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Leukemogenic Fusion Gene (p190 BCR-ABL) Transduction into Hematopoietic Stem/Progenitor Cells in the Common Marmoset

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Open Journal of Blood Diseases 2012年第1期2卷 1-10页

作者： Yan Dong Seiichiro Kobayashi Yamin Tian Manabu Ozawa Takafumi Hiramoto Kiyoko Izawa Yuansong Bai Yasushi Soda Erika Sasaki Toshio Itoh Yoshiro Maru Satoshi Takahashi kaoru uchimaru Naoki Oyaizu Arinobu Tojo Chieko Kai Kenzaburo Tani Central Institute for Experimental Animals Kawasaki Japan Department of Laboratory Medicine Research Hospital Institute of Medical Science the University of Tokyo Tokyo Japan Department of Molecular Genetics Medical Institute of Bioregulation Kyushu University Fukuoka Japan Department of Pharmacology Tokyo Woman’s Medical University Japan Division of Molecular Therapy Institute of Medical Science the University of Tokyo Tokyo Japan Laboratory Animal Research Center Institute of Medical Science the University of Tokyo Tokyo Japan.

Patients with Philadelphia chromosome (p190 BCR-ABL fusion gene)-positive acute lymphoblastic leukemia have a poor prognosis despite intensive therapeutic intervention.In this study, we attempted to develop a leukemia nonhuman primate model that mimics various human systems. Hematopoietic stem/progenitor cells in the common marmoset were transduced with a lentiviral vector containing the p190 BCR-ABL fusion gene by ex vivo transduction or in vivo direct bone marrow injection. In the latter model, BCR-ABL gene expression was maintained for more than one and a half years. One marmoset unexpectedly developed myelofibrosis-like disease. However, none of the marmosets have developed leukemia to date. In conclusion, we successfully achieved sustained p190 BCR-ABL gene expression in vivo. However, a genetic mutation in addition to p190 BCR-ABL may be required for the malignant transformation of hematopoietic stem/progenitor cells in the common marmoset during the short observation period. This novel in vivo approach will help develop a marmoset leukemia model in the future.

关键词： Leukemia Lentiviral Vector Myelofibrosis Common Marmoset

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Significance of oxidative stress and antioxidant capacity tests as biomarkers of premature ovarian insufficiency: A case control study

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World Journal of Clinical Cases 2024年第3期12卷 479-487页

作者： kaoru Kakinuma Toshiyuki Kakinuma Department of Obstetrics and Gynecology International University of Health and Welfare HospitalTochigi 329-2763Japan Graduate School of Medicine International University of Health and WelfareTokyo 107-8402Japan

BACKGROUND Premature ovarian insufficiency(POI)is a condition that causes secondary amenorrhea owing to ovarian hypofunction at an early stage.Early follicular depletion results in intractable infertility,thereby considerably reducing the quality of life of females.Given the continuum in weakened ovarian function,progressing from incipient ovarian failure(IOF)to transitional ovarian failure and further to POI,it is necessary to develop biomarkers for predicting POI.The oxidative stress states in IOF and POI were comprehensively evaluated via oxidative stress[diacron-reactive oxygen metabolites(d-ROMs)]test and anti-oxidant capacity[biological antioxidant potential(BAP)].METHODS Females presenting with secondary amenorrhea over 4 mo and a follicle stimulating hormone level of>40 mIU/mL were categorized into the POI group.Females presenting with a normal menstrual cycle and a follicle stimulating hormone level of>10.2 mIU/mL were categorized into the IOF group.Healthy females without ovarian hypofunction were categorized into the control group.Among females aged<40 years who visited our hospital from January 2021 to June 2022,we recruited 11 patients into both POI and IOF groups.For the potential antioxidant capacity,the relative oxidative stress index(BAP/d-ROMs×100)was calculated,and the oxidative stress defense system was comprehensively evaluated.RESULTS d-ROMs were significantly higher in the POI and IOF groups than in the control group,(478.2±58.7 U.CARR,434.5±60.6 U.CARR,and 341.1±35.1 U.CARR,respectively)(U.CARR is equivalent to 0.08 mg/dL of hydrogen peroxide).However,no significant difference was found between the POI and IOF groups.Regarding BAP,no significant difference was found between the control,IOF,and POI groups(2078.5±157.4μmol/L,2116.2±240.2μmol/L,and 2029.0±186.4μmol/L,respectively).The oxidative stress index was significantly higher in the POI and IOF groups than in the control group(23.7±3.3,20.7±3.6,and 16.5±2.1,respectively).However,no significant difference was found between the POI and IO

