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Journal of Cancer Therapy 2021年第3期12卷 136-145页

作者： kanta ka Doudou Diouf Sidy ka El Hadj Amadou Sall Daniele Presti Mamadou Moustapha Dieng Papa Macoumba Gaye Ahmadou Dem Radiotherapy Department CHNU Dalal Jamm Guédiawaye Senegal Oncology Department Institute Joliot Curie Dakar Senegal Cheikh Anta Diop University of Dakar Dakar Senegal Medical Oncology Service ICS Maugeri IRCCS SpA University of Pavia Pavia Italy

Objectives: To study the epidemiological, diagnostic, therapeutic and prognostic aspects of gastric adenocarcinoma at the Joliot Curie Institute in Dakar. Materials and Methods: We conducted a retrospective study over a seven-year period from January 2010 to December 2017 at the Joliot Curie Institute in Dakar. All cases of gastric adenocarcinoma proven by fibroscopy followed by histology or proven on the histological analysis of a surgical specimen were taken into account. The parameters studied were age, risk factors, stages of the disease, treatment and prognosis. Results: There were 54 cases of gastric adenocarcinoma over a period of 7 years. The average age was 54.74 years with extremes of 25 and 84 years. A male predominance was noted (35/54). The main risk factors found were alcohol (5/54), tobacco (13/54), Helicobacter pilori (4/54), gastric ulcer (12/54). Epigastralgia was the most frequent clinical manifestation. FOGD was carried out in 77.8% of patients. Histology was obtained before surgery in 40 patients (74.1% of cases) and

A Shoulder Mass Revealing a Metastatic Prostate Cancer

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Case Reports in Clinical Medicine 2021年第4期10卷 133-139页

作者： kanta ka Mohamed Jalloh Babacar Sine Oumar Gaye Awa Sadikh Badiane Ibrahima Thiam Mamadou Moustapha Dieng Papa Macoumba Gaye Radiotherapy Department Centre Hospitalier National Universitaire Dalal Jamm Guédiawaye Senegal Urology Department H&ocirc pital Général Idrissa Pouye Grand Yoff Senegal Cheikh Anta Diop University Dakar Senegal Urology Department Centre Hospitalier Universitaire Aristide Le Dantec Dakar Senegal

Introduction: A shoulder mass revealing metastatic prostate cancer is very rare. We report a case of metastatic prostate cancer diagnosed on a shoulder mass and treated with analgesic radiotherapy and chemotherapy and androgen deprivation therapy (ADT). Observations: A 66 years old patient was referred for a painful right shoulder mass whose biopsy and pathological examination found a Gleason 8 (4 + 4) moderately differentiated adenocarcinoma. The PSA level was 508.52 ng/ml. The patient was treated with analgesic radiotherapy on the right shoulder and chemo-hormonal therapy. At 2 years follow-up, the disease was well controlled. Conclusion: A shoulder mass revealing metastatic prostate cancer is not common. Local treatment of the symptomatic metastasis while continuing chemotherapy and ADT improves the quality of life.

关键词： Shoulder Prostate Cancer Metastasis

Radiotherapy of Oligoprogressive Lesions in Castration-Resistant Prostate Cancer: Impact on Second-Generation Hormone Therapy

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Journal of Cancer Therapy 2021年第5期12卷 302-310页

作者： kanta ka Papa Macoumba Gaye Awa Sadikh Badiane Ibrahima Thiam Mouhamadou Bachir Ba Papa Massamba Diene Maimouna Mané Lamine Niang Fatou Samba Ndiaye Radiotherapy Department of Centre Hospitalier National Universitaire Dalal Jamm Guédiawaye Senegal Cheikh Anta Diop University of Dakar Dakar Senegal Hematology Department of Centre Hospitalier Universitaire Dalal Jamm Guédiawaye Senegal

