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The isolation and identification of apolipoprotein C-I in hormone-refractory prostate cancer using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry

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Asian Journal of Andrology 2009年第3期11卷 299-307页

作者： kaori yamamoto-Ishikawa Hiroyoshi Suzuki Masahiko Nezu Naoto Kamiya Takashi Imamoto Akira Komiya Kazuyuki Sogawa Takeshi Tomonaga Fumlo Nomur Tomohiko Ichikawa Department of Urology Graduate School of Medicine Chiba University Chiba 260-8670 Japan Department of Molecular Diagnosis Graduate School of Medicine Chiba University Chiba 260-8670 Japan

Androgens play a central role in prostate cancer pathogenesis, and hence most of the patients respond to androgen deprivation therapies. However, patients tend to relapse with aggressive prostate cancer, which has been termed as hormone refractory. To identify the proteins that mediate progression to the hormone-refractory state, we used protein-chip technology for mass profiling of patients＇ sera. This study included 16 patients with metastatic hormone-refractory prostate cancer who were initially treated with androgen deprivation therapy. Serum samples were collected from each patient at five time points： point A, pre-treatment; point B, at the nadir of the prostate- specific antigen （PSA） level; point C, PSA failure; point D, the early hormone-refractory phase; and point E, the late hormone-refractory phase. Using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry, we performed protein mass profiling of the patients＇ sera and identified a 6 640-Da peak that increased with disease progression. Target proteins were partially purified, and by amino acid sequencing the peak was identified as a fragment of apolipoprotein C-I （ApoC-I）. Serum ApoC-I protein levels increased with disease progression. On immunohistochemical analysis, the ApoC-i protein was found localized to the cytoplasm of the hormone-refractory cancer cells. In this study, we showed an increase in serum ApoC-I protein levels in prostate cancer patients during their progression to the hormone-refractory state, which suggests that ApoC-I protein is related to progression of prostate cancer. However, as the exact role of ApoC-I in prostate cancer pathogenesis is unclear, further research is required.

关键词： apolipoprotein C-I hormonal therapy prognosis prostate cancer surface-enhanced laser desorption/ionization time-offlight mass spectrometry

糖尿病黄斑水肿玻璃体手术治疗1a预后(英文)

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国际眼科杂志 2005年第6期5卷 1097-1103页

作者：张玮山本香织堀贞夫日本东京女子医科大学眼科

目的:观察玻璃体手术治疗糖尿病黄斑水肿(DME)术后1a的疗效。方法:对89例(116眼)糖尿病黄斑水肿患者行玻璃体手术,观察手术前、后患者的视力、黄斑水肿改善程度以及手术并发症的情况。随访时间为1a。结果:随诊1a,术后最佳矫正视力(0.428... 详细信息

目的:观察玻璃体手术治疗糖尿病黄斑水肿(DME)术后1a的疗效。方法:对89例(116眼)糖尿病黄斑水肿患者行玻璃体手术,观察手术前、后患者的视力、黄斑水肿改善程度以及手术并发症的情况。随访时间为1a。结果:随诊1a,术后最佳矫正视力(0.428±0.387〔mean±SD〕)与术前最佳矫正视力(0.285±0.249)比较,差异有非常显著意义(P<0.0001);41只非增殖性糖尿病视网膜病变眼中,术后最佳矫正视力(0.450±0.410)与术前最佳矫正视力(0.291±0.201)比较,差异有显著意义(P=0.0171);75只增殖性糖尿病视网膜病变眼中,术后最佳矫正视力(0.416±0.376)与术前最佳矫正视力(0.282±0.272)比较,差异有非常显著意义(P<0.0001);糖尿病视网膜病变分期对最终视力并无影响。术后,74眼黄斑水肿吸收,占63.8%。随诊中,53眼最佳矫正视力提高2行或2行以上,占45.7%;39眼视力不变,占33.6%;24眼视力下降2行或2行以上,占20.7%。术中及术后并发症包括,医源性视网膜裂孔,玻璃体积血,新生血管性青光眼,黄斑中心凹硬性渗出,黄斑萎缩及黄斑上膜。这些并发症中造成最佳矫正视力下降2行或2行以上的原因是新生血管性青光眼(4眼),黄斑萎缩(10眼),硬性渗出(9眼)及黄斑上膜(1眼)。结论:玻璃体手术可以有效提高糖尿病黄斑水肿患者的视力及改善黄斑水肿,但此治疗有着严重的并发症,因而应仔细认真行术前术后检查,掌握手术技巧。

