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Primary Multiple Cerebral Hydatid Cyst in 8 Year-Old Girl: A Rare Cause of Childhood Seizure

Open Journal of Modern Neurosurgery 2024年第2期14卷 149-157页

作者： kaoutar stitou Ilias Zahir Oualid Mohammed Hmamouche Marouane Hammoud Faycal Lakhdar Mohammed Benzagmout Khalid Chakour Mohammed El Faiz Chaoui Department of Neurosurgery University Hospital of Fez Fez Morocco

Background: Cystic echinococcosis is a zoonotic infection that occurs worldwide. Humans are infected through ingestion of parasite eggs in contaminated food, water or through direct contact with infected dogs, which are the definite host. Humans serve accidentally as intermediate host, and occurrences are common in children and young adults. Cystic echinococcosis is endemic in Mediterranean, South American, Middle Eastern, Central Asia, East Africa countries and Australia. Multiple cerebral hydatid cysts are very rare with only a few reports in the literature. Case Description: We present the case of an 8-year-old girl who presented with focal seizures, hemiparesis, headache, vomiting and bilateral optic atrophy. Diagnostic workup was performed, and magnetic resonance imaging revealed multiple intracranial cysts predominantly in the right frontal region with significant mass effect. A total of 11 intracranial cysts were removed surgically, and the child recovered uneventfully. Conclusion: Neurosurgeons should keep hydatidosis in the list of differentials when evaluating patients with cystic diseases of the brain. Although the removal of such cysts is challenging, outcomes are excellent when cysts are evacuated without rupture and patients show complete resolution of symptoms.

关键词： Hydatid Cysts Multiple Hydatic Cysts Childhood Seizures

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Extra-Axial Anaplastic Pleomorphic Xanthoastrocytoma Mimicking Meningioma: A Case Report with Literature Review

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Open Journal of Modern Neurosurgery 2024年第3期14卷 203-211页

Background: A number of meningeal neoplastic lesions may radiologically and clinically simulate meningioma, include hemangiopericytomas, solitary fibrous tumors, schwannomas, hematolymphoid lesions, metastases, and others very rarely, also may clinically mimic meningiomas. Case Description: We present the case of A 28-year-old male patient, with no notable medical history, who presented with worsening headaches for 3 months, imbalance, and visual deficits, An initial MRI revealed extra-axial lesion involving the right Parieto-occipital, The tumor was hypointense on T1-weighted MR images, hyperintense signals on T2-weightedMR images, and heterogeneously enhanced suggestive of a meningioma, total resection was achieved, and the histopathological analysis confirmed the diagnosis of an angioblastic meningioma. However, 15 months later, the patient presented with the same initial visual complaints. A subsequent MRI showed lesion recurrence, leading to a second surgical intervention. The histopathological analysis confirmed the diagnosis of an anaplastic xanthoastrocytoma. Conclusion: This represents an unusual location for an anaplastic pleomorphic xanthoastrocytoma, which should broaden the differential diagnosis of extra-axial lesions.

关键词： Anaplastic Features BRAF Extra-Axial High Mitotic Rate High Proliferation Index Meningeal Pleomorphic Xanthoastrocytoma

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Primary Extra-Gastrointestinal Stromal Tumors (E-GIST) of the Liver, about Two Cases and Review of the Literature Oncology Hospital Experience at Chu Hassan II in FES

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Journal of Cancer Therapy 2023年第3期14卷 117-126页

作者： Oumaima Siyouri Mohammed Ismaili Khaoula Alaoui Ismaili Imane stitou Hajar Medyouni Jihane Chouef Lamiae Amaadour Karima Oualla Zineb Benbrahim Samia Arifi Nawfel Mellas Hospital Center University Hassan II Fez Morocco

Introduction: Primary extra-gastrointestinal stromal tumors (E-GIST) of the liver are rare. The clinical presentation can range from asymptomatic to bleeding or manifestations of mass effect. Cancer surgery followed by adjuvant treatment with imatinib is the standard of care. However, in special circumstances, a cytoreductive approach may represent a therapeutic option. We describe here the case of two patients who presented with a painful and protruding epigastric mass, the first case was a localized E-GIST candidate for neoadjuvant treatment with imatinib with complete resection surgery thereafter with very good evolution, and the second is that of an E-GIST of the liver at an advanced stage with an evolution very quick to death. Conclusion: Primary liver E-GIST is a rare condition. Treatment is based on systemic therapy and total resection surgery. However, cytoreductive surgery will be required when complete resection is not possible.

关键词： Extra GIST Foie Imatinib

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Pre-Sacral Chordomas, about Two Cases and Review of the Literature

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Journal of Cancer Therapy 2023年第4期14卷 152-160页

作者： Oumaima Siyouri Khaoula Alaoui Ismaili Imane stitou Mohammed Ismaili Hajar Medyouni Jihane Chouef Lamiae Amaadour Karima Oualla Zineb Benbrahim Samia Arifi Nawfel Mellas Department of Oncology University Hospital Center Fes Morocco

The World Health Organization (WHO) defines chordoma as a malignant tumor of intermediate or low grade, developing at the expense of embryonic remnants of the notochord. These tumors represent 8.4% of all malignant bone tumors. We report 2 cases collected in the medical oncology department at the CHU Hassan II in Fes. In whom the clinical examination revealed a mass and/or signs of loco-regional compression. The tumor was located in the sacrum in both patients. The diagnosis was based on the data of the anatomopathological examination showing the association of a lobulated architecture with classic physaliphore cells and a mucoid intercellular substance. Immunohistochemistry was performed for both patients. The principle of therapeutic management was based on radiotherapy and targeted therapy since surgery was difficult given the local tumor extension.

关键词： Chordomas Imatinib Radiotherapy

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