检索结果-南通市图书馆

Mutation analysis and prenatal diagnosis of a family with Griscelli syndrome type 2: two novel mutations in the RAB27A gene

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2017年第4期13卷 392-394页

作者： Patra Yeetong kanya Suphapeetiporn Vorasuk Shotelersuk Division of Human Genetics Department of BotanyFaculty of ScienceChulalongkorn UniversityBangkokThailand Excellence Center for Medical Genetics King Chulalongkorn Memorial Hospitalthe Thai Red Cross SocietyBangkokThailand Center of Excellence for Medical Genetics Department of PediatricsFaculty of MedicineChulalongkorn UniversityBangkokThailand

Griscelli syndrome type 2 (GS2;OMIM#607624) is a rare autosomal recessive disorder characterized by hypomelanosis with immunologic abnormalities and haemophagocytic lymphohistocytosis.[1] Neurological manifestations were reported in 67% of GS2 patients.[2]It is caused by mutations in the RAB27A gene.[3] The RAB27A gene encodes Rab27a,a member of the small GTPase superfamily,involved in vesicular fusion and trafficking.[3] Mutations in the MYO5A,RAB27A,or MLPH genes cause GS 1,GS2 or GS3,*** has been demonstrated that the tripartite protein complex (Rab27a/melanophilin/myosin Va) in melanocytes is needed for capturing mature melanosomes for transferring to keratinocytes.

关键词： Mutation analysis Griscelli syndrome Mutations

Novel mutations in the STK11 gene in Thai patients with Peutz-Jeghers syndrome

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第42期15卷 5364-5367页

作者： Surasawadee Ausavarat Petcharat Leoyklang Paisarn Vejchapipat Voranush Chongsrisawat kanya Suphapeetiporn Vorasuk Shotelersuk Interdepartment of Biomedical Sciences Faculty of Graduate SchoolDivision of Medical Genetics and MetabolismDepartment of PediatricsFaculty of MedicineChulalongkorn UniversityBangkok 10330Thailand Division of Pediatric Surgery Department of SurgeryFaculty of MedicineChulalongkorn UniversityBangkok 10330Thailand Division of Gastroenterology Department of PediatricsFaculty of MedicineChulalongkorn UniversityBangkok 10330Thailand Division of Medical Genetics and Metabolism Department of PediatricsFaculty of MedicineChulalongkorn UniversityBangkok 10330Thailand

Peutz-Jeghers syndrome （PJS）, a rare autosomal dominant inherited disorder, is characterized by hamartomatous gastrointestinal polyps and mucocutaneous pigmentation. Patients with this syndrome have a predisposition to a variety of cancers in multiple organs. Mutations in the serine/threonine kinase 11 （STK11） gene have been identified as a major cause of PJS. Here we present the clinical and molecular findings of two unrelated Thai individuals with PJS. Mutation analysis by Polymerase Chain Reaction-sequencing of the entire coding region of STK11 revealed two potentially pathogenic mutations. One harbored a single nucleotide deletion （c.182delG） in exon 1 resulting in a frameshift leading to premature termination at codon 63 （***61AlafsX63）. The other carried an in-frame 9-base-pair （bp） deletion in exon 7, c.907_915del9 （***303_GIn305del）. Both deletions were de novo and have never been previously described. This study has expanded the genotypic spectrum of the STK11 gene.

关键词： Peutz-Jeghers syndrome Serine/threonine kinase 11 Novel mutations

Effects of anthropogenic disturbances on natural regeneration and population structure of gum arabic tree (Acacia senegal)in the woodlands of Lake Baringo ecosystem, Kenya

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Forestry Research 2017年第4期28卷 775-785页

作者： Stephen F. Omondi David W. Odee George O. Ongamo James I. kanya Damase P. Khasa Kenya Forestry Research Institute P.O. Box 2041200200 NairobiKenya School of Biological Sciences University of NairobiP. O. Box 30197-00100NairobiKenya Centre for Forest Research and Institute for Systems andIntegrative Biology Universite′ LavalSainte-FoyQC G1V 0A6Canada

Despite the ecological and economic importance of Acacia senegal, little is known about the effects of anthropogenic disturbances on its natural regeneration patterns and population structure. We investigated the effects of these factors within the Lake Baringo woodland ecosystem. Data was collected from 60 plots of 20 m × 20 m systematically distributed in four A. senegal-dominated populations within the Lake Baringo woodland. Sample populations spanned a degradation gradient measured by a population disturbance index (PDI). Trees were measured for diameter at breast height (DBH) and categorized by growth stages: seedling, sapling and adult tree. Higher seedling and sapling densities were recorded in lightly than heavily disturbed populations, but only sapling density was significantly different between the two disturbance levels (P = 0.02). Lightly disturbed populations revealed a reversed J-shape size-class distribution (SCD) indicative of stable structure unlike the heavily disturbed populations. The quotient and permutation indices indicated unstable populations with episodic recruitment and mortality. Our study reveals that natural regeneration and population structure of A. senegal were affected majorly by selective harvesting and heavy browsing. Suitable management strategies to control livestock grazing and illegal tree harvesting within the woodland is required to promote conservation of the species genetic resources