Background: The therapeutic standard for oligoprogressive prostate cancer resistant to castration is second-generation hormone therapy. This systemic treatment is expensive. There are oligoprogressive lesions accessible to radiotherapy. Objectives: To study the impact of radiotherapy of oligoprogressive lesions on the implementation of second generation hormone therapy. Patients and Methods: A retrospective study from 2012 to 2020 was carried out. All patients with oligoprogressive prostate cancer who had received radiotherapy on one or more lesions in progression were collated. Survival was calculated using the Kaplan-Meier method. Results: 8 patients were treated with stereotactic and conformational radiotherapy between August 2012 and August 2020 in the context of oligoprogressive prostate cancer resistant to castration. The median age at diagnosis of oligoprogression was 73 years with a median PSA level of 3.11 ng/ml. Nine lesions were diagnosed with PET scan PSMA. All the lesions were treated by radiotherapy with different regimens. After a median follow-up of 12.5 months, 7 patients showed a biochemical response to treatment with a median decrease in PSA of 67%. The median survival without clinical or biochemical progression was 7 months. The median survival without the need for further systemic treatment was 9 months. During the follow-up period, six patients received second-generation hormone therapy to treat their relapse, and

关键词： Ablative Radiotherapy Hormone Therapy Oligometastasis Prostate Castration-Resistant Cancer

Curative 3D Conformal Radiotherapy of Non-Operated Prostate Adenocarcinoma at Pointe-a-Pitre University Hospital (Guadeloupe): About 29 Cases

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Journal of Cancer Therapy 2021年第5期12卷 279-288页

作者： Ibrahima Thiam kanta ka Awa Sadikh Badiane Mouhamadou Bachir Bâ El Hadj Amadou Sall Boucar Ndong Papa Ahmet Fall Mamadou Moustapha Dieng Papa Macoumba Gaye Joliot Curie Institute of Aristide Le Dantec Hospital Dakar Senegal Radiotherapy Department of the University Hospital Center of Dalal Jamm Guédiawaye Senegal Cheikh Anta Diop University Dakar Senegal Urology Department of the University Hospital Center of Dalal Jamm Guédiawaye Senegal

Context: Technological advances have improved the toxicities of radiotherapy. We are evaluating the 3D technique in prostate cancer. Materials and Methods: Retrospective study from January 2015 to December 2015 with 29 files. Survival was calculated by Kaplan-Meier method. Results: We collected 29 patient records over the study period. The median age was 75 years with the following extremes: 54 years and 83 years. The median PSA level was 12 ng/ml with a range of 3.05 to 79 ng/ml. Gleason score analysis showed 6 patients (20.69%) with a score of 6 (3 + 3), 23 patients (79.31%) with a score of 7 including 12 patients (41.38%) with grade 3 and 11 patients (37.93%) with grade 4. The median dose delivered was 74 Gy, with a mean dose of 73.79 Gy and extremes of 70 Gy for the minimum and 76 Gy for the maximum. Hormone therapy was combined with radiotherapy in 17 patients (58.62%). Seven patients (24.14%) had grade 1 acute bladder toxicity and one patient (3.45%) had grade 2 acute toxicity. Late bladder toxicity was grade 1 in 5 patients (17.24%), grade 2 in 3 patients (10.34%) and grade 3 in 1 patient (3.45%). Late rectal toxicity, grade 2 in 3 patients (10.34%), grade 3 in 1 patient, was noted. Overall survival at 2 years was 100% and 89.65% at 5 years. Relapse-free survival at 2 years was 82.76% and 62.07% at 5 years. There were 3 deaths (10.34%) of which only one was related to prostate cancer.

Management of Phylloid Sarcomas: A Retrospective Study of 12 Cases

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Advances in Breast Cancer Research 2021年第2期10卷 25-33页

作者： kanta ka Abdoul Halim Bague Ibrahim Mounkeila Mamadou Lassana Foba N. Zongo Davide Soldato Filippo Dall’Olio Mamadou Moustapha Dieng Papa Macoumba Gaye Daniele Presti Radiotherapy Department Centre Hospitalier National Universitaire Dalal Jamm de Guédiawaye Guédiawaye Senegal School of Cancer Sciences Paris Sud Orsay French Unité D’oncologie Chirurgicale CHU Yalgado Ouedraogo Ouagadougou Burkina Faso Servie d’Oncologie Institut Joliot Curie Centre Hospitalier Universitaire Aristide Le Dantec Dakar Senegal Department of Plastic Surgery Aristide Le Dantec University Hospital Dakar Senegal University Cheikh Anta Diop of Dakar Dakar Senegal Medical Oncology Service ICS Maugeri IRCCS SpA University of Pavia Pavia Italy