关键词： Premature ovarian insufficiency Oxidative stress Diacron-reactive oxygen metabolites test Biological antioxidant potential Infertility Biomarker

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Abnormal uterine bleeding successfully treated via ultrasoundguided microwave ablation of uterine myoma lesions: Three case reports

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World Journal of Clinical Cases 2024年第5期12卷 980-987页

作者： Toshiyuki Kakinuma kaoru Kakinuma Rora Okamoto kaoru Yanagida Michitaka Ohwada NobuhiroTakeshima Takeshima Department of Obstetrics and GynecologyInternational University of Health and Welfare HospitalTochigi 329-2763Japan

BACKGROUND Microwave endometrial ablation(MEA)is a minimally invasive treatment method for heavy menstrual bleeding.However,additional treatment is often required after recurrence of uterine myomas treated with MEA.Additionally,because this treatment ablates the endometrium,it is not indicated for patients planning to become pregnant.To overcome these issues,we devised a method for ultrasound-guided microwave ablation of uterine myoma feeder vessels.We report three patients successfully treated for heavy menstrual bleeding,secondary to uterine myoma,using our novel method.CASE SUMMARY All patients had a favorable postoperative course,were discharged within 4 h,and experienced no complications.Further,no postoperative recurrence of heavy menstrual bleeding was noted.Our method also reduced the myoma’s maximum diameter.CONCLUSION This method does not ablate the endometrium,suggesting its potential appli-cation in patients planning to become pregnant.

关键词： Uterine myoma Microwave Heavy menstrual bleeding Dysmenorrhea Fertility preservation Case report

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An LESO Based Backstepping Controller Considering Coal Seam Hardness for Rotary Speed in Coal Mine Tunnel Drilling Process

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Journal of Systems Science & Complexity 2024年第5期 1789-1808页

作者： CHEN Luefeng LIU Xiao WU Min LU Chengda PEDRYCZ Witold HIROTA kaoru School of Automation China University of Geosciences Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems Engineering Research Center of Intelligent Technology for Geo-Exploration Ministry of Education Department of Electrical and Computer Engineering University of Alberta The Tokyo Institute of Technology

In the process of coal mine drilling, controlling the rotary speed is important as it determines the efficiency and safety of drilling. In this paper, a linear extended state observer(LESO) based backstepping controller for rotary speed is proposed, which can overcome the impact of changes in coal seam hardness on rotary speed. Firstly, the influence of coal seam hardness on the drilling rig's rotary system is considered for the first time, which is reflected in the numerical variation of load torque, and a dynamic model for the design of rotary speed controller is established. Then an LESO is designed to observe the load torque, and feedforward compensation is carried out to overcome the influence of coal seam hardness. Based on the model of the compensated system, a backstepping method is used to design a controller to achieve tracking control of the rotary speed. Finally, the effectiveness of the controller designed in this paper is demonstrated through simulation and field experiments, the steady-state error of the rotary speed in field is 1 r/min, and the overshoot is reduced to 5.8%. This greatly improves the stability and security, which is exactly what the drilling process requires.

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Uterine artery pseudoaneurysm caused by hysteroscopic surgery: A case report

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World Journal of Clinical Cases 2024年第26期12卷 5968-5973页

作者： kaoru Kakinuma Toshiyuki Kakinuma Kyouhei Ueyama Rora Okamoto kaoru Yanagida Nobuhiro Takeshima Michitaka Ohwada Department of Obstetrics and Gynecology International University of Health and Welfare Hospital537-3 IguchiNasushiobaraTochigi 329-2763Japan

BACKGROUND We report a case of uterine artery pseudoaneurysm(UAP)occurrence during hysteroscopic endometrial polypectomy and its treatment via uterine artery embolization(UAE).CASE SUMMARY A 48-year-old primigravid,primiparous patient was incidentally found to have an endometrial polyp during a health checkup,and underwent a hysteroscopic polypectomy at another hospital.Her cervix was dilated with a Laminken-R®device.After the Laminken-R®was withdrawn,a large amount of genital bleeding was observed.This bleeding persisted after the hysteroscopic polypectomy,and,as hemostasis became impossible,the patient was transferred to our hospital by ambulance.On arrival,transvaginal ultrasonography revealed a 3-cm hypoechoic mass with a swirling internal pulse on the right side of the uterus,and color Doppler ultrasonography showed feeder vessels penetrating the mass.Pelvic contrast-enhanced computed tomography(CT)confirmed the presence of a mass at this site,and vascular proliferation was observed within the uterine cavity.Consequently,UAP was diagnosed,and UAE was performed.The patient’s postoperative course was uneventful,and 6 mo post-UAE,no recurrence of blood flow to the UAP was observed.CONCLUSION When abnormal genital bleeding occurs during hysteroscopic surgery,ultrasonography and contrast-enhanced CT can assist in the detection of early UAPs.