关键词： Anthropogenic disturbance Population dynamics Renewal rate Selective harvesting Tropical woodland

泰国清莱地区高校本土汉语教师培养现状调查分析

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

泰国清莱地区高校本土汉语教师培养现状调查分析

作者：甘雅（SAKSITPHINYO kanya）辽宁大学

学位级别：硕士

中泰两国正式建交后,在各个领域的交流日益增强,如政治、经济、社会、教育等领域。泰国汉语学习者的人数随之逐年增长,赴华留学的泰国学生也日益增加。在中国政府的大力支持下,泰国汉语教学出现了快速发展的势头。在汉语教师的师资方面... 详细信息

中泰两国正式建交后,在各个领域的交流日益增强,如政治、经济、社会、教育等领域。泰国汉语学习者的人数随之逐年增长,赴华留学的泰国学生也日益增加。在中国政府的大力支持下,泰国汉语教学出现了快速发展的势头。在汉语教师的师资方面,除了中国国家汉办派往泰国的志愿者以外,泰国本土汉语教师凭借着自身的独特优势,成为了一支重要的力量。但泰国本土教师的师资队伍建设和教师教育方面,还存在许多不足,还不能完全满足泰国汉语教学的需求。因此,本文以泰国清莱地区的两所高校,清莱皇家大学和清莱皇太后大学的汉语教育专业的在校生、毕业生以及在校任教的本土汉语教师为研究对象,调查分析泰国本土汉语教师师资队伍建设、教师培养的现状。研究采取调查问卷和个别采访相结合的方式,首先调查和分析泰国清莱地区高校本土汉语教师培养的基本情况,接着指出其中存在的问题及深层原因,进而针对问题提出解决方案。本文共有五部分,下面逐一概述。绪论部分,主要论述研究原因、研究目的和意义、研究内容、研究方法、研究综述等内容。第一章,从泰国汉语教学的背景、泰国汉语教师师资的困境、本土汉语教师的优势、本土汉语教学的现存问题等几个方面论述泰国本土汉语教师的现实需求。第二章,为泰国高校本土汉语教师培养情况的调查和分析,主要对清莱皇家大学与清莱皇太后大学汉语教师的培养模式、毕业生就业意向和就业情况进行了调查。第三章,对泰国本土汉语教师培养效果进行了评价和分析。主要采用访谈的方式,对目前清莱地区高校本土汉语教师培养的效果进行了解,从而发现本土汉语教师培养的疑难问题并对原因进行分析。第四章,主要针对泰国本土汉语教师培养中的一系列问题提出了自己的建议。最后为结语,主要对本文的内容进行总结,并指出存在的不足。主要问题包括生源质量低、生源数量不稳定、课程内容设置缺乏针对性和实用性、汉语专业能力要求标准较低、师资数量低、就业前景不乐观等问题。本文建议,应建立适用于泰国本土需求的教师标准,支持泰国本土汉语教师赴华进修等。希望能够解决目前泰国汉语教学中的问题,从而使泰国汉语教学事业发展得更好。

关键词：泰国清莱地区高校本土汉语教师培养

Real-Time Computer Analytical Application in Pressure Transient Analysis of Petroleum Reservoirs

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

International Journal of Geosciences 2013年第8期4卷 1186-1192页

作者： kanya Khatri Sadiq A. Shah Agha F. H. Pathan Bilal Shams Ashfaque A. Memon Faisal Hussain Kanwal K. Pinjani Department of Civil Engineering Mehran University of E & T Jamshoro Pakistan Department of Civil Engineering Mehran University of E & T Khaipur Mir’s Campus Khairpur Mir’s Pakistan Department of Mechanical Engineering Mehran University of E & T Khaipur Mir’s Campus Khairpur Mir’s Pakistan Department of Petroleum & Natural Gas Engineering Mehran University of E & T Khairpur Mir’s Pakistan Water Resources Division National Engineering Services Lahore Pakistan

Today with certainty, the petroleum industry is fostering sanguinely the fields’ development programs for the optimization of reservoir characterization through worth-full appliances of computer analysis techniques. The time element is of prime importance for optimistic petroleum development projects. Therefore, the frontline of “Real-time Analysis” is added into the applications of computer solving techniques for achieving and sketching up the real-time cost effectiveness in analyzing field development programs. It focuses on the phases of real-time well test data acquisition system, real-time secure access to the well test data either on field or in office and real-time data interpretation unit. This interface will yield the productive results for the field of reservoir’s pressure transient analysis and wells’ systems analysis by following the up-to-date preferred, accurate and effective well test analytical principles with modern real-time computer applications and techniques. It also lays emphasis for the comfort and reliability of data in creating best interpersonal working modes within a reputable and esteemed petroleum development organization.