Background: Phylloid sarcomas are rare. There is not enough data to codify the management. Objectives: The objective was to study the clinical and therapeutic aspects and the fate of patients after a follow-up of at least 4 years. Thus contributing to the limited body of knowledge on these tumors. Methods: a retrospective analysis of the files from 2013 to 2017 was carried out and patients were followed up until 2021at Hassan II Hospital. Epidemiological, clinical and therapeutic aspects were studied. Survival was calculated using the Kaplan-Meier method. Results: We collected 12 charts of patients treated for phyllodeal sarcoma from 2013 to 2017. The median age was 43 years. The circumstance of discovery was marked by the presence of nodule in all patients. The coupled echo-mammography examination classified the nodules, ACR 4 in 7 patients and ACR 3 in 3 and ACR 5 in 2 patients. Histological examination revealed a phylloid sarcoma in 11 patients and a borderline phylloid tumor in 1 patient. All patients had radical surgery with positive margins in 2 patients, 16.66%. One patient had revision surgery. Histological examination of the surgical specimens showed phylloid sarcoma on all specimens. All patients had adjuvant radiotherapy with doses of 50 Gy in 25 fractions of 2 Gy and a boost of 10 Gy was done in one patient. The median spread of radiotherapy was 37 days. Grade 1 and 2 skin toxicities were noted in 5 and 3 patients respectively. The median time from surgery to radiotherapy was 2.95 months. 3 patients relapsed after 13.6 months of follow-up. The recurrence-free survival at 1 and 3 years was 83% and

关键词： Phylloid Sarcoma Radiotherapy Survival

Kohonen’s Algorithm Applied to the Scintigraphic Image for an Aid in the Diagnosis of Prostate Cancer Metastasis

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Open Journal of Medical Imaging 2022年第2期12卷 37-47页

作者： Boucar Ndong El Hadji Amadou Lamine Bathily Mamoudou Salif Djigo Mamadou Lamine Mboup François kaly kanta ka Ousseynou Diop Ibrahima Thiam Gora Mbaye Omar Ndoye Mamadou Mbodj Biophysics and Nuclear Medicine Laboratory Cheikh Anta Diop University Dakar Senegal Sustainable Development and Society Doctoral School Thies University Thies Senegal Laboratoire du traitement de l’information/ESP/UCAD Senegal Radiotherapy Department of the National Hospital University Center Dalal Jamm Guédiawaye Dakar Sénégal Physics Pharmaceutical Laboratory Cheikh Anta Diop University Dakar Senegal

To partition the scintigraphic image, several methods are used, among which is Kohonen’s self-organizing map algorithm. The objective of this study was to perform an ascending hierarchical classification (HAC) on the results of the Kohonen self-organizing map. This makes it possible to carry out the second phase necessary for the elaboration of the classifier by grouping the neurons as well as possible into 3 classes then by reconstituting the scintigraphic image from the 3 classes. This partition proceeds by successive groups, thus merging at each iteration two subsets of neurons using a measure of similarity which is Ward’s method. In this method, the algorithm aggregates the nearest neurons into classes. This allows us to obtain a dendrogram that looks like a tree. And this one needs to be cut. And to have an adequate cut-off level, we have established the variation of the Davies Bouldin index as a function of the number of classes. The minimum value of this index gave the optimal number of classes which corresponded to 3 in the study. These three groups A, B, C have a variable intensity. This intensity can be high, it can be medium or low. The high, medium and low intensities corresponded respectively to metastases for class A, to degenerative or inflammatory phenomena for class B and to normal radiopharmaceutical uptake for class C. To confirm this strong suspicion, we performed reconstructions using a filter. And after this reconstruction, we had images like at the entrance. And for the interpretation of these images, we used a visual metric. This enabled us to note that for the interval [0 - 50[, the image is not contrasted and no lesion could be detected. Over the interval [50 - 200[, we observed the distribution of the radiopharmaceutical over the entire skeletal whole body. On this reconstruction interval, the visual metric shows hypofixation in the bladder and areas suspected of metastases. Over the interval [200 - 250[, we detected hyperfixations linked

