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Oocyte Cryopreservation before Tumorectomy in Gorlin-Goltz Syndrome with Recurrent Ovarian Fibroma: A Case Report

Open Journal of Obstetrics and Gynecology 2018年第10期8卷 836-846页

作者： Makoto Chihara Atsushi Fujimoto kanna ogi Tatsuya Ishiguro Kunihiko Yoshida Masayuki Sekine Koich Takakuwa Hiroki Fujikawa Yutaka Shimomura Takayuki Enomoto Department of Dermatology Niigata University Graduate School of Medical and Dental Sciences Niigata Japan Department of Obstetrics and Gynecology Niigata University Graduate School of Medical and Dental Sciences Niigata Japan Department of Dermatology Niigata University Graduate School of Medical and Dental Sciences Niigata Japan Department of Dermatology Yamaguchi University Graduate School of Medicine Yamaguchi Japan

Background: Gorlin-Goltz syndrome is a very rare syndrome that reportedly occurs in 1 of 235,800 people in Japan. The proportion of women with Gorlin-Goltz syndrome complicated with an ovarian fibroma ranges from 12.5% to 17.0%. Some surgical cases of Gorlin-Goltz syndrome with an ovarian tumor have been reported. However, no studies have mentioned subsequent fertility preservation by using oocyte cryopreservation process. Case: In this case report, the patient with Gorlin-Goltz syndrome underwent laparotomy for bilateral ovarian fibrothecoma at 15 years of age. At 20 years of age, a recurrent ovarian tumor was detected in the remaining ovary. During the follow-up, we detected an increase in its size. As tumor torsion requiring left salpingo-oophorectomy was possible, tumorectomy was considered. However, her anti-Müllerian hormone level was low. As she was at risk for premature ovarian failure after tumorectomy, we planned to cryopreserve her oocytes to preserve her fertility before tumorectomy. Outcome: When the patient underwent surgery, the diameter of her left ovarian tumor was found to have increased to 56 mm. Egg collection was performed twice, and two oocytes were cryopreserved. Subsequently, she underwent tumorectomy of the left ovarian tumor. No recurrence has been observed. Conclusion: If a recurrent ovarian tumor is detected in patients with Gorlin-Goltz syndrome and a low anti-Müllerian hormone level, cryopreservation of oocytes before tumorectomy may be effective for preserving their fertility.

关键词： Case Reports Cryopreservation Fibroma Gorlin-Goltz Syndrome Recurrence

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