关键词： Cervical dilation Hysteroscopic surgery Uterine artery pseudoaneurysm Uterine artery embolization Case report

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面向动态场景去模糊的对偶学习生成对抗网络

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控制与决策 2024年第4期39卷 1305-1314页

作者：纪野戴亚平廣田薰邵帅北京理工大学自动化学院北京100081 北京理工大学复杂系统智能控制与决策国家重点实验室北京100081

针对动态场景下的图像去模糊问题,提出一种对偶学习生成对抗网络(dual learning generative adversarial network,DLGAN),该网络可以在对偶学习的训练模式下使用非成对的模糊图像和清晰图像进行图像去模糊计算,不再要求训练图像集合必... 详细信息

针对动态场景下的图像去模糊问题,提出一种对偶学习生成对抗网络(dual learning generative adversarial network,DLGAN),该网络可以在对偶学习的训练模式下使用非成对的模糊图像和清晰图像进行图像去模糊计算,不再要求训练图像集合必须由模糊图像与其对应的清晰图像成对组合而成.DLGAN利用去模糊任务与重模糊任务之间的对偶性建立反馈信号,并使用这个信号约束去模糊任务和重模糊任务从两个不同的方向互相学习和更新,直到收敛.实验结果表明,在结构相似度和可视化评估方面,DLGAN与9种使用成对数据集训练的图像去模糊方法相比具有更好的性能.

关键词：动态场景去模糊对偶学习生成对抗网络注意力引导特征图损耗函数

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一种用于“远程课堂”的学生听课专注度自动评估方法

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北京理工大学学报 2024年第5期44卷 530-537页

作者：邵帅李思敏广田薰戴亚平北京理工大学自动化学院北京100081 中国电子科技集团公司第五十研究所上海200331 北京理工大学唐山研究所河北唐山063611

在基于互联网的“远程课堂”中,如何利用学生课堂状态视频数据建立教师与学生授课−听课之间的评价关联关系,是一项富有挑战性的科学问题.本文针对“远程课堂”中的学生行为检测识别问题,提出针对课堂学生“面部姿态角度”检测模块与“... 详细信息

在基于互联网的“远程课堂”中,如何利用学生课堂状态视频数据建立教师与学生授课−听课之间的评价关联关系,是一项富有挑战性的科学问题.本文针对“远程课堂”中的学生行为检测识别问题,提出针对课堂学生“面部姿态角度”检测模块与“身体动作行为”识别模块,对学生的课堂行为进行识别分类;针对“学生听课专注度”的定量分析问题,提出一种基于学生面部姿态角度和行为分类结果的量化评估算法;运用证据理论对“面部姿态”与“动作行为”并行进行数据融合计算,建立用于“远程课堂”的在线“学生听课专注度”自动评估系统模型.本文所提模型能够对课堂学生的听课行为进行在线检测与分析,完成“学生听课专注度”的定量评分并输出评估结果.实验中,系统对“学生听课专注度”的评估准确度达到90.4%,验证了系统的有效性.

关键词：深度学习图像分析行为识别数据融合远程课堂专注度评估

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Successful live birth following hysteroscopic adhesiolysis under laparoscopic observation for Asherman’s syndrome: A case report

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World Journal of Clinical Cases 2022年第32期10卷 11949-11954页

作者： Toshiyuki Kakinuma kaoru Kakinuma Yoshio Matsuda Michitaka Ohwada kaoru Yanagida Department of Obstetrics and Gynecology International University of Health and Welfare HospitalNasushiobara-City 329-2763TochigiJapan

BACKGROUND Asherman’s syndrome is characterized by reduced menstrual volume and adhesions within the uterine cavity and cervix,resulting in inability to carry a pregnancy to term,placental malformation,or infertility.We present the case of a 40-year-old woman diagnosed with Asherman’s syndrome who successfully gave birth to a live full-term neonate after hysteroscopic adhesiolysis under laparoscopic observation,intrauterine device insertion,and Kaufmann therapy.CASE SUMMARY A 40-year-old woman(Gravida 3,Para 0)arrived at our hospital for specialist care to carry her pregnancy to term.She had previously undergone six sessions of dilation and curettage owing to a hydatidiform mole and persistent trophoblastic disease,followed by chemotherapy.She subsequently became pregnant twice,but both pregnancies resulted in spontaneous miscarriages during the first trimester.Her menstrual periods were very light and of short duration.Hysteroscopic adhesiolysis with concurrent laparoscopy was performed,and Asherman’s syndrome was diagnosed.The uterine adhesions covered the area from the internal cervical os to the uterine fundus.Postoperative Kaufmann therapy was administered,and endometrial regeneration was confirmed using hysteroscopy.She became pregnant 9 mo postoperatively and delivered through elective cesarean section at 37 wk of gestation.The postpartum course was uneventful,and she was discharged on postoperative day 7.CONCLUSION Hysteroscopic adhesiolysis with concurrent laparoscopy enables identification and resection of the affected area and safe and accurate surgery,without complications.