关键词： Neural Networks Hierarchical Ascending Classification Scintigraph

Inventory of Radiation Protection in Hospitals of Level III in Senegal

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Open Journal of Biophysics 2021年第4期11卷 397-406页

作者： Boucar Ndong Sidi Ahmed Dia Mamadou Salif Djigo Herbert Fachinan El Hadji Lamine Bathily Ousseynou Diop kanta ka Gérard Léra Kelvin Akpo El Hadji Fallou Diouf Louis Auguinstin Diaga Diouf Pape Mady Sy Alphonse Djiboune Gora Mbaye Maguette Diagne Omar Ndoye Mamadou Mbodji Laboratoire de Biophysique Médecine Nucléaire Universite Cheikh Anta Diop Dakar Senegal Service de Médecine du Travail Universite Cheikh Anta Diop Dakar Senegal Faculté de Médecine Université de Parakou Parakou Benin Service de Radiothérapie de Dalal Jamm Dakar Senegal Service de Radiologie de l’Hô pital Aristide Le Dantec Dakar Senegal Laboratoire de Physique Pharmaceutique Universite Cheikh Anta Diop Dakar Senegal Service de Radiothérapie de l’Hô pital Aristide Le Dantec Dakar Senegal

The aim of this study was to evaluate the level of protection of employees who are exposed to radiation in a level III hospital establishment. It was a descriptive cross-sectional survey of six months’ duration, involving eight level III Hospitals (Aristide Le Dantec, Fann, Hoggy, Hear, Abass Ndao, Pikine, Touba, and Thiès) in Senegal. Sixty-one of the one hundred questionnaires were recovered (overall response rate of 61%). The population of the study was mainly female (54.1%). The average age was 38.57 with extremes ranging from 23 to 65 years old. In the places where ionizing radiation sources are handled, only at the Aristide Le Dantec Hospital did we find a “competent person in radiation protection”. This explained the lack of a classification of employees and work areas. Forty out of sixty-one (73.77%) had no knowledge of the basic principles of radiation protection (justification, optimisation, dose limitation) and had not ever taken radiation holidays. For radiovigilance, exposure time limits to ionizing radiation concerned only 29/61 or 47.54% of the study population. The inverse square law of distance was known by only 40 workers, of whom 15 had no compliance. We found the presence of dosifilms in only 7/61 or 11.47% of the workers. On the other hand, the use of lead aprons was well established and concerned 57/61 workers, i.e., 93.44%. In sum, ionizing radiation causes adverse health effects. The absence of a good radiation protection culture in Senegal requires the presence of at least 4 to 5 competent persons in radiation protection for quality training of workers in radiobiology, radiopathology and radiation protection.

关键词： Ionizing Radiation Radiation Protection Workers Senegal

Gastric Adenocarcinoma at the Joliot Curie Institute in Dakar: Epidemiological, Diagnostic and Therapeutic Aspects about 54 Cases

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A Shoulder Mass Revealing a Metastatic Prostate Cancer

Journal of Cancer Therapy 2021年第3期

作者： kanta ka Doudou Diouf Sidy ka El Hadj Amadou Sall Daniele Presti Mamadou Moustapha Dieng Papa Macoumba Gaye Ahmadou Dem

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Management of Phylloid Sarcomas:A Retrospective Study of 12 Cases

Case Reports in Clinical Medicine 2021年第4期

作者： kanta ka Mohamed Jalloh Babacar Sine Oumar Gaye Awa Sadikh Badiane Ibrahima Thiam Mamadou Moustapha Dieng Papa Macoumba Gaye

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