined. RESULTS： Ultrasonographic liver steatosis was strongly associated with metabolic syndrome and common metabolic abnormalities. Compared with people without steatosis, people with mild, moderate, and severe steatosis had adjusted odds ratios for metabolic syndrome of 2.72 （95% CI, 1.01-2.94）, 2.89 （1.75-4.76） and 3.53 （1.25-9.98） in men, and 2.86 （1.64-5.01）, 3.19 （1.80-5.65） and 3.70 （0.82-16.73） in women, respectively. The serum AST level was not associated with metabolic syndrome. The serum ALT and γ-GT levels were significantly associated with metabolic syndrome in men but not in women.CONCLUSION： The occurrence of metabolic syndrome shows a stronger association with the severity of ultrasonographic steatosis than with the serum liver enzyme levels. The degree of fatty infiltration detected on ultrasonography can be used as an indicator of liver dysfunction attributable to metabolic abnormalities.

关键词： Metabolic syndrome Liver steatosis Nonalcoholic fatty liver disease Ultrasonography

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