关键词：糖尿病黄斑水肿玻璃体手术非增殖性糖尿病视网膜病变增殖性糖尿病视网膜病变术后视力

光学相干断层扫描技术在糖尿病黄斑水肿的应用(英文)

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国际眼科杂志 2006年第1期6卷 30-34页

作者：张玮山本香织堀贞夫日本东京女了医科大学眼科

光学相干断层扫描技术是一种高分辨率,非接触性的生物组织成像技术,能在活体上动态的观察一些眼底疾病发生发展的过程,近年来光学相干断层扫描技术在对糖尿病黄斑水肿的临床诊治和研究工作中发挥了很大的作用。本文就光学相干断层扫描... 详细信息

光学相干断层扫描技术是一种高分辨率,非接触性的生物组织成像技术,能在活体上动态的观察一些眼底疾病发生发展的过程,近年来光学相干断层扫描技术在对糖尿病黄斑水肿的临床诊治和研究工作中发挥了很大的作用。本文就光学相干断层扫描技术对糖尿病黄斑水肿的应用作一综述。

关键词：糖尿病黄斑水肿光学相干断层扫描技术干涉容积光学相干断层扫描技术

Clinically diagnosed late-onset fulminant Wilson's disease without cirrhosis: A case report

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World Journal of Gastroenterology 2018年第2期24卷 290-296页

作者： Takahiro Amano Tokuhiro Matsubara Tsutomu Nishida Hiromi Shimakoshi Akiyoshi Shimoda Aya Sugimoto Kei Takahashi kaori Mukai Masashi yamamoto Shiro Hayashi Sachiko Nakajima Koji Fukui Masami Inada Department of Gastroenterology and Hepatology Toyonaka Municipal Hospital

A 64-year-old woman was referred to our hospital with jaundice of the bulbar conjunctiva and general fatigue. After admission, she developed hepatic encephalopathy and was diagnosed with fulminant hepatitis based on the American Association for the Study of Liver Disease(AASLD) position paper. Afterwards, additional laboratory findings revealed that serum ceruloplasmin levels were reduced, urinary copper levels were greatly elevated and Wilson's disease(WD)-specific routine tests were positive, but the Kayser-Fleischer ring was not clear. Based on the AASLD practice guidelines for the diagnosis and treatment of WD, the patient was ultimately diagnosed with fulminant WD. Then, administration of penicillamine and zinc acetate was initiated; however, the patient unfortunately died from acute pneumonia on the 28 th day of hospitalization. At autopsy, the liver did not show a bridging pattern of fibrosis suggestive of chronic liver injury. Here, we present the case of a patient with clinically diagnosed late-onset fulminant WD without cirrhosis, who had positive disease-specific routine tests.

关键词： Wilson’s disease Fulminant hepatitis Lateonset Liver cirrhosis Copper

Factor Structure and Measurement Invariance of the Japanese Version of the Mother-to-Infant Bonding Scale

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Advances in Reproductive Sciences 2023年第4期11卷 159-170页

作者： Mami yamamoto Fumie Takauma Katsuhiko Tada kaori Baba Toshinori Kitamura Graduate School of Nursing Science St. Luke’s International University Tokyo Japan Toubi Branch Bizen Public Health Center Okayama Japan Department of Obstetrics and Gynaecology National Hospital Organization Okayama Medical Centre Okayama Japan Unit for Mental Health Promotion Research Center for Social Science & Medicine Tokyo Metropolitan Institute of Medical Science Tokyo Japan Kitamura Institute of Mental Health Tokyo Tokyo Japan Kitamura KOKORO Clinic Mental Health Tokyo Japan T. and F. Kitamura Foundation for Studies and Skill Advancement in Mental Health Tokyo Japan Department of Psychiatry Graduate School of Medicine Nagoya University Nagoya Japan

Background: Bonding disorders affect the growth and development of infants. In Japan, the Japanese version of the Mother-to-Infant Bonding Scale (MIBS-J) is widely used for early detection of bonding disorders. Repeated use of a questionnaire has problems of reduced validity. In order to correctly detect bonding disorders at multiple time points, it is necessary to confirm the measurement invariance of the scale. Baba et al. reported that invariance of the MIBS-J factor structure could only be obtained by abridging the scale into three items. Purpose: The aim of this study was to 1) confirm the factor structure and measurement invariance of the MIBS-J between two measurement times and 2) to examine factors that can be used without being affected by measurement time in order to identify item that contribute to measure met invariance. Methods: We analysed the data of 1049 and 878 mothers with a neonate collected in two waves: 5 days (Wave 1) and 1 month postpartum (Wave 2). Exploratory and confirmatory factor analyses were conducted on the data randomly divided into two groups in each wave. Results: The three-item model (MIBS-J items 1, 6, and 8) was most accepted. Measurement invariance and structural invariance were confirmed in the model. This was consistent with Baba et al.’s model. Conclusion: The three MIBS-J items showed measurement invariance and structural invariance in Japanese mothers during 1 month postpartum.

关键词： Bonding Disorders Mother-to-Infant Bonding Scale Factor Analysis Measurement Invariance

Impact of time from diagnosis to chemotherapy in advanced gastric cancer: A Propensity Score Matching Study to Balance Prognostic Factors

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World Journal of Gastrointestinal Oncology 2019年第1期11卷 28-38页

作者： Tsutomu Nishida Aya Sugimoto Ryo Tomita Yu Higaki Naoto Osugi Kei Takahashi kaori Mukai Tokuhiro Matsubara Dai Nakamatsu Shiro Hayashi Masashi yamamoto Sachiko Nakajima Koji Fukui Masami Inada Department of Gastroenterology Toyonaka Municipal Hospital

BACKGROUND It is unclear whether treatment delay affects the clinical outcomes of chemotherapy in advanced gastric cancer(A-GC).AIM To assess whether treatment delay affects the clinical outcomes of chemotherapy in *** This single-center retrospective study examined consecutive patients with A-GC between April 2012 and July 2018. In total, 110 patients with stage Ⅳ A-GC who underwent chemotherapy were enrolled. We defined the wait time(WT) as the interval between diagnosis and chemotherapy initiation. We evaluated the influence of WT on overall survival(OS).RESULTS The mean OS was 303 d. The median WT was 17 d. We divided the patients into early and elective WT groups, with a 2-wk cutoff point. There were 46 and 64 patients in the early and elective WT groups, respectively. Compared with the elective WT group, the early WT group had significantly lower albumin(Alb)levels and higher neutrophil/lymphocyte ratios and C-reactive protein(CRP)levels but not a lower performance status. The elective WT group underwent more combination chemotherapy than did the early WT group. OS was different between the two groups(230 d vs 340 d, respectively). Multivariate analysis revealed that higher CRP levels, lower Alb levels and monotherapy were significantly related to a poor prognosis. To minimize potential selection bias,patients in the elective WT group were 1:1 propensity score matched with patients in the early WT group; no significant difference in OS was found(303 d vs 311 d, respectively, log-rank P = 0.9832).CONCLUSION A longer WT in patients with A-GC does not appear to be associated with a worse prognosis.

关键词： Advanced gastric cancer Waiting time Chemotherapy Prognosis Overall survival

Genetic Characterization of Streptococcus pyogenes emm89 Strains Isolated in Japan From 2011 to 2019

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Infectious Microbes & Diseases 2020年第4期2卷 160-166页