关键词： Reservoir Pressure Transient Real-Time Analysis Comfort Computer Applications

Real-Time Modelling and Optimisation for Water and Energy Efficient Surface Irrigation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Water Resource and Protection 2013年第7期5卷 681-688页

作者： kanya L. Khatri Ashfaque A. Memon Yasin Shaikh Agha F. H. Pathan Sadiq A. Shah Kanwal K. Pinjani Rabia Soomro Rod Smith Zaheer Almani Department of Civil Engineering Mehran University of E & T Jamshoro Pakistan Department of Civil Engineering Mehran University of E & T Khairpur Campus Pakistan Department of Industrial Engineering Mehran University of E & T Jamshoro Pakistan Faculty of Engineering and Surveying Queensland USQ Toowoomba Australia Water Resources Division National Engineering Services Lahore Pakistan

The viability and sustainability of crop production is currently threatened by increasing water scarcity. Water scarcity problems can be addressed through improved water productivity and the options usually presumed in this context are efficient water use and conversion of surface irrigation to pressurised systems. By replacing furrow irrigation with drip or centre pivot systems, the water efficiency can be improved by up to 30% to 45%. However, the installation and application of pumps and pipes, and the associated fuels needed for these alternatives increase energy consumption. A balance between the improvement in water use and the potential increase in energy consumption is required. When surface water is used, pressurised irrigation systems increase energy consumption substantially, by between 65% to 75%, and produce greenhouse gas emissions around 1.75 times higher than that of gravity based irrigation systems so their use should be carefully planned keeping in view adverse impact of carbon emissions on the environment and threat of increasing energy prices. With gravity-fed surface irrigation methods, the energy consumption is assumed to be negligible. This study has shown that a novel real-time infiltration model REIP has enabled implementation of real-time optimisation and gravity fed surface irrigation with real-time optimisation has potential to bring significant improvements in irrigation performance along with substantial water savings of 2.92 ML/ha which is equivalent to that given by pressurised systems. The real-time optimisation and control thus offers a modern, environment friendly and water efficient system with close to zero increase in energy consumption and minimal greenhouse gas emissions.

关键词： Water Scarcity Real-Time Optimisation Furrow Irrigation Carbon Emissions REIP

Design and Evaluation of Dadu Canal Lining for Sustainable Water Saving

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Water Resource and Protection 2013年第7期5卷 689-698页

作者： Ashfaque A. Memon Khalifa Q. Leghari Agha F. H. Pathan kanya L. Khatri Sadiq A. Shah Kanwal K. Pinjani Rabia Soomro Kameran Ansari Department of Civil Engineering Mehran UET Khairpur Campus Sindh Pakistan Department of Civil Engineering Mehran UET Jamshoro Sindh Pakistan Water Resources Division National Engineering Services Lahore Pakistan

Pakistan livelihood depends on agriculture and so for this on irrigation system. The irrigation system in Sindh province depends on three barrages. The canals off taking from these three barrages irrigate 5.5 million hectares of agriculture land. Sukkur Barrage, which is the oldest one, irrigates more than 2.0 million hectares of land. The Dadu Canal off taking from Sukkur barrage is an earthen canal. A huge amount of irrigation water is lost from the canal in the form of seepage from banks and bed. It is estimated that 40 to 50 per cent of water is lost between the canal head works to the farm-gate. The seepage from the canal creates twin problems of salinity and water logging consequently a large agriculture land has gone out of use, and this process is continued particularly in Sindh. Lining of Canals is considered an effective solution to this problem. But lining of canals in Sindh is a great issue as canals will need to be closed long enough to deprive the farmers at least one crop season and the farmers are unable to pay this price for canal. Therefore, in this study, the Dadu Canal is proposed to be redesigned as an adjacent lined canal which involves design of cross section for various lining options at locations where changes in the hydraulic conditions occur at cross regulators and fall structures. The proposed lining is preferred to be plain cement concrete lining which is selected after investigating local conditions. Quantity and cost estimation at selected RDs (Reduced Distance) proved feasible and significant in long term functioning of Dadu Canal.

关键词： Dadu Canal Concrete Lining Canal Design Lining Evaluation Sustainable Water Saving