关键词： Hysteroscopic surgery Laparoscopy Intrauterine devices Live birth Pregnancy Case report

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Efficacy of transvaginal ultrasound-guided local injections of absolute ethanol for ectopic pregnancies with intrauterine implantation sites

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World Journal of Clinical Cases 2023年第4期11卷 788-796页

作者： Toshiyuki Kakinuma kaoru Kakinuma Yoshio Matsuda kaoru Yanagida Michitaka Ohwada HirotsuneKaijima Department of Obstetrics and Gynecology International University of Health and Welfare HospitalNasushiobara 329-2763Japan Minatomirai Yume Clinic Yokohama 2200012Japan

BACKGROUND Cervical pregnancies,interstitial tubal pregnancies,and cesarean scar pregnancies,which are ectopic pregnancies with intrauterine implantation sites exhibit increasing trends with the recent widespread use of assisted reproductive technologies and increased rate of cesarean deliveries.The development of highsensitivity human chorionic gonadotropin testing reagents and the increased precision of transvaginal ultrasonic tomography have made early diagnosis possible and have enabled treatment.Removal of ectopic pregnancies using methotrexate therapy and/or uterine artery embolization has been reported.However,delayed resumption of infertility treatments after methotrexate therapy is indicated,and negative effects on the next pregnancy after uterine artery embolization have been reported.AIM To examine the efficacy and safety of ultrasound-guided topical absolute ethanol injection in ectopic pregnancies with an intrauterine implantation site.METHODS In this study,we retrospectively examined the medical records of 21 patients who were diagnosed with an ectopic pregnancy with an intrauterine implantation site at our hospital,between April 2010 and December 2018,and underwent transvaginal ultrasound-guided local injections of absolute ethanol to determine the treatment outcomes.We evaluated the treatment methods,treatment outcomes,presence of bleeding requiring hemostasis measures and blood transfusion,complications,and treatment periods.Successful treatment was defined as the completion of treatment using transvaginal ultrasound-guided local injections of absolute ethanol alone.RESULTS There were 21 total cases comprising 10 cervical pregnancies,10 interstitial tubal pregnancies,and 1 cesarean scar pregnancy.All patients completed treatment with this method.No massive hemorrhaging or serious adverse reactions were observed during treatment.The mean gestation ages at the time of diagnosis were 5.9 wk(SD,±0.9 wk)for cervical and 6.9 wk(SD,±2.1 wk)for interstitial tubal pregnancies.The total ethanol doses were

关键词： Embryo transfer Fertility Fertilization in vitro Pregnancy complications Prenatal care Ectopic pregnancy

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Ultrasound-guided local ethanol injection for fertility-preserving cervical pregnancy accompanied by fetal heartbeat: Two case reports

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World Journal of Clinical Cases 2022年第11期10卷 3587-3592页

作者： Toshiyuki Kakinuma kaoru Kakinuma Yoshio Matsuda Michitaka Ohwada kaoru Yanagida Hirotsune Kaijima Department of Obstetrics and Gynecology International University of Health and Welfare HospitalNasushiobara 329-2763Japan Minatomirai Yume Clinic Yokohama 220-0012Japan

BACKGROUND The incidence of cervical pregnancy is increasing due to the recent widespread application of assisted reproductive technology.Although hysterectomy has been a treatment option,high-sensitivity human chorionic gonadotropin testing and improved accuracy of transvaginal ultrasound imaging have increased possibility of uterine preservation.Dilation and curettage with methotrexate therapy and uterine artery embolization have been reported as treatments with fertility preservation;however,certain disadvantages limit their use.CASE SUMMARY In our two reported cases,we avoided massive bleeding and immediately resumed infertility treatment using ultrasound-guided local ethanol injection for cervical pregnancies with fetal heartbeats.CONCLUSION This treatment may be a new fertility-preserving option for cervical pregnancy.

关键词： Ultrasonography Ethanol Infertility Fertility preservation Methotrexate Case report

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