作者： Yujiro Hirose Masaya Yamaguchi Norihiko Takemoto Tohru Miyoshi-Akiyama Tomoko Sumitomo Masanobu Nakata Tadayoshi Ikebe Tomoki Hanada Takahiro Yamaguchi Ryuji Kawahara Rumi Okuno Hitoshi Otsuka Yuko Matsumoto Yuji Terashima Yu Kazawa Noriko Nakanishi Kaoru Uchida Yumi Akiyama kaori Iwabuchi Chikara Nakagawa Kazunari yamamoto Victor Nizet Shigetada Kawabata Department of Oral and Molecular Microbiology Osaka University Graduate School of DentistrySuitaOsakaJapan Department of Pediatrics University of California at San Diego School of MedicineLa JollaCAUSA Department of Infectious Diseases Research InstituteNational Center for Global Health and MedicineTokyoJapan Department of Oral Microbiology Kagoshima University Graduate School of Medical and Dental SciencesKagoshimaJapan Department of Bacteriology I National Institute of Infectious DiseasesTokyoJapan Division of Microbiology Osaka Institute of Public HealthOsaka CityOsakaJapan Department of Microbiology Tokyo Metropolitan Institute of Public HealthTokyoJapan Department of Public Health Sciences Yamaguchi Prefectural Institute of Public Health and Environment Yamaguchi CityYamaguchiJapan Microbiological Testing and Research Division Yokohama City Institute of Public HealthYokohamaKanagawaJapan Department of Microbiology Fukushima Prefectural Institute of Public HealthFukushima CityFukushimaJapan Department of Infectious Diseases Kobe Institute of HealthKobeHyogoJapan Department of Bacteriology Toyama Institute of HealthImizuToyamaJapan Infectious Disease Research Division Hyogo Prefectural Institute of Public Health ScienceKakogawaHyogoJapan Department of Health Science Iwate Prefectural Research Institute for Environmental Sciences and Public HealthMoriokaIwateJapan Division of Microbiology Kyoto City Institute of Health and Environmental SciencesKyoto CityKyotoJapan Niigata City Institute of Public Health and the Environment Niigata CityNiigataJapan Skaggs School of Pharmaceutical Sciences University of California at San DiegoLa JollaCAUSA.

Invasive infection caused by Streptococcus pyogenes emm89 strains has been increasing in several countries linked to a recently emergent clade of emm89 strains,designated clade *** Japan,the features of emm89 *** strains,such as clade classification,remains *** this study,we collected emm89 strains isolated from both streptococcal toxic shock syndrome(STSS)(89 STSS isolates)and noninvasive infections(72 non-STSS isolates)in Japan from 2011 to 2019,and conducted wholegenome sequencing and comparative analysis,which resulted in classification of a large majority into clade 3 regardless of disease *** addition,invasive disease-associated factors were found among emm89 strains,including mutations of control of virulence sensor,and absence of the hylP1 gene encoding *** findings provide new insights into genetic features of emm89 strains.

关键词： clade 3 emm89 streptococcal toxic shock syndrome Streptococcus pyogenes

Combination of two-hour post-endoscopic retrograde cholangiopancreatography amylase levels and cannulation times is useful for predicting post-endoscopic retrograde cholangiopancreatography pancreatitis

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World Journal of Gastrointestinal Endoscopy 2016年第20期8卷 777-784页

作者： Shiro Hayashi Tsutomu Nishida Hiromi Shimakoshi Akiyoshi Shimoda Takahiro Amano Aya Sugimoto Kei Takahashi kaori Mukai Tokuhiro Matsubara Masashi yamamoto Sachiko Nakajima Koji Fukui Masami Inada Department of Gastroenterology and Hepatology Toyonaka Municipal Hospital

AIM To estimate the efficacy of 2 h post-endoscopic retrograde cholangiopancreatography(ERCP) serum amylase levels and other factors for predicting postERCP *** This was a retrospective,single-center cohort study of consecutive patients who underwent ERCP from January 2010 to December *** amylase levels were measured 2 h post-procedure,and patient- and procedure-related pancreatitis(PEP) risk factors wereanalyzed using a logistic *** A total of 1520 cases(average age 72 ± 12 years,60% male) were initially enrolled in this study,and 1403 cases(725 patients) were ultimately analyzed after the exclusion of 117 ***-five of these cases developed *** established a 2 h serum amylase cutoff level of two times the upper limit of normal for predicting *** analysis revealed that a cannulation time of more than 13 min [odds ratio(OR) 2.28,95%CI:1.132-4.651,P=0.0210] and 2 h amylase levels greater than the cutoff level(OR=24.1,95%CI:11.56-57.13,P<0.0001) were significant predictive factors for ***-seven of the 55 patients who developed PEP exhibited 2 h amylase levels greater than the cutoff level(85%),and six of the remaining eight patients who developed PEP(75%) required longer cannulation *** 2 of the 1403 patients(0.14%) who developed PEP did not exhibit concerning 2 h amylase levels or require longer cannulation *** These findings indicate that the combination of 2 h post-ERCP serum amylase levels and cannulation times represents a valuable marker for identifying patients at high risk for PEP.

关键词： Serum amylase levels Cannulation time Post-endoscopic retrograde cholangiopancreatography pancreatitis